
Professor Levon Khachigian
Fields of research: Cardiovascular Medicine and Haematology, Cancer Cell Biology
Contact Details
Phone: +61 2 9385 2537
Fax: 51797
Email: l.khachigian@unsw.edu.au
Tabs
Publications related to this Person
Books
Khachigian LM, 2004, Preface
Khachigian LM, 2004, High-risk atherosclerotic plaques: Mechanisms, imaging, models, and therapy
Book Chapters
Prado-Lourenço L; Alhendi AMN; Khachigian LM, 2013, 'Insights into roles of immediate-early genes in angiogenesis', in Angiogenesis and Vascularisation: Cellular and Molecular Mechanisms in Health and Diseases, pp. 145 - 162, http://dx.doi.org/10.1007/978-3-7091-1428-5_7
Khachigian LM; Midgley VC, 2007, 'Early growth response-1 coupling in vascular endothelium', in Endothelial Biomedicine, pp. 818 - 821, http://dx.doi.org/10.1017/CBO9780511546198.091
Lowe HC; Khachigian LM; Kritharides L; Johnson JL, 2005, 'Animal Models of Vulnerable Plaque', in High-Risk Atherosclerotic Plaques Mechanisms, Imaging, Models, and Therapy, edn. 1, CRC Press, Florida, pp. 35 - 52
Khachigian LM; Silverman ES; Lindner V; Williams A; Chesterman CN; Collins TF, 2000, 'Platelet-derived growth factor: regulation of gene expression and roles in vascular pathobiology', in Platelets, Thrombosis and the Vessel Wall, edn. Original, Harwood Academic Publishers, Amsterdam, The Netherlands, pp. 267 - 286
Khachigian LM; Geczy C, 2000, 'Growth factors and cytokines in atherogenesis', in Athersclerosis, edn. Original, Oxford University Press, Oxford, UK, pp. 250 - 266
Lowe HC; Rafty LA; Collins TF; Khachigian LM, 2000, 'Biology of platelet derived growth factor', in Skeletal Growth Factors, edn. Original, Lippincott Williams OEM_sqlplus_input_finished, Philadelphia, USA, pp. 129 - 152
Journal articles
Santiago FS; Li Y; Zhong L; Raftery MJ; Lins L; Khachigian LM, 2021, 'Truncated YY1 interacts with BASP1 through a 339KLK341 motif in YY1 and suppresses vascular smooth muscle cell growth and intimal hyperplasia after vascular injury.', Cardiovasc Res, http://dx.doi.org/10.1093/cvr/cvab021
Meara CHO; Coupland LA; Kordbacheh F; Quah BJC; Chang CW; Simon Davis DA; Bezos A; Browne AM; Freeman C; Hammill DJ; Chopra P; Pipa G; Madge PD; Gallant E; Segovis C; Dulhunty AF; Arnolda LF; Mitchell I; Khachigian LM; Stephens RW; von Itzstein M; Parish CR, 2020, 'Neutralizing the pathological effects of extracellular histones with small polyanions', Nature Communications, vol. 11, http://dx.doi.org/10.1038/s41467-020-20231-y
Allahwala UK; Khachigian LM; Nour D; Ridiandres A; Billah M; Ward M; Weaver J; Bhindi R, 2020, 'Recruitment and maturation of the coronary collateral circulation: Current understanding and perspectives in arteriogenesis', Microvascular Research, vol. 132, http://dx.doi.org/10.1016/j.mvr.2020.104058
Khachigian LM, 2020, 'Pharmaceutical patents: reconciling the human right to health with the incentive to invent', Drug Discovery Today, vol. 25, pp. 1135 - 1141, http://dx.doi.org/10.1016/j.drudis.2020.04.009
Li Y; Alhendi AMN; Yeh MC; Elahy M; Santiago FS; Deshpande NP; Wu B; Chan E; Inam S; Prado-Lourenco L; Marchand J; Joyce RD; Wilkinson-White LE; Raftery MJ; Zhu M; Adamson SJ; Barnat F; Viaud-Quentric K; Sockler J; Mackay JP; Chang A; Mitchell P; Marcuccio SM; Khachigian LM, 2020, 'Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB-VCAM-1 axis', Science Advances, vol. 6, pp. eaaz7815, http://dx.doi.org/10.1126/sciadv.aaz7815
Alam T; Agrawal S; Severin J; Young RS; Andersson R; Arner E; Hasegawa A; Lizio M; Ramilowski JA; Abugessaisa I; Ishizu Y; Noma S; Tarui H; Taylor MS; Lassmann T; Itoh M; Kasukawa T; Kawaji H; Marchionni L; Sheng G; Forrest ARR; Khachigian LM; Hayashizaki Y; Carninci P; De Hoon MJL, 2020, 'Comparative transcriptomics of primary cells in vertebrates', Genome Research, vol. 30, pp. 951 - 961, http://dx.doi.org/10.1101/gr.255679.119
Billah M; Ridiandries A; Allahwala UK; Mudaliar H; Dona A; Hunyor S; Khachigian LM; Bhindi R, 2020, 'Remote ischemic preconditioning induces cardioprotective autophagy and signals through the IL-6-dependent JAK-STAT pathway', International Journal of Molecular Sciences, vol. 21, pp. 1692 - 1692, http://dx.doi.org/10.3390/ijms21051692
Billah M; Ridiandries A; Rayner BS; Allahwala UK; Dona A; Khachigian LM; Bhindi R, 2020, 'Egr-1 functions as a master switch regulator of remote ischemic preconditioning-induced cardioprotection', Basic Research in Cardiology, vol. 115, http://dx.doi.org/10.1007/s00395-019-0763-9
Khachigian LM, 2020, 'Repurposing drugs for skin cancer', Current Medicinal Chemistry, vol. 27, pp. 7214 - 7221, http://dx.doi.org/10.2174/0929867327666191220103901
Li Y; Alhendi AMN; Yeh M-C; Elahy M; Santiago FS; Deshpande NP; Wu B; Chan E; Inam S; Prado-Lourenco L; Marchand J; Joyce RD; Wilkinson-White LE; Raftery MJ; Zhu M; Adamson SJ; Barnat F; Viaud-Quentric K; Sockler J; Mackay JP; Chang A; Mitchell P; Marcuccio SM; Khachigian LM, 2020, 'Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB-VCAM-1 axis.', Sci Adv, vol. 6, http://dx.doi.org/10.1126/sciadv.aaz7815
Khachigian LM, 2019, 'Transcription factors targeted by miRNAs regulating smooth muscle cell growth and intimal thickening after vascular injury', International Journal of Molecular Sciences, vol. 20, http://dx.doi.org/10.3390/ijms20215445
Li Y; Acharya G; Elahy M; Xin H; Khachigian LM, 2019, 'The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation', Cancer Letters, vol. 459, pp. 268 - 276, http://dx.doi.org/10.1016/j.canlet.2019.05.026
Santiago FS; Sanchez-Guerrero E; Zhang G; Zhong L; Raftery MJ; Khachigian LM, 2019, 'Extracellular signal-regulated kinase-1 phosphorylates early growth response-1 at serine 26', Biochemical and Biophysical Research Communications, vol. 510, pp. 345 - 351, http://dx.doi.org/10.1016/j.bbrc.2019.01.019
Khachigian LM, 2019, 'Deoxyribozymes as catalytic nanotherapeutic agents', Cancer Research, vol. 79, pp. 879 - 888, http://dx.doi.org/10.1158/0008-5472.CAN-18-2474
Billah M; Ridiandries A; Allahwala U; Mudaliar H; Dona A; Hunyor S; Khachigian LM; Bhindi R, 2019, 'Circulating mediators of remote ischemic preconditioning: Search for the missing link between non-lethal ischemia and cardioprotection', Oncotarget, vol. 10, pp. 216 - 244, http://dx.doi.org/10.18632/oncotarget.26537
Alhendi AMN; Patrikakis M; Daub CO; Kawaji H; Itoh M; de Hoon M; Carninci P; Hayashizaki Y; Arner E; Khachigian LM, 2018, 'Promoter Usage and Dynamics in Vascular Smooth Muscle Cells Exposed to Fibroblast Growth Factor-2 or Interleukin-1β', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-30702-4
Cai H; Cho EA; Li Y; Sockler J; Parish CR; Chong BH; Edwards J; Dodds TJ; Ferguson PM; Wilmott JS; Scolyer RA; Halliday GM; Khachigian LM, 2018, 'Melanoma protective antitumor immunity activated by catalytic DNA', Oncogene, vol. 37, pp. 5115 - 5126, http://dx.doi.org/10.1038/s41388-018-0306-0
Khachigian LM, 2018, 'The Yin and Yang of YY1 in tumor growth and suppression', International Journal of Cancer, vol. 143, pp. 460 - 465, http://dx.doi.org/10.1002/ijc.31255
Sheahan AV; Biankin AV; Parish CR; Khachigian LM, 2018, 'Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: A systematic review', Oncotarget, vol. 9, pp. 21613 - 21627, http://dx.doi.org/10.18632/oncotarget.25085
Cannistraci CV; Nieminen T; Nishi M; Khachigian LM; Viikilä J; Laine M; Cianflone D; Maseri A; Yeo KK; Bhindi R; Ammirati E, 2018, '"Summer Shift": A potential effect of sunshine on the time onset of ST-elevation acute myocardial infarction', Journal of the American Heart Association, vol. 7, http://dx.doi.org/10.1161/JAHA.117.006878
Buckler JN; Banwell MG; Kordbacheh F; Parish CR; Santiago FS; Khachigian LM, 2017, 'Developing neolignans as proangiogenic agents: Stereoselective total syntheses and preliminary biological evaluations of the four guaiacylglycerol 8-O-4'-coniferyl ethers', ACS Omega, vol. 2, pp. 7375 - 7388, http://dx.doi.org/10.1021/acsomega.7b01459
Noguchi S; Arakawa T; Fukuda S; Furuno M; Hasegawa A; Hori F; Ishikawa-Kato S; Kaida K; Kaiho A; Kanamori-Katayama M; Kawashima T; Kojima M; Kubosaki A; Manabe RI; Murata M; Nagao-Sato S; Nakazato K; Ninomiya N; Nishiyori-Sueki H; Noma S; Saijyo E; Saka A; Sakai M; Simon C; Suzuki N; Tagami M; Watanabe S; Yoshida S; Arner P; Axton RA; Babina M; Kenneth Baillie J; Barnett TC; Beckhouse AG; Blumenthal A; Bodega B; Bonetti A; Briggs J; Brombacher F; Carlisle AJ; Clevers HC; Davis CA; Detmar M; Dohi T; Edge BAS; Edinger M; Ehrlund A; Ekwall K; Endoh M; Enomoto H; Eslami A; Fagiolini M; Fairbairn L; Farach-Carson MC; Faulkner GJ; Ferrai C; Fisher ME; Forrester LM; Fujita R; Furusawa JI; Geijtenbeek TB; Gingeras T; Goldowitz D; Guhl S; Guler R; Gustincich S; Ha TJ; Hamaguchi M; Hara M; Hasegawa Y; Herlyn M; Heutink P; Hitchens KJ; Hume DA; Ikawa T; Ishizu Y; Kai C; Kawamoto H; Kawamura YI; Kempfle JS; Kenna TJ; Kere J; Khachigian LM; Kitamura T; Klein S; Peter Klinken S; Knox AJ; Kojima S; Koseki H; Koyasu S; Lee W; Lennartsson A; MacKay-Sim A; Mejhert N; Mizuno Y; Morikawa H; Morimoto M; Moro K; Morris KJ; Motohashi H, 2017, 'FANTOM5 CAGE profiles of human and mouse samples', Scientific Data, vol. 4, http://dx.doi.org/10.1038/sdata.2017.112
Murrell M; Khachigian L; Ward MR, 2017, 'Corrigendum to “The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting” [Atherosclerosis 194 (2) (2007) 364–371] (S0021915006006836) (10.1016/j.atherosclerosis.2006.11.016)', Atherosclerosis, vol. 261, pp. 172, http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.011
Li Y; McRobb LS; Khachigian LM, 2016, 'Inhibition of intimal thickening after vascular injury with a cocktail of vascular endothelial growth factor and cyclic Arg-Gly-Asp peptide', International Journal of Cardiology, vol. 220, pp. 185 - 191, http://dx.doi.org/10.1016/j.ijcard.2016.06.300
Khachigian LM, 2016, 'Early growth response-1 in the pathogenesis of cardiovascular disease', Journal of Molecular Medicine, vol. 94, pp. 747 - 753, http://dx.doi.org/10.1007/s00109-016-1428-x
Li Y; McRobb LS; Khachigian LM, 2016, 'MicroRNA miR-191 targets the zinc finger transcription factor Egr-1 and suppresses intimal thickening after carotid injury', International Journal of Cardiology, vol. 212, pp. 299 - 302, http://dx.doi.org/10.1016/j.ijcard.2016.03.037
