Professor Levon Khachigian

Fields of research: Cardiovascular Medicine and Haematology, Cancer Cell Biology

Contact Details

Phone: +61 2 9385 2537
Fax: 51797
Email: l.khachigian@unsw.edu.au

Tabs

Main

Qualifications: BSc (Hons I) PhD DSc UNSW MIP (Law) UTS

Research Interests

Cardiovascular disease and cancer remain the most prevalent causes of morbidity and mortality. The pathogenesis of these and a myriad of other inflammatory, proliferative, migratory and autoimmune diseases are underpinned by molecular and cellular changes in our blood vessels. Professor Levon Khachigian’s research is uncovering key networks of transcriptional control and inducible gene-regulatory circuits that lead to vascular disease. Building on these mechanistic insights, his group is developing new experimental drugs that have the potential to treat a myriad of health problems, from cancer and arthritis through to eye and heart disease.

Levon heads the Vascular Biology and Translational Research Laboratory within the School of Medical Sciences, UNSW Faculty of Medicine. His research program sits within UNSW Medicine’s Thematic Areas of Triple I (Infection, Immunity & Inflammation) and Cancer, and has two major objectives:

To better understand how potentially harmful genes are controlled in vascular cells. This arm investigates signalling and transcriptional mechanisms of growth factor and pro-inflammatory cytokine-dependent gene expression, post-translational mechanisms that modify protein behaviour, isolation and characterization of new genes that are induced or repressed by acute vascular cell injury, and the molecular control of vascular cell migration and proliferation. The group has considerable expertise in animal models of neointima formation, angiogenesis, tumour growth, myocardial ischemia and inflammatory disease.
To develop novel vascular therapeutic agents. The lab is harnessing the outcomes of its fundamental research by pioneering the development of novel “anti-gene” (e.g. DNAzyme, siRNA, microRNA) and “gene-therapeutic” strategies targeting regulatory genes in experimental vascular diseases. The group is also actively developing new small molecule pharmacologic agents. This involves in-house laboratory research and strategic national and international collaborations with a range of clinical and preclinical specialists, global contract research organisations, leading industrial medicinal chemists and drug development consultants.

Levon received his PhD from UNSW in 1993 and after postdoctoral training in vascular pathobiology at Harvard Medical School returned to the UNSW Centre for Vascular Research in 1996 where he established an independent research group. He was appointed Professor in 2004.

Broad Research Areas

Cardiology and Vascular Disease
Cell Biology and Gene Regulation
Pathology
Cancer
Inflammation

Specific Research Keywords

Atherogenesis and Inflammation
Cardiology and Vascular Disease
Genetics
Signalling and Transcription
Molecular Mechanisms

Teaching Interests

Molecular pathobiology
Molecular biology, signalling and transcriptional control
Atherosclerosis and post-angioplasty restenosis
Inflammation
Angiogenesis
Cancer
Drug discovery

Funding Sources

National Health and Medical Research Council (NHMRC)
Australian Research Council (ARC)

Prizes and Distinctions

2017 NHMRC Senior Principal Research Fellowship
2016 Scopus Eureka Prize for Excellence in International Scientific Collaboration (FANTOM5 consortium)
2012 Distinguished Researcher Award, Australian Vascular Biology Society
2010 The Royal Society of Victoria Medal for Excellence in Scientific Research
2010 Premier’s Award for Excellence in Translational Cancer Research
2010 Business Events Sydney Ambassador
2009 NHMRC Australia Fellowship
2009 Rotary International Vocational Excellence Award
2007 OSMR Eureka James Callachor Prize for Medical Research
2006 GlaxoSmithKline Award for Research Excellence
2006 Wakefield Medal for Research Supervision
2005 Khwarizmi International Award for Science and Technology
2005 NHMRC Senior Principal Research Fellowship
2004 Australasian Science Prize
2003 C'wealth Health Minister's Award for Excellence in Health and Medical Research
2003 Gottschalk Medal, Australian Academy of Science
2003 Eureka Prize for Scientific Research
2003 Alumni Award for Achievement
2002 NHMRC Principal Research Fellowship
2002 RT Hall Prize, Cardiac Society of Australia & New Zealand
2001 Eppendorf Award for Young Australian Researcher (now Millennium Science Award)
2001 AMGEN Medical Researcher Award
2001 Young Tall Poppy Award
1999 NHMRC Research Fellowship
1997 Glaxo-Wellcome Australia Research Award (NSW)
1997 NHMRC R. Douglas Wright Research Fellowship
1993 NHMRC C.J. Martin Fellowship
1993 J. William Fulbright Award
1993 Rotary Foundation International Ambassadorial Award
1988 Queen Elizabeth II Silver Jubilee Trust Award for Young Australians

Society Past Presidencies

Australian Society for Medical Research (ASMR)
Australian Vascular Biology Society (AVBS)

Conference Organization

Chair, 15th International Vascular Biology Meeting, Sydney
Vascular Biology Section Chair & Conference Treasurer, 20th Congress of the International Society on Thrombosis and Haemostasis, Sydney

Selected Publications

Billah M, Ridiandries A, Allahwala UK, Mudaliar H, Dona A, Hunyor S, Khachigian LM, Bhindi R. Remote ischemic preconditioning induces cardioprotective autophagy and signals through IL-6 dependent JAK-STAT pathway. International Journal of Molecular Sciences 2020; 21:1692

Khachigian LM. Repurposing drugs for skin cancer. Current Medicinal Chemistry 2020; 27:1-7

Li Y, Acharya G, Elahy M, Xin H, Khachigian LM. The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation. Cancer Letters 2019: 459:268-276

Khachigian LM. Deoxyribozymes as catalytic nanotherapeutic agents. Cancer Research 2019; 79: 879-888

Billah M, Ridiandries A, Rayner BS, Allahwala U, Dona A, Khachigian LM, Bhindi R. Egr-1 functions as a master switch regulator of remote ischemic preconditioning-induced cardioprotection. Basic Research in Cardiology 2019; 115:2

Santiago FS, Sanchez-Guerrero E, Zhang G, Zhong L, Raftery MJ, Khachigian LM. Extracellular signal-regulated kinase-1 phosphorylates early growth response-1 at serine 26. Biochemical and Biophysical Research Communications 2019: 510:345-351

Billah M, Ridiandries A, Allahwala U, Mudaliar H, Dona A, Hunyor S, Khachigian LM, Bhindi R. Circulating mediators of remote ischemic preconditioning. Oncotarget 2019; 10:216-244

Khachigian LM. Transcription factors targeted by miRNAs regulating smooth muscle cell growth and intimal thickening after vascular injury. International Journal of Molecular Sciences 2019; 20:E5445

Alhendi AMN, Patrikakis M, Daub CO, Kawaji H, Itoh M, de Hoon M, Carninci P, Hayashizaki Y, Arner E, Khachigian LM. Promoter usage and dynamics in vascular smooth muscle cells exposed to fibroblast growth factor-2 or interleukin-1β. Scientific Reports 2018; 8:13164

Cai H, Cho EA, Li Y, Sockler J, Parish CR, Chong BH, Edwards J, Dodds TJ, Ferguson PM, Wilmott JS, Scolyer RA, Halliday GM, Khachigian LM. Melanoma protective anti-tumor immunity activated by catalytic DNA. Oncogene 2018; 37:5115-26

Cannistraci CV, Nieminen T, Nishi M, Khachigian LM, Viikila J, Laine M, Cianflone D, Maseri A, Keong YK, Bhindi R, Ammirati E. “Summer shift”: a potential effect of sunshine on the time onset of ST-elevation acute myocardial infarction. Journal of the American Heart Association 2018; 7:e006878

Sheahan AV, Biankin AV, Parish CR, Khachigian LM. Targeted therapies in the management of locally advanced and metastatic pancreatic cancer. Oncotarget 2018; 9:21613-21627

Khachigian LM. The yin and yang of YY1 in tumor growth and suppression. International Journal of Cancer 2018; 143:460-465

Buckler JN, Banwell MG, Kordbacheh F, Parish CR, Santiago FS, Khachigian LM. Developing neolignans as pro-angiogenic agents: stereoselective total syntheses and preliminary biological evaluations of the four guaiacylglycerol 8-O-4′-coniferyl ethers. ACS Omega 2017; 2: 7375-7388

Noguchi S, Arakawa T, Fukuda S, Furuno M, Hasegawa A, Hori F, Kato S, Kaida K, Kaiho A, Kanamori-Katayama M, Kawashima T, Kojima M, Kubosaki A, Manade R, Murata M, Nagao-Sato S, Nakazato K, Ninomiya N, Nishiyori-Sueki H, Noma S, Saijyo E, Saka A, Sakai M, Simon C, Suzuki N, Tagami M, Watanabe S, Yoshida S, Arner P, Axton R, Babina M, Baillie LM, Barnett T, Beckhouse A, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Carlisle A, Clevers H, Davis C, Dietmar M, Dohi T, Edge A, Edinger M, Ehrlund A, Ekwall K, Endoh M, Enomoto H, Eslami A, Baglioni M, Fairbairn L, Farah-Carson M, Faulkner G, Ferrai C, Fisher M, Forrester L, Fujita R, Furusawa J, Geijtenbeek T, Gingeras T, Goldowitz D, Guhl S, Guler R, Gustincich S, Ha T, Hamaguchi M, Hara M, Hasegawa Y, Herlyn M, Heating P, Hitchens K, Hume D, Ikawa T, Ishizu Y, Kai C, Kawamoto H, Kawamura Y, Kempfle J, Kenna T, Kere J, Khachigian LM, Kitamura T, Klein S, Klinken P, Knox A, Kojima S, Koseki H, Koyasu S, Lee W, Lennartsson A, Mackay-Sim A, Mejhert N, Mizuno Y, Morikawa H, Morimoto M, Moro K, Morris K, Mothashi H, Mummery C, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nozaki T, Ogishima S, Ohkura N, Ohno H, Ohshima M, Okada M, Okazaki Y, Orlando V, Ovchinnikov D, Passier R, Patrikakis M, Pombo A, Pradhan-Bhatt S, Qin X, Rehli M, Rizzu P, Roy S, Sajantila A, Shimon S, Sato H, Satoh H, Savvi S, Saxena A, Schmidt C, Schneider C, Schulze-Tanzöl G, Schneemann A, Sheng G, Shin J, Sugiyama D, Sugiyama T, Summers K, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tomoiu A, Toyota H, van de Wetering M, van den Berg L, Verardo R, Vijayan D, Wells C, Winterinham L, Wolventang E, Yamaguchi Y, Yamamoto M, Yanagi-Mizuochi C, Yoneda M, Yonekura Y, Zhang P, Zucchelli S, Abugessaisa I, Arner E, Harshbarger J, Kondo A, Lassmann T, Lizio M, Sahin A, Sengstag T, Severin J, Shimoji H, Suzuki M, Kawai J, Suzuki H, Kondo N, Itoh M, Daub C, Kasukawa T, Carninci P, Kawaji H, Forrest A, Hayashizaki Y. FANTOM5 CAGE profiles of human and mouse samples. Scientific Data 2017; 4:170112

