Scientia Professor Katharina Gaus

Fields of research: Receptors and Membrane Biology, Signal Transduction, Medical Biochemistry: Lipids, Animal Cell and Molecular Biology

Contact Details

Phone: +61 2 9385 1377
Fax: +61 2 9385 1389
Email: k.gaus@unsw.edu.au

Tabs

Main

After studying physics and mathematics at the University of Heidelberg, Germany, I received an MPhil (1996) and PhD (1999) from the University of Cambridge, UK while being supported by the German National Scholarship Foundation (Studienstiftung des deutschen Volkes) that supports the top 1% of the German students and the European Trust of the University of Cambridge. After the applied research at Cambridge, I joined the Cell Biology Group led by Professor Roger Dean and Professor Wendy Jessup at the Heart Research Institute in Sydney on a BASF-sponsored fellowship from the German National Scholarship Foundation (1999-2001).

In 2001, I spent three months at the University of Urbana-Champagne, USA, on an NHF travel grant working with Professor Enrico Gratton. I returned to Australia to take up ARC postdoctoral fellowship linked to a Discovery Grant (2002-2004)

In 2005, I established my own independent research group at the University of New South Wales; having been awarded an NHMRC/NHF co-funded Career Development Award and an ARC Research Fellowship. The focus of the Membrane Cell Biology Group at the Centre for Vascular Research is to understand how lipid domains in the plasma membrane organize and regulate signal transduction processes.

Also in 2005, I received the ARC Early Researcher Award, a NSW Young Tall Poppy Award and an Alexander von Humboldt Fellowship, which allowed me to spend six months in the laboratory of Professor Kai Simons at the Max Planck Institute for Cell Biology and Genetics in Dresden, Germany.

Since 2009, I am an NHMRC Senior Research Fellow and Associate Professor.

In 2010, I received the Young Investigator Award from the Australia and New Zealand Society for Cell and Developmental Biology

University role:

Senior Research Fellow (UNSW)

Research

Research Activity Links:

Socio-economic Objective (SEO) tags:

Expanding Knowledge in the Biological Sciences

Publications related to this Person

Book Chapters

Magenau A; Gaus K, 2014, '3D super-resolution imaging by localization microscopy', in Methods in Membrane Lipids: Second Edition, pp. 123 - 198, http://dx.doi.org/10.1007/978-1-4939-1752-5_11

Cornely R; Grewal T; Gaus K, 2012, 'The actin cytoskeleton and membrane organisation in T lymphocytes', in Cytoskeleton and Human Disease, pp. 103 - 121, http://dx.doi.org/10.1007/978-1-61779-788-0_5

Journal articles

Li YX; Gautam V; Brüstle A; Cockburn IA; Daria VR; Gillespie C; Gaus K; Alt C; Lee WM, 2017, 'Flexible polygon-mirror based laser scanning microscope platform for multiphoton in-vivo imaging', Journal of Biophotonics, http://dx.doi.org/10.1002/jbio.201600289

Pandzic E; Gelissen IC; Whan R; Barter PJ; Sviridov D; Gaus K; Rye KA; Cochran BJ, 2017, 'The ATP binding cassette transporter, ABCG1, localizes to cortical actin filaments', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep42025

Chu EPF; Elso CM; Pollock AH; Alsayb MA; Mackin L; Thomas HE; Kay TWH; Silveira PA; Mansell AS; Gaus K, 2017, 'Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility', Molecular Immunology, vol. 82, pp. 19 - 33, http://dx.doi.org/10.1016/j.molimm.2016.12.007

Lu X; Nicovich PR; Gaus K; Gooding JJ, 2017, 'Towards single molecule biosensors using super-resolution fluorescence microscopy', Biosensors and Bioelectronics, vol. 93, pp. 1 - 8, http://dx.doi.org/10.1016/j.bios.2016.10.048

Goyette J; Gaus K, 2017, 'Mechanisms of protein nanoscale clustering', Current Opinion in Cell Biology, vol. 44, pp. 86 - 92, http://dx.doi.org/10.1016/j.ceb.2016.09.004

Hinde E; Thammasiraphop K; Duong HTT; Yeow J; Karagoz B; Boyer C; Gooding JJ; Gaus K, 2017, 'Pair correlation microscopy reveals the role of nanoparticle shape in intracellular transport and site of drug release', Nature Nanotechnology, vol. 12, pp. 81 - 89, http://dx.doi.org/10.1038/nnano.2016.160

Lou J; Rossy J; Deng Q; Pageon SV; Gaus K, 2016, 'New Insights into How Trafficking Regulates T Cell Receptor Signaling', Frontiers in Cell and Developmental Biology, vol. 4, http://dx.doi.org/10.3389/fcell.2016.00077

Nicovich PR; Janco M; Sobey T; Gajwani M; Obeidy P; Whan R; Gaus K; Gunning PW; Coster ACF; Böcking T, 2016, 'Effect of surface chemistry on tropomyosin binding to actin filaments on surfaces', Cytoskeleton, vol. 73, pp. 729 - 738, http://dx.doi.org/10.1002/cm.21342

Pageon SV; Tabarin T; Yamamoto Y; Ma Y; Nicovich PR; Bridgeman JS; Cohnen A; Benzing C; Gao Y; Crowther MD, 2016, 'Erratum: Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination (National Academy of Sciences (2016) 113:37 (E5454-E5463) DOI: 10.1073/pnas.1607436113)', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, pp. E6905, http://dx.doi.org/10.1073/pnas.1615763113

Pageon SV; Nicovich PR; Mollazade M; Tabarin T; Gaus K, 2016, 'Clus-DoC: A combined cluster detection and colocalization analysis for single-molecule localization microscopy data', Molecular Biology of the Cell, vol. 27, pp. 3627 - 3636, http://dx.doi.org/10.1091/mbc.E16-07-0478