Tan NY; Li J-M; Stocker R; Khachigian LM, 2016, 'Angiotensin II-Inducible Smooth Muscle Cell Apoptosis Involves the Angiotensin II Type 2 Receptor, GATA-6 Activation, and FasL-Fas Engagement (Retraction of vol 105, pg 422, 2009)', CIRCULATION RESEARCH, vol. 118, pp. E31 - E31, http://dx.doi.org/10.1161/RES.0000000000000090
Hurst LD; Ghanbarian AT; Forrest ARR; Huminiecki L; Rehli M; Kenneth Baillie J; de Hoon MJL; Haberle V; Lassmann T; Kulakovskiy IV; Lizio M; Itoh M; Andersson R; Mungall CJ; Meehan TF; Schmeier S; Bertin N; Jørgensen M; Dimont E; Arner E; Schmidl C; Schaefer U; Medvedeva YA; Plessy C; Vitezic M; Severin J; Semple CA; Ishizu Y; Young RS; Francescatto M; Alam I; Albanese D; Altschuler GM; Arakawa T; Archer JAC; Arner P; Babina M; Baker S; Balwierz PJ; Beckhouse AG; Pradhan SB; Blake JA; Blumenthal A; Bodega B; Bonetti A; Briggs J; Brombacher F; Maxwell Burroughs A; Califano A; Cannistraci CV; Carbajo D; Chen Y; Chierici M; Ciani Y; Clevers HC; Dalla E; Davis CA; Detmar M; Diehl AD; Dohi T; Drabløs F; Edge ASB; Edinger M; Ekwall K; Endoh M; Enomoto H; Fagiolini M; Fairbairn L; Fang H; Farach-Carson MC; Faulkner GJ; Favorov AV; Fisher ME; Frith MC; Fujita R; Fukuda S; Furlanello C; Furuno M; Furusawa JI; Geijtenbeek TB; Gibson A; Gingeras T; Goldowitz D; Gough J; Guhl S; Guler R; Gustincich S; Ha TJ; Hamaguchi M; Hara M; Harbers M; Harshbarger J; Hasegawa A; Hasegawa Y; Hashimoto T; Herlyn M; Hitchens KJ; Ho Sui SJ; Hofmann OM, 2015, 'The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome', PLoS Biology, vol. 13, http://dx.doi.org/10.1371/journal.pbio.1002315
Fahmy RG; Waldman A; Zhang G; Mitchell A; Tedla N; Cai H; Geczy CR; Chesterman CN; Perry M; Khachigian LM, 2015, 'Erratum: Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun(Nat.Biotechnol.(2006) 24(856-863))', Nature Biotechnology, vol. 33, pp. 882, http://dx.doi.org/10.1038/nbt0815-882c
Aitken S; Magi S; Alhendi AMN; Itoh M; Kawaji H; Lassmann T; Daub CO; Arner E; Carninci P; Forrest ARR; Hayashizaki Y; Khachigian LM; Okada-Hatakeyama M; Semple CA; Sandelin A; Wells C; Hume DA; Summers KM; Vitting-Seerup K; Andersson R; Yumoto MN, 2015, 'Transcriptional Dynamics Reveal Critical Roles for Non-coding RNAs in the Immediate-Early Response', PLoS Computational Biology, vol. 11, http://dx.doi.org/10.1371/journal.pcbi.1004217
Arner E; Daub CO; Vitting-Seerup K; Andersson R; Lilje B; Drabløs F; Lennartsson A; Rönnerblad M; Hrydziuszko O; Vitezic M; Freeman TC; Alhendi AMN; Arner P; Axton R; Baillie JK; Beckhouse A; Bodega B; Briggs J; Brombacher F; Davis M; Detmar M; Ehrlund A; Endoh M; Eslami A; Fagiolini M; Fairbairn L; Faulkner GJ; Ferrai C; Fisher ME; Forrester L; Goldowitz D; Guler R; Ha T; Hara M; Herlyn M; Ikawa T; Kai C; Kawamoto H; Khachigian LM; Klinken SP; Kojima S; Koseki H; Klein S; Mejhert N; Miyaguchi K; Mizuno Y; Morimoto M; Morris KJ; Mummery C; Nakachi Y; Ogishima S; Okada-Hatakeyama M; Okazaki Y; Orlando V; Ovchinnikov D; Passier R; Patrikakis M; Pombo A; Qin XY; Roy S; Sato H; Savvi S; Saxena A; Schwegmann A; Sugiyama D; Swoboda R; Tanaka H; Tomoiu A; Winteringham LN; Wolvetang E; Yanagi-Mizuochi C; Yoneda M; Zabierowski S; Zhang P; Abugessaisa I; Bertin N; Diehl AD; Fukuda S; Furuno M; Harshbarger J; Hasegawa A; Hori F; Ishikawa-Kato S; Ishizu Y; Itoh M; Kawashima T; Kojima M; Kondo N; Lizio M; Meehan TF; Mungall CJ; Murata M; Nishiyori-Sueki H; Sahin S; Nagao-Sato S; Severin J; De Hoon MJL; Kawai J; Kasukawa T; Lassmann T, 2015, 'Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells', Science, vol. 347, pp. 1010 - 1014, http://dx.doi.org/10.1126/science.1259418
Xie J; Zhang S; Hu Y; Li D; Cui J; Xue J; Zhang G; Khachigian LM; Wong J; Sun L; Wang M, 2014, 'Regulatory roles of c-jun in H5N1 influenza virus replication and host inflammation', Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1842, pp. 2479 - 2488, http://dx.doi.org/10.1016/j.bbadis.2014.04.017
Young JA; Ting KK; Li J; Moller T; Dunn L; Lu Y; Lay AJ; Moses J; Prado-Lourenço L; Khachigian LM; Ng M; Gregory PA; Goodall GJ; Tsykin A; Lichtenstein I; Hahn CN; Tran N; Shackel N; Kench JG; McCaughan G; Vadas MA; Gamble JR, 2014, 'Erratum: Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted mirna antagonists of mir-27 (Blood (2012) 122:16 (2911-2919))', Blood, vol. 124, pp. 3034, http://dx.doi.org/10.1182/blood-2014-09-604066
Chaabane SC; De Brachéne AC; Essaghir A; Velghe A; Re SL; Stockis J; Lucas S; Khachigian LM; Huaux F; Demoulin JB, 2014, 'PDGF-D expression is down-regulated by TGFβ in fibroblasts', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0108656
Forrest ARR; Kawaji H; Rehli M; Baillie JK; De Hoon MJL; Haberle V; Lassmann T; Kulakovskiy IV; Lizio M; Itoh M; Andersson R; Mungall CJ; Meehan TF; Schmeier S; Bertin N; Jørgensen M; Dimont E; Arner E; Schmidl C; Schaefer U; Medvedeva YA; Plessy C; Vitezic M; Severin J; Semple CA; Ishizu Y; Young RS; Francescatto M; Altschuler IA; Albanese D; Altschule GM; Arakawa T; Archer JAC; Arner P; Babina M; Rennie S; Balwierz PJ; Beckhouse AG; Pradhan-Bhatt S; Blake JA; Blumenthal A; Bodega B; Bonetti A; Briggs J; Brombacher F; Burroughs AM; Califano A; Cannistraci CV; Carbajo D; Chen Y; Chierici M; Ciani Y; Clevers HC; Dalla E; Davis CA; Detmar M; Diehl AD; Dohi T; Drabløs F; Edge ASB; Edinger M; Ekwall K; Endoh M; Enomoto H; Fagiolini M; Fairbairn L; Fang H; Farach-Carson MC; Faulkner GJ; Favorov AV; Fisher ME; Frith MC; Fujita R; Fukuda S; Furlanello C; Furuno M; Furusawa JI; Geijtenbeek TB; Gibson AP; Gingeras T; Goldowitz D; Gough J; Guhl S; Guler R; Gustincich S; Ha TJ; Hamaguchi M; Hara M; Harbers M; Harshbarger J; Hasegawa A; Hasegawa Y; Hashimoto T; Herlyn M; Hitchens KJ; Sui SJH; Hofmann OM; Hoof I; Hori F; Huminiecki L, 2014, 'A promoter-level mammalian expression atlas', Nature, vol. 507, pp. 462 - 470, http://dx.doi.org/10.1038/nature13182
Charni Chaabane S; Coomans de Brachène A; Essaghir A; Velghe A; Lo Re S; Stockis J; Lucas S; Khachigian LM; Huaux F; Demoulin JB, 2014, 'PDGF-D expression is down-regulated by TGFβ in fibroblasts', PloS one, vol. 9, pp. e108656, http://dx.doi.org/10.1371/journal.pone.0108656
Ni J; Waldman A; Khachigian LM, 2013, 'Erratum: C-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins (The Journal of Biological Chemistry (2010) 285 (4038-4048))', Journal of Biological Chemistry, vol. 288, pp. 31918, http://dx.doi.org/10.1074/jbc.A109.078345
Li Y; Bhindi R; Deng ZJ; Morton SW; Hammond PT; Khachigian LM, 2013, 'Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)', International Journal of Cardiology, vol. 168, pp. 3659 - 3664, http://dx.doi.org/10.1016/j.ijcard.2013.05.092
Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2013, 'Acute local elevation in monocyte chemoattractant protein-1 (MCP-1), distal to the culprit lesion in acute ST elevation myocardial infarction', International Journal of Cardiology, vol. 168, pp. 1679 - 1680, http://dx.doi.org/10.1016/j.ijcard.2013.03.078
Chan CWS; Khachigian LM, 2013, 'DNAzyme delivery approaches in biological settings', Current Medicinal Chemistry, vol. 20, pp. 3448 - 3455, http://dx.doi.org/10.2174/09298673113209990033
Sheahan AV; Phillips PA; Khachigian LM, 2013, 'Therapeutic perspectives on pancreatic cancer', Current Cancer Drug Targets, vol. 13, pp. 400 - 410, http://dx.doi.org/10.2174/1568009611313040004
Perdomo J; Jiang XM; Carter DR; Khachigian LM; Chong BH, 2013, 'Correction: SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4 (PLoS ONE)', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/annotation/3d7a31cd-09e7-47d1-af57-c58c7082058d
Rayner B; Figtree G; Lay W; Sabaretnam T; Shang P; Mazhar J; Weaver J; Grieve S; Hunyor S; Khachigian L; Bhindi R, 2013, 'SELECTIVE INHIBITION OF THE MASTER REGULATOR TRANSCRIPTION FACTOR EGR-1 USING CATALYTIC OLIGONUCLEOTIDES REDUCES MYOCARDIAL INJURY AND IMPROVES LV SYSTOLIC FUNCTION IN A PRECLINICAL MODEL OF MYOCARDIAL INFARCTION', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 61, pp. E213 - E213, http://dx.doi.org/10.1016/S0735-1097(13)60214-4
Li D; Ilnytskyy Y; Kovalchuk A; Khachigian LM; Bronson RT; Wang B; Kovalchuk O, 2013, 'Crucial role for early growth response-1 in the transcriptional regulation of miR-20b in breast cancer', Oncotarget, vol. 4, pp. 1373 - 1387, http://dx.doi.org/10.18632/oncotarget.1165
Sanchez-Guerrero E; Jo SR; Chong BH; Khachigian LM, 2013, 'EGFR and the complexity of receptor crosstalk in the cardiovascular system', Current Molecular Medicine, vol. 13, pp. 3 - 12, http://dx.doi.org/10.2174/156652413804486313
Young JA; Ting KK; Li J; Moller T; Dunn L; Lu Y; Lay AJ; Moses J; Prado-Lourenço L; Khachigian LM; Ng M; Gregory PA; Goodall GJ; Tsykin A; Lichtenstein I; Hahn CN; Tran N; Shackel N; Kench JG; McCaughan G; Vadas MA; Gamble JR, 2013, 'Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27', Blood, vol. 122, pp. 2911 - 2919, http://dx.doi.org/10.1182/blood-2012-12-473017
Khachigian LM, 2013, 'Inhibition of intimal thickening and acceleration of reendothelialization after vascular injury using a cocktail approach', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 32, pp. S64 - S64, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324507400238&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM, 2013, 'Nephron regeneration after acute kidney injury in the zebrafish', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 32, pp. S63 - S63, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324507400237&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Rayner BS; Figtree GA; Sabaretnam T; Shang P; Mazhar J; Weaver JC; Lay WN; Witting PK; Hunyor SN; Grieve SM; Khachigian LM; Bhindi R, 2013, 'Selective inhibition of the master regulator transcription factor Egr-1 with catalytic oligonucleotides reduces myocardial injury and improves left ventricular systolic function in a preclinical model of myocardial infarction.', Journal of the American Heart Association, vol. 2, http://dx.doi.org/10.1161/JAHA.113.000023
Chong BH; Choi PY; Khachigian LM; Perdomo JS, 2013, 'Drug-induced immune thrombocytopenia', Hematology - Oncology Clinics of North America, vol. 27, pp. 521 - 540, http://dx.doi.org/10.1016/j.hoc.2013.02.003
