Regenerated branched fibres are responsible for end stage muscle weakness and necrosis in dystrophinopathies

Project members:

Project main description:

This project examines the role of branched fibres in the pathogenesis of Duchenne muscular dystrophy. The muscle degeneration in this disease is commonly believed to be a direct consequence of dystrophin deficiency. However, the aim of this project will be to show that muscle damage may actually be a consequence of the morphologically abnormal, branched fibres, raising the possibility that dystrophin?s primary function may not be a purely structural one.

Project supporters:

  • University of New South Wales - Goldstar-NHMRC|APP1023523