Gaus K; Inoue T, 2016, 'New Biological Frontiers Illuminated by Molecular Sensors and Actuators', Biophysical Journal, vol. 111, pp. E01 - E02, http://dx.doi.org/10.1016/j.bpj.2016.08.012

Gaus K, 2016, 'Biologists Wanted: New Fluorescence Fluctuation Tools for Cell Biology', Biophysical Journal, vol. 111, pp. 677 - 678, http://dx.doi.org/10.1016/j.bpj.2016.07.012

Pageon SV; Tabarin T; Yamamoto Y; Ma Y; Bridgeman JS; Cohnen A; Benzing C; Gao Y; Crowther MD; Tungatt K, 2016, 'Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, pp. E5454 - E5463, http://dx.doi.org/10.1073/pnas.1607436113

Vittorio O; Brandl M; Cirillo G; Kimpton K; Hinde E; Gaus K; Yee E; Kumar N; Duong H; Fleming C, 2016, 'Dextran-Catechin: An anticancer chemically-modified natural compound targeting copper that attenuates neuroblastoma growth', Oncotarget, vol. 7, pp. 47479 - 47493, http://dx.doi.org/10.18632/oncotarget.10201

Gooding JJ; Gaus K, 2016, 'Single-Molecule Sensors: Challenges and Opportunities for Quantitative Analysis', Angewandte Chemie - International Edition, vol. 55, pp. 11354 - 11366, http://dx.doi.org/10.1002/anie.201600495

Pollock AH; Tedla N; Hancock SE; Cornely R; Mitchell TW; Yang Z; Kockx M; Parton RG; Rossy J; Gaus K, 2016, 'Prolonged intake of dietary lipids alters membrane structure and T cell responses in LDLr^-/- mice', Journal of Immunology, vol. 196, pp. 3993 - 4002, http://dx.doi.org/10.4049/jimmunol.1501261

Kapoor-Kaushik N; Hinde E; Compeer EB; Yamamoto Y; Kraus F; Yang Z; Lou J; Pageon SV; Tabarin T; Gaus K, 2016, 'Distinct mechanisms regulate Lck spatial organization in activated T cells', Frontiers in Immunology, vol. 7, http://dx.doi.org/10.3389/fimmu.2016.00083

Al-Zyoud WA; Hynson RMG; Ganuelas LA; Coster ACF; Duff AP; Baker MAB; Stewart AG; Giannoulatou E; Ho JWK; Gaus K, 2016, 'Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site', Nucleic Acids Research, vol. 44, pp. 1411 - 1420, http://dx.doi.org/10.1093/nar/gkv1466

Ma Y; Benda A; Nicovich PR; Gaus K, 2016, 'Measuring membrane association and protein diffusion within membranes with supercritical angle fluorescence microscopy', Biomedical Optics Express, vol. 7, pp. 1561 - 1576, http://dx.doi.org/10.1364/BOE.7.001561

Tran J; Magenau A; Rodriguez M; Rentero C; Royo T; Enrich C; Thomas SR; Grewal T; Gaus K, 2016, 'Activation of endothelial nitric oxide (eNOS) occurs through different membrane domains in endothelial cells', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0151556

Hinde E; Pand E; Yang Z; Ng IHW; Jans DA; Bogoyevitch MA; Gratton E; Gaus K, 2016, 'Quantifying the dynamics of the oligomeric transcription factor STAT3 by pair correlation of molecular brightness', Nature Communications, vol. 7, http://dx.doi.org/10.1038/ncomms11047

Cornely R; Pollock AH; Rentero C; Norris SE; Alvarez-Guaita A; Grewal T; Mitchell T; Enrich C; Moss SE; Parton RG, 2016, 'Annexin A6 regulates interleukin-2-mediated T-cell proliferation', Immunology and Cell Biology, vol. 94, pp. 543 - 553, http://dx.doi.org/10.1038/icb.2016.15

Abu-Siniyeh A; Owen DM; Benzing C; Rinkwitz S; Becker TS; Majumdar A; Gaus K, 2016, 'The aPKC/Par3/Par6 Polarity Complex and Membrane Order Are Functionally Interdependent in Epithelia During Vertebrate Organogenesis', Traffic, vol. 17, pp. 66 - 79, http://dx.doi.org/10.1111/tra.12339

Pandžić E; Rossy J; Gaus K, 2015, 'Tracking molecular dynamics without tracking: Image correlation of photo-activation microscopy', Methods and Applications in Fluorescence, vol. 3, http://dx.doi.org/10.1088/2050-6120/3/1/014006

Magenau A; Owen DM; Yamamoto Y; Tran J; Kwiatek JM; Parton RG; Gaus K, 2015, 'Discreet and distinct clustering of five model membrane proteins revealed by single molecule localization microscopy', Molecular Membrane Biology, vol. 32, pp. 11 - 18, http://dx.doi.org/10.3109/09687688.2014.990997

Benda A; Ma Y; Gaus K, 2015, 'Self-calibrated line-scan STED-FCS to quantify lipid dynamics in model and cell membranes', Biophysical Journal, vol. 108, pp. 596 - 609, http://dx.doi.org/10.1016/j.bpj.2014.12.007

Cheng X; Hinde E; Owen DM; Lowe SB; Reece PJ; Gaus K; Gooding JJ, 2015, 'Enhancing Quantum Dots for Bioimaging using Advanced Surface Chemistry and Advanced Optical Microscopy: Application to Silicon Quantum Dots (SiQDs)', Advanced Materials, vol. 27, pp. 6144 - 6150, http://dx.doi.org/10.1002/adma.201503223