Li Y, McRobb LS, Khachigian LM. MicroRNA miR-191 targets the zinc finger transcription factor Egr-1 and suppresses intimal thickening after carotid injury. International Journal of Cardiology 2016; 212:299-302

Li Y, McRobb LS, Khachigian LM. Inhibition of intimal thickening after vascular injury with a cocktail of vascular endothelial growth factor and cyclic Arg-Gly-Asp peptide. International Journal of Cardiology 2016; 220:185-191

Khachigian LM. Early growth response-1 in the pathogenesis of cardiovascular disease. Journal of Molecular Medicine 2016; 94:747-53

Arner E, Daub CO, Vitting-Seerup K, Andersson RA, Lilje B, Drablos F, Lennartsson A, Rönnerblad M, Hrydziuszko O, Vitezic M, Freeman TC, Alhendi A, Arner P, Baillie JK, Beckhouse A, Bodega B, Briggs J, Brombacher F, Davis M, Detmar M, Ehrlund A, Endoh M, Eslami A, Fagiolini M, Fairbairn L, Faulkner GJ, Ferrai C, Fisher ME, Forrester L, Goldowitz D, Guler R, Ha T, Hara M, Herlyn M, Ikawa T, Kai C, Kawamoto H, Khachigian LM, et al. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science 2015; 347:1010-4

Aitken S, Shigeyuki Magi S, Alhendi AMN, Itoh M, Kawaji H, Lassmann T, Daub CO, Erik Arner E, Carninci P, Forrest ARR, Hayashizak Y, FANTOM Consortium, Khachigian LM, Okada-Hatakeyama M, Semple CA. Transcriptional dynamics reveal critical roles for non-coding RNAs in the immediate-early response. PLoS Computational Biology 2015; 11:e1004217

Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, Bertin N, Jørgensen M, Dimont E, Arner E, Schmidl C, Schaefer U, Medvedeva YA, Plessy C, Vitezic M, Severin J, Semple CA, Ishizu Y, Young RS, Francescatto M, Alam I, Albanese D, Altschuler GM, Arakawa T, Archer JA, Arner P, Babina M, Rennie S, Balwierz PJ, Beckhouse AG, Pradhan-Bhatt S, Blake JA, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Burroughs AM, Califano A, Cannistraci CV, Carbajo D, Chen Y, Chierici M, Ciani Y, Clevers HC, Dalla E, Davis CA, Detmar M, Diehl AD, Dohi T, Drabløs F, Edge AS, Edinger M, Ekwall K, Endoh M, Enomoto H, Fagiolini M, Fairbairn L, Fang H, Farach-Carson MC, Faulkner GJ, Favorov AV, Fisher ME, Frith MC, Fujita R, Fukuda S, Furlanello C, Furuno M, Furusawa J, Geijtenbeek TB, Gibson A, Gingeras T, Goldowitz D, Gough J, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Harbers M, Harshbarger J, Hasegawa A, Hasegawa Y, Hashimoto T, Herlyn M, Hitchens KJ, Shannan J, Sui H, Hofmann OM, Hoof I, Hori F, Huminiecki L, Iida K, Ikawa T, Jankovic BR, Jia H, Joshi A, Jurman G, Kaczkowski B, Kai C, Kaida K, Kaiho A, Kajiyama K, Kanamori-Katayama M, Kasianov AS, Kasukawa T, Katayama S, Kato S, Kawaguchi S, Kawamoto H, Kawamura YI, Kawashima T, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, et al. A promoter level mammalian expression atlas. Nature 2014; 507:462-70

Xie J, Zhang S, Hu Y, Li D, Cui J, Xue J, Zhang G, Khachigian LM, Wong J, Sun L, Wang M. Regulatory roles of c-jun in H5N1 influenza virus replication and host inflammation. Biochimica et Biophysica Acta-Molecular Basis of Disease 2014; 1842(12 Pt A):2479-88

Cho EA, Moloney FJ, Cai H, Au-Yeung A, China C, Scolyer RA, Yosufi B, Raftery MJ, Deng JZ, Morton SW, Hammond PT, Arkenau HT, Damian DL, Francis DJ, Chesterman CN, Barnetson RStC, Halliday GM, Khachigian LM. Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a Phase 1 first-in-human trial (DISCOVER). The Lancet 2013;381:1835-43

Yee GPC, de Souza P, Khachigian LM. Current and potential treatments for cervical cancer. Current Cancer Drug Targets 2013;13:205-20

Li Y, Bhindi R, Deng ZJ, Morton SW, Hammond PT, Khachigian LM. Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1,2-dioleoyl-3-trimethylammonium propane/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine. International Journal of Cardiology 2013;168:3659-3664

Sanchez-Guerrero E, Jo SR, Chong BH, Khachigian LM. EGFR and the complexity of receptor crosstalk in the cardiovascular system. Current Molecular Medicine 2013; 13:3-12

Sheahan AV, Phillips PA, Khachigian LM. Therapeutic perspectives on pancreatic cancer. Current Cancer Drug Targets 2013;13:400-10

Cai H, Santiago FS, Prado-Lourenco L, Wang B, Patrikakis M, Davenport MP, Maghzal GJ, Stocker R, Parish CR, Chong BH, Lieschke GJ, Wong TW, Chesterman CN, Francis DJ, Moloney FJ, Barnetson RStC, Halliday GM, Khachigian LM. DNAzyme targeting c-jun suppresses skin cancer growth. Science Translational Medicine 2012;4:139ra82

Sanchez-Guerrero E, Chen E, Kockx M, An SW, Chong BH, Khachigian LM. IL-1beta signals through the EGF receptor and activates Egr-1 through MMP-ADAM. PLoS ONE 2012;7:e39811

Chan CWS, Kaplan W, Parish CR, Khachigian LM. Reduced retinal microvascular density, improved forepaw reach, comparative microarray and gene set enrichment analysis with c-jun targeting DNA enzyme. PLoS ONE 2012;7:e39160

Malabanan K, Nath A, Khachigian LM. Platelet-derived growth factor-BB mediates cell migration through Induction of activation transcription factor-4 and tenascin C. American Journal of Pathology 2012;180:2590-7

Zhang N, Chan CS, Sanchez-Guerrero E, Khachigian LM. Repression of PDGF-R-alpha after cellular injury involves TNF-alpha, formation of a c-Fos-YY1 complex and negative regulation by HDAC. American Journal of Physiology-Cell Physiology 2012;302:C1590-8

Ishii H, Hulett MD, Li JM, Santiago FS, Parish CR, Khachigian LM. Yin yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1. International Journal of Oncology 2012;40:1575-80

Little PJ, Getachew R, Rezaei HB, Sanchez-Guerrero E, Khachigian LM, Wang H, Liao S, Zheng W, Ballinger ML, Osman N. Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGF-beta receptor phosphorylation. Archives of Biochemistry and Biophysics 2012;525:25-31

Bhindi R, Fahmy RG, McMahon AC, Khachigian LM, Lowe HC. Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion. Journal of Pathology 2012;227:157-64

Perdomo J, Jiang X-M, Khachigian LM, Chong BH. SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4. PLoS ONE 2012;7:e50637

Hitchins M, Rapkins R, Chau-To K, Srivastava S, Wong J, Khachigian LM, Polly P, Goldblatt J, Ward RL. Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5'UTR. Cancer Cell 2011;20:200-13

Chen JB, Liu M, Parish CR, Chong BH, Khachigian LM. Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine. International Journal of Biochemistry & Cell Biology 2011;43:905-12

Li D, Bhindi R, Khachigian LM. Recent developments in drug eluting stents. Journal of Molecular Medicine 2011;89:545-53

Truong A, Wong TY, Khachigian LM. Emerging therapeutic approaches in the management of retinal angiogenesis and edema. Journal of Molecular Medicine 2011; 89:343-61

Beck K, Wu BJ, Ni J, Santiago FS, Malabanan K, Li C, Wang Y, Khachigian LM, Stocker R. Interplay between heme oxygenase-1 and the multifunctional transcription factor Yin Yang 1. Circulation Research 2010;107:1490-7

Liang SX, Pinkevych M, Khachigian LM, Parish CR, Davenport MP, Chong BH. Drug-induced thrombocytopenia: Development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG. Blood 2010;116:1958-60

Chan JC, Prado-Lourenco L, Khachigian LM, Di Bartolo B, Bennett MR, Kavurma MM. TRAIL promotes VSMC proliferation and neointima formation after arterial injury in a FGF-2, Sp1 and NFkappaB-dependent manner. Circulation Research 2010;106:1061-71

Wang B, Chen J, Santiago FS, Janes M, Kavurma MM, Chong BH, Pimanda JE, Khachigian LM. Phosphorylation and acetylation of histone H3 and autoregulation by EGR-1 mediate IL-1beta induction of EGR-1 transcription. Arteriosclerosis, Thrombosis and Vascular Biology 2010;30:536-45

