
Dr Lindsay Wu
Fields of research: Animal Cell and Molecular Biology, Biochemistry and Cell Biology, Protein Targeting and Signal Transduction, Cell Metabolism, Reproduction
Contact Details
Phone: +61 2 9385 1621
Email: lindsay.wu@unsw.edu.au
Supervision
- PHD
- Masters
- Honours
Tabs
Publications related to this Person
Book Chapters
Wu L, 2020, 'Hepatic regeneration in aging: Cell type plasticity and redundancies', in Nilsson S (ed.), The Stem Cell Niche during Ageing, Academic Press, http://dx.doi.org/10.1016/bs.asn.2020.07.002
Massudi H; Wu LE; Sinclair DA, 2016, 'Sirtuin Activation by Small Molecules', in Houtkooper RH (ed.), SIRTUINS, edn. Proteins and Cell Regulation, SPRINGER, pp. 243 - 266, http://dx.doi.org/10.1007/978-94-024-0962-8_12
Journal articles
Bertoldo MJ; Rodriguez Paris V; Gook DA; Edwards MC; Wu K; Liang CJJ; Marinova MB; Wu LE; Walters KA; Gilchrist RB, 2021, 'Impact of nicotinamide mononucleotide on transplanted mouse ovarian tissue.', Reproduction, vol. 161, pp. 215 - 226, http://dx.doi.org/10.1530/REP-20-0539
Bertoldo MJ; Smitz J; Wu LE; Lee HC; Woodruff TK; Gilchrist RB, 2020, 'Prospects of Rescuing Young Eggs for Oncofertility', Trends in Endocrinology and Metabolism, vol. 31, pp. 708 - 711, http://dx.doi.org/10.1016/j.tem.2020.07.004
Yu J; Laybutt R; Kim L-J; Quek L-E; Wu L; Morris M; Youngson N, 2020, 'EXERCISE-INDUCED BENEFITS ON GLUCOSE HANDLING IN A MODEL OF DIET-INDUCED OBESITY ARE REDUCED BY CONCURRENT NICOTINAMIDE MONONUCLEOTIDE', , http://dx.doi.org/10.1101/2020.06.22.164459
Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2020, 'Erratum: The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice (Cell Metabolism (2014) 19(3) (418–430), (S1550413114000655), (10.1016/j.cmet.2014.02.009))', Cell Metabolism, vol. 31, pp. 654, http://dx.doi.org/10.1016/j.cmet.2020.01.010
Chalmers TJ; Wu LE, 2020, 'Transposable Elements Cross Kingdom Boundaries and Contribute to Inflammation and Ageing: Somatic Acquisition of Foreign Transposable Elements as a Catalyst of Genome Instability, Epigenetic Dysregulation, Inflammation, Senescence, and Ageing', BioEssays, vol. 42, http://dx.doi.org/10.1002/bies.201900197
Bertoldo MJ; Listijono DR; Ho WHJ; Riepsamen AH; Goss DM; Richani D; Jin XL; Mahbub S; Campbell JM; Habibalahi A; Loh WGN; Youngson NA; Maniam J; Wong ASA; Selesniemi K; Bustamante S; Li C; Zhao Y; Marinova MB; Kim LJ; Lau L; Wu RM; Mikolaizak AS; Araki T; Le Couteur DG; Turner N; Morris MJ; Walters KA; Goldys E; O'Neill C; Gilchrist RB; Sinclair DA; Homer HA; Wu LE, 2020, 'NAD+ Repletion Rescues Female Fertility during Reproductive Aging', Cell Reports, vol. 30, pp. 1670 - 1681.e7, http://dx.doi.org/10.1016/j.celrep.2020.01.058
Bertoldo MJ; Listijono DR; Ho WHJ; Riepsamen AH; Goss DM; Richani D; Jin XL; Mahbub S; Campbell JM; Habibalahi A; Loh WGN; Youngson NA; Maniam J; Wong ASA; Selesniemi K; Bustamante S; Li C; Zhao Y; Marinova MB; Kim LJ; Lau L; Wu RM; Mikolaizak AS; Araki T; Le Couteur DG; Turner N; Morris MJ; Walters KA; Goldys E; O'Neill C; Gilchrist RB; Sinclair DA; Homer HA; Wu LE, 2020, 'NAD+ Repletion Rescues Female Fertility during Reproductive Aging', Cell Reports, vol. 30, pp. 1670 - 1681.e7, http://dx.doi.org/10.1016/j.celrep.2020.01.058
Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2019, 'Erratum: Impairment of an Endothelial NAD+-H
Wu LE; Sinclair DA, 2019, 'The elusive NMN transporter is found', Nature Metabolism, vol. 1, pp. 8 - 9, http://dx.doi.org/10.1038/s42255-018-0015-6
Latorre-Muro P; Baeza J; Armstrong EA; Hurtado-Guerrero R; Corzana F; Wu LE; Sinclair DA; López-Buesa P; Carrodeguas JA; Denu JM, 2018, 'Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions', Molecular Cell, vol. 71, pp. 718 - 732.e9, http://dx.doi.org/10.1016/j.molcel.2018.07.031
Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2018, 'Impairment of an Endothelial NAD+-H
Bustamante S; Jayasena T; Richani D; Gilchrist RB; Wu LE; Sinclair DA; Sachdev PS; Braidy N, 2018, 'Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach', Metabolomics, vol. 14, http://dx.doi.org/10.1007/s11306-017-1310-z
Nelson ME; Lahiri S; Chow JDY; Byrne FL; Hargett SR; Breen DS; Olzomer EM; Wu LE; Cooney GJ; Turner N; James DE; Slack-Davis JK; Lackner C; Caldwell SH; Hoehn KL, 2017, 'Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival', Nature Communications, vol. 8, http://dx.doi.org/10.1038/ncomms14689
Chowdhury MKH; Turner N; Bentley NL; Das A; Wu LE; Richani D; Bustamante S; Gilchrist RB; Morris MJ; Shepherd PR; Smith GC, 2017, 'Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep40159
Wu LE; Sinclair DA, 2016, 'Restoring stem cells-all you need is NAD+', Cell Research, vol. 26, pp. 971 - 972, http://dx.doi.org/10.1038/cr.2016.80
Mohamad M; Mitchell SJ; Wu LE; White MY; Cordwell SJ; Mach J; Solon-Biet SM; Boyer D; Nines D; Das A; Catherine Li SY; Warren A; Hilmer SN; Fraser R; Sinclair DA; Simpson SJ; de Cabo R; Le Couteur DG; Cogger VC, 2016, 'Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance', Aging Cell, vol. 15, pp. 706 - 715, http://dx.doi.org/10.1111/acel.12481
Awan Z; Tay ESE; Eyre NS; Wu LE; Beard MR; Boo I; Drummer HE; George J; Douglas MW, 2016, 'Calsyntenin-1 mediates hepatitis C virus replication', Journal of General Virology, vol. 97, pp. 1877 - 1887, http://dx.doi.org/10.1099/jgv.0.000511
Chowdhury MKH; Wu LE; Coleman JLJ; Smith NJ; Morris MJ; Shepherd PR; Smith GC, 2016, 'Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling', Biochemical Journal, vol. 473, pp. 1247 - 1255, http://dx.doi.org/10.1042/BCJ20160121
Cagnone GLM; Tsai TS; Makanji Y; Matthews P; Gould J; Bonkowski MS; Elgass KD; Wong ASA; Wu LE; McKenzie M; Sinclair DA; John JCS, 2016, 'Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep23229
Wu LE; Levina A; Harris HH; Cai Z; Lai B; Vogt S; James DE; Lay PA, 2016, 'Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes', Angewandte Chemie - International Edition, vol. 55, pp. 1742 - 1745, http://dx.doi.org/10.1002/anie.201509065
Wu LE; Levina A; Harris HH; Cai Z; Lai B; Vogt S; James DE; Lay PA, 2016, 'Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes', Angewandte Chemie, vol. 128, pp. 1774 - 1777, http://dx.doi.org/10.1002/ange.201509065
Wu LE; Fazakerley DJ; Cantley J, 2015, 'Circulating AFABP promotes insulin secretion', Obesity, vol. 23, pp. 1525, http://dx.doi.org/10.1002/oby.21175
Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair DA; Homer H, 2015, 'Erratum: Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes (PLoS ONE (2015) 10:5 (e0126194) DOI:10.1371/journal.pone.0126194)', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0126194
Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair D; Homer H, 2015, 'Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0130058
Wu LE; Sinclair DA, 2014, 'SIRT2 controls the pentose phosphate switch', EMBO Journal, vol. 33, pp. 1287 - 1288, http://dx.doi.org/10.15252/embj.201488713
Wu LE; Samocha-Bonet D; Whitworth PT; Fazakerley DJ; Turner N; Biden TJ; James DE; Cantley J, 2014, 'Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity', Molecular Metabolism, vol. 3, pp. 465 - 473, http://dx.doi.org/10.1016/j.molmet.2014.02.005
Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice', Cell Metabolism, vol. 19, pp. 418 - 430, http://dx.doi.org/10.1016/j.cmet.2014.02.009
Wu LE; Solon S; McMahon AC; Ballard JWO; Ruohonen K; Cogger VC; Warren A; Pichaud N; Melvin RG; Gokarn R; Khalil M; Huang X; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'Disparate consequences of macronutrients on appetite, longevity and cardiometabolic health reconciled by nutritional geometry', Cell Metabolism
Wu LE; Gomes AP; Sinclair DA, 2014, 'Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis', Cancer Cell, vol. 25, pp. 12 - 19, http://dx.doi.org/10.1016/j.ccr.2013.12.005
North BJ; Rosenberg MA; Jeganathan KB; Hafner AV; Michan S; Dai J; Baker DJ; Cen Y; Wu LE; Sauve AA; Van Deursen JM; Rosenzweig A; Sinclair DA, 2014, 'SIRT2 induces the checkpoint kinase BubR1 to increase lifespan', EMBO Journal, vol. 33, pp. 1438 - 1453, http://dx.doi.org/10.15252/embj.201386907
Wu LE; Meoli CC; Mangiafico SP; Fazakerley DJ; Cogger VC; Mohamad M; Pant H; Kang MJ; Powter E; Burchfield JG; Xirouchaki CE; Mikolaizak AS; Stöckli J; Kolumam G; Van Bruggen N; Gamble JR; Le Couteur DG; Cooney GJ; Andrikopoulos S; James DE, 2014, 'Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction', Diabetes, vol. 63, pp. 2656 - 2667, http://dx.doi.org/10.2337/db13-1665
Ma X; Yang P; Kaplan WH; Lee BH; Wu LE; Yang JYH; Yasunaga M; Sato K; Chisholm DJ; James DE, 2014, 'ISL1 regulates peroxisome proliferator-activated receptor γ activation and early adipogenesis via bone morphogenetic protein 4-dependent and -independent mechanisms', Molecular and Cellular Biology, vol. 34, pp. 3607 - 3617, http://dx.doi.org/10.1128/MCB.00583-14
Poorten DVD; Samer CF; Ramezani-Moghadam M; Coulter S; Kacevska M; Schrijnders D; Wu LE; McLeod D; Bugianesi E; Komuta M; Roskams T; Hebbard L; George J, 2013, 'Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause?†', Hepatology, vol. 57, pp. 2180 - 2188, http://dx.doi.org/10.1002/hep.26072
Hocking SL; Wu LE; Guilhaus M; Chisholm DJ; James DE, 2010, 'Intrinsic depot-specific differences in the secretome of adipose tissue, preadipocytes, and adipose tissue-derived microvascular endothelial cells', Diabetes, vol. 59, pp. 3008 - 3016, http://dx.doi.org/10.2337/db10-0483
Wu LE; Hocking SL; James DE, 2010, 'Macrophage infiltration and cytokine release in adipose tissue: angiogenesis or inflammation?', Diabetology International, vol. 1, pp. 26 - 34, http://dx.doi.org/10.1007/s13340-010-0003-x
Wu LE; Carter EA; Rayner BS; McLeod AI; Marshall CP; Levina A; Aitken JB; Witting PK; Lai B; Cai Z; Vogt S; Lee YC; Tobin MJ; Harris HH; Lay PA, 2010, 'Silicon Nitride as a Versatile Growth Substrate for Microspectroscopic Imaging and Mapping of Individual Cells.', Molecular Biosystems, vol. 6, pp. 1316 - 1322, http://dx.doi.org/10.1039/c001499k
Crowe SM; Wu LE; Economou C; Turpin S; Matzaris M; Hoehn KL; Hevener A; James DE; Duh E; Watt M, 2009, 'Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity', Cell Metabolism, vol. 10, pp. 40 - 47, http://dx.doi.org/10.1016/j.cmet.2009.06.001
Hoehn K; Hohnen-Behrens C; Cederberg A; Wu LE; Turner N; Yuasa T; Ebina Y; James DE, 2008, 'IRS1-independent defects define major nodes of insulin resistance', Cell Metabolism, vol. 7, pp. 421 - 433, http://dx.doi.org/10.1016/j.cmet.2008.04.005
Vogt S; Lai B; Finney L; Palmer B; Wu LE; Harris H; Paunesku T; de Jonge M; Legnini D; Maser J; Glesne D; Lay P; Woloschak G, 2007, 'Imaging trace elements in cells with x-ray fluorescence microscopy', MICROSCOPY AND MICROANALYSIS, vol. 13, pp. 40 - 41, http://dx.doi.org/10.1017/S1431927607076283
Kim L-J; Chalmers TJ; Smith GC; Das A; Poon EWK; Wang J; Tucker SP; Sinclair DA; Quek L-E; Wu LE, 'Nicotinamide mononucleotide (NMN) deamidation by the gut microbiome and evidence for indirect upregulation of the NAD+ metabolome', , http://dx.doi.org/10.1101/2020.09.10.289561
Conference Papers
Murphy T; Wu L; Sandow S; Das A; Naim H, 2020, 'Effect of Dietary Nicotinamide Mononucleotide (NMN) on Function and Mechanics of Skeletal Muscle Arteries from Aged Mice', in FASEB JOURNAL, WILEY, San Diego, CA, presented at Annual Meeting on Experimental Biology, San Diego, CA, 04 April 2020 - 07 April 2020, http://dx.doi.org/10.1096/fasebj.2020.34.s1.04752
Riepsamen A; Listijono D; Kalani S; Cooke S; Ledger W; Wu L; Sinclair D, 2019, 'Sirtuins are required for forming fertilization-ready eggs', in BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, BJOG: An International Journal of Obstetrics & Gynaecology, Brisbane, Australia, pp. 40 - 40, presented at Royal College of Obstetricians and Gynaecologists World Congress, Brisbane, Australia, 10 April 2019, http://dx.doi.org/10.1111/1471-0528.13368
Chowdhury MKH; Morris M; Turner N; Wu L; Shepherd P; Smith G, 2017, 'Niclosamide blocks glucagon phosphorylation of serine 552 on beta-catenin leading to decrease target genes expression and improve glucose metabolism via PKA signalling pathway', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Chicago, IL, presented at Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology Meeting, Chicago, IL, 22 April 2017 - 26 April 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000405461402087&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Homer H; Riepsamen A; Wu LE; Sinclair D, 2015, 'Sirt2-mediated BubR1 regulation promotes oocyte maturation', in HUMAN REPRODUCTION, OXFORD UNIV PRESS, Lisbon, PORTUGAL, pp. 11 - 11, presented at 31st Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Lisbon, PORTUGAL, 14 June 2015 - 17 June 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359740300024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Wu LE; James DE; Cantley J, 2010, 'Secreted adipocyte fatty acid binding protein (FABP4) forms the molecular basis of the adipo-insular axis', in DIABETOLOGIA, SPRINGER, Stockholm, SWEDEN, pp. S58 - S58, presented at 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), Stockholm, SWEDEN, 20 September 2010 - 24 September 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000280689700124&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Wu LE; Larance M; Ramm G; Raftery M; Guilhaus M; James DE, 2009, 'Proteomic Analysis of Adipokine Secretion in Insulin Resistance', in DIABETES, AMER DIABETES ASSOC, New Orleans, LA, pp. A333 - A334, presented at 69th Annual Meeting of the American-Diabetes-Association, New Orleans, LA, 05 June 2009 - 09 June 2009, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000266352602014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Patents
Sinclair D; Gomes A; Wu L, 2018, NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation, Patent No. 9877981, Patent Agent:, https://pdfpiw.uspto.gov/.piw?Docid=09877981&homeurl=http:%2F%2Fpatft.uspto.gov%2Fnetacgi%2Fnph-Parser%3FSect1%3DPTO1%2526Sect2%3DHITOFF%2526d%3DPALL%2526p%3D1%2526u%3D%25252Fnetahtml%25252FPTO%25252Fsrchnum.htm%2526r%3D1%2526f%3DG%2526l%3D50%2526s1%3D9877981.PN.%2526OS%3DPN%2F9877981%2526RS%3DPN%2F9877981&PageNum=&Rtype=&SectionNum=&idkey=NONE&Input=View+first+page
Working Papers
Bertoldo M; Listijono D; Ho W-HJ; Riepsamen A; Jin X; Selesniemi K; Goss D; Mahbub S; Campbell J; Habibalahi A; Loh W-GN; Youngson N; Maniam J; Wong ASA; Richani D; Li C; Zhao Y; Marinova M; Kim L-J; Lau L; Wu R; Mikolaizak S; Araki T; Le Couteur D; Turner N; Morris M; Walters K; Goldys E; O’Neill C; Gilchrist R; Sinclair D; Homer H; Wu L, 2019, NAD+repletion rescues female fertility during reproductive ageing, http://dx.doi.org/10.1101/721985
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