SoMS Honours

SoMS Honours

Potential Projects » Molecular & Drug Discovery

 

Academic Project Title

Dr Matthew Baker & Dr Lawrence Lee

EMBL Australia Node for Single Molecule Science, SoMS

Adapting bacterial motility in the laboratory using experimental evolution

A/Prof Till Boecking

Single Molecule Science, SoMS

Packing a punch: How do cytolytic proteins from natural killer cells form membrane pores?

A/Prof Till Boecking

Single Molecule Science, SoMS

Watching protein folding in real time

Prof Peter Gunning

Cellular and Genetic Medicine Unit, SoMS

Molecular mechanisms of a novel class of cytoskeleton targeted anti-cancer compounds

Dr Charles Cox & Prof Boris Martinac

Victor Chang Cardiac Research Institute

Unravelling the 'Mechanome': mechanically-induced changes of cellular signalling pathways

A/Prof Rob Gilchrist

Oocyte and Ovarian Biology Research Unit

Non-invasive markers for oocyte quality/reproductive potential

Dr Daniel Hesselson

Garvan Institute of Medical Research

How does diabetes promote neurodegeneration?

Dr Lawrence Lee

EMBL Australia Node for Single Molecule Science, SoMS

Building nature’s extraordinary machines: The development of new vaccines and diagnostics

A/Prof Megan Lord & Prof John Whitelock

Graduate School of Biomedical Engineering

Development of antibodies to understand the tumour microenvironment and treat disease - This project aims to epitope map antibodies to tumour microenvironment molecules to further fundamental understanding of their role in cancer and to develop therapeutic approaches to modify the tumour microenvironment

A/Prof Megan Lord & Prof John Whitelock

Graduate School of Biomedical Engineering

Harnessing glycosaminoglycan biosynthesis for next-generation anticoagulant drugs - This project aims to understand the regulators of glycosaminoglycan biosynthesis to bioengineer functional molecules with anticoagulant activity

A/Prof Megan LordProf John Whitelock & Dr Jelena Rnjak-Kovacina

Graduate School of Biomedical Engineering

Cell-instructive bioengineered molecules for blood vessel tissue engineering - This project will bioengineer cell-instructive molecules called proteoglycans and incorporate them into biomaterials for blood vessel tissue engineering

A/Prof Lu Liu

Gastrointestinal & Bladder Disease Group, SoMS

Extracellular ATP signalling in the gut and bladder: a role in inflammation?

A/Prof Lu Liu

Gastrointestinal & Bladder Disease Group, SoMS

Mas‐related G protein‐coupled receptors as a potential novel target for modulating inflammatory bowel disease

A/Prof Lu Liu

Gastrointestinal & Bladder Disease Group, SoMS

Urinary microbiome and bladder disorders

Prof Boris Martinac & Dr Charles Cox

Victor Chang Cardiac Research Institute

Understanding the role of mechanosensitive channels in cardiac physiology and pathophysiology

A/Prof Andrew Moorhouse

Membrane & Cellular Biophysics, SoMS

Novel flavonoid modulators of glycine receptors

Dr Kadla Rosholm, Dr Lawrence Lee & Prof Boris Martinac

EMBL Australia Node for Single Molecule Science, SoMS

Structure and activity of membrane proteins with simultaneous single molecule fluorescence and electrophysiologal measurements

Prof Nicholas Shackel

SWS Clinical School and Ingham Institute for Applied Medical Research

Identification of novel genetic markers of liver fibrosis and cirrhosis: Development of new diagnostic and therapeutic agents (Honours & MSc)

Prof Nicholas Shackel

SWS Clinical School and Ingham Institute for Applied Medical Research

Novel antibody and siRNA mediated therapy in liver cancer (Honours & MSc)

Dr Nicola J Smith & Dr Angela Finch

Orphan Receptor Laboratory, SoMS

Understanding the molecular pharmacology of orphan G protein-coupled receptors

Dr Nicola J Smith & Dr Angela Finch

Orphan Receptor Laboratory, SoMS

Signalling bias at the sweet taste receptor

Dr Angela Finch & Dr Nicola J Smith

G Protein-Coupled Receptor Laboratory, SoMS

Effect of single nucleotide polymorphisms in the sweet taste receptor on expression, trafficking and signalling

Dr Angela Finch & Dr Nicola J Smith

G Protein-Coupled Receptor Laboratory, SoMS

Characterisation of novel allosteric modulators for GPCRs

Dr Angela Finch & Dr Nicola J Smith

G Protein-Coupled Receptor Laboratory, SoMS

How is residence time modulated? The role of the orthosteric vestibule and orthosteric binding site in adrenoceptors.

Dr Alastair Stewart

Victor Chang Cardiac Research Institute

Antibiotic peptides that inhibit ATP synthase

Prof Jamie Vandenberg & Dr Carus Lau

Victor Chang Cardiac Research Institute

The structural basis for promiscuity of drug binding to hERG K+ channels

Dr Shafagh Waters & Prof Adam Jaffe

Australasian Centre for Personalized Cystic Fibrosis Medicine (ACPCFM)

Cystic fibrosis derived mini-organs; a model system for precision medicine

Dr Shafagh Waters & Prof Adam Jaffe

Australasian Centre for Personalized Cystic Fibrosis Medicine (ACPCFM)

Targeted activation of CFTR via manipulation of a non-coding RNA pathway

Dr Shafagh Waters & Prof Adam Jaffe

Australasian Centre for Personalized Cystic Fibrosis Medicine (ACPCFM)

Harnessing protective and antiapoptotic function of stress granules (SGs) in CF

Dr Shafagh Waters & Prof Adam Jaffe

Australasian Centre for Personalized Cystic Fibrosis Medicine (ACPCFM)

Serum biomarkers of Cystic Fibrosis Related Diabetes (CFRD)