Luo X, Cai H, Ni J, Bhindi R, Lowe HC, Chesterman CN, Khachigian LM. c-Jun DNAzymes inhibit myocardial inflammation, ROS generation, infarct size, and improve cardiac function after ischemia-reperfusion injury. Arteriosclerosis, Thrombosis and Vascular Biology 2009;29:1836-42

Tan NY, Khachigian LM. Sp1 phosphorylation and its regulation of gene transcription. Molecular and Cellular Biology 2009;29:2483-8

Abdel-Malak NA, Mayaki D, Khachigian LM, Hussain SNA. Early growth response-1 regulates angiopoeitin-1-induced endothelial cell proliferation, migration and differentiation. Arteriosclerosis, Thrombosis and Vascular Biology 2009;29:209-16

Malabanan K, Kanellakis P, Bobik A, Khachigian LM. ATF-4 induced by FGF-2 regulates VEGF-A transcription in vascular SMCs and mediates intimal thickening in rat arteries following balloon injury. Circulation Research 2008;103:378-87

Tan N, Midgley VC, Kavurma MM, Santiago FS, Luo X, Peden R, Fahmy RG, Berndt MC, Molloy MP, Khachigian LM. Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1. Circulation Research 2008;102:e38-51

Santiago FS, Ishii H, Shafi S, Khurana R, Kanellakis P, Bhindi R, Ramirez M, Bobik A, Martin J, Chesterman CN, Zachary IC, Khachigian LM. Yin yang-1 inhibits intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-Cyclin D1 assembly. Circulation Research 2007;101:146-55

Fahmy RG, Waldman A, Zhang G, Mitchell A, Tedla N, Cai H, Chesterman CN, Geczy CR, Perry MA, Khachigian LM. Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun. Nature Biotechnology 2006;24:856-863

Liu MY, Eyries M, Zhang C, Santiago FS, Khachigian LM. Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1. Blood 2006;107:2322-9

Santiago FS, Khachigian LM. Ets-1 stimulates platelet-derived growth factor A-chain gene transcription and vascular smooth muscle cell growth via co-operative interactions with Sp1. Circulation Research 2004;95:479-487

Zhang G, Dass CR, Sumithran E, Di Girolamo NR, Sun LQ, Khachigian LM. Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents. Journal of the National Cancer Institute 2004;96:683-696

Fahmy RG, Dass CR, Sun LQ, Chesterman CN, Khachigian LM. Zinc finger transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth. Nature Medicine 2003;9:1026-1032

Francis DJ, Parish CR, McGarry M, Santiago FS, Lowe HC, Brown KJ, Bingley J, Hayward IP, Cowden WB, Campbell JH, Campbell GR, Chesterman CN, Khachigian LM. Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88: phosphomannopentaose sulfate directly binds FGF-2, blocks cellular signaling and inhibits proliferation. Circulation Research 2003;92:e70-77

Khachigian LM, Fahmy RG, Zhang G, Bobryshev YV, Kaniaros A. c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury: inhibition by a novel DNAzyme targeting c-Jun. Journal of Biological Chemistry 2002;277:22985-22991

Rafty LA, Santiago FS, Khachigian LM. NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter. EMBO Journal 2002;21:334-343

Lowe HC, Fahmy RG, Kavurma MM, Baker A, Chesterman CN, Khachigian LM. Catalytic oligodeoxynucleotides define a critical regulatory role for early growth response factor-1 in the porcine coronary artery model of in-stent restenosis. Circulation Research 2001;89:670-677

Santiago FS, Lowe HC, Kavurma MM, Chesterman CN, Atkins DG, Khachigian LM. Novel DNA enzyme targeting NGFI-A mRNA inhibits vascular smooth muscle proliferation and regrowth after injury. Nature Medicine 1999;5:1264-1269

Khachigian LM, Lindner V, Williams AJ, Collins T. Egr-1-induced endothelial gene expression: a common theme in vascular injury. Science 1996; 271:1427-1431

University role:

Head, Vascular Biology and Translational Research

Research

Teaching & Supervision

Supervision keywords:

diseases and disorders

research and development

Media

LinkedIn:

https://www.linkedin.com/in/levon-khachigian-47276043/

Publications related to this Person

Books

Khachigian LM, 2004, High-risk atherosclerotic plaques: Mechanisms, imaging, models, and therapy

Khachigian LM, 2004, Preface

Book Chapters

Journal articles

Santiago FS; Sanchez-Guerrero E; Zhang G; Zhong L; Raftery MJ; Khachigian LM, 2019, 'Extracellular signal-regulated kinase-1 phosphorylates early growth response-1 at serine 26', Biochemical and Biophysical Research Communications, vol. 510, pp. 345 - 351, http://dx.doi.org/10.1016/j.bbrc.2019.01.019

Billah M; Ridiandries A; Allahwala U; Mudaliar H; Dona A; Hunyor S; Khachigian LM; Bhindi R, 2019, 'Circulating mediators of remote ischemic preconditioning: Search for the missing link between non-lethal ischemia and cardioprotection', Oncotarget, vol. 10, pp. 216 - 244

Alhendi AMN; Patrikakis M; Daub CO; Kawaji H; Itoh M; de Hoon M; Carninci P; Hayashizaki Y; Arner E; Khachigian LM, 2018, 'Promoter Usage and Dynamics in Vascular Smooth Muscle Cells Exposed to Fibroblast Growth Factor-2 or Interleukin-1β', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-30702-4

Cai H; Cho EA; Li Y; Sockler J; Parish CR; Chong BH; Edwards J; Dodds TJ; Ferguson PM; Wilmott JS, 2018, 'Melanoma protective antitumor immunity activated by catalytic DNA', Oncogene, vol. 37, pp. 5115 - 5126, http://dx.doi.org/10.1038/s41388-018-0306-0

Cannistraci CV; Nieminen T; Nishi M; Khachigian LM; Viikilä J; Laine M; Cianflone D; Maseri A; Yeo KK; Bhindi R, 2018, '"Summer Shift": A potential effect of sunshine on the time onset of ST-elevation acute myocardial infarction', Journal of the American Heart Association, vol. 7, http://dx.doi.org/10.1161/JAHA.117.006878

Sheahan AV; Biankin AV; Parish CR; Khachigian LM, 2018, 'Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: A systematic review', Oncotarget, vol. 9, pp. 21613 - 21627, http://dx.doi.org/10.18632/oncotarget.25085

Khachigian LM, 2018, 'The Yin and Yang of YY1 in tumor growth and suppression', International Journal of Cancer, vol. 143, pp. 460 - 465, http://dx.doi.org/10.1002/ijc.31255

Buckler JN; Banwell MG; Kordbacheh F; Parish CR; Santiago FS; Khachigian LM, 2017, 'Developing neolignans as proangiogenic agents: Stereoselective total syntheses and preliminary biological evaluations of the four guaiacylglycerol 8-O-4'-coniferyl ethers', ACS Omega, vol. 2, pp. 7375 - 7388, http://dx.doi.org/10.1021/acsomega.7b01459

Noguchi S; Arakawa T; Fukuda S; Furuno M; Hasegawa A; Hori F; Ishikawa-Kato S; Kaida K; Kaiho A; Kanamori-Katayama M, 2017, 'FANTOM5 CAGE profiles of human and mouse samples', Scientific Data, vol. 4, http://dx.doi.org/10.1038/sdata.2017.112

Murrell M; Khachigian L; Ward MR, 2017, 'Corrigendum to “The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting” [Atherosclerosis 194 (2) (2007) 364–371] (S0021915006006836) (10.1016/j.atherosclerosis.20', Atherosclerosis, vol. 261, pp. 172, http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.011

Li Y; McRobb LS; Khachigian LM, 2016, 'Inhibition of intimal thickening after vascular injury with a cocktail of vascular endothelial growth factor and cyclic Arg-Gly-Asp peptide', International Journal of Cardiology, vol. 220, pp. 185 - 191, http://dx.doi.org/10.1016/j.ijcard.2016.06.300

Khachigian LM, 2016, 'Early growth response-1 in the pathogenesis of cardiovascular disease', Journal of Molecular Medicine, vol. 94, pp. 747 - 753, http://dx.doi.org/10.1007/s00109-016-1428-x

Li Y; McRobb LS; Khachigian LM, 2016, 'MicroRNA miR-191 targets the zinc finger transcription factor Egr-1 and suppresses intimal thickening after carotid injury', International Journal of Cardiology, vol. 212, pp. 299 - 302, http://dx.doi.org/10.1016/j.ijcard.2016.03.037

Tan NY; Li J-M; Stocker R; Khachigian LM, 2016, 'Angiotensin II-Inducible Smooth Muscle Cell Apoptosis Involves the Angiotensin II Type 2 Receptor, GATA-6 Activation, and FasL-Fas Engagement (Retraction of vol 105, pg 422, 2009)', CIRCULATION RESEARCH, vol. 118, pp. E31 - E31, http://dx.doi.org/10.1161/RES.0000000000000090

Aitken S; Magi S; Alhendi AMN; Itoh M; Kawaji H; Lassmann T; Daub CO; Arner E; Carninci P; Forrest ARR, 2015, 'Transcriptional Dynamics Reveal Critical Roles for Non-coding RNAs in the Immediate-Early Response', PLoS Computational Biology, vol. 11, http://dx.doi.org/10.1371/journal.pcbi.1004217

Hurst LD; Ghanbarian AT; Forrest ARR; Huminiecki L; Rehli M; Kenneth Baillie J; de Hoon MJL; Haberle V; Lassmann T; Kulakovskiy IV, 2015, 'The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome', PLoS Biology, vol. 13, http://dx.doi.org/10.1371/journal.pbio.1002315

Fahmy RG; Waldman A; Zhang G; Mitchell A; Tedla N; Cai H; Geczy CR; Chesterman CN; Perry M; Khachigian LM, 2015, 'Erratum: Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun(Nat.Biotechnol.(2006) 24(856-863))', Nature Biotechnology, vol. 33, pp. 882, http://dx.doi.org/10.1038/nbt0815-882c