Pham S; Tabarin T; Garvey M; Pade C; Rossy J; Monaghan P; Hyatt A; Böcking T; Leis A; Gaus K, 2015, 'Cryo-electron microscopy and single molecule fluorescent microscopy detect CD4 receptor induced HIV size expansion prior to cell entry', Virology, vol. 486, pp. 121 - 133, http://dx.doi.org/10.1016/j.virol.2015.09.006

Gupta B; Mai K; Lowe SB; Wakefield D; Di Girolamo N; Gaus K; Reece PJ; Gooding JJ, 2015, 'Ultrasensitive and Specific Measurement of Protease Activity Using Functionalized Photonic Crystals', Analytical Chemistry, vol. 87, pp. 9946 - 9953, http://dx.doi.org/10.1021/acs.analchem.5b02529

Yaffe Y; Hugger I; Yassaf IN; Shepshelovitch J; Sklan EH; Elkabetz Y; Yeheskel A; Pasmanik-Chor M; Benzing C; Macmillan A, 2015, 'The myelin proteolipid plasmolipin forms oligomers and induces liquid-ordered membranes in the Golgi complex', Journal of Cell Science, vol. 128, pp. 2293 - 2302, http://dx.doi.org/10.1242/jcs.166249

Gomez GA; McLachlan RW; Wu SK; Caldwell BJ; Moussa E; Verma S; Bastiani M; Priya R; Parton RG; Gaus K, 2015, 'An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions', Molecular Biology of the Cell, vol. 26, pp. 1249 - 1262, http://dx.doi.org/10.1091/mbc.E14-07-1223

Alvarez-Guaita A; Vilà De Muga S; Owen DM; Williamson D; Magenau A; García-Melero A; Reverter M; Hoque M; Cairns R; Cornely R, 2015, 'Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains', British Journal of Pharmacology, vol. 172, pp. 1677 - 1690, http://dx.doi.org/10.1111/bph.13022

Ma Y; Hinde E; Gaus K, 2015, 'Nanodomains in biological membranes', Essays in Biochemistry, vol. 57, pp. 93 - 107, http://dx.doi.org/10.1042/BSE0570093

Klotzsch E; Stiegler J; Ben-Ishay E; Gaus K, 2015, 'Do mechanical forces contribute to nanoscale membrane organisation in T cells?', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1853, pp. 822 - 829, http://dx.doi.org/10.1016/j.bbamcr.2014.10.025

Gambin Y; Ariotti N; McMahon KA; Bastiani M; Sierecki E; Kovtun O; Polinkovsky ME; Magenau A; Jung W; Okano S, 2014, 'Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae', eLife, vol. 3, pp. e01434, http://dx.doi.org/10.7554/eLife.01434

Hinde E; Yokomori K; Gaus K; Hahn KM; Gratton E, 2014, 'Fluctuation-based imaging of nuclear Rac1 activation by protein oligomerisation', Scientific Reports, vol. 4, http://dx.doi.org/10.1038/srep04219

Caldwell BJ; Lucas C; Kee AJ; Gaus K; Gunning PW; Hardeman EC; Yap AS; Gomez GA, 2014, 'Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens', Cytoskeleton, vol. 71, pp. 663 - 676, http://dx.doi.org/10.1002/cm.21202

Bach CT; Murray RZ; Owen D; Gaus K; O'Neill GM, 2014, 'Tropomyosin Tm5NM1 spatially restricts Src kinase activity through perturbation of Rab11 vesicle trafficking', Molecular and Cellular Biology, vol. 34, pp. 4436 - 4446, http://dx.doi.org/10.1128/MCB.00796-14

Kockx M; Karunakaran D; Traini M; Xue J; Huang KY; Nawara D; Gaus K; Jessup W; Robinson PJ; Kritharides L, 2014, 'Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0111186

Lakshminarayan R; Wunder C; Becken U; Howes MT; Benzing C; Arumugam S; Sales S; Ariotti N; Chambon V; Lamaze C, 2014, 'Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers.', Nature cell biology, vol. 16, pp. 595 - 606, http://dx.doi.org/10.1038/ncb2970

Kwiatek JM; Hinde E; Gaus K, 2014, 'Microscopy approaches to investigate protein dynamics and lipid organization', Molecular Membrane Biology, vol. 31, pp. 141 - 151, http://dx.doi.org/10.3109/09687688.2014.937469

Guan B; Magenau A; Ciampi S; Gaus K; Reece PJ; Gooding JJ, 2014, 'Antibody modified porous silicon microparticles for the selective capture of cells', Bioconjugate Chemistry, vol. 25, pp. 1282 - 1289, http://dx.doi.org/10.1021/bc500144u

Chockalingam M; Magenau A; Parker SG; Parviz M; Vivekchand SRC; Gaus K; Gooding JJ, 2014, 'Biointerfaces on indium-tin oxide prepared from organophosphonic acid self-assembled monolayers', Langmuir, vol. 30, pp. 8509 - 8515, http://dx.doi.org/10.1021/la501774b

Chaudhary N; Gomez GA; Howes MT; Lo HP; McMahon KA; Rae JA; Schieber NL; Hill MM; Gaus K; Yap AS, 2014, 'Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate Clathrin-Independent Endocytosis', PLoS Biology, vol. 12, http://dx.doi.org/10.1371/journal.pbio.1001832

Rossy J; Ma Y; Gaus K, 2014, 'The organisation of the cell membrane: Do proteins rule lipids?', Current Opinion in Chemical Biology, vol. 20, pp. 54 - 59, http://dx.doi.org/10.1016/j.cbpa.2014.04.009

Cheng X; Lowe SB; Ciampi S; Magenau A; Gaus K; Reece PJ; Gooding JJ, 2014, 'Versatile "click chemistry" Approach to functionalizing silicon quantum dots: Applications toward fluorescent cellular imaging', Langmuir, vol. 30, pp. 5209 - 5216, http://dx.doi.org/10.1021/la500945f