Perdomo J; Jiang X-M; Carter DR; Khachigian LM; Chong BH, 2012, 'SUMOylation Regulates the Transcriptional Repression Activity of FOG-2 and Its Association with GATA-4', PLoS ONE, vol. 7, pp. e50637 - e50637, http://dx.doi.org/10.1371/journal.pone.0050637
Ishii H; Hulett M; Li J; Santiago FS; Parish CR; Khachigian LM, 2012, 'Yin Yang-1 inhibits tumor cell growth and inhibits p21 WAF1/Cip1complex formation with cdk4 and cyclin D1', International Journal of Oncology, vol. 40, pp. 1575 - 1580, http://dx.doi.org/10.3892/ijo.2012.1362
Chan CWS; Kaplan W; Parish CR; Khachigian LM, 2012, 'Reduced retinal microvascular density, improved forepaw reach, comparative microarray and gene set enrichment analysis with c-jun targeting DNA enzyme', PLoS One, vol. 7, pp. e39160, http://dx.doi.org/10.1371/journal.pone.0039160
Zhang N; Chan CWS; Sanchez-Guerrero E; Khachigian LM, 2012, 'Repression of PDGF-R-á after cellular injury involves TNF-á, formation of a c-Fos-YY1 complex, and negative regulation by HDAC', American Journal of Physiology - Cell Physiology, vol. 302, pp. 1590 - 1598, http://dx.doi.org/10.1152/ajpcell.00429.2011
Little PJ; Getachew R; Rezaei HB; Sanchez-Guerrero E; Khachigian LM; Wang H; Liao S; Zheng W; Ballinger ML; Osman N, 2012, 'Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFâ receptor phosphorylation', Archives of Biochemistry and Biophysics, vol. 525, pp. 25 - 31, http://dx.doi.org/10.1016/j.abb.2012.05.025
Midwinter R; Maghzal GJ; Dennis JM; Wu BJ; Cai H; Kapralov AA; Natalia A; Belikova NA; Tyurina YY; Dong LF; Khachigian LM; Neuzil J; Kagan VE; Stocker R, 2012, 'Succinobucol induces apoptosis in vascular smooth muscle cells', Free Radical Biology and Medicine, vol. 52, pp. 871 - 879, http://dx.doi.org/10.1016/j.freeradbiomed.2011.11.029
Malabanan KP; Sheahan A; Khachigian LM, 2012, 'Platelet-derived growth factor-BB mediates cell migration through induction of activating transcription factor 4 and tenascin-C', American Journal of Pathology, vol. 180, pp. 2590 - 2597, http://dx.doi.org/10.1016/j.ajpath.2012.02.009
Bhindi R; Fahmy RG; McMahon AC; Khachigian LM; Lowe HC, 2012, 'Intracoronary delivery of DNAzymes targeting human Egr-1 reduces infarct size following myocardial ischaemia reperfusion', Journal of Pathology, vol. 227, pp. 157 - 164, http://dx.doi.org/10.1002/path.2991
Truong A; Wong TY; Khachigian LM, 2011, 'Emerging therapeutic approaches in the management of retinal angiogenesis and edema', Journal of Molecular Medicine, vol. 89, pp. 343 - 361, http://dx.doi.org/10.1007/s00109-010-0709-z
Khachigian LM; Nath A; Malabanan KP, 2011, 'Regulation of cell migration by activation transcription factor-4', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 28, pp. S71 - S71, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295422700267&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM, 2011, 'Catalytic DNA as new drugs for vascular disease and cancer', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 28, pp. S70 - S70, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295422700266&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Liang S; Khachigian LM; Ahmadi Z; Yang ; Liu S; Chong BH, 2011, 'In vitro and in vivo proliferation, differentiation and migration of cardiac endothelial progenitor cells (SCA1(+) /CD31(+) side-population cells).', Journal of Thrombosis and Haemostasis, vol. 9, pp. 1628 - 1637, http://dx.doi.org/10.1111/j.1538-7836.2011.04375.x
Chen J; Liu M; Parish CR; Chong BH; Khachigian LM, 2011, 'Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine', International Journal of Biochemistry and Cell Biology, vol. 43, pp. 905 - 912, http://dx.doi.org/10.1016/j.biocel.2011.03.004
Cheng Q; McKeown SJ; Santos L; Santiago FS; Khachigian LM; Morand EF; Hickey MJ, 2010, 'Erratum: Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules (Journal of Immunology (2010) 185 (1238-1247))', Journal of Immunology, vol. 185, pp. 4959, http://dx.doi.org/10.4049/jimmunol.1090092
Kavurma MM; Bobryshev Y; Khachigian LM, 2010, 'Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1 (Retraction of vol 277, pg 36244, 2002)', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 21902 - 21902, http://dx.doi.org/10.1074/jbc.A110.200463
Liu MY; Khachigian LM, 2010, 'Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1 beta and forms a cytokine-inducible gene-silencing complex with NF-kappa B p65 and interferon regulatory factor-1 (Retraction of vol 284, pg 35101, 2009)', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 21902 - 21902, http://dx.doi.org/10.1074/jbc.A209.061903
Zhang N; Khachigian LM, 2010, 'Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1 beta (IL-1 beta) release and cooperative transactivation by NF-kappa B and ATF-4. IL-1 beta FACILITATES HDAC-1/2 DISSOCIATION FROM PROMOTER (Retraction of vol 284, pg 27933, 2009)', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 21902 - 21902, http://dx.doi.org/10.1074/jbc.A109.025742
Liu MY; Khachigian LM, 2010, 'Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1β and forms a cytokine-inducible gene-silencing complex with NF-κB p65 and interferon regulatory factor-1 (Journal of Biological Chemistry (2009) 284, (35101-35112)) DOI: 10.1074/jbc.A109.061903', Journal of Biological Chemistry, vol. 285, pp. 4363
Liu MY; Khachigian LM, 2010, 'Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1 beta and forms a cytokine-inducible gene-silencing complex with NF-kappa B p65 and interferon regulatory factor-1 (vol 284, pg 35101, 2009)', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 4263 - 4263, http://dx.doi.org/10.1074/jbc.A109.061903
Ni J; Waldman A; Khachigian LM, 2010, 'Erratum: C-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins(Journal of Biological Chemistry (2018) 293(20307) DOI: 10.1074/jbc.M109.078345)', Journal of Biological Chemistry, vol. 293, pp. 20307, http://dx.doi.org/10.1074/jbc.W118.007069
Ye ; Chan G; Qiao ; Meng ; Luo ; Khachigian LM; Ma ; Deng R; Chen ; Chong BH; Yang , 2010, 'Platelet-derived growth factor enhances platelet recovery in a murine model of radiation-induced thrombocytopenia and reduces apoptosis in megakaryocytes via its receptors and the PI3-k/Akt pathway', Haematologica, vol. 95, pp. 1745 - 1753, http://dx.doi.org/10.3324/haematol.2009.020958
Kavurma MM, 2010, 'TRAIL promotes VSMC proliferation and neointima formation in a FGF-2-, Sp1 phosphorylation-, and NFkappaB-dependent manner', Circulation Research, vol. 106, pp. 1061 - 1071, http://dx.doi.org/10.1161/CIRCRESAHA.109.206029
Wang B; Chen J; Santiago FS; Janes ME; Kavurma MM; Chong BH; Pimanda JE; Khachigian LM, 2010, 'Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 30, pp. 536 - 545, http://dx.doi.org/10.1161/ATVBAHA.109.193821
Pourgholami MH; Khachigian LM; Fahmy R; Badar S; Wang L; Chu SW; Morris DL, 2010, 'Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis', Biochemical and Biophysical Research Communications, vol. 397, pp. 729 - 734, http://dx.doi.org/10.1016/j.bbrc.2010.06.019
Ni J; Waldman A; Khachigian LM, 2010, 'c-Jun regulates shear-and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins.', The Journal of Biological Chemistry, vol. 285, pp. 4038 - 4048, http://dx.doi.org/10.1074/jbc.M109.078345
Perdomo JS; Fock E; Kaur G; Yan F; Khachigian LM; Jans D; Chong BH, 2010, 'A monopartite sequence is essential for p45 NF-E2 nuclear translocation, transciptional activity and platelet production', Journal of Thrombosis and Haemostasis, vol. 8, pp. 2542 - 2553, http://dx.doi.org/10.1111/j.1538-7836.2010.04058.x
Liang SX; Pinkevych M; Khachigian LM; Parish CR; Davenport MP; Chong BH, 2010, 'Drug-induced thrombocytopenia (DITP): development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG', Blood, vol. 116, pp. 1958 - 1960, http://dx.doi.org/10.1182/blood-2010-02-268326
Getachew R; Ballinger M; Burch M; Reid J; Khachigian LM, 2010, 'PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminologycan elongationon biglycan and increases binding to LDL.', Endocrinology, vol. 151, pp. 4356 - 4367, http://dx.doi.org/10.1210/en.2010-0027
Cheng Q; Mckeown S; Santos L; Santiago FS; Khachigian LM; Morand E; Hickey M, 2010, 'Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules.', Journal of Immunology, vol. 185, pp. 1238 - 1247, http://dx.doi.org/10.4049/jimmunol.0904104
Malabanan KP; Khachigian LM, 2010, 'Activation transcription factor-4 and the acute vascular response to injury.', Journal of Molecular Medicine - Jmm, vol. 88, pp. 545 - 552, http://dx.doi.org/10.1007/s00109-010-0615-4
Zhang C; Song QH; Khachigian LM; Lubenec I; Shie J-L; Yang B; Li J; Tian Y, 2009, 'Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells (Retraction of vol 380, pg 689, 2009)', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 388, pp. 464 - 464, http://dx.doi.org/10.1016/j.bbrc.2009.08.011
Dass CR; Khachigian LM; Choong PFM, 2009, 'C-Jun is critical for the progression of osteosarcoma: Proof in an orthotopic spontaneously metastasizing model (Molecular Cancer Research (2008) 6, (1289-1292))', Molecular Cancer Research, vol. 7, pp. 1594, http://dx.doi.org/10.1158/1541-7786.MCR-07-9-COR2
Ni J; Waldman A; Khachigian L, 2009, 'DNA enzyme targeting transcription factor c-Jun reduces intimal hyperplasia in human saphenous vein explants and inhibits Vein Graft stenosis in rabbits', EUROPEAN HEART JOURNAL, vol. 30, pp. 322 - 322, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208702603073&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Li C; Wu B; Midwinter R; Beck K; Collinson E; Maghzal G; Cassano C; Santiago F; Khachigian L; Gamble J; Stocker R, 2009, 'PROTECTION AGAINST ATHEROSCLEROSIS BY HEME OXYGENASE-1', ATHEROSCLEROSIS SUPPLEMENTS, vol. 10, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207957100820&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian L, 2009, 'DNAZYME TARGETING TRANSCRIPTION FACTOR C-JUN INHIBITS MYOCARDIAL INFLAMMATION, ROS GENERATION AND INFARCT SIZE AFTER ISCHEMIA-REPERFUSION INJURY', ATHEROSCLEROSIS SUPPLEMENTS, vol. 10, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207957101541&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM, 2009, 'Immediate-early genes as master regulators in cancer and other vascular disease', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 24, pp. S77 - S77, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000270497500292&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Zhang C; Song Q; Khachigian LM; Lubenec I; Shie J; Yang B; Li J; Tian Y, 2009, 'Retraction notice to `Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells` [Biophys. Res. Commun. 380 (3) (2009) 689-694] (DOI:10.1016/j.bbrc.2009.01.151)', Biochemical and Biophysical Research Communications, vol. 388, pp. 464, http://dx.doi.org/10.1016/j.bbrc.2009.08.011