Arner E; Daub CO; Vitting-Seerup K; Andersson R; Lilje B; Drabløs F; Lennartsson A; Rönnerblad M; Hrydziuszko O; Vitezic M, 2015, 'Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells', Science, vol. 347, pp. 1010 - 1014, http://dx.doi.org/10.1126/science.1259418

Charni Chaabane S; Coomans de Brachène A; Essaghir A; Velghe A; Lo Re S; Stockis J; Lucas S; Khachigian LM; Huaux F; Demoulin JB, 2014, 'PDGF-D expression is down-regulated by TGFβ in fibroblasts', PloS one, vol. 9, pp. e108656, http://dx.doi.org/10.1371/journal.pone.0108656

Chaabane SC; De Brachéne AC; Essaghir A; Velghe A; Re SL; Stockis J; Lucas S; Khachigian LM; Huaux F; Demoulin JB, 2014, 'PDGF-D expression is down-regulated by TGFβ in fibroblasts', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0108656

Young JA; Ting KK; Li J; Moller T; Dunn L; Lu Y; Lay AJ; Moses J; Prado-Lourenço L; Khachigian LM, 2014, 'Erratum: Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted mirna antagonists of mir-27 (Blood (2012) 122:16 (2911-2919))', Blood, vol. 124, pp. 3034, http://dx.doi.org/10.1182/blood-2014-09-604066

Xie J; Zhang S; Hu Y; Li D; Cui J; Xue J; Zhang G; Khachigian LM; Wong J; Sun L, 2014, 'Regulatory roles of c-jun in H5N1 influenza virus replication and host inflammation', Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1842, pp. 2479 - 2488, http://dx.doi.org/10.1016/j.bbadis.2014.04.017

Forrest ARR; Kawaji H; Rehli M; Baillie JK; De Hoon MJL; Haberle V; Lassmann T; Kulakovskiy IV; Lizio M; Itoh M, 2014, 'A promoter-level mammalian expression atlas', Nature, vol. 507, pp. 462 - 470, http://dx.doi.org/10.1038/nature13182

Rayner B; Figtree G; Lay W; Sabaretnam T; Shang P; Mazhar J; Weaver J; Grieve S; Hunyor S; Khachigian L, 2013, 'SELECTIVE INHIBITION OF THE MASTER REGULATOR TRANSCRIPTION FACTOR EGR-1 USING CATALYTIC OLIGONUCLEOTIDES REDUCES MYOCARDIAL INJURY AND IMPROVES LV SYSTOLIC FUNCTION IN A PRECLINICAL MODEL OF MYOCARDIA', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 61, pp. E213 - E213, http://dx.doi.org/10.1016/S0735-1097(13)60214-4

Perdomo J; Jiang XM; Carter DR; Khachigian LM; Chong BH, 2013, 'Correction: SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4 (PLoS ONE)', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/annotation/3d7a31cd-09e7-47d1-af57-c58c7082058d

Rayner BS; Figtree GA; Sabaretnam T; Shang P; Mazhar J; Weaver JC; Lay WN; Witting PK; Hunyor SN; Grieve SM, 2013, 'Selective inhibition of the master regulator transcription factor Egr-1 with catalytic oligonucleotides reduces myocardial injury and improves left ventricular systolic function in a preclinical model', Journal of the American Heart Association, vol. 2, http://dx.doi.org/10.1161/JAHA.113.000023

Khachigian LM, 2013, 'Nephron regeneration after acute kidney injury in the zebrafish', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 32, pp. S63 - S63, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324507400237&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM, 2013, 'Inhibition of intimal thickening and acceleration of reendothelialization after vascular injury using a cocktail approach', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 32, pp. S64 - S64, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324507400238&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Young JA; Ting KK; Li J; Moller T; Dunn L; Lu Y; Lay AJ; Moses J; Prado-Lourenço L; Khachigian LM, 2013, 'Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27', Blood, vol. 122, pp. 2911 - 2919, http://dx.doi.org/10.1182/blood-2012-12-473017

Ni J; Waldman A; Khachigian LM, 2013, 'Erratum: C-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins (Th', Journal of Biological Chemistry, vol. 288, pp. 31918, http://dx.doi.org/10.1074/jbc.A109.078345

Li Y; Bhindi R; Deng ZJ; Morton SW; Hammond PT; Khachigian LM, 2013, 'Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)/1,2-dioleoyl-sn-glycero-3-phosphoethano', International Journal of Cardiology, vol. 168, pp. 3659 - 3664, http://dx.doi.org/10.1016/j.ijcard.2013.05.092

Sanchez-Guerrero E; Jo SR; Chong BH; Khachigian LM, 2013, 'EGFR and the complexity of receptor crosstalk in the cardiovascular system', Current Molecular Medicine, vol. 13, pp. 3 - 12, http://dx.doi.org/10.2174/156652413804486313

Li D; Ilnytskyy Y; Kovalchuk A; Khachigian LM; Bronson RT; Wang B; Kovalchuk O, 2013, 'Crucial role for early growth response-1 in the transcriptional regulation of miR-20b in breast cancer', Oncotarget, vol. 4, pp. 1373 - 1387, http://dx.doi.org/10.18632/oncotarget.1165

Chan CWS; Khachigian LM, 2013, 'DNAzyme delivery approaches in biological settings', Current Medicinal Chemistry, vol. 20, pp. 3448 - 3455, http://dx.doi.org/10.2174/09298673113209990033

Chong BH; Young-Ill Choi P; Khachigian L; Perdomo J, 2013, 'Drug-induced immune thrombocytopenia', Hematology/Oncology Clinics of North America, vol. 27, pp. 521 - 540, http://dx.doi.org/10.1016/j.hoc.2013.02.003

Benson VL; McMahon AC; Lowe HC; Khachigian LM, 2013, 'Acute local elevation in monocyte chemoattractant protein-1 (MCP-1), distal to the culprit lesion in acute ST elevation myocardial infarction', International Journal of Cardiology, http://dx.doi.org/10.1016/j.ijcard.2013.03.078

Sheahan AV; Phillips PA; Khachigian LM, 2013, 'Therapeutic perspectives on pancreatic cancer', Current Cancer Drug Targets, vol. 13, pp. 400 - 410, http://dx.doi.org/10.2174/1568009611313040004

Bhindi R; Fahmy RG; McMahon AC; Khachigian LM; Lowe HC, 2012, 'Intracoronary delivery of DNAzymes targeting human Egr-1 reduces infarct size following myocardial ischaemia reperfusion', Journal of Pathology, vol. 227, pp. 157 - 164, http://dx.doi.org/10.1002/path.2991

Malabanan KP; Sheahan AV; Khachigian LM, 2012, 'Platelet-derived growth factor-BB mediates cell migration through induction of activating transcription factor 4 and tenascin-C', American Journal of Pathology, vol. 180, pp. 2590 - 2597, http://dx.doi.org/10.1016/j.ajpath.2012.02.009

Perdomo J; Jiang XM; Carter DR; Khachigian LM; Chong BH, 2012, 'SUMOylation Regulates the Transcriptional Repression Activity of FOG-2 and Its Association with GATA-4', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0050637

Midwinter RG; Maghzal GJ; Dennis JM; Wu BJ; Cai H; Kapralov AA; Belikova NA; Tyurina YY; Dong LF; Khachigian L, 2012, 'Succinobucol induces apoptosis in vascular smooth muscle cells', Free Radical Biology and Medicine, vol. 52, pp. 871 - 879, http://dx.doi.org/10.1016/j.freeradbiomed.2011.11.029

Little PJ; Getachew R; Rezaei HB; Sanchez-Guerrero E; Khachigian LM; Wang H; Liao S; Zheng W; Ballinger ML; Osman N, 2012, 'Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFβ receptor phosphorylation', Archives of Biochemistry and Biophysics, vol. 525, pp. 25 - 31, http://dx.doi.org/10.1016/j.abb.2012.05.025

Ishii H; Hulett MD; Li JM; Santiago FS; Parish CR; Khachigian LM, 2012, 'Yin Yang-1 inhibits tumor cell growth and inhibits p21 ^WAF1/Cip1complex formation with cdk4 and cyclin D1', International Journal of Oncology, vol. 40, pp. 1575 - 1580, http://dx.doi.org/10.3892/ijo.2012.1362

Zhang N; Chan CWS; Sanchez-Guerrero E; Khachigian LM, 2012, 'Repression of PDGF-R-α after cellular injury involves TNF-α, formation of a c-Fos-YY1 complex, and negative regulation by HDAC', American Journal of Physiology - Cell Physiology, vol. 302, pp. 1590 - 1598, http://dx.doi.org/10.1152/ajpcell.00429.2011

Chan CWS; Kaplan W; Parish CR; Khachigian LM, 2012, 'Reduced retinal microvascular density, improved forepaw reach, comparative microarray and gene set enrichment analysis with c-jun targeting DNA enzyme', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0039160

Khachigian LM, 2011, 'Catalytic DNA as new drugs for vascular disease and cancer', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 28, pp. S70 - S70, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295422700266&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM; Nath A; Malabanan KP, 2011, 'Regulation of cell migration by activation transcription factor-4', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 28, pp. S71 - S71, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295422700267&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Truong A; Wong TY; Khachigian LM, 2011, 'Emerging therapeutic approaches in the management of retinal angiogenesis and edema', Journal of Molecular Medicine, vol. 89, pp. 343 - 361, http://dx.doi.org/10.1007/s00109-010-0709-z

Chen J; Liu MY; Parish CR; Chong BH; Khachigian L, 2011, 'Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine', International Journal of Biochemistry and Cell Biology, vol. 43, pp. 905 - 912, http://dx.doi.org/10.1016/j.biocel.2011.03.004

Liang SX; Khachigian LM; Ahmadi Z; Yang M; Liu S; Chong BH, 2011, 'In vitro and in vivo proliferation, differentiation and migration of cardiac endothelial progenitor cells (SCA1 ⁺/CD31 ⁺ side-population cells)', Journal of Thrombosis and Haemostasis, vol. 9, pp. 1628 - 1637, http://dx.doi.org/10.1111/j.1538-7836.2011.04375.x