Gambin Y; Ariotti N; McMahon KA; Bastiani M; Sierecki E; Kovtun O; Polinkovsky ME; Magenau A; Jung WR; Okano S, 2014, 'Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae', eLife, vol. 2014, http://dx.doi.org/10.7554/eLife.01434.001

Gooding JJ; Parker SG; Lu Y; Gaus K, 2014, 'Molecularly engineered surfaces for cell biology: From static to dynamic surfaces', Langmuir, vol. 30, pp. 3290 - 3302, http://dx.doi.org/10.1021/la4037919

Rossy J; Gaus K; Cohen E; Owen DM, 2014, 'Method for co-cluster analysis in multichannel single-molecule localisation data', Histochemistry and Cell Biology, http://dx.doi.org/10.1007/s00418-014-1208-z

Tabarin T; Pageon SV; Bach CTT; Lu Y; O'Neill GM; Gooding JJ; Gaus K, 2014, 'Insights into adhesion biology using single-molecule localization microscopy', ChemPhysChem, vol. 15, pp. 606 - 618, http://dx.doi.org/10.1002/cphc.201301041

Benda A; Kapusta P; Hof M; Gaus K, 2014, 'Fluorescence spectral correlation spectroscopy (FSCS) for probes with highly overlapping emission spectra', Optics Express, vol. 22, pp. 2973 - 2988, http://dx.doi.org/10.1364/OE.22.002973

Choi YI; Duke-Cohan JS; Chen W; Liu B; Rossy J; Tabarin T; Ju L; Gui J; Gaus K; Zhu C, 2014, 'Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, pp. 379 - 384, http://dx.doi.org/10.1073/pnas.1314209111

Ngalim SHA; Magenau A; Zhu Y; Tønnesen L; Fairjones Z; Gooding JJ; Böcking T; Gaus K, 2013, 'Creating adhesive and soluble gradients for imaging cell migration with fluorescence microscopy', Journal of visualized experiments : JoVE, http://dx.doi.org/10.3791/50310

Owen DM; Gaus K, 2013, 'Imaging lipid domains in cell membranes: The advent of super-resolution fluorescence microscopy', Frontiers in Plant Science, vol. 4, http://dx.doi.org/10.3389/fpls.2013.00503

Benzing C; Rossy J; Gaus K, 2013, 'Do signalling endosomes play a role in T cell activation?', FEBS Journal, vol. 280, pp. 5164 - 5176, http://dx.doi.org/10.1111/febs.12427

Owen DM; Magenau A; Williamson DJ; Gaus K, 2013, 'Super-resolution imaging by localization microscopy', Methods in Molecular Biology, vol. 950, pp. 81 - 93, http://dx.doi.org/10.1007/978-1-62703-137-0_6

Rossy J; Owen DM; Williamson DJ; Yang Z; Gaus K, 2013, 'Conformational states of the kinase Lck regulate clustering in early T cell signaling', Nature Immunology, vol. 14, pp. 82 - 89, http://dx.doi.org/10.1038/ni.2488

Kwiatek JM; Owen DM; Abu-Siniyeh A; Yan P; Loew LM; Gaus K, 2013, 'Characterization of a New Series of Fluorescent Probes for Imaging Membrane Order', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0052960

Billcliff PG; Rollason R; Prior I; Owen DM; Gaus K; Banting G, 2013, 'CD317/tetherin is an organiser of membrane microdomains', Journal of Cell Science, vol. 126, pp. 1553 - 1564, http://dx.doi.org/10.1242/jcs.112953

Larghi P; Williamson DJ; Carpier JM; Dogniaux S; Chemin K; Bohineust A; Danglot L; Gaus K; Galli T; Hivroz C, 2013, 'VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites', Nature Immunology, vol. 14, pp. 723 - 731, http://dx.doi.org/10.1038/ni.2609

Owen DM; Williamson DJ; Boelen L; Magenau A; Rossy J; Gaus K, 2013, 'Quantitative analysis of three-dimensional fluorescence localization microscopy data', Biophysical Journal, vol. 105, http://dx.doi.org/10.1016/j.bpj.2013.05.063

Rossy J; Pageon SV; Davis DM; Gaus K, 2013, 'Super-resolution microscopy of the immunological synapse', Current Opinion in Immunology, vol. 25, pp. 307 - 312, http://dx.doi.org/10.1016/j.coi.2013.04.002

Rossy J; Williamson DJ; Gaus K, 2012, 'How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism', Frontiers in Immunology, vol. 3, http://dx.doi.org/10.3389/fimmu.2012.00167

Owen DM; Rentero C; Magenau A; Abu-Siniyeh A; Gaus K, 2012, 'Quantitative imaging of membrane lipid order in cells and organisms', Nature Protocols, vol. 7, pp. 24 - 35, http://dx.doi.org/10.1038/nprot.2011.419

Böcking T; Kilian KA; Reece PJ; Gaus K; Gal M; Gooding JJ, 2012, 'Biofunctionalization of free-standing porous silicon films for self-assembly of photonic devices', Soft Matter, vol. 8, pp. 360 - 366, http://dx.doi.org/10.1039/c1sm06651j

Ciampi S; James M; Le Saux G; Gaus K; Justin Gooding J, 2012, 'Electrochemical "switching" of Si(100) modular assemblies', Journal of the American Chemical Society, vol. 134, pp. 844 - 847, http://dx.doi.org/10.1021/ja210048x

Owen DM; Williamson D; Magenau A; Gaus K, 2012, 'Optical techniques for imaging membrane domains in live cells (live-cell palm of protein clustering)', Methods in Enzymology, vol. 504, pp. 221 - 235, http://dx.doi.org/10.1016/B978-0-12-391857-4.00011-2