Chan C; Khachigian LM, 2009, 'DNAzymes and their therapeutic possibilities', Internal Medicine Journal, vol. 39, pp. 249 - 251, http://dx.doi.org/10.1111/j.1445-5994.2009.01799.x
Tan N; Li J; Stocker R; Khachigian LM, 2009, 'Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and fasl-fas engagement', Circulation Research, vol. 105, pp. 422 - 430, http://dx.doi.org/10.1161/CIRCRESAHA.109.203323
Zhang C; Song Q; Khachigian LM; Lubenec I; Shie J; Yang B; Li J; Tian Y, 2009, 'Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells', Biochemical and Biophysical Research Communications, vol. 380, pp. 689 - 694, http://dx.doi.org/10.1016/j.bbrc.2009.01.151
Wang B; Khachigian LM; Esau L; Birrer M; Zhao X; Parker M; Hendricks D, 2009, 'A Key Role for Early Growth Response-1 and Nuclear Factor-kappa B in Mediating and Maintaining GRO/CXCR2 Proliferative Signaling in Esophageal Cancer', Molecular Cancer Research, vol. 7, pp. 755 - 764, http://dx.doi.org/10.1158/1541-7786.MCR-08-0472
Luo X; Cai H; Ni J; Bhindi R; Lowe HC; Chesterman CN; Khachigian LM, 2009, 'c-Jun DNAzymes Inhibit Myocardial Inflammation, ROS Generation, Infarct Size, and Improve Cardiac Function After Ischemia-Reperfusion Injury', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 29, pp. 1836 - U282, http://dx.doi.org/10.1161/ATVBAHA.109.189753
Khachigian LM; Peter K; Berndt MC, 2009, 'Recent advances in vascular biology: Selected highlights from IVBM 2008', Thrombosis and Haemostasis, vol. 101, pp. 997 - 998, http://dx.doi.org/10.1160/TH09-05-0294
Tan N; Khachigian LM, 2009, 'Sp1 phosphorylation and its regulation of gene transcription', Molecular and Cellular Biology, vol. 29, pp. 2483 - 2488, http://dx.doi.org/10.1128/MCB.01828-08
Abdel-Malak N; Mofarrahi M; Mayaki D; Khachigian LM; Hussain S, 2009, 'Early growth response-1 regulates angiopoietin-1-induced endothelial cell proliferation, migration, and differentiation', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 29, pp. 209 - 216, http://dx.doi.org/10.1161/ATVBAHA.108.181073
Khachigian LM; Bobik A; Kanellakis P; Malabanan K, 2008, 'Response to abcouwer and roybal', Circulation Research, vol. 103, http://dx.doi.org/10.1161/CIRCRESAHA.108.187559
Dass CR; Friedhuber AM; Khachigian LM; Dunstan DM; Choong PFM, 2008, 'Biocompatible chitosan-DNAzyme nanoparticle exhibits enhanced biological activity', Journal of Microencapsulation, vol. 25, pp. 421 - 425, http://dx.doi.org/10.1080/02652040802033673
Khachigian LM; Berndt MC; Tan NY, 2008, 'Ang II-Inducible PDGF-D Transcription Requires Ser/Thr Residues In The Second Zinc Finger Region of Sp1: Novel Phosphospecific Antibodies Demonstrate that Sp1 is Phosphorylated by SMC Injury', FASEB JOURNAL, vol. 22, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208467808746&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Kavurma MM; Schoppet M; Bobryshev YV; Khachigian LM; Bennett MR, 2008, 'TRAIL stimulates proliferation of vascular smooth muscle cells via activation of NF-kappa B and induction of insulin-like growth factor-1 receptor', The Journal of Biological Chemistry, vol. 283, pp. 7754 - 7762, http://dx.doi.org/10.1074/jbc.M706927200
Dass CR; Khachigian LM; Choong P, 2008, 'c-Jun knockdown sensitizes osteosarcoma to doxorubicin', Molecular Cancer Therapeutics, vol. 7, pp. 1909 - 1912, http://dx.doi.org/10.1158/1535-7163.MCT-08-0086
Dass CR; Khachigian LM; Choong P, 2008, 'C-Jun is critical for the progression of osteosarcoma: Proof in an orthotopic spontaneously metastasizing model', Molecular Cancer Research, vol. 6, pp. 1289 - 1292, http://dx.doi.org/10.1158/1541-7786.MCR-08-0036
Dass CR; Galloway S; Clark J; Khachigian LM; Choong P, 2008, 'Involvement of c-jun in human liposarcoma growth - Supporting data from clinical immunohistochemistry and DNAzyme efficacy', Cancer Biology and Therapy, vol. 7, pp. 1297 - 1301, http://dx.doi.org/10.4161/cbt.7.8.6301
Dass CR; Friedhuber A; Khachigian LM; Dunstan D; Choong P, 2008, 'Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model', Cancer Biology and Therapy, vol. 7, pp. 1033 - 1036, http://dx.doi.org/10.4161/cbt.7.7.6037
Malabanan KP; Kanellakis P; Bobik A; Khachigian LM, 2008, 'Activation transcription factor-4 induced by fibroblast growth factor-2 regulates vascular endothelial growth factor-A transcription in vascular smooth muscle cells and mediates intimal thickening in rat arteries following balloon injury', Circulation Research, vol. 103, pp. 378 - 387, http://dx.doi.org/10.1161/CIRCRESAHA.107.168682
Benson VL; Khachigian LM; Lowe HC, 2008, 'DNAzymes and cardiovascular disease', British Journal of Pharmacology, vol. 154, pp. 741 - 748, http://dx.doi.org/10.1038/bjp.2008.145
Kavallaris M; Meachem S; Hulett M; West C; Pitt R; Chesters J; Laffan W; Boreham P; Khachigian LM, 2008, 'Perceptions in health and medical research careers: the Australian Society for Medical Research Workforce Survey', Medical Journal of Australia, vol. 188, pp. 520 - 524
Sanchez-Guerrero E; Midgley VC; Khachigian LM, 2008, 'Angiotensin II induction of PDGF-C expression is mediated by AT1 receptor-dependent Egr-1 transactivation', Nucleic Acids Research, vol. 36, pp. 1941 - 1951, http://dx.doi.org/10.1093/nar/gkm923
Dass CR; Choong P; Khachigian LM, 2008, 'DNAzyme technology and cancer therapy: cleave and let die', Molecular Cancer Therapeutics, vol. 7, pp. 243 - 251, http://dx.doi.org/10.1158/1535-7163.MCT-07-0510
Tan N; Midgley VC; Kavurma MM; Santiago FS; Luo X; Peden RS; Fahmy R; Berndt MC; Molloy M; Khachigian LM, 2008, 'Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific ser/thr residues in the second zinc finger region of Sp1', Circulation Research, vol. 102, pp. E38 - E51, http://dx.doi.org/10.1161/CIRCRESAHA.107.167395
Khachigian LM; Bobik A; Kanellakis P; Malabanan KP, 2008, 'Regulation of Vascular Endothelial Growth Factor A by Activating Transcription Factor 4 Response', Circulation Research, vol. 103, pp. E119 - E119, http://dx.doi.org/10.1161/CIRCRESAHA.108.187559
Kavurma MM; Figg N; Bennett MR; Mercer J; Khachigian LM; Uttlewood TD, 2007, 'Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment', Biochemical Journal, vol. 407, pp. 79 - 87, http://dx.doi.org/10.1042/BJ20070380
Lowe HC; Mcmahon AC; Khachigian LM; Benson VL, 2007, 'The transcription factor early growth response gene 1 (Egr-1) is implicated in acute myocardial ischemic reperfusion injury in an in vivo model of diabetes', EUROPEAN HEART JOURNAL, vol. 28, pp. 434 - 434, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208702202289&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Benson VL; McMahon AC; Lowe HC; Khachigian LM, 2007, 'The streptozotocin-treated Sprague-Dawley rat: A useful model for the assessment of acute and chronic effects of myocardial ischaemia reperfusion injury in experimental diabetes', Diabetes and Vascular Disease Research, vol. 4, pp. 153 - 154, http://dx.doi.org/10.3132/dvdr.2007.035
Bhindi R; Fahmy R; Lowe HC; Chesterman CN; Dass CR; Cairns MJ; Saravolac E; Sun L; Khachigian LM, 2007, 'Brothers in arms - DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies', American Journal of Pathology, vol. 171, pp. 1079 - 1088, http://dx.doi.org/10.2353/ajpath.2007.070120
Santiago FS; Ishii H; Shafi S; Khurana R; Kanellakis P; Bhindi R; Ramirez M; Bobik A; Martin J; Chesterman CN; Zachary I; Khachigian LM, 2007, 'Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21(WAF1/Cip1) transcription and p21(WAF1/Cip1)-Cdk4-cyclin D1 assembly', Circulation Research, vol. 101, pp. 146 - 155, http://dx.doi.org/10.1161/CIRCRESAHA.106.145235
Fahmy R; Khachigian LM, 2007, 'Suppression of growth factor expression and human vascular smooth muscle cell growth by small interfering RNA targeting EGR-1', Journal of Cellular Biochemistry, vol. 100, pp. 1526 - 1535, http://dx.doi.org/10.1002/jcb.21145
Kavurma MM; Figg N; Bennett MR; Mercer JL; Khachigian LM; Littlewood T, 2007, 'Oxidative stress regulates IGF1R expression in vascular smooth muscle cells via p53/TBP promoter interactions', Biochemical Journal, vol. 407, pp. 79 - 87, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243520700040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Murrell MJ; Khachigian LM; Ward M, 2007, 'The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting', Atherosclerosis, vol. 194, pp. 364 - 371, http://dx.doi.org/10.1016/j.atherosclerosis.2006.11.016
Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2007, 'The transcription factor Egr-1 is implicated in myocardial ischaemic reperfusion injury in an in vivo model of diabetes', Journal of Molecular and Cellular Cardiology, vol. 42, pp. S194 - S194, http://dx.doi.org/10.1016/j.yjmcc.2007.03.590
Khachigian LM; Santiago FS; Ishii H; Shafi S; Khurana R; Kanellakis P; Bhindi R; Ramirez M; Bobik A; Martin JL; Chesterman CN; Zachary I, 2007, 'Yin yang-1 inhibits intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-Cyclin D1 assembly', Federation of American Societies for Experimantal Biology Journal, vol. 21, pp. A69 - A69, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245708500329&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Khachigian LM, 2007, 'Science never sleeps: Tucker Collins, MD, PhD', Endothelium - Journal of Endothelial Cell Research, vol. 14, pp. 173 - 174, http://dx.doi.org/10.1080/10623320701670026
Lowe HC; Khachigian LM, 2006, 'The endothelium and cardiovascular disease: New developments, new challenges', Endothelium: Journal of Endothelial Cell Research, vol. 13, pp. 365, http://dx.doi.org/10.1080/10623320601125303