Ni J; Waldman A; Khachigian LM, 2010, 'Erratum: C-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins(Jou', Journal of Biological Chemistry, vol. 293, pp. 20307, http://dx.doi.org/10.1074/jbc.W118.007069

Liu MY; Khachigian LM, 2010, 'Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1 beta and forms a cytokine-inducible gene-silencing complex with NF-kappa B p65 and inter', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 4263 - 4263, http://dx.doi.org/10.1074/jbc.A109.061903

Zhang N; Khachigian LM, 2010, 'Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1 beta (IL-1 beta) release and cooperative transactivation by NF-kappa B and ATF-4. IL-1 beta FACILITATE', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 21902 - 21902, http://dx.doi.org/10.1074/jbc.A109.025742

Liu MY; Khachigian LM, 2010, 'Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1 beta and forms a cytokine-inducible gene-silencing complex with NF-kappa B p65 and inter', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 21902 - 21902, http://dx.doi.org/10.1074/jbc.A209.061903

Kavurma MM; Bobryshev Y; Khachigian LM, 2010, 'Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1 (Retraction of vol 277, pg 36244, 2002)', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, pp. 21902 - 21902, http://dx.doi.org/10.1074/jbc.A110.200463

Liu MY; Khachigian LM, 2010, 'Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1β and forms a cytokine-inducible gene-silencing complex with NF-κB p65 and interferon reg', Journal of Biological Chemistry, vol. 285, pp. 4363

Malabanan KP; Khachigian LM, 2010, 'Activation transcription factor-4 and the acute vascular response to injury', Journal of Molecular Medicine, vol. 88, pp. 545 - 552, http://dx.doi.org/10.1007/s00109-010-0615-4

Cheng Q; McKeown SJ; Santos L; Santiago FS; Khachigian LM; Morand EF; Hickey MJ, 2010, 'Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules', Journal of Immunology, vol. 185, pp. 1238 - 1247, http://dx.doi.org/10.4049/jimmunol.0904104

Getachew R; Ballinger ML; Burch ML; Reid JJ; Khachigian LM; Wight TN; Little PJ; Osman N, 2010, 'PDGF β-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL', Endocrinology, vol. 151, pp. 4356 - 4367, http://dx.doi.org/10.1210/en.2010-0027

Liang SX; Pinkevych M; Khachigian LM; Parish CR; Davenport MP; Chong BH, 2010, 'Drug-induced thrombocytopenia: Development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG', Blood, vol. 116, pp. 1958 - 1960, http://dx.doi.org/10.1182/blood-2010-02-268326

Cheng Q; McKeown SJ; Santos L; Santiago FS; Khachigian LM; Morand EF; Hickey MJ, 2010, 'Erratum: Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules (Journal of Immunology (2010)', Journal of Immunology, vol. 185, pp. 4959, http://dx.doi.org/10.4049/jimmunol.1090092

Perdomo J; Fock EL; Kaur G; Yan F; Khachigian LM; Jans DA; Chong BH, 2010, 'A monopartite sequence is essential for p45 NF-E2 nuclear translocation, transcriptional activity and platelet production', Journal of Thrombosis and Haemostasis, vol. 8, pp. 2542 - 2553, http://dx.doi.org/10.1111/j.1538-7836.2010.04058.x

Ni J; Waldman A; Khachigian LM, 2010, 'c-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins', Journal of Biological Chemistry, vol. 285, pp. 4038 - 4048, http://dx.doi.org/10.1074/jbc.M109.078345

Pourgholami MH; Khachigian LM; Fahmy RG; Badar S; Wang L; Chu SWL; Morris DL, 2010, 'Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis', Biochemical and Biophysical Research Communications, vol. 397, pp. 729 - 734, http://dx.doi.org/10.1016/j.bbrc.2010.06.019

Wang B; Chen J; Santiago FS; Janes M; Kavurma MM; Chong BH; Pimanda JE; Khachigian LM, 2010, 'Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1β induction of early growth response 1 transcription', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, pp. 536 - 545, http://dx.doi.org/10.1161/ATVBAHA.109.193821

Chan J; Prado-Lourenco L; Khachigian LM; Bennett MR; Di Bartolo BA; Kavurma MM, 2010, 'TRAIL promotes VSMC proliferation and neointima formation in a FGF-2-, Sp1 Phosphorylation-, and NFκB-Dependent Manner', Circulation Research, vol. 106, pp. 1061 - 1071, http://dx.doi.org/10.1161/CIRCRESAHA.109.206029

Ye JY; Chan GCF; Qiao L; Lian Q; Meng FY; Luo XQ; Khachigian LM; Ma M; Deng R; Chen JL, 2010, 'Platelet-derived growth factor enhances platelet recovery in a murine model of radiation-induced thrombocytopenia and reduces apoptosis in megakaryocytes via its receptors and the PI3-k/Akt pathway', Haematologica, vol. 95, pp. 1745 - 1753, http://dx.doi.org/10.3324/haematol.2009.020958

Khachigian L, 2009, 'DNAZYME TARGETING TRANSCRIPTION FACTOR C-JUN INHIBITS MYOCARDIAL INFLAMMATION, ROS GENERATION AND INFARCT SIZE AFTER ISCHEMIA-REPERFUSION INJURY', ATHEROSCLEROSIS SUPPLEMENTS, vol. 10, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207957101541&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Li C; Wu B; Midwinter R; Beck K; Collinson E; Maghzal G; Cassano C; Santiago F; Khachigian L; Gamble J, 2009, 'PROTECTION AGAINST ATHEROSCLEROSIS BY HEME OXYGENASE-1', ATHEROSCLEROSIS SUPPLEMENTS, vol. 10, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207957100820&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM, 2009, 'Immediate-early genes as master regulators in cancer and other vascular disease', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 24, pp. S77 - S77, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000270497500292&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Ni J; Waldman A; Khachigian L, 2009, 'DNA enzyme targeting transcription factor c-Jun reduces intimal hyperplasia in human saphenous vein explants and inhibits Vein Graft stenosis in rabbits', EUROPEAN HEART JOURNAL, vol. 30, pp. 322 - 322, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208702603073&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Zhang C; Song QH; Khachigian LM; Lubenec I; Shie J-L; Yang B; Li J; Tian Y, 2009, 'Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells (Retraction of vol 380, pg 689, 2009)', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 388, pp. 464 - 464, http://dx.doi.org/10.1016/j.bbrc.2009.08.011

Abdel-Malak NA; Mofarrahi M; Mayaki D; Khachigian LM; Hussain SNA, 2009, 'Early growth response-1 regulates angiopoietin-1-induced endothelial cell proliferation, migration, and differentiation', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 29, pp. 209 - 216, http://dx.doi.org/10.1161/ATVBAHA.108.181073

Tan NY; Khachigian LM, 2009, 'Sp1 phosphorylation and its regulation of gene transcription', Molecular and Cellular Biology, vol. 29, pp. 2483 - 2488, http://dx.doi.org/10.1128/MCB.01828-08

Khachigian LM; Peter K; Berndt MC, 2009, 'Recent advances in vascular biology: Selected highlights from IVBM 2008', Thrombosis and Haemostasis, vol. 101, pp. 997 - 998, http://dx.doi.org/10.1160/TH09-05-0294

Dass CR; Khachigian LM; Choong PFM, 2009, 'C-Jun is critical for the progression of osteosarcoma: Proof in an orthotopic spontaneously metastasizing model (Molecular Cancer Research (2008) 6, (1289-1292))', Molecular Cancer Research, vol. 7, pp. 1594, http://dx.doi.org/10.1158/1541-7786.MCR-07-9-COR2

Luo X; Cai H; Ni J; Bhindi R; Lowe HC; Chesterman CN; Khachigian LM, 2009, 'C-jun DNAzymes inhibit myocardial inflammation, ROS generation, infarct size, and improve cardiac function after ischemia-reperfusion injury', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 29, pp. 1836 - 1842, http://dx.doi.org/10.1161/ATVBAHA.109.189753

Wang B; Khachigian LM; Esau L; Birrer MJ; Zhao X; Parker MI; Hendricks DT, 2009, 'A key role for early growth response-1 and nuclear factor-κB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancer', Molecular Cancer Research, vol. 7, pp. 755 - 764, http://dx.doi.org/10.1158/1541-7786.MCR-08-0472

Zhang C; Song QH; Khachigian LM; Lubenec I; Shie JL; Yang B; Li J; Tian Y, 2009, 'Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells', Biochemical and Biophysical Research Communications, vol. 380, pp. 689 - 694, http://dx.doi.org/10.1016/j.bbrc.2009.01.151

Tan NY; Li JM; Stocker R; Khachigian LM, 2009, 'Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and fasl-fas engagement', Circulation Research, vol. 105, pp. 422 - 430, http://dx.doi.org/10.1161/CIRCRESAHA.109.203323

Zhang C; Song QH; Khachigian LM; Lubenec I; Shie JL; Yang B; Li J; Tian Y, 2009, 'Retraction notice to "Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells" [Biophys. Res. Commun. 380 (3) (2009) 689-694] (DOI:10.1016', Biochemical and Biophysical Research Communications, vol. 388, pp. 464, http://dx.doi.org/10.1016/j.bbrc.2009.08.011

Chan CWS; Khachigian LM, 2009, 'DNAzymes and their therapeutic possibilities', Internal Medicine Journal, vol. 39, pp. 249 - 251, http://dx.doi.org/10.1111/j.1445-5994.2009.01799.x

Khachigian LM; Bobik A; Kanellakis P; Malabanan K, 2008, 'Regulation of Vascular Endothelial Growth Factor A by Activating Transcription Factor 4 Response', CIRCULATION RESEARCH, vol. 103, pp. E119 - E119, http://dx.doi.org/10.1161/CIRCRESAHA.108.187559