Cui HL; Grant A; Mukhamedova N; Pushkarsky T; Jennelle L; Dubrovsky L; Gaus K; Fitzgerald ML; Sviridov D; Bukrinsky M, 2012, 'HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux', Journal of Lipid Research, vol. 53, pp. 696 - 708, http://dx.doi.org/10.1194/jlr.M023119

Pereira CF; Rossy J; Owen DM; Mak J; Gaus K, 2012, 'HIV taken by STORM: Super-resolution fluorescence microscopy of a viral infection', Virology Journal, vol. 9, http://dx.doi.org/10.1186/1743-422X-9-84

Owen DM; Sauer M; Gaus K, 2012, 'Fluorescence localization microscopy: The transition from concept to biological research tool', Communicative and Integrative Biology, vol. 5, pp. 345 - 349, http://dx.doi.org/10.4161/cib.20348

Ng CCA; Magenau A; Ngalim SH; Ciampi S; Chockalingham M; Harper JB; Gaus K; Gooding JJ, 2012, 'Using an electrical potential to reversibly switch surfaces between two states for dynamically controlling cell adhesion', Angewandte Chemie - International Edition, vol. 51, pp. 7706 - 7710, http://dx.doi.org/10.1002/anie.201202118

Yaffe Y; Shepshelovitch J; Nevo-Yassaf I; Yeheskel A; Shmerling H; Kwiatek JM; Gaus K; Pasmanik-Chor M; Hirschberg K, 2012, 'The MARVEL transmembrane motif of occludin mediates oligomerization and targeting to the basolateral surface in epithelia', Journal of Cell Science, vol. 125, pp. 3545 - 3556, http://dx.doi.org/10.1242/jcs.100289

Owen DM; Magenau A; Williamson D; Gaus K, 2012, 'The lipid raft hypothesis revisited - new insights on raft composition and function from super-resolution fluorescence microscopy', BioEssays, vol. 34, pp. 739 - 747, http://dx.doi.org/10.1002/bies.201200044

Rossy J; Williamson DJ; Benzing C; Gaus K, 2012, 'The integration of signaling and the spatial organization of the T cell synapse', Frontiers in Immunology, vol. 3, http://dx.doi.org/10.3389/fimmu.2012.00352

Owen DM; Williamson DJ; Magenau A; Gaus K, 2012, 'Sub-resolution lipid domains exist in the plasma membrane and regulate protein diffusion and distribution', Nature Communications, vol. 3, http://dx.doi.org/10.1038/ncomms2273

Guan B; Magenau A; Kilian KA; Ciampi S; Gaus K; Reece PJ; Gooding JJ, 2011, 'Mesoporous silicon photonic crystal microparticles: Towards single-cell optical biosensors', Faraday Discussions, vol. 149, pp. 301 - 317, http://dx.doi.org/10.1039/c005340f

Cornely R; Rentero C; Enrich C; Grewal T; Gaus K, 2011, 'Annexin A6 is an organizer of membrane microdomains to regulate receptor localization and signalling', IUBMB Life, vol. 63, pp. 1009 - 1017, http://dx.doi.org/10.1002/iub.540

Magenau A; Benzing C; Proschogo N; Don AS; Hejazi L; Karunakaran D; Jessup W; Gaus K, 2011, 'Phagocytosis of IgG-Coated Polystyrene Beads by Macrophages Induces and Requires High Membrane Order', Traffic, vol. 12, pp. 1730 - 1743, http://dx.doi.org/10.1111/j.1600-0854.2011.01272.x

Zhu X; Gaus K; Lu Y; Magenau A; Truscott RJW; Mitchell TW, 2010, 'alpha- and beta-Crystallins Modulate the Head Group Order of Human Lens Membranes during Aging', INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 51, pp. 5162 - 5167, http://dx.doi.org/10.1167/iovs.09-4947

Munday AD; Gaus K; Lopez JA, 2010, 'The platelet glycoprotein Ib-IX-V complex anchors lipid rafts to the membrane skeleton: Implications for activation-dependent cytoskeletal translocation of signaling molecules', Journal of Thrombosis and Haemostasis, vol. 8, pp. 163 - 172, http://dx.doi.org/10.1111/j.1538-7836.2009.03656.x

Römer W; Pontani LL; Sorre B; Rentero C; Berland L; Chambon V; Lamaze C; Bassereau P; Sykes C; Gaus K, 2010, 'Actin Dynamics Drive Membrane Reorganization and Scission in Clathrin-Independent Endocytosis', Cell, vol. 140, pp. 540 - 553, http://dx.doi.org/10.1016/j.cell.2010.01.010

Owen DM; Gaus K, 2010, 'Optimized time-gated generalized polarization imaging of Laurdan and di-4-ANEPPDHQ for membrane order image contrast enhancement', Microscopy Research and Technique, vol. 73, pp. 618 - 622, http://dx.doi.org/10.1002/jemt.20801

Owen DM; Magenau A; Majumdar A; Gaus K, 2010, 'Imaging membrane lipid order in whole, living vertebrate organisms.', Biophysical journal, vol. 99, http://dx.doi.org/10.1016/j.bpj.2010.04.022

Owen DM; Magenau A; Majumdar A; Gaus K, 2010, 'Imaging membrane lipid order in whole, living vertebrate organisms', Biophysical Journal, vol. 99, http://dx.doi.org/10.1016/j.bpj.2010.04.022

Gaus K; Ngalim SH; Magenau A; Le Saux G; Gooding JJ, 2010, 'How do cells make decisions: Engineering micro- and nanoenvironments for cell migration', Journal of Oncology, http://dx.doi.org/10.1155/2010/363106