Khachigian L, 2006, 'Molecular assassin targets master regulator gene', Australian Life Scientist, vol. 3, pp. 15
Kingwell B; Anderson GP; Duckett S; Hoole E; Jackson Pulver L; Khachigian LM; Morris ME; Roder D; Rothwell-Short J; Wilson A, 2006, 'Evaluation of NHMRC funded research completed in 1992, 1997 and 2003: gains in knowledge, health and wealth', Medical Journal of Australia, vol. 184, pp. 282 - 286
Liu M; Eyries MM; Zhang C; Santiago FS; Khachigian LM, 2006, 'Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1', Blood, vol. 107, pp. 2322 - 2329, http://dx.doi.org/10.1182/blood-2005-06-2377
Khachigian LM; Luo X; Sumithran E; Pua VS; Barnetson R; Halliday GM; Zhang GS, 2006, 'Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix metalloproteinase-2 and -9 expression', Oncogene, vol. 25, pp. 7260 - 7266, http://dx.doi.org/10.1038/sj.onc.1209726
Khachigian LM; Fahmy R; Di Girolamo N; Zhang GS, 2006, 'JUN siRNA regulates matrix metalloproteinase-2 expression, microvascular endothelial growth and retinal neovascularisation', Journal of Cell Science, vol. 119, pp. 3219 - 3226, http://dx.doi.org/10.1242/jcs.03059
Fahmy R; Waldman A; Zhang GS; Mitchell A; Tedla NT; Cai H; Geczy C; Chesterman CN; Perry MA; Khachigian LM, 2006, 'Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun', Nature Biotechnology, vol. 24, pp. 856 - 863, http://dx.doi.org/10.1038/nbt1225
Khachigian LM, 2006, 'Collagen antibody-induced arthritis', Nature Protocols, vol. 1, pp. 2512 - 2516, http://dx.doi.org/10.1038/nprot.2006.393
Khachigian LM; Witting PK; McMahon AC; Lowe HC; Bhindi R, 2006, 'Rat models of myocardial infarction', Thrombosis and Haemostasis, vol. 96, pp. 602 - 610, http://dx.doi.org/10.1160/TH05-07-0514
Khachigian LM, 2006, 'Health and medical research funding: an investment in Australia`s future', Medical Journal of Australia, vol. 185, pp. 348 - 350
Khachigian LM; Lowe HC; Bhindi R, 2006, 'DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats', Journal of Thrombosis and Haemostasis, vol. 4, pp. 1479 - 1483, http://dx.doi.org/10.1111/j.1538-7836.2006.02022.x
Khachigian LM, 2006, 'Early growth response-1 in Cardiovascular Pathobiology', Circulation Research, vol. 98, pp. 186 - 191, http://dx.doi.org/10.1161/01.RES.0000200177.53882.c3
Khachigian LM; Waldman A; Fahmy R; Perry M; Geczy C; Zhang G, 2005, 'Novel Insights into Functions of Immediate-Early Genes In Vascular Permeability and Inflammation using Catalytic DNA', INFLAMMATION RESEARCH, vol. 54, pp. S89 - S89, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000205501600014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Bonello MR; Khachigian LM, 2005, 'Erratum: Fibroblast growth factor-2 represses platelet-derived growth factor receptor-α (PDGFR-α) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-α promoter (Journal of Biological Chemistry (2004) 279 (2377-2382))', Journal of Biological Chemistry, vol. 280, pp. 1704
Bonello MR; Khachigian LM, 2005, 'Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter (vol 279, pg 2377, 2004)', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, pp. 1704 - 1704, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000226195200102&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Bhindi R; Brieger D; Ishii H; Di Girolamo N; Kumar RK; Khachigian LM; Lowe HC, 2005, 'Fibroblast growth factor 2 and the transcription factor Egr-l localiseto endothelial cell microvascular channels in human coronary artery occlusion', Thrombosis and Haemostasis, vol. 93, pp. 172 - 174
Bonello M; Bobryshev YV; Khachigian LM, 2005, 'Peroxide-inducible Ets-1 mediates platelet-derived growth factor receptor-alpha gene transcription in vascular smooth muscle cells', American Journal of Pathology, vol. 167, pp. 1149 - 1159, http://dx.doi.org/10.1016/S0002-9440(10)61203-5
de Mestre A; Rao S; Hornby J; Soe-Htwe T; Khachigian LM; Hulett M, 2005, 'Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells', The Journal of Biological Chemistry, vol. 280, pp. 35136 - 35147, http://dx.doi.org/10.1074/jbc.M503414200
Khachigian LM, 2005, 'Suppressing a sick heart', Nature Medicine, vol. 11, pp. 828 - 829, http://dx.doi.org/10.1038/nm0805-828
Kavurma MM; Bhindi R; Lowe HC; Chesterman CN; Khachigian LM, 2005, 'Vessel wall apoptosis and atherosclerotic plaque instability', Journal of Thrombosis and Haemostasis, vol. 3, pp. 465 - 472, http://dx.doi.org/10.1111/j.1538-7836.2005.01120.x
Lowe HC; James B; Khachigian LM, 2005, 'A novel model of in-stent restenosis: rat aortic stenting', Heart, vol. 91, pp. 393 - 395, http://dx.doi.org/10.1136/hrt.2003.028076
Waldman A; Fahmy R; Khachigian LM, 2005, 'DNAzymes targeting c-Jun inhibit inflammation and downregulate endothelial ICAM-1, VCAM-1 and E-selectin expression', Circulation, vol. 112, pp. U319 - U319, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000232956401573&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Fisher C; Sanchez-Ruderisch H; Welzel M; Wiedenmann B; Sakai T; Andre S; Gabius H; Khachigian LM; Detjen K; Rosewicz S, 2005, 'Galectin-1 Interacts with the alpha 5 Beta 1 Fibronectin Receptor to Restrict Carcinoma Cell growth via Induction of p21 and p27', The Journal of Biological Chemistry, vol. 280, pp. 37266 - 37277, http://dx.doi.org/10.1074/jbc.M411580200
Bhindi R; Khachigian LM; Lowe HC, 2005, 'DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats', Circulation, vol. 112, pp. U239 - U239, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000232956401200&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Eisbacher M; Holmes ML; Newton A; Hogg PJ; Khachigian LM; Crossley M; Chong BH, 2004, 'Erratum: Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding (Molecular and Cellular Biology (2003) 23, 10 (3427-3441))', Molecular and Cellular Biology, vol. 24, pp. 5088, http://dx.doi.org/10.1128/MCB.24.11.5088.2004
Zhang GS; Dass CR; Sun L; Khachigian LM, 2004, 'DNAZYMES TARGETING C-JUN BLOCK ENDOTHELIAL PROLIFERATION, MIGRATION, TUBULE FORMATION, ANGIOGENESIS AND SOLID TUMOR GROWTH', Cardiovascular Pathology, vol. 13, pp. 131 - 131, http://www.sciencedirect.com/science/article/B6T13-4C88SSS-FR/2/5289ac8546a33c5e6f75f4effe492cdc
Zhang GS; Dass CR; Sumithran E; Di Girolamo N; Sun L; Khachigian LM, 2004, 'Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents', Journal of the National Cancer Institute, vol. 96, pp. 683 - 696, http://dx.doi.org/10.1093/jnci/djh120
Mitchell A; Dass CR; Sun L; Khachigian LM, 2004, 'Inhibition of human breast carcinoma proliferation, migration, chemoinvasion and solid tumour growth by DNAzymes targeting the zinc finger transcription factor EGR-1', Nucleic Acids Research, vol. 32, pp. 3065 - 3069, http://dx.doi.org/10.1093/nar/gkh626
Bonello M; Khachigian LM, 2004, 'Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter', The Journal of Biological Chemistry, vol. 279, pp. 2377 - 2382, http://dx.doi.org/10.1074/jbc.M308254200
Hanratty C; Murrell MJ; Khachigian LM; Tsao P; Ward M, 2004, 'Low flow promotes instent intimal hyperplasia: Comparison with lumen loss in balloon-injured and uninjured vessels and the effects of the antioxidant pyrrolidine dithiocarbamate', Atherosclerosis, vol. 177, pp. 269 - 274, http://dx.doi.org/10.1016/j.atherosclerosis.2004.07.016
Santiago FS; Khachigian LM, 2004, 'Ets-1 Stimulates Platelet-Derived Growth Factor A-Chain Gene Transcription and Vascular Smooth Muscle Cell Growth via Cooperative Interactions With Sp1', Circulation Research, vol. 95, pp. 479 - 487, http://dx.doi.org/10.1161/01.RES.0000141135.36279.67
Khachigian LM, 2004, 'Deoxyribozymes as inhibitors of vascular smooth muscle cell growth', Current Pharmaceutical Biotechnology, vol. 5, pp. 337 - 339, http://dx.doi.org/10.2174/1389201043376788
Sharma L; Melis E; Hickey M; Clyne C; Erlich JH; Khachigian LM; Morand E; Carmeliet P; Tipping P; Davenport P, 2004, 'The cytoplasmic domain of tissue factor contributes to leukocyterecruitment and death in endotoxemia', American Journal of Pathology, vol. 165, pp. 331 - 340, http://dx.doi.org/10.1016/S0002-9440(10)63300-7
Kavurma MM; Khachigian LM, 2004, 'Vascular smooth muscle cell-specific regulation of cyclin-dependent kinase inhibitor p21(WAF1/Cip1) transcription by Sp1 is mediated via distinct cis-acting positive and negative regulatory elements in the proximal p21(WAF1/Cip1) promoter', Journal of Cellular Biochemistry, vol. 93, pp. 904 - 916, http://dx.doi.org/10.1002/jcb.20238
Midgley VC; Khachigian LM, 2004, 'Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1', The Journal of Biological Chemistry, vol. 279, pp. 40289 - 40295, http://dx.doi.org/10.1074/jbc.M406063200
Khachigian LM, 2004, 'DNAzymes as molecular agents that manipulate Egr-1 gene expression', Biochemical Pharmacology, vol. 68, pp. 1023 - 1025, http://dx.doi.org/10.1016/j.bcp.2004.03.042
Fahmy R; Khachigian LM, 2004, 'Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth', Nucleic Acids Research, vol. 32, pp. 2281 - 2285, http://dx.doi.org/10.1093/nar/gkh543
Khachigian LM; Parish CR, 2004, 'Phosphomannopentaose sulfate (PI-88): heparan sulfate mimetic with clinical potential in multiple vascular pathologies', Cardiovascular Drug Reviews, vol. 22, pp. 1 - 6
Khachigian LM, 2004, 'Oxidative stress and endothelial dysfunction', Endothelium - Journal of Endothelial Cell Research, vol. 11, pp. 77 - 78, http://dx.doi.org/10.1080/10623320490492339
Khachigian LM, 2004, 'Early growth response-1: blocking angiogenesis by shooting the messenger', Cell Cycle, vol. 3, pp. 10 - 11
Eyries MM; Collins TF; Khachigian LM, 2004, 'Modulation of growth factor gene expression in vascular cells by oxidative stress', Endothelium - Journal of Endothelial Cell Research, vol. 11, pp. 133 - 139, http://dx.doi.org/10.1080/10623320490482691
Eisbacher M; Holmes ML; Newton A; Hogg PJ; Khachigian LM; Crossley M; Chong BH, 2004, 'Protein-protein interaction between Fli-1 and GATA-1 mediatessynergistic expression of megakaryocyte-specific genes throughcooperative DNA binding (vol 23, pg 3427, 2003)', Molecular and Cellular Biology, vol. 24, pp. 5088 - 5088, http://dx.doi.org/10.1128/MCB.24.11.5088.2004
De Mestre AM; Khachigian LM; Santiago FS; Staykova MA; Hulett MD, 2003, 'Regulation of Inducible Heparanase Gene Transcription in Activated T Cells by Early Growth Response 1', Journal of Biological Chemistry, vol. 278, pp. 50377 - 50385, http://dx.doi.org/10.1074/jbc.M310154200
Kavurma MM; Khachigian LM, 2003, 'Sp1 inhibits proliferation and induces apoptosis in vascular smooth muscle cells by repressing p21WAF1/Cip1 transcription and cyclin D1-Cdk4-p21WAF1/Cip1 complex formation', Journal of Biological Chemistry, vol. 278, pp. 32537 - 32543, http://dx.doi.org/10.1074/jbc.M305650200
Zhang C; Kavurma MM; Lai A; Khachigian LM, 2003, 'Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and inducible p21WAF1/Cip1 transcription via distinct cis-acting elements in the p21WAF1/Cip1 promoter', Journal of Biological Chemistry, vol. 278, pp. 27903 - 27909, http://dx.doi.org/10.1074/jbc.M304328200
Burkhart CA; Cheng AJ; Madafiglio J; Kavallaris M; Mili M; Marshall GM; Weiss WA; Khachigian LM; Norris MD; Haber M, 2003, 'Effects of MYCN antisense oligonucleotide administration on tumorigenesis in a murine model of neuroblastoma', Journal of National Cancer Institute, vol. 95, pp. 1394 - 1403, http://dx.doi.org/10.1093/jnci/djg045
Fahmy R; Dass CR; Sun L; Chesterman CN; Khachigian LM, 2003, 'Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumour growth', Nature Medicine, vol. 9, pp. 1026 - 1032, http://dx.doi.org/10.1038/nm905
Eisbacher M; Holmes ML; Newton A; Hogg PJ; Crossley M; Chong BH; Khachigian LM, 2003, 'Protein-protein interaction between Fli-1 and GATA 1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding', Molecular and Cellular Biology, vol. 23, pp. 3427 - 3441, http://dx.doi.org/10.1128/MCB.23.10.3427-3441.2003
Pimanda JE; Lowe HC; Hogg PJ; Chesterman CN; Khachigian LM, 2003, 'Novel and Emerging Therapies in Cardiology and Haematology', Current Drug Targets, vol. 3, pp. 101 - 103, http://dx.doi.org/10.2174/1568006033481465
Lowe HC; Jang IK; Khachigian LM, 2003, 'Animal models of vulnerable plaque', Thrombosis and Haemostasis, vol. 90, pp. 774 - 780
Kavurma MM; Khachigian LM, 2003, 'ERK, JNK, and p38 MAP Kinases Differentially Regulate Proliferation and Migration of Phenotypically Distinct Smooth Muscle Cell Subtypes', Journal of Cellular Biochemistry, vol. 89, pp. 289 - 300, http://dx.doi.org/10.1002/jcb.10497
Francis DJ; Parish CR; McGarry M; Santiago FS; Lowe HC; Brown KJ; Bingley JA; Hayward IP; Cowden WB; Campbell JH; Campbell GR; Chesterman CN; Khachigian LM, 2003, 'Blockade of Vascular Smooth Muscle Cell Proliferation and Intimal Thickening After Balloon Injury by the Sulfated Oligosaccharide PI-88', Circulation Research, vol. 92, pp. 70 - 77
Kavurma MM; Khachigian LM, 2003, 'Signaling and transcriptional control of Fas ligand gene expresion', Cell death and differentiation, vol. 10, pp. 36 - 44, http://dx.doi.org/10.1038/sj.cdd.4401179
MacNeill BD; James B; Chesterman CN; Khachigian LM, 2002, 'Overstretch stent injury to the rat aorta leads to in-stent restenosis', American Journal of Cardiology, vol. 89, pp. 1010, http://dx.doi.org/10.1016/S0002-9149(02)02264-6
Lowe HC; Khachigian LM, 2002, 'Coating stents with antirestenotic drugs: the blunderbuss or the magic bullet?', Circulation, vol. 105, http://dx.doi.org/10.1161/circ.105.4.e29
Khachigian LM; Fahmy R; Zhang GS; Bobryshev YV; Kaniaros A, 2002, 'c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury. Inhibition by a novel DNA enzyme targeting c-Jun', The Journal of Biological Chemistry, vol. 277, pp. 22985 - 22991, http://dx.doi.org/10.1074/jbc.M200977200
Kavurma MM; Bobryshev YV; Khachigian LM, 2002, 'Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1', The Journal of Biological Chemistry, vol. 277, pp. 36244 - 36252, http://dx.doi.org/10.1074/jbc.M200463200
Lowe HC; Burkoff D; Khachigian LM; MacNeill BD; Hayase M; Oesterle SN, 2002, 'Beyond angioplasty: novel developments in interventional cardiology', Internal Medicine Journal, vol. 32, pp. 470 - 474, http://dx.doi.org/10.1046/j.1445-5994.2002.00261.x
Khachigian LM, 2002, 'DNAzymes: cutting a path to a new class of therapeutics', Current Opinion in Molecular Therapeutics, vol. 4, pp. 119 - 121
Rafty LA; Khachigian LM, 2002, 'von Hippel-Lindau tumor suppressor protein represses platelet-derived growth factor B-chain gene expression via the Sp1 binding element in the proximal PDGF-B promoter', Journal of Cellular Biochemistry, vol. 85, pp. 490 - 495, http://dx.doi.org/10.1002/jcb.10152
Lowe HC; Chesterman CN; Khachigian LM, 2002, 'Catalytic Antisense DNA Molecules Targeting Egr-1 Inhibit Neointima Formation following Permanent Ligation of Rat Common Carotid Arteries', Thrombosis and Haemostasis, vol. 87, pp. 134 - 140
Rafty LA; Santiago FS; Khachigian LM, 2002, 'NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter', European Molecular Biology Organization, vol. 21, pp. 334 - 343, http://dx.doi.org/10.1093/emboj/21.3.334
Lowe HC; Oesterle SN; Khachigian LM, 2002, 'Coronary In-Stent Restenosis: Current Status and Future Strategies', Journal of the American College of Cardiology, vol. 39, pp. 183 - 193, http://dx.doi.org/10.1016/S0735-1097(01)01742-9
Fahmy R; Khachigian LM, 2002, 'Antisense Egr-1 RNA driven by the CMV promoter is an inhibitor of vascular smooth muscle cell proliferation and regrowth after injury', Journal of Cellular Biochemistry, vol. 84, pp. 575 - 582, http://dx.doi.org/10.1002/jcb.10057
Eisbacher M; Newton A; Holmes ML; Khachigian LM; Crossley M; Chong BH, 2001, 'The protein-protein interaction between FLI-1 and GATA-1 is crucial for expression of the megakaryocyte-specific gene Glycoprotein IX.', BLOOD, vol. 98, pp. 286A - 286A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172134101211&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Lowe HC; Fahmy R; Chesterman CN; Khachigian LM, 2001, 'Catalytic oligodeoxynucleotides targeting the human transcription factor EGR-1 as inhibitors of restenosis', CIRCULATION, vol. 104, pp. 265 - 265, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000171895001261&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Rafty LA; Khachigian LM, 2001, 'Sp1 phosphorylation mediates inducible platelet-derived growth factor B-chain gene expression: Phosphorylation mediated by atypical protein kinase C-zeta', FASEB JOURNAL, vol. 15, pp. A1185 - A1185, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000167454202722&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM, 2001, 'Catalytic oligonucleotides targeting Egr-1 as potential inhibitors of in-stent restenosis', Annals of the New York Academy of Sciences, vol. 947, pp. 412 - 415, http://dx.doi.org/10.1111/j.1749-6632.2001.tb03975.x
Khachigian LM, 2001, 'Single-stranded catalytic dna as potential therapeutic agents in vascular disease', Today's Life Science, vol. 13, pp. 30 - 31
Lowe HC; Kumar RK; Chesterman CN; Fahmy R; Khachigian LM, 2001, 'Coronary Stent Thrombosis: Insights from the Porcine Coronary Stent Model', Journal of Thrombosis and Thrombolysis, vol. 86, pp. 937 - 938
Santiago FS; Khachigian LM, 2001, 'Nucleic acid based strategies as potential therapeutic tools: mechanistic considerations and implications to restenosis.', Molecular Medicine, vol. 79, pp. 695 - 706, http://dx.doi.org/10.1007/s001090100272
Santiago FS; Lowe HC; Bobryshev YV; Khachigian LM, 2001, 'Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2.', The Journal of Biological Chemistry, vol. 276, pp. 41143 - 41149, http://dx.doi.org/10.1074/jbc.M104913200
Lowe HC; Fahmy R; Kavurma MM; Baker A; Chesterman CN; Khachigian LM, 2001, 'Catalytic Oligodeoxynucleotides Define a Key Regulatory Role for Early Growth Response Factor-1 in the Porcine Model of Coronary In-Stent Restenosis', Circulation Research, vol. 89, pp. 670 - 677, http://dx.doi.org/10.1161/hh2001.097867
Lowe HC; Chesterman CN; Khachigian LM, 2001, 'Rat Aortic Stenting: Toward a Simple Model of In-Stent Restenosis', American Journal of Cardiology, vol. 88, pp. 720 - 721, http://dx.doi.org/10.1016/S0002-9149(01)01795-7
Lowe HC; Chesterman CN; Khachigian LM, 2001, 'Does Thrombus Contribute to In-stent Restenosis in the Porcine Coronary Stent Model?', Journal of Thrombosis and Thrombolysis, vol. 85, pp. 1117 - 1118
Lowe HC; Chesterman CN; Hopkins AP; Juergens CP; Khachigian LM, 2001, 'Acute Local Release of Fibroblast Growth Factor 2 but not Transforming Growth Factor B1 following Coronary Stenting', Journal of Thrombosis and Thrombolysis, vol. 85, pp. 574 - 576
Rafty LA; Khachigian LM, 2001, 'Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical proten kinase C-', Nucleic Acids Research, vol. 29, pp. 1027 - 1033
Gousseva N; Kugathasan K; Chesterman CN; Khachigian LM, 2001, 'Early Growth Response Factor-1 Mediates Insulin-Inducible Vascular Endothelial Cell Proliferation and Regrowth After Injury', Journal of Cellular Biochemistry, vol. 81, pp. 523 - 534, http://dx.doi.org/10.1002/1097-4644(20010601)81:3<523::AID-JCB1066>3.0.CO;2-E
Kavurma MM; Santiago FS; Bonfoco E; Khachigian LM, 2001, 'Sp1 Phosphorylation Regulates Apoptosis via Extracellular FasL-Fas Engagement', The Journal of Biological Chemistry, vol. 276, pp. 4964 - 4971, http://dx.doi.org/10.1074/jbc.M009251200
Chong BH; Eisbacher M; Khin TH; Khachigian LM, 2000, 'Inducible expression of GPIX by PMA and TPO in megakaryocytic cells requires an intact Ets site and upstream activation of ERK.', BLOOD, vol. 96, pp. 672A - 672A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000165256102891&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Lowe HC; Chesterman CN; Hopkins AP; Juergens CP; Khachigian LM, 2000, 'Acute local release of fibroblast growth factor-2, but not transforming growth factor-beta(1), following coronary stenting', CIRCULATION, vol. 102, pp. 732 - 732, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000090072303532&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Lowe HC; Santiago FS; Chesterman CN; Khachigian LM, 2000, 'A novel catalytic DNA molecule targeting the transcription factor Egr-1 inhibits neointimal formation following rat carotid angioplasty', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 35, pp. 15A - 15A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000085209700059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Lowe HC; Santiago FS; Chesterman CN; Khachigian LM, 2000, 'Immobilized hyaluronic acid as a thromboresistant coating for cardiovascular devices', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 35, pp. 15A - 15A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000085209700057&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM, 2000, 'Catalytic DNAs as potential therapeutic agents and sequent-specific molecular tools to dissect biological function', Journal of Clinical Investigation, vol. 106, pp. 1189 - 1195, http://dx.doi.org/10.1172/JCI11620
Khachigian LM; Takuwa Y; Collins TF, 2000, 'Mechanisms of angiotensin II-induced platelet-derived growth factor gene expression', Molecular and Cellular Biochemistry, vol. 212, pp. 183 - 186
Larkin L; Khachigian LM; Jessup W, 2000, 'Regulation of apolipoprotein E production in macrophages', International Journal of Molecular Medicine, vol. 6, pp. 253 - 258
Tapsall JW; Khachigian LM, 2000, 'Induction of platelet-derived growth factor B-chain expression by transforming growth factor-b involves transactivation by smads', The Journal of Biological Chemistry, vol. 275, pp. 16709 - 16716, http://dx.doi.org/10.1074/jbc.275.22.16709
Sungaran R; Chisholm OT; Markovic B; Khachigian LM; Tanaka Y; Chong BH, 2000, 'The role of platelet ?-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells.', Blood, vol. 95, pp. 3094 - 3101
Rafty LA; Khachigian LM, 2000, 'Novel negative regulatory element in the platelet-derived growth factor B chain promoter that mediates ERK-dependent transcriptional repression', The Journal of Biological Chemistry, vol. 275, pp. 11478 - 11483, http://dx.doi.org/10.1074/jbc.275.15.11478
Lowe HC; Murray BJ; Chong BH; Chesterman CN; Khachigian LM, 2000, 'Intracoronary blood sampling using the multifunction probing catheter does not cause platelet activation', Journal of Invasive Cardiology, vol. 12, pp. 144 - 146
Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker A; Atkins DG; Khachigian LM, 1999, 'New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury (vol 5, pg 1264, 1999)', NATURE MEDICINE, vol. 5, pp. 1438 - 1438, http://dx.doi.org/10.1038/71020
Khachigian LM; Santiago FS; Rafty LA; Chan OLW; Delbridge GJ; Bobik A; Collins T; Johnson AC, 1999, 'GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury.', FASEB JOURNAL, vol. 13, pp. A42 - A42, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082033300240&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker A; Atkins DG; Khachigian LM, 1999, 'Erratum: New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury (Nature Medicine (1999) 5 (1264-1269))', Nature Medicine, vol. 5, pp. 1438, http://dx.doi.org/10.1038/71020
Silverman ES; Khachigian LM; Santiago FS; Williams A; Lindner V; Collins TF, 1999, 'Vascular smooth muscle cells express the transcriptional corepressor NAB2 in response to injury.', American Journal of Pathology, vol. 155, pp. 1311 - 1317, http://dx.doi.org/10.1016/S0002-9440(10)65233-9
Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker AT; Atkins D; Khachigian LM, 1999, 'New DNA enzyme targeting Egr1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury', Nature Medicine, vol. 5, pp. 1264 - 1269, http://dx.doi.org/10.1038/15215
Santiago FS; Atkins D; Khachigian LM, 1999, 'Vascular smooth muscle cell proliferation and regrowth after mechanical injury in vitro are Egr1/NGFIAdependent.', American Journal of Pathology, vol. 155, pp. 897 - 905, http://dx.doi.org/10.1016/S0002-9440(10)65189-9
Day FL; Rafty LA; Chesterman CN; Khachigian LM, 1999, 'Angiotensin II (ATII)inducible plateletderived growth factor Achain gene expression is p42/44 extracellular signalregulated kinase1/2 and Egr1dependent and mediated via the ATII type 1 but not type 2 receptor. Induction by ATII a', The Journal of Biological Chemistry, vol. 274, pp. 23726 - 23733, http://dx.doi.org/10.1074/jbc.274.34.23726
Khachigian LM; Santiago FS; Rafty LA; Onza CL; Delbridge G; Bobik A; Collins TF; Johnson AG, 1999, 'GC Factor 2 represses plateletderived growth factor Achain gene transcription and is itself induced by arterial injury', Circulation Research, vol. 84, pp. 1258 - 1267, http://dx.doi.org/10.1161/01.RES.84.11.1258
Santiago FS; Lowe HC; Day FL; Chesterman CN; Khachigian LM, 1999, 'Early growth response factor1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor2.', American Journal of Pathology, vol. 154, pp. 937 - 944, http://dx.doi.org/10.1016/S0002-9440(10)65341-2
Lowe HC; Chesterman CN; Khachigian LM, 1999, 'Left main coronary artery stenosis after percutaneous transluminal coronary angioplast: Importance of remaining `Minimally Invasive`', Catheterization and Cardiovascular Interventions, vol. 46, pp. 254 - 255
Khachigian LM, 1999, 'The imtimacies of blood vessel injury.', Today's Life Science, vol. 11, pp. 74 - 78
Khachigian LM; Santiago FS; Delbridge GJ; Chesterman CN, 1998, 'Endothelial injury triggers FGF-2 release and a signaling cascade involving MAPK and Egr-1.', FASEB JOURNAL, vol. 12, pp. A467 - A467, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000076006402706&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Santiago FS; Atkins D; Khachigian LM, 1998, 'Antisense oligonucleotides directed against Egr-1 inhibit vascular smooth muscle cell proliferation.', FASEB JOURNAL, vol. 12, pp. A189 - A189, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000076006401100&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM; Collins TF, 1998, 'Early growth response factor-1: a pleiotropic mediator of inducible gene expression.', Journal of Molecular Medicine - Jmm, vol. 76, pp. 613 - 616, http://dx.doi.org/10.1007/s001090050258
Sumpio RE; Du W; Galagher G; Wang H; Khachigian LM; Collins TF; Gimbrone MA; Resnick N, 1998, 'Regulation of PDGF-B in endothelial cells exposed to cyclic strain.', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 18, pp. 349 - 355, http://dx.doi.org/10.1161/01.ATV.18.3.349
Rafty LA; Khachigian LM, 1998, 'Zinc finger transcription factors mediate high constitutive PDGF-B expression in smooth muscle cells derived from aortae of newborn rats.', The Journal of Biological Chemistry, vol. 273, pp. 5758 - 5764, http://dx.doi.org/10.1074/jbc.273.10.5758
Khachigian LM; Santiago FS; Delbridge GJ; Chesterman CN, 1997, 'Endothelial injury and transcriptional activation: bFGF induction of Egr-1 and PDGF-A', ATHEROSCLEROSIS, vol. 134, pp. 265 - 265, http://dx.doi.org/10.1016/S0021-9150(97)89392-6
Resnick N; Yahav H; Khachigian LM; Collins T; Anderson KR; Dewey FC; Gimbrone MA, 1997, 'Endothelial gene regulation by laminar shear stress', Advances in Experimental Medicine and Biology, vol. 430, pp. 155 - 164, http://dx.doi.org/10.1007/978-1-4615-5959-7_13
Gimbrone MA; Resnick N; Nagel T; Khachigian LM; Collins T; Topper JN, 1997, 'Hemodynamics, endothelial gene expression, and atherogenesis', Annals of the New York Academy of Sciences, vol. 811, pp. 1 - 11, http://dx.doi.org/10.1111/j.1749-6632.1997.tb51983.x
Yang M; Khachigian LM; Hicks C; Chesterman CN; Chong BH, 1997, 'Identification of PDGF receptors on human megakaryocytes and megakarocytic cell lines', Thrombosis and Haemostasis, vol. 78, pp. 892 - 896
Khachigian LM; Dixon GJ; Huang XF; Catts SV; Hickie IB; Wakefield D, 1997, 'Molecular biology and the major psychoses', Australian and New Zealand Journal of Psychiatry, vol. 31, pp. 12 - 16, http://dx.doi.org/10.3109/00048679709073794
Silverman ES; Khachigian LM; Lindner V; Williams A; Collins TF, 1997, 'Inducible PDGF A-chain transcription in smooth muscle cells is mediated by Egr-1 displacement of Sp1 and Sp3', American Journal of Physiology - Cell Physiology, vol. 273, pp. H1415 - H1426
Khachigian LM; Collins TF; Fries JW, 1997, 'N-acetyl cysteine blocks mesangial VCAM-1 and NF-kappa B expression in vivo', American Journal of Pathology, vol. 151, pp. 1225 - 1229
Khachigian LM; Collins TF, 1997, 'Inducible expression of Egr-1-dependent genes. A paradigm of transcriptional activation in vascular endothelium', Circulation Research, vol. 81, pp. 457 - 461, http://dx.doi.org/10.1161/01.RES.81.4.457
Khachigian LM; Anderson KJ; Halnon NJ; Gimbrone MA; Resnick N; Collins TF, 1997, 'Egr-1 is activated in endothelial cells exposed to fluid shear stress and interacts with a novel shear-stress-response element in the PDGF A-chain promoter', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 17, pp. 2280 - 2286, http://dx.doi.org/10.1161/01.ATV.17.10.2280
Delbridge G; Khachigian LM, 1997, 'FGF-1-induced platelet-derived growth factor-A chain gene expression in endothelial cells involves transcriptional activation by early growth response factor-1', Circulation Research, vol. 81, pp. 282 - 288, http://dx.doi.org/10.1161/01.RES.81.2.282
Khachigian LM; Anderson KR; Halnon NJ; Gimbrone MA; Resnick N; Collins T, 1996, 'Shear-induced endothelial pdgf-a chain gene expression involves EGR-1', FASEB Journal, vol. 10
Field ST; Khachigian LM; Sleigh MJ; Yang G; Hogg PJ; Chesterman CN, 1996, 'Extracellular matrix as a source of mitogenically active platelet-derived growth factor', Journal of Cellular Physiology, vol. 168, pp. 322 - 332, http://dx.doi.org/10.1002/(SICI)1097-4652(199608)168:2<322::AID-JCP11>3.0.CO;2-5
Khachigian LM; Lindner V; Williams A; Collins TF, 1996, 'Egr-1-induced endothelial gene expression: a common theme in vascular injury', Science, vol. 271, pp. 1427 - 1431, http://dx.doi.org/10.1126/science.271.5254.1427
Khachigian LM; Williams AJ; Collins T, 1995, 'Interplay of Sp1 and Egr-1 in the PDGF A-chain proximal promoter in cultured vascular endothelial cells.', BLOOD, vol. 86, pp. 1246 - 1246, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TH91001248&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
KHACHIGIAN LM; RESNICK N; GIMBRONE MA; COLLINS T, 1995, 'NUCLEAR FACTOR-KAPPA-B INTERACTS FUNCTIONALLY WITH THE SHEAR-STRESS-RESPONSE-ELEMENT IN THE PLATELET-DERIVED GROWTH-FACTOR B-CHAIN PROMOTER', FASEB JOURNAL, vol. 9, pp. A412 - A412, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QL98702410&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM; Collins T; Fries JWU, 1995, 'Nuclear factor-κB mediates induction of vascular cell adhesion molecule-1 in glomerular mesangial cells', Biochemical and Biophysical Research Communications, vol. 206, pp. 462 - 467, http://dx.doi.org/10.1006/bbrc.1995.1065