Khachigian LM; Berndt MC; Tan NY, 2008, 'Ang II-Inducible PDGF-D Transcription Requires Ser/Thr Residues In The Second Zinc Finger Region of Sp1: Novel Phosphospecific Antibodies Demonstrate that Sp1 is Phosphorylated by SMC Injury', FASEB JOURNAL, vol. 22, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208467808746&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Tan NY; Midgley VC; Kavurma MM; Santiago FS; Luo X; Peden R; Fahmy RG; Berndt MC; Molloy MP; Khachigian LM, 2008, 'Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1', Circulation Research, vol. 102, http://dx.doi.org/10.1161/CIRCRESAHA.107.167395

Dass CR; Choong PFM; Khachigian LM, 2008, 'DNAzyme technology and cancer therapy: Cleave and let die', Molecular Cancer Therapeutics, vol. 7, pp. 243 - 251, http://dx.doi.org/10.1158/1535-7163.MCT-07-0510

Sanchez-Guerrero E; Midgley VC; Khachigian LM, 2008, 'Angiotensin II induction of PDGF-C expression is mediated by AT1 receptor-dependent Egr-1 transactivation', Nucleic Acids Research, vol. 36, pp. 1941 - 1951, http://dx.doi.org/10.1093/nar/gkm923

Kavallaris M; Meachem SJ; Hulett MD; West CM; Pitt RE; Chesters JJ; Laffan WS; Boreham PR; Khachigian LM, 2008, 'Perceptions in health and medical research careers: The Australian society for medical research workforce survey', Medical Journal of Australia, vol. 188, pp. 520 - 524

Benson VL; Khachigian LM; Lowe HC, 2008, 'DNAzymes and cardiovascular disease', British Journal of Pharmacology, vol. 154, pp. 741 - 748, http://dx.doi.org/10.1038/bjp.2008.145

Dass CR; Friedhuber AM; Khachigian LM; Dunstan DE; Choong PFM, 2008, 'Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model', Cancer Biology and Therapy, vol. 7, pp. 1033 - 1036, http://dx.doi.org/10.4161/cbt.7.7.6037

Dass CR; Galloway SJ; Clark JCM; Khachigian LM; Choong PFM, 2008, 'Involvement of c-jun in human liposarcoma growth: Supporting data from clinical immunohistochemistry and DNAzyme efficacy', Cancer Biology and Therapy, vol. 7, pp. 1297 - 1301, http://dx.doi.org/10.4161/cbt.7.8.6301

Dass CR; Khachigian LM; Choong PFM, 2008, 'c-Jun is critical for the progression of osteosarcoma: Proof in an orthotopic spontaneously metastasizing model', Molecular Cancer Research, vol. 6, pp. 1289 - 1292, http://dx.doi.org/10.1158/1541-7786.MCR-08-0036

Dass CR; Friedhuber AM; Khachigian LM; Dunstan DM; Choong PFM, 2008, 'Biocompatible chitosan-DNAzyme nanoparticle exhibits enhanced biological activity', Journal of Microencapsulation, vol. 25, pp. 421 - 425, http://dx.doi.org/10.1080/02652040802033673

Malabanan KP; Kanellakis P; Bobik A; Khachigian LM, 2008, 'Activation transcription factor-4 induced by fibroblast growth factor-2 regulates vascular endothelial growth factor-A transcription in vascular smooth muscle cells and mediates intimal thickening in', Circulation Research, vol. 103, pp. 378 - 387, http://dx.doi.org/10.1161/CIRCRESAHA.107.168682

Dass CR; Khachigian LM; Choong PFM, 2008, 'c-Jun knockdown sensitizes osteosarcoma to doxorubicin', Molecular Cancer Therapeutics, vol. 7, pp. 1909 - 1912, http://dx.doi.org/10.1158/1535-7163.MCT-08-0086

Khachigian LM; Bobik A; Kanellakis P; Malabanan K, 2008, 'Response to abcouwer and roybal', Circulation Research, vol. 103, http://dx.doi.org/10.1161/CIRCRESAHA.108.187559

Kavurma MM; Schoppet M; Bobryshev YV; Khachigian LM; Bennett MR, 2008, 'TRAIL stimulates proliferation of vascular smooth muscle cells via activation of NF-κB and induction of insulin-like growth factor-1 receptor', Journal of Biological Chemistry, vol. 283, pp. 7754 - 7762, http://dx.doi.org/10.1074/jbc.M706927200

Khachigian LM, 2007, 'Science Never Sleeps: Tucker Collins, MD, PhD', Endothelium: Journal of Endothelial Cell Research, vol. 14, pp. 173 - 174, http://dx.doi.org/10.1080/10623320701670026

Lowe HC; Mcmahon AC; Khachigian LM; Benson VL, 2007, 'The transcription factor early growth response gene 1 (Egr-1) is implicated in acute myocardial ischemic reperfusion injury in an in vivo model of diabetes', EUROPEAN HEART JOURNAL, vol. 28, pp. 434 - 434, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208702202289&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM; Santiago F; Ishii H; Shafi S; Khurana R; Kanellakis P; Bhindi R; Ramirez M; Bobik A; Martin J, 2007, 'Yin yang-1 inhibits intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-Cyclin D1 assembly', FASEB JOURNAL, vol. 21, pp. A69 - A69, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245708500329&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2007, 'The transcription factor Egr-1 is implicated in myocardial ischaemic reperfusion injury in an in vivo model of diabetes', JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 42, pp. S194 - S194, http://dx.doi.org/10.1016/j.yjmcc.2007.03.590

Murrell M; Khachigian L; Ward MR, 2007, 'The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting', Atherosclerosis, vol. 194, pp. 364 - 371, http://dx.doi.org/10.1016/j.atherosclerosis.2006.11.016

Kavurma MM; Figg N; Bennett MR; Mercer J; Khachigian LM; Littlewood TD, 2007, 'Oxidative stress regulates IGF1R expression in vascular smooth muscle cells via p53/TBP promoter interactions', HEART, vol. 93, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243520700040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Fahmy RG; Khachigian LM, 2007, 'Suppression of growth factor expression and human vascular smooth muscle cell growth by small interfering RNA targeting EGR-1', Journal of Cellular Biochemistry, vol. 100, pp. 1526 - 1535, http://dx.doi.org/10.1002/jcb.21145

Benson VL; McMahon AC; Lowe HC; Khachigian LM, 2007, 'The streptozotocin-treated Sprague-Dawley rat: A useful model for the assessment of acute and chronic effects of myocardial ischaemia reperfusion injury in experimental diabetes', Diabetes and Vascular Disease Research, vol. 4, pp. 153 - 154, http://dx.doi.org/10.3132/dvdr.2007.035

Kavurma MM; Figg N; Bennett MR; Mercer J; Khachigian LM; Uttlewood TD, 2007, 'Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment', Biochemical Journal, vol. 407, pp. 79 - 87, http://dx.doi.org/10.1042/BJ20070380

Santiago FS; Ishii H; Shafi S; Khurana R; Kanellakis P; Bhindi R; Ramirez MJ; Bobik A; Martin JF; Chesterman CN, 2007, 'Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21^WAF1/Cip1 transcription and p21 ^WAF1/Cip1-Cdk4-Cyclin D1 assembly', Circulation Research, vol. 101, pp. 146 - 155, http://dx.doi.org/10.1161/CIRCRESAHA.106.145235

Bhindi R; Fahmy RG; Lowe HC; Chesterman CN; Dass CR; Cairns MJ; Saravolac EG; Sun LQ; Khachigian LM, 2007, 'Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies', American Journal of Pathology, vol. 171, pp. 1079 - 1088, http://dx.doi.org/10.2353/ajpath.2007.070120

Khachigian L, 2006, 'Molecular assassin targets master regulator gene', Australian Life Scientist, vol. 3, pp. 15

Khachigian LM, 2006, 'Early growth response-1 in cardiovascular pathobiology', Circulation Research, vol. 98, pp. 186 - 191, http://dx.doi.org/10.1161/01.RES.0000200177.53882.c3

Bhindi R; Khachigian LM; Lowe HC, 2006, 'DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats', Journal of Thrombosis and Haemostasis, vol. 4, pp. 1479 - 1483, http://dx.doi.org/10.1111/j.1538-7836.2006.02022.x

Khachigian LM, 2006, 'Health and medical research funding: An investment in Australia's future', Medical Journal of Australia, vol. 185, pp. 348 - 349

Bhindi R; Witting PK; McMahon AC; Khachigian LM; Lowe HC, 2006, 'Rat models of myocardial infarction. Pathogenetic insights and clinical relevance', Thrombosis and Haemostasis, vol. 96, pp. 602 - 610, http://dx.doi.org/10.1160/TH05-07-0514

Lowe HC; Khachigian LM, 2006, 'The endothelium and cardiovascular disease: New developments, new challenges', Endothelium: Journal of Endothelial Cell Research, vol. 13, pp. 365, http://dx.doi.org/10.1080/10623320601125303

Khachigian LM, 2006, 'Collagen antibody-induced arthritis', Nature Protocols, vol. 1, pp. 2512 - 2516, http://dx.doi.org/10.1038/nprot.2006.393

Fahmy RG; Waldman A; Zhang G; Mitchell A; Tedla N; Cai H; Geczy CR; Chesterman CN; Perry M; Khachigian LM, 2006, 'Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun', Nature Biotechnology, vol. 24, pp. 856 - 863, http://dx.doi.org/10.1038/nbt1225

Zhang G; Fahmy RG; diGirolamo N; Khachigian LM, 2006, 'JUN siRNA regulates matrix metalloproteinase-2 expression, microvascular endothelial growth and retinal neovascularisation', Journal of Cell Science, vol. 119, pp. 3219 - 3226, http://dx.doi.org/10.1242/jcs.03059

Zhang G; Luo X; Sumithran E; Pua VSC; Barnetson RSC; Halliday GM; Khachigian LM, 2006, 'Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix metalloproteinase-2 and -9 expression', Oncogene, vol. 25, pp. 7260 - 7266, http://dx.doi.org/10.1038/sj.onc.1209726

Liu MY; Eyries M; Zhang C; Santiago FS; Khachigian LM, 2006, 'Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1', Blood, vol. 107, pp. 2322 - 2329, http://dx.doi.org/10.1182/blood-2005-06-2377