Owen DM; Gaus K; Magee AI; Cebecauer M, 2010, 'Dynamic organization of lymphocyte plasma membrane: Lessons from advanced imaging methods', Immunology, vol. 131, pp. 1 - 8, http://dx.doi.org/10.1111/j.1365-2567.2010.03319.x

Böcking T; Kilian KA; Reece PJ; Gaus K; Gal M; Gooding JJ, 2010, 'Substrate independent assembly of optical structures guided by biomolecular interactions', ACS Applied Materials and Interfaces, vol. 2, pp. 3270 - 3275, http://dx.doi.org/10.1021/am1007084

Zhu X; Gaus K; Lu Y; Magenau A; Truscott RJW; Mitchell TW, 2010, 'α- and β-crystallins modulate the head group order of human lens membranes during aging', Investigative Ophthalmology and Visual Science, vol. 51, pp. 5162 - 5167, http://dx.doi.org/10.1167/iovs.09-4947

Owen DM; Rentero C; Rossy J; Magenau A; Williamson D; Rodriguez M; Gaus K, 2010, 'PALM imaging and cluster analysis of protein heterogeneity at the cell surface', Journal of Biophotonics, vol. 3, pp. 446 - 454, http://dx.doi.org/10.1002/jbio.200900089

Gelissen IC; Cartland S; Brown AJ; Sandoval C; Kim M; Dinnes DL; Lee Y; Hsieh V; Gaus K; Kritharides L, 2010, 'Expression and stability of two isoforms of ABCG1 in human vascular cells', Atherosclerosis, vol. 208, pp. 75 - 82, http://dx.doi.org/10.1016/j.atherosclerosis.2009.06.028

Zech T; Ejsing CS; Gaus K; De Wet B; Shevchenko A; Simons K; Harder T, 2009, 'Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling', EMBO Journal, vol. 28, pp. 466 - 476, http://dx.doi.org/10.1038/emboj.2009.6

Ingelmo-Torres M; Gaus K; Herms A; González-Moreno E; Kassan A; Bosch M; Grewal T; Tebar F; Enrich C; Pol A, 2009, 'Triton X-100 promotes a cholesterol-dependent condensation of the plasma membrane', Biochemical Journal, vol. 420, pp. 373 - 381, http://dx.doi.org/10.1042/BJ20090051

Magal LG; Yaffe Y; Shepshelovich J; Aranda JF; De Marco MDC; Gaus K; Alonso MA; Hirschberg K, 2009, 'Clustering and lateral concentration of raft lipids by the MAL protein', Molecular Biology of the Cell, vol. 20, pp. 3751 - 3762, http://dx.doi.org/10.1091/mbc.E09-02-0142

Kockx M; Guo DL; Traini M; Gaus K; Kay J; Wimmer-Kleikamp S; Rentero C; Burnett JR; Le Goff W; Van Eck M, 2009, 'Cyclosporin A decreases apolipoprotein E secretion from human macrophages via a protein phosphatase2B-dependent and ATP-binding cassette transporter A1 (ABCA1)-independent pathway', Journal of Biological Chemistry, vol. 284, pp. 24144 - 24154, http://dx.doi.org/10.1074/jbc.M109.032615

Rajendran L; Beckmann J; Magenau A; Boneberg EM; Gaus K; Viola A; Giebel B; Illges H, 2009, 'Flotillins are involved in the polarization of primitive and mature hematopoietic cells', PLoS ONE, vol. 4, http://dx.doi.org/10.1371/journal.pone.0008290

Kilian KA; Lai LMH; Magenau A; Cartland S; Bocking T; Girolamo ND; Gal M; Gaus K; Gooding JJ, 2009, 'Smart tissue culture: in situ monitoring of the activity of protease enzymes secreted from live cells using nanostructured photonic crystals', Nano Letters, vol. 9, pp. 2021 - 2025, http://dx.doi.org/10.1021/nl900283j

Le Lay S; Li Q; Proschogo N; Rodriguez M; Gunaratnam K; Cartland S; Rentero C; Jessup W; Mitchell T; Gaus K, 2009, 'Caveolin-1-dependent and -independent membrane domains', Journal of Lipid Research, vol. 50, pp. 1609 - 1620, http://dx.doi.org/10.1194/jlr.M800601-JLR200

Kilian KA; Böcking T; Gaus K; Gooding JJ, 2008, 'Introducing distinctly different chemical functionalities onto the internal and external surfaces of mesoporous materials', Angewandte Chemie - International Edition, vol. 47, pp. 2697 - 2699, http://dx.doi.org/10.1002/anie.200704784

Rentero C; Magenau A; Williamson D; Tedla N; Gaus K, 2008, 'Membrane domains as signaling centers in macrophages and T-cells: From concepts to experiments', Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, vol. 8, pp. 336 - 348, http://dx.doi.org/10.2174/187152208787169152

Böcking T; Kilian KA; Gaus K; Gooding JJ, 2008, 'Modifying porous silicon with self-assembled monolayers for biomedical applications: The influence of surface coverage on stability and biomolecule coupling', Advanced Functional Materials, vol. 18, pp. 3827 - 3833, http://dx.doi.org/10.1002/adfm.200800640

Kilian KA; Böcking T; Lai LMH; Ilyas S; Gaus K; Gal M; Gooding JJ, 2008, 'Organic modification of mesoporous silicon rugate filters: The influence of nanoarchitecture on optical behaviour', International Journal of Nanotechnology, vol. 5, pp. 170 - 178, http://dx.doi.org/10.1504/IJNT.2008.016914

Rentero C; Zech T; Quinn CM; Engelhardt K; Williamson D; Grewal T; Jessup W; Harder T; Gaus K, 2008, 'Functional implications of plasma membrane condensation for T cell activation', PLoS ONE, vol. 3, http://dx.doi.org/10.1371/journal.pone.0002262

Ilyas S; Böcking T; Kilian K; Reece PJ; Gooding J; Gaus K; Gal M, 2007, 'Porous silicon based narrow line-width rugate filters', Optical Materials, vol. 29, pp. 619 - 622, http://dx.doi.org/10.1016/j.optmat.2005.10.012

Kilian KA; Böcking T; Gaus K; King-Lacroix J; Gal M; Gooding JJ, 2007, 'Hybrid lipid bilayers in nanostructured silicon: A biomimetic mesoporous scaffold for optical detection of cholera toxin', Chemical Communications, pp. 1936 - 1938, http://dx.doi.org/10.1039/b702762a

Kilian KA; Böcking T; Gaus K; Gal M; Gooding JJ, 2007, 'Si-C linked oligo(ethylene glycol) layers in silicon-based photonic crystals: Optimization for implantable optical materials', Biomaterials, vol. 28, pp. 3055 - 3062, http://dx.doi.org/10.1016/j.biomaterials.2007.03.014

Harder T; Rentero C; Zech T; Gaus K, 2007, 'Plasma membrane segregation during T cell activation: probing the order of domains', Current Opinion in Immunology, vol. 19, pp. 470 - 475, http://dx.doi.org/10.1016/j.coi.2007.05.002

Kockx M; Guo DL; Huby T; Lesnik P; Kay J; Sabaretnam T; Jary E; Hill M; Gaus K; Chapman J, 2007, 'Secretion of apolipoprotein E from macrophages occurs via a protein kinase A- and calcium-dependent pathway along the microtubule network', Circulation Research, vol. 101, pp. 607 - 616, http://dx.doi.org/10.1161/CIRCRESAHA.107.157198

Kilian KA; Böcking T; Ilyas S; Gaus K; Jessup W; Gal M; Gooding J, 2007, 'Forming antifouling organic multilayers on porous silicon rugate filters towards in vivo/ex vivo biophotonic devices', Advanced Functional Materials, vol. 17, pp. 2884 - 2890, http://dx.doi.org/10.1002/adfm.200600790

Kilian KA; Böcking T; Gaus K; Gal M; Gooding JJ, 2007, 'Peptide-modified optical filters for detecting protease activity', ACS Nano, vol. 1, pp. 355 - 361, http://dx.doi.org/10.1021/nn700141n

Römer W; Berland L; Chambon V; Gaus K; Windschiegl B; Tenza D; Aly MRE; Fraisier V; Florent JC; Perrais D, 2007, 'Shiga toxin induces tubular membrane invaginations for its uptake into cells', Nature, vol. 450, pp. 670 - 675, http://dx.doi.org/10.1038/nature05996

Cubells L; Vilà De Muga S; Tebar F; Wood P; Evans R; Ingelmo-torres M; Calvo M; Gaus K; Pol A; Grewal T, 2007, 'Annexin a6-Induced alterations in cholesterol transport and caveolin export from the Golgi complex', Traffic, vol. 8, pp. 1568 - 1589, http://dx.doi.org/10.1111/j.1600-0854.2007.00640.x

Gaus K; Zech T; Harder T, 2006, 'Visualizing membrane microdomains by Laurdan 2-photon microscopy (review)', Molecular Membrane Biology, vol. 23, pp. 41 - 48, http://dx.doi.org/10.1080/09687860500466857

Böcking T; Kilian KA; Gaus K; Gooding JJ, 2006, 'Single-step DNA immobilization on antifouling self-assembled monolayers covalently bound to silicon (111)', Langmuir, vol. 22, pp. 3494 - 3496, http://dx.doi.org/10.1021/la060331a

Jessup W; Gelissen IC; Gaus K; Kritharides L, 2006, 'Roles of ATP binding cassette transporters A1 and G1, scavenger receptor BI and membrane lipid domains in cholesterol export from macrophages', Current Opinion in Lipidology, vol. 17, pp. 247 - 257, http://dx.doi.org/10.1097/01.mol.0000226116.35555.eb

Proszynski TJ; Klemm R; Bagnat M; Gaus K; Simons K, 2006, 'Plasma membrane polarization during mating in yeast cells', Journal of Cell Biology, vol. 173, pp. 861 - 866, http://dx.doi.org/10.1083/jcb.200602007

Stetzkowski-Marden F; Gaus K; Recouvreur M; Cartaud A; Cartaud J, 2006, 'Agrin elicits membrane lipid condensation at sites of acetylcholine receptor clusters in C2C12 myotubes', Journal of Lipid Research, vol. 47, pp. 2121 - 2133, http://dx.doi.org/10.1194/jlr.M600182-JLR200

Fitzner D; Schneider A; Kippert A; Möbius W; Willig KI; Hell SW; Bunt G; Gaus K; Simons M, 2006, 'Myelin basic protein-dependent plasma membrane reorganization in the formation of myelin', EMBO Journal, vol. 25, pp. 5037 - 5048, http://dx.doi.org/10.1038/sj.emboj.7601376

Vieira OV; Gaus K; Verkade P; Fullekrug J; Vaz WLC; Simons K, 2006, 'FAPP2, cilium formation, and compartmentalization of the apical membrane in polarized Madin-Darby canine kidney (MDCK) cells', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 18556 - 18561, http://dx.doi.org/10.1073/pnas.0608291103

Gaus K; Le Lay S; Balasubramanian N; Schwartz MA, 2006, 'Integrin-mediated adhesion regulates membrane order', Journal of Cell Biology, vol. 174, pp. 725 - 734, http://dx.doi.org/10.1083/jcb.200603034

