SoMS Honours
Potential Projects » Molecular & Drug Discovery
Academic | Project Title |
Adapting bacterial motility in the laboratory using experimental evolution | |
Single Molecule Science, SoMS |
Packing a punch: How do cytolytic proteins from natural killer cells form membrane pores? |
Single Molecule Science, SoMS |
Watching protein folding in real time
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Molecular mechanisms of a novel class of cytoskeleton targeted anti-cancer compounds | |
Dr Charles Cox & Prof Boris Martinac Victor Chang Cardiac Research Institute |
Unravelling the 'Mechanome': mechanically-induced changes of cellular signalling pathways |
Oocyte and Ovarian Biology Research Unit |
Non-invasive markers for oocyte quality/reproductive potential |
Garvan Institute of Medical Research |
How does diabetes promote neurodegeneration? |
Building nature’s extraordinary machines: The development of new vaccines and diagnostics | |
A/Prof Megan Lord & Prof John Whitelock Graduate School of Biomedical Engineering |
Development of antibodies to understand the tumour microenvironment and treat disease - This project aims to epitope map antibodies to tumour microenvironment molecules to further fundamental understanding of their role in cancer and to develop therapeutic approaches to modify the tumour microenvironment
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A/Prof Megan Lord & Prof John Whitelock Graduate School of Biomedical Engineering |
Harnessing glycosaminoglycan biosynthesis for next-generation anticoagulant drugs - This project aims to understand the regulators of glycosaminoglycan biosynthesis to bioengineer functional molecules with anticoagulant activity |
A/Prof Megan Lord, Prof John Whitelock & Dr Jelena Rnjak-Kovacina Graduate School of Biomedical Engineering |
Cell-instructive bioengineered molecules for blood vessel tissue engineering - This project will bioengineer cell-instructive molecules called proteoglycans and incorporate them into biomaterials for blood vessel tissue engineering |
Extracellular ATP signalling in the gut and bladder: a role in inflammation? |
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Mas‐related G protein‐coupled receptors as a potential novel target for modulating inflammatory bowel disease |
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Urinary microbiome and bladder disorders | |
Prof Boris Martinac & Dr Charles Cox Victor Chang Cardiac Research Institute |
Understanding the role of mechanosensitive channels in cardiac physiology and pathophysiology |
Novel flavonoid modulators of glycine receptors | |
Structure and activity of membrane proteins with simultaneous single molecule fluorescence and electrophysiologal measurements | |
SWS Clinical School and Ingham Institute for Applied Medical Research |
Identification of novel genetic markers of liver fibrosis and cirrhosis: Development of new diagnostic and therapeutic agents (Honours & MSc) |
SWS Clinical School and Ingham Institute for Applied Medical Research |
Novel antibody and siRNA mediated therapy in liver cancer (Honours & MSc) |
Understanding the molecular pharmacology of orphan G protein-coupled receptors |
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Victor Chang Cardiac Research Institute |
Antibiotic peptides that inhibit ATP synthase |
Prof Jamie Vandenberg & Dr Carus Lau Victor Chang Cardiac Research Institute |
The structural basis for promiscuity of drug binding to hERG K+ channels |
Dr Shafagh Waters & Prof Adam Jaffe Australasian Centre for Personalized Cystic Fibrosis Medicine (ACPCFM) |
Cystic fibrosis derived mini-organs; a model system for precision medicine |
Dr Shafagh Waters & Prof Adam Jaffe Australasian Centre for Personalized Cystic Fibrosis Medicine (ACPCFM) |
Targeted activation of CFTR via manipulation of a non-coding RNA pathway |
Dr Shafagh Waters & Prof Adam Jaffe Australasian Centre for Personalized Cystic Fibrosis Medicine (ACPCFM) |
Harnessing protective and antiapoptotic function of stress granules (SGs) in CF |
Dr Shafagh Waters & Prof Adam Jaffe Australasian Centre for Personalized Cystic Fibrosis Medicine (ACPCFM) |
Serum biomarkers of Cystic Fibrosis Related Diabetes (CFRD) |