Kingwell BA; Anderson GP; Duckett SJ; Hoole EA; Jackson-Pulver LR; Khachigian LM; Morris ME; Roder DM; Rothwell-Short J; Wilson AJ, 2006, 'Evaluation of NHMRC funded research completed in 1992, 1997 and 2003: Gains in knowledge, health and wealth', Medical Journal of Australia, vol. 184, pp. 282 - 286

Bonello MR; Khachigian LM, 2005, 'Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proxim', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, pp. 1704 - 1704, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000226195200102&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM; Waldman A; Fahmy R; Perry M; Geczy C; Zhang G, 2005, 'Novel Insights into Functions of Immediate-Early Genes In Vascular Permeability and Inflammation using Catalytic DNA', INFLAMMATION RESEARCH, vol. 54, pp. S89 - S89, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000205501600014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Bhindi R; Khachigian LM; Lowe HC, 2005, 'DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats', CIRCULATION, vol. 112, pp. U239 - U239, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000232956401200&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Fischer C; Sanchez-Ruderisch H; Welzel M; Wiedenrmann B; Sakai T; André S; Gabius HJ; Khachigian L; Detjen KM; Rosewicz S, 2005, 'Galectin-1 interacts with the α5β1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27', Journal of Biological Chemistry, vol. 280, pp. 37266 - 37277, http://dx.doi.org/10.1074/jbc.M411580200

Waldman A; Fahmy R; Khachigian L, 2005, 'DNAzymes targeting c-Jun inhibit inflammation and downregulate endothelial ICAM-1, VCAM-1 and E-selectin expression', CIRCULATION, vol. 112, pp. U319 - U319, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000232956401573&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lowe HC; James B; Khachigian LM, 2005, 'A novel model of in-stent restenosis: Rat aortic stenting', Heart, vol. 91, pp. 393 - 395, http://dx.doi.org/10.1136/hrt.2003.028076

Kavurma MM; Bhindi R; Lowe HC; Chesterman C; Khachigian LM, 2005, 'Vessel wall apoptosis and atherosclerotic plaque instability', Journal of Thrombosis and Haemostasis, vol. 3, pp. 465 - 472, http://dx.doi.org/10.1111/j.1538-7836.2005.01120.x

Khachigian LM, 2005, 'Suppressing a sick heart', Nature Medicine, vol. 11, pp. 828 - 829, http://dx.doi.org/10.1038/nm0805-828

De Mestre AM; Rao S; Hornby JR; Soe-Htwe T; Khachigian LM; Hulett MD, 2005, 'Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells', Journal of Biological Chemistry, vol. 280, pp. 35136 - 35147, http://dx.doi.org/10.1074/jbc.M503414200

Bonello MR; Khachigian LM, 2005, 'Erratum: Fibroblast growth factor-2 represses platelet-derived growth factor receptor-α (PDGFR-α) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proxi', Journal of Biological Chemistry, vol. 280, pp. 1704

Bonello MR; Bobryshev YV; Khachigian LM, 2005, 'Peroxide-inducible Ets-1 mediates platelet-derived growth factor receptor-α gene transcription in vascular smooth muscle cells', American Journal of Pathology, vol. 167, pp. 1149 - 1159, http://dx.doi.org/10.1016/S0002-9440(10)61203-5

Bhindi R; Brieger D; Ishii H; Di Girolamo N; Kumar RK; Khachigian LM; Lowe HC, 2005, 'Fibroblast growth factor 2 and the transcription factor Egr-1 localise to endothelial cell microvascular channels in human coronary artery occlusion', Thrombosis and Haemostasis, vol. 93, pp. 172 - 174

Khachigian LM, 2004, 'Early growth response-1: Blocking angiogenesis by shooting the messenger', Cell Cycle, vol. 3, pp. 9 - 10

Eisbacher M; Holmes ML; Newton A; Hogg PJ; Khachigian LM; Crossley M; Chong BH, 2004, 'Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding (vol 23, pg 3427, 2003)', MOLECULAR AND CELLULAR BIOLOGY, vol. 24, pp. 5088 - 5088, http://dx.doi.org/10.1128/MCB.24.11.5088.2004

Eyries M; Collins T; Khachigian LM, 2004, 'Modulation of growth factor gene expression in vascular cells by oxidative stress', Endothelium: Journal of Endothelial Cell Research, vol. 11, pp. 133 - 139, http://dx.doi.org/10.1080/10623320490482691

Khachigian LM, 2004, 'Oxidative stress and endothelial dysfunction', Endothelium: Journal of Endothelial Cell Research, vol. 11, pp. 77 - 78, http://dx.doi.org/10.1080/10623320490492339

Khachigian LM; Parish CR, 2004, 'Phosphomannopentaose Sulfate (PI-88): Heparan Sulfate Mimetic with Clinical Potential in Multiple Vascular Pathologies', Cardiovascular Drug Reviews, vol. 22, pp. 1 - 6

Eisbacher M; Holmes ML; Newton A; Hogg PJ; Khachigian LM; Crossley M; Chong BH, 2004, 'Erratum: Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding (Molecular and Cellular Biology (2003) 23,', Molecular and Cellular Biology, vol. 24, pp. 5088, http://dx.doi.org/10.1128/MCB.24.11.5088.2004

Sharma L; Melis E; Hickey MJ; Clyne CD; Erlich J; Khachigian LM; Davenport P; Morand E; Carmeliet P; Tipping PG, 2004, 'The cytoplasmic domain of tissue factor contributes to leukocyte recruitment and death in endotoxemia', American Journal of Pathology, vol. 165, pp. 331 - 340, http://dx.doi.org/10.1016/S0002-9440(10)63300-7

Fahmy RG; Khachigian LM, 2004, 'Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth', Nucleic Acids Research, vol. 32, pp. 2281 - 2285, http://dx.doi.org/10.1093/nar/gkh543

Khachigian LM, 2004, 'Deoxyribozymes as inhibitors of vascular smooth muscle cell growth', Current Pharmaceutical Biotechnology, vol. 5, pp. 337 - 339, http://dx.doi.org/10.2174/1389201043376788

Santiago FS; Khachigian LM, 2004, 'Ets-1 stimulates platelet-derived growth factor A-chain gene transcription and vascular smooth muscle cell growth via cooperative interactions with Sp1', Circulation Research, vol. 95, pp. 479 - 487, http://dx.doi.org/10.1161/01.RES.0000141135.36279.67

Khachigian LM, 2004, 'DNAzymes as molecular agents that manipulate Egr-1 gene expression', Biochemical Pharmacology, vol. 68, pp. 1023 - 1025, http://dx.doi.org/10.1016/j.bcp.2004.03.042

Midgley VC; Khachigian LM, 2004, 'Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1', Journal of Biological Chemistry, vol. 279, pp. 40289 - 40295, http://dx.doi.org/10.1074/jbc.M406063200

Kavurma MM; Khachigian LM, 2004, 'Vascular smooth muscle cell-specific regulation of cyclin-dependent kinase inhibitor p21^WAF1/Cip1 transcription by Sp1 is mediated via distinct cis-acting positive and negative regulatory e', Journal of Cellular Biochemistry, vol. 93, pp. 904 - 916, http://dx.doi.org/10.1002/jcb.20238

Hanratty CG; Murrell M; Khachigian LM; Tsao PS; Ward MR, 2004, 'Low flow promotes instent intimal hyperplasia: Comparison with lumen loss in balloon-injured and uninjured vessels and the effects of the antioxidant pyrrolidine dithiocarbamate', Atherosclerosis, vol. 177, pp. 269 - 274, http://dx.doi.org/10.1016/j.atherosclerosis.2004.07.016

Bonello MR; Khachigian LM, 2004, 'Fibroblast Growth Factor-2 Represses Platelet-derived Growth Factor Receptor-α (PDGFR-α) Transcription via ERK1/2-dependent Sp1 Phosphorylation and an Atypical cis-Acting Element in the Proximal PDGFR', Journal of Biological Chemistry, vol. 279, pp. 2377 - 2382, http://dx.doi.org/10.1074/jbc.M308254200

Zhang G; Dass CR; Sumithran E; Di Girolamo N; Sun LQ; Khachigian LM, 2004, 'Effect of deoxyribzymes targeting c-Jun on solid tumor growth and angiogenesis in rodents', Journal of the National Cancer Institute, vol. 96, pp. 683 - 696, http://dx.doi.org/10.1093/jnci/djh120

Mitchell A; Dass CR; Sun LQ; Khachigian LM, 2004, 'Inhibition of human breast carcinoma proliferation, migration, chemoinvasion and solid tumour growth by DNAzymes targeting the zinc finger transcription factor EGR-1', Nucleic Acids Research, vol. 32, pp. 3065 - 3069, http://dx.doi.org/10.1093/nar/gkh626

Zhang GS; Dass CR; Sun L; Khachigian LM, 2004, 'DNAZYMES TARGETING C-JUN BLOCK ENDOTHELIAL PROLIFERATION, MIGRATION, TUBULE FORMATION, ANGIOGENESIS AND SOLID TUMOR GROWTH', Cardiovascular Pathology, vol. 13, pp. 131 - 131, http://www.sciencedirect.com/science/article/B6T13-4C88SSS-FR/2/5289ac8546a33c5e6f75f4effe492cdc

Kavurma MM; Khachigian LM, 2003, 'Signaling and transcriptional control of Fas ligand expression', Cell Death and Differentiation, vol. 10, pp. 36 - 44, http://dx.doi.org/10.1038/sj.cdd.4401179

Francis DJ; Parish CR; McGarry M; Santiago FS; Lowe HC; Brown KJ; Bingley JA; Hayward IP; Cowden WB; Campbell JH, 2003, 'Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88: phosphomannopentaose sulfate directly binds FGF-2, blocks cellu', Circulation research, vol. 92

Kavurma MM; Khachigian LM, 2003, 'ERK, JNK, and p38 MAP kinases differentially regulate proliferation and migration of phenotypically distinct smooth muscle cell subtypes', Journal of Cellular Biochemistry, vol. 89, pp. 289 - 300, http://dx.doi.org/10.1002/jcb.10497