Turró S; Ingelmo-Torres M; Estanyol JM; Tebar F; Fernández MA; Albor CV; Gaus K; Grewal T; Enrich C; Pol A, 2006, 'Identification and characterization of associated with lipid droplet protein 1: A novel membrane-associated protein that resides on hepatic lipid droplets', Traffic, vol. 7, pp. 1254 - 1269, http://dx.doi.org/10.1111/j.1600-0854.2006.00465.x

Gaus K; Zech T; Harder T, 2006, 'Visualizing membrane microdomains by Laurdan 2-photon microscopy', Molecular Membrane Biology, vol. 23, pp. 41 - 48

Gaus K; Proszynski TJ; Klemm R; Bagnat M; Simons K, 2006, 'Plama membrane polarization during mating in yeast cells', Journal of Cell Biology, vol. 173, pp. 861 - 866

Jessup W; Gelissen I; Gaus K; Kritharides L, 2006, 'Roles of ATP binding cassette transporters A1 and G1, scavenger receptor BI and membrane lipid domains in cholesterol export from macrophages', Current Opinion in Lipidology, vol. 17, pp. 247 - 257

Gaus K; Chklovskaia E; Fazekas De St Groth B; Jessup W; Harder T, 2005, 'Condensation of the plasma membrane at the site of T lymphocyte activation', Journal of Cell Biology, vol. 171, pp. 121 - 131, http://dx.doi.org/10.1083/jcb.200505047

Böcking T; Gal M; Gaus K; Gooding JJ, 2005, 'Evidence for why tri(ethylene oxide) functionalized Si-C linked monolayers on Si(111) have inferior protein antifouling properties relative to the equivalent alkanethiol monolayers assembled on gold', Australian Journal of Chemistry, vol. 58, pp. 660 - 663, http://dx.doi.org/10.1071/CH05121

Böcking T; Kilian KA; Hanley T; Ilyas S; Gaus K; Gal M; Gooding JJ, 2005, 'Formation of tetra(ethylene oxide) terminated Si - C linked monolayers and their derivatization with glycine: An example of a generic strategy for the immobilization of biomolecules on silicon', Langmuir, vol. 21, pp. 10522 - 10529, http://dx.doi.org/10.1021/la051191s

McCormick MM; Rahimi F; Bobryshev YV; Gaus K; Zreiqat H; Cai H; Lord RSA; Geczy CL, 2005, 'S100A8 and S100A9 in human arterial wall: Implications for atherogenesis', Journal of Biological Chemistry, vol. 280, pp. 41521 - 41529, http://dx.doi.org/10.1074/jbc.M509442200

Gaus K; Rodriguez M; Ruberu KR; Gelissen I; Sloane TM; Kritharides L; Jessup W, 2005, 'Domain-specific lipid distribution in macrophage plasma membranes', Journal of Lipid Research, vol. 46, pp. 1526 - 1538, http://dx.doi.org/10.1194/jlr.M500103-JLR200

Gaus K; Kritharides L; Schmitz G; Boettcher A; Drobnik W; Langmann T; Quinn CM; Death A; Dean RT; Jessup W, 2004, 'Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages.', The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 18, pp. 574 - 576

Gooding JJ; Gaus K, 2004, '... yet even flawed films raise interest in research [3]', Nature, vol. 431, pp. 244

Campbell S; Gaus K; Bittman R; Jessup W; Crowe S; Mak J, 2004, 'The raft-promoting property of virion-associated cholesterol, but not the presence of virion-associated Brij 98 rafts, is a determinant of human immunodeficiency virus type 1 infectivity', Journal of Virology, vol. 78, pp. 10556 - 10565, http://dx.doi.org/10.1128/JVI.78.19.10556-10565.2004

Kockx M; Rye KA; Gaus K; Quinn CM; Wright J; Sloane T; Sviridov D; Fu Y; Sullivan D; Burnett JR, 2004, 'Apolipoprotein A-I-stimulated apolipoprotein E secretion from human macrophages is independent of cholesterol efflux', Journal of Biological Chemistry, vol. 279, pp. 25966 - 25977, http://dx.doi.org/10.1074/jbc.M401177200

Liu SM; Cogny A; Kockx M; Dean RT; Gaus K; Jessup W; Kritharides L, 2003, 'Cyclodextrins differentially mobilize free and esterified cholesterol from primary human foam cell macrophages', Journal of Lipid Research, vol. 44, pp. 1156 - 1166, http://dx.doi.org/10.1194/jlr.M200464-JLR200

Gaus K; Gratton E; Kable EPW; Jones AS; Gelissen I; Kritharides L; Jessup W, 2003, 'Visualizing lipid structure and raft domains in living cells with two-photon microscopy', Proceedings of the National Academy of Sciences of the United States of America, vol. 100, pp. 15554 - 15559, http://dx.doi.org/10.1073/pnas.2534386100

Jessup W; Wilson P; Gaus K; Kritharides L, 2002, 'Oxidized lipoproteins and macrophages', Vascular Pharmacology, vol. 38, pp. 239 - 248, http://dx.doi.org/10.1016/S1537-1891(02)00174-X

Gaus K; Dean RT; Kritharides L; Jessup W, 2001, 'Inhibition of cholesterol efflux by 7-ketocholesterol: Comparison between cells, plasma membrane vesicles, and liposomes as cholesterol donors', Biochemistry, vol. 40, pp. 13002 - 13014, http://dx.doi.org/10.1021/bi010833h

Gaus K; Gooding JJ; Dean RT; Kritharides L; Jessup W, 2001, 'A kinetic model to evaluate cholesterol efflux from THP-1 macrophages to apolipoprotein A-1', Biochemistry, vol. 40, pp. 9363 - 9373, http://dx.doi.org/10.1021/bi010323n

Scientia Professor Katharina Gaus

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