Khachigian LM; Field SL; Crouch R; Chesterman CN, 1995, 'Platelet-derived growth factor A-chain synthetic peptide inhibits human glioma xenograft proliferation in nude mice', Anticancer Research, vol. 15, pp. 337 - 341
Khachigian LM; Williams AJ; Collins T, 1995, 'Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells', Journal of Biological Chemistry, vol. 270, pp. 27679 - 27686, http://dx.doi.org/10.1074/jbc.270.46.27679
Khachigian LM; Resnick N; Gimbrone MA; Collins T, 1995, 'Nuclear factor-κB interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress', Journal of Clinical Investigation, vol. 96, pp. 1169 - 1175, http://dx.doi.org/10.1172/JCI118106
Williams A; Khachigian LM; Shows T; Collins TF, 1995, 'Isolation and characterisation of a novel zinc-finger protein with transcriptional repressor activity', The Journal of Biological Chemistry, vol. 270, pp. 22143 - 22152, http://dx.doi.org/10.1074/jbc.270.38.22143
Neish AS; Khachigian LM; Baichwal VR; Park A; Collins TF, 1995, 'Sp1 is a component of the cytokine-inducible enhancer in the promoter of vascular cell adhesion molecule-1', The Journal of Biological Chemistry, vol. 270, pp. 28903 - 28908, http://dx.doi.org/10.1074/jbc.270.48.28903
KHACHIGIAN LM; BENZ MW; NEISH AS; BONTHRON DT; COLLINS T, 1994, 'NOVEL DNA-BINDING ELEMENTS IN THE PROMOTER OF HUMAN PLATELET-DERIVED GROWTH-FACTOR B-CHAIN GENE', FASEB JOURNAL, vol. 8, pp. A392 - A392, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994ND19602268&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM; Fries JWU; Benz MW; Bonthron DT; Collins T, 1994, 'Novel cis-acting elements in the human platelet-derived growth factor B- chain core promoter that mediate gene expression in cultured vascular endothelial cells', Journal of Biological Chemistry, vol. 269, pp. 22647 - 22656
Khachigian LM; Chesterman CN, 1994, 'Structural basis for the extracellular retention of PDGF A-chain using a synthetic peptide corresponding to exon 6', Peptides, vol. 15, pp. 133 - 137, http://dx.doi.org/10.1016/0196-9781(94)90181-3
KHACHIGIAN LM; SLEIGH MJ; CHESTERMAN CN, 1993, 'PLATELET-DERIVED GROWTH FACTOR-A-CHAIN EXON-6 PRODUCT ASSOCIATES WITH EXTRACELLULAR HEPARIN-LIKE GLYCOSAMINOGLYCANS', THROMBOSIS AND HAEMOSTASIS, vol. 69, pp. 972 - 972, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993LT57701547&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM; Chesterman CN, 1993, 'Platelet-derived growth factor and its receptor: Structure and roles in normal growth and pathology', Platelets, vol. 4, pp. 304 - 315, http://dx.doi.org/10.3109/09537109309013233
KHACHIGIAN LM, 1992, 'CORRECTION', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, pp. 6449 - 6449, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992HK31800110&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM; Chesterman CN, 1992, 'Platelet-derived growth factor and alternative splicing: A review', Pathology, vol. 24, pp. 280 - 290, http://dx.doi.org/10.3109/00313029209068882
Khachigian LM; Evin G; Morgan FJ; Owensby DA; Chesterman CN, 1992, 'A crossreactive antipeptide monoclonal antibody with specificity for lysyl-lysine (J. Immunol. Methods 140 (1991) 249-258)', Journal of Immunological Methods, vol. 149, pp. 267, http://dx.doi.org/10.1016/0022-1759(92)90259-v
Khachigian LM; Owensby DA; Chesterman CN, 1992, 'A tyrosinated peptide representing the alternatively spliced exon of the platelet-derived growth factor A-chain binds specifically to cultured cells and interferes with binding of several growth factors', Journal of Biological Chemistry, vol. 267, pp. 1660 - 1666
Khachigian LM; Chesterman CN, 1992, 'Synthetic peptides representing the alternatively spliced exon of the platelet-derived growth factor A-chain modulate mitogenesis stimulated by normal human serum and several growth factors', Journal of Biological Chemistry, vol. 267, pp. 7478 - 7482
Khachigian LM; Owensby DA; Chesterman CN, 1992, 'Erratum: A tyrosinated peptide representing the alternatively spliced exon of the platelet-derived growth factor A-chain binds specifically to cultured cells and interferes with binding of several growth factors (Journal of Biological Chemistry (1992) 267 (1660-1666))', Journal of Biological Chemistry, vol. 267, pp. 6449
Khachigian LM; Evin G; Morgan FJ; Owensby DA; Chesterman CN, 1991, 'A crossreactive antipeptide monoclonal antibody with specificity for lysyl-lysine', Journal of Immunological Methods, vol. 140, pp. 249 - 258, http://dx.doi.org/10.1016/0022-1759(91)90378-S
Conference Papers
Billah M; Ridiandries A; Khachigian L; Dona A; Bhindi R, 2017, 'Autophagy is Essential for Remote Preconditioning Induced Cardioprotection and May Involve JAK-STAT Pathway for Autophagy Activation', in CIRCULATION RESEARCH, LIPPINCOTT WILLIAMS & WILKINS, Portland, OR, presented at Basic Cardiovascular Sciences Scientific Sessions of the American-Heart-Association - Pathways to Cardiovascular Therapeutics, Portland, OR, 10 July 2017 - 13 July 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000520552700360&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Yee GPC; De Souza PL; Khachigian LM, 2013, 'Reducing invasion potential of cervical cancer cells via targeted knockdown of c-Jun', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Chicago, IL, presented at 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago, IL, 31 May 2013 - 04 June 2013, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335419605150&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Cho E; Moloney FJ; Cai H; Au-Yeung A; China C; Scolyer RA; Francis DJ; Halliday GM; Khachigian LM, 2012, 'First-in-Human Trial of Dz13 DNAzyme Targeting c-jun in Patients with Basal Cell Carcinoma', in JOURNAL OF INVESTIGATIVE DERMATOLOGY, NATURE PUBLISHING GROUP, Venice, ITALY, pp. S66 - S66, presented at 42nd Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Venice, ITALY, 07 September 2012 - 10 September 2012, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000307814000367&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM, 2011, 'Catalytic DNA as new drugs for vascular disease and cancer', in VASCULAR PHARMACOLOGY, ELSEVIER SCIENCE INC, Krakow, POLAND, pp. 335 - 336, presented at 6th European Meeting on Vascular Biology and Medicine (EMVBM), Krakow, POLAND, 21 September 2011 - 24 September 2011, http://dx.doi.org/10.1016/j.vph.2011.08.088
Khachigian LM, 2008, 'IMMEDIATE-EARLY GENES AS MASTER SWITCHES IN DISEASE', in Cell Biology International, Academic Press Ltd Elsevier Science Ltd, London, England, pp. S3 - S3, presented at Cell Biology International, http://dx.doi.org/10.1016/j.cellbi.2008.01.018
Bhindi R; Khachigian LM; Lowe HC, 2006, 'Egr-1 targeting DNAzymes reduce myocardial infarct size following ischaemia-reperfusion', in EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, Barcelona, SPAIN, pp. 409 - 409, presented at 28th Congress of the European-Society-of-Cardiology/World Congress of Cardiology, Barcelona, SPAIN, 02 September 2006 - 06 September 2006, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000240668402465&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Eisbacher M; Holmes ML; Hogg PJ; Newton A; Khachigian LM; Crossley M; Chong BH, 2003, 'Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA-binding', in Journal of Thrombosis and Haemostasis, Blackwell Publishing Ltd, Oxford, England, pp. 357 - 357, presented at XIXth Congress of the International Society on Thrombosis and Haematosis, Birmingham, England, 12 July 2003 - 18 July 2003
Murrell MJ; Khachigian LM; Tsao P; Ward MR, 2003, 'The effect of oxidant stress, injury and flow on c-jun and egr-1 expression', in ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, WASHINGTON, D.C., pp. A20 - A20, presented at 4th Annual Conference on Arteriosclerosis Thrombosisand Vascular Biology, WASHINGTON, D.C., 08 May 2003 - 10 May 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000182742500140&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM, 2002, 'Insulin and vascular growth regulation by transcription', in CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, BLACKWELL PUBLISHING ASIA, MELBOURNE, AUSTRALIA, pp. A27 - A27, presented at Joint Symposium of the Australian-Athersclerosis-Society/Australian-Vascular-Biology-Society, MELBOURNE, AUSTRALIA, 27 December 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183582000071&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM, 2002, 'Control of immediate-early transcription factor expression in injured arteries', in CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, BLACKWELL PUBLISHING ASIA, MELBOURNE, AUSTRALIA, pp. A12 - A12, presented at Joint Symposium of the Australian-Athersclerosis-Society/Australian-Vascular-Biology-Society, MELBOURNE, AUSTRALIA, 27 December 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183582000041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM; Resnick N; Gimbrone MA; Collins TF, 1995, 'Nuclear factor-kB interacts functionally with the platelet-derived growth factor B-chain promoter', in Journal of Clinical Investigation, American Society Clinical Investigation Inc, Ann Arbor, MI, USA, presented at Experimental Biology Meeting 1995, Atlanta, Georgia USA, 08 April 1995 - 12 April 1995
Conference Abstracts
Khachigian LM, 2016, 'New insights on the regulatory roles of early growth response-1 in the reparative response to vascular injury', in INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, SPANDIDOS PUBL LTD, Vol. 38, pp. S79 - S79, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383733000298&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Patents
Khachigian LM; Atkins D; Baker AT, 1999, Catalytic molecules, Patent No. , Patent Agent:
Khachigian LM, 1999, Treatment of asthma, Patent No. , Patent Agent:
Khachigian LM, 1999, Treatment of cancer, Patent No. , Patent Agent:
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