Kavurma MM; Khachigian LM, 2003, 'Sp1 inhibits proliferation and induces apoptosis in vascular smooth muscle cells by repressing p21^WAF1/Cip1 transcription and cyclin D1-Cdk4-p21^WAF1/Cip1 complex formation', Journal of Biological Chemistry, vol. 278, pp. 32537 - 32543, http://dx.doi.org/10.1074/jbc.M305650200

Lowe HC; Jang IK; Khachigian LM, 2003, 'Animal models of vulnerable plaque: Clinical context and current status', Thrombosis and Haemostasis, vol. 90, pp. 774 - 780

De Mestre AM; Khachigian LM; Santiago FS; Staykova MA; Hulett MD, 2003, 'Regulation of Inducible Heparanase Gene Transcription in Activated T Cells by Early Growth Response 1', Journal of Biological Chemistry, vol. 278, pp. 50377 - 50385, http://dx.doi.org/10.1074/jbc.M310154200

Pimanda JE; Lowe HC; Hogg PJ; Chesterman CN; Khachigian LM, 2003, 'Novel and emerging therapies in cardiology and haematology', Current Drug Targets - Cardiovascular and Haematological Disorders, vol. 3, pp. 101 - 123, http://dx.doi.org/10.2174/1568006033481465

Eisbacher M; Holmes ML; Newton A; Hogg PJ; Khachigian LM; Crossley M; Chong BH, 2003, 'Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding', Molecular and Cellular Biology, vol. 23, pp. 3427 - 3441, http://dx.doi.org/10.1128/MCB.23.10.3427-3441.2003

Fahmy RG; Dass CR; Sun LQ; Chesterman CN; Khachigian LM, 2003, 'Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth', Nature Medicine, vol. 9, pp. 1026 - 1032, http://dx.doi.org/10.1038/nm905

Zhang C; Kavurma MM; Lai A; Khachigian LM, 2003, 'Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21^WAF1/Cip1: ETS-1 regulates basal and inducible p21^WAF1/Cip1 transcription via distinct cis-', Journal of Biological Chemistry, vol. 278, pp. 27903 - 27909, http://dx.doi.org/10.1074/jbc.M304328200

Burkhart CA; Cheng AJ; Madafiglio J; Kavallaris M; Mili M; Marshall GM; Weiss WA; Khachigian LM; Norris MD; Haber M, 2003, 'Effects of MYCN antisense oligonucleotide administration on tumorigenesis in a murine model of neuroblastoma', Journal of the National Cancer Institute, vol. 95, pp. 1394 - 1403, http://dx.doi.org/10.1093/jnci/djg045

MacNeill BD; James B; Chesterman CN; Khachigian LM, 2002, 'Overstretch stent injury to the rat aorta leads to in-stent restenosis', American Journal of Cardiology, vol. 89, pp. 1010, http://dx.doi.org/10.1016/S0002-9149(02)02264-6

Fahmy RG; Khachigian LM, 2002, 'Antisense Egr-1 RNA driven by the CMV promoter is an inhibitor of vascular smooth muscle cell proliferation and regrowth after injury', Journal of Cellular Biochemistry, vol. 84, pp. 575 - 582, http://dx.doi.org/10.1002/jcb.10057

Lowe HC; Oesterle SN; Khachigian LM, 2002, 'Coronary in-stent restenosis: Current status and future strategies', Journal of the American College of Cardiology, vol. 39, pp. 183 - 193, http://dx.doi.org/10.1016/S0735-1097(01)01742-9

Lowe HC; Khachigian LM, 2002, 'Coating stents with antirestenotic drugs: the blunderbuss or the magic bullet?', Circulation, vol. 105

Rafty LA; Santiago FS; Khachigian LM, 2002, 'NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter', EMBO Journal, vol. 21, pp. 334 - 343, http://dx.doi.org/10.1093/emboj/21.3.334

Lowe HC; Chesterman CN; Khachigian LM, 2002, 'Catalytic antisense DNA molecules targeting Egr-1 inhibit neointima formation following permanent ligation of rat common carotid arteries', Thrombosis and Haemostasis, vol. 87, pp. 134 - 140

Rafty LA; Khachigian LM, 2002, 'Von Hippel-Lindau tumor suppressor protein represses platelet-derived growth factor B-chain gene expression via the Sp1 binding element in the proximal PDGF-B promoter', Journal of Cellular Biochemistry, vol. 85, pp. 490 - 495, http://dx.doi.org/10.1002/jcb.10152

Khachigian LM, 2002, 'DNAzymes: Cutting a path to a new class of therapeutics', Current Opinion in Molecular Therapeutics, vol. 4, pp. 119 - 121

Lowe HC; Burkoff D; Khachigian LM; MacNeill BD; Hayase M; Oesterle SN, 2002, 'Beyond angioplasty: Novel developments in interventional cardiology', Internal Medicine Journal, vol. 32, pp. 470 - 474, http://dx.doi.org/10.1046/j.1445-5994.2002.00261.x

Kavurma MM; Bobryshev Y; Khachigian LM, 2002, 'Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1', Journal of Biological Chemistry, vol. 277, pp. 36244 - 36252, http://dx.doi.org/10.1074/jbc.M200463200

Khachigian LM; Fahmy RG; Zhang G; Bobryshev YV; Kaniaros A, 2002, 'c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury. Inhibition by a novel DNA enzyme targeting c-Jun', Journal of Biological Chemistry, vol. 277, pp. 22985 - 22991, http://dx.doi.org/10.1074/jbc.M200977200

Lowe HC; Fahmy R; Chesterman CN; Khachigian LM, 2001, 'Catalytic oligodeoxynucleotides targeting the human transcription factor EGR-1 as inhibitors of restenosis', CIRCULATION, vol. 104, pp. 265 - 265, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000171895001261&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Rafty LA; Khachigian LM, 2001, 'Sp1 phosphorylation mediates inducible platelet-derived growth factor B-chain gene expression: Phosphorylation mediated by atypical protein kinase C-zeta', FASEB JOURNAL, vol. 15, pp. A1185 - A1185, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000167454202722&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Eisbacher M; Newton A; Holmes ML; Khachigian LM; Crossley M; Chong BH, 2001, 'The protein-protein interaction between FLI-1 and GATA-1 is crucial for expression of the megakaryocyte-specific gene Glycoprotein IX.', BLOOD, vol. 98, pp. 286A - 286A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172134101211&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM, 2001, 'Single-stranded catalytic dna as potential therapeutic agents in vascular disease', Today's Life Science, vol. 13, pp. 30 - 31

Kavurma MM; Santiago FS; Bonfoco E; Khachigian LM, 2001, 'Sp1 Phosphorylation Regulates Apoptosis via Extracellular FasL-Fas Engagement', Journal of Biological Chemistry, vol. 276, pp. 4964 - 4971, http://dx.doi.org/10.1074/jbc.M009251200

Rafty LA; Khachigian LM, 2001, 'Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical protein kinase C-ζ', Nucleic Acids Research, vol. 29, pp. 1027 - 1033

Lowe HC; Chesterman CN; Hopkins AP; Juergens CP; Khachigian LM, 2001, 'Acute local release of fibroblast growth factor-2 but not transforming growth factor-β1 following coronary stenting', Thrombosis and Haemostasis, vol. 85, pp. 574 - 576

Gousseva N; Kugathasan K; Chesterman CN; Khachigian LM, 2001, 'Early growth response factor-1 mediates insulin-inducible vascular endothelial cell proliferation and regrowth after injury', Journal of Cellular Biochemistry, vol. 81, pp. 523 - 534, http://dx.doi.org/10.1002/1097-4644(20010601)81:3<523::AID-JCB1066>3.0.CO;2-E

Lowe HC; Chesterman CN; Khachigian LM, 2001, 'Does thrombus contribute to in-stent restenosis in the porcine coronary stent model?', Thrombosis and Haemostasis, vol. 85, pp. 1117 - 1118

Lowe HC; Chesterman CN; Khachigian LM, 2001, 'Rat aortic stenting: Toward a simple model of in-stent restenosis', American Journal of Cardiology, vol. 88, pp. 720 - 721, http://dx.doi.org/10.1016/S0002-9149(01)01795-7

Lowe HC; Fahmy RG; Kavurma MM; Baker A; Chesterman CN; Khachigian LM, 2001, 'Catalytic oligodeoxynucleotides define a key regulatory role for early growth response factor-1 in the porcine model of coronary in-stent restenosis', Circulation Research, vol. 89, pp. 670 - 677, http://dx.doi.org/10.1161/hh2001.097867

Santiago FS; Lowe HC; Bobryshev YV; Khachigian LM, 2001, 'Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2', Journal of Biological Chemistry, vol. 276, pp. 41143 - 41149, http://dx.doi.org/10.1074/jbc.M104913200

Santiago FS; Khachigian LM, 2001, 'Nucleic acid based strategies as potential therapeutic tools: Mechanistic considerations and implications to restenosis', Journal of Molecular Medicine, vol. 79, pp. 695 - 706, http://dx.doi.org/10.1007/s001090100272

Khachigian LM, 2001, 'Catalytic oligonucleotides targeting Egr-1 as potential inhibitors of in-stent restenosis', Annals of the New York Academy of Sciences, vol. 947, pp. 412 - 415

Lowe HC; Kumar RK; Chesterman CN; Fahmy RG; Khachigian LM, 2001, 'Coronary stent thrombosis: Insights from the porcine coronary stent model', Thrombosis and Haemostasis, vol. 86, pp. 937 - 938

Lowe HC; Santiago FS; Chesterman CN; Khachigian LM, 2000, 'Immobilized hyaluronic acid as a thromboresistant coating for cardiovascular devices', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 35, pp. 15A - 15A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000085209700057&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lowe HC; Santiago FS; Chesterman CN; Khachigian LM, 2000, 'A novel catalytic DNA molecule targeting the transcription factor Egr-1 inhibits neointimal formation following rat carotid angioplasty', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 35, pp. 15A - 15A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000085209700059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lowe HC; Chesterman CