Interactive Electrophysiology Software

for Research and Teaching

SOFTWARE

MemPotW, ArtMemW and MemCableW are computer-aided learning programs aimed to simulate actual experiments and teach some difficult concepts in electrophysiology. 

  • ArtMemW - simulates an experiment to illustrate how membrane potentials are set up across an ion-selective artificial membrane. It is a good first introduction to membrane potentials, prior to using MemPotW.
  • MemPotW - interactive teaching program simulating the measurement of membrane potentials on excitable cells. MemPotW demonstrates how resting membrane potentials and action potential peaks depend on [K] and [Na] concentrations and on their relative permeabilities
  • MemCableW - simulates a microelectrode experiment which illustrated the passive time-dependent properties of a spherical neuron and the cable properties of a nerve and muscle fibre. Further details are also given in an accompanying screen.

They are available as Windows 32 and 64-bit programs which may be run on Macintosh systems provided they have fully compatible Windows emulation packages.

>> Prices and Teaching background

 MemPotW

 

Liquid Junction Potential Calculator (JPCalcWin) is a new stand-alone  program redeveloped for 32/64-bit Windows by E. Crawford of UNSW from revised and extended MSDOS C++ JPCalc source code, in consultation with P H Barry. 

A special upgrade path is now available for researchers who have purchased JPCalcW.

  • The stand-alone version of JPCalcW can be run under Windows XP, Vista, Windows 7 (32/64-bit), provided it is run under Windows XP Mode (free for Windows 7; see  JPCalcW).  
  • The Liquid Junction Potential Calculator version that comes bundled with pClamp 10 from Axon Instruments (now Molecular Devices) is 32/64-bit compatible. 

>>> Sample screens and demo version details

 image - Interactive Electrophysiology Software

REFERENCE MATERIAL

  • For general information about ion mobility listings, ion mobility-conductivity relationship, JPCalcW manual and demo download (a DOS version only), correction in AxoBits 39 article, etc., click here.
  • Please note sign corrections in the article on liquid junction potentials in the original printed and original pdf version of AxoBits 39 for a priori corrections.  For details and how to get corrected article from the AxoBits 39 pdf download click here.
  • An author preprint of the following paper, which both describes an optimised technique to measure liquid junction potentials and also validates their calculation by the Henderson equation used by the above programs (for monovalent salts and the limited addition of divalent ions), is available at 2013Barry_etal-EBJ&ESM2013-hq.pdf
    •       Barry P.H., Lewis T.M. & Moorhouse A.J. (2013)   An optimised 3 M KCl salt-bridge technique used to measure and validate theoretical liquid junction potential values in patch-clamping and electrophysiology, Eur. Biophys. J., DOI 10.1007/s00249-013-0911-3.   
  • Ionic Mobility Tables The tables in this listing give lists of the ionic mobilities stored in the Junction Potential Calculator programs, JPCalc, JPCalcW and the new JPCalcWin, together with more recent additional ionic values and references for further information. (last updates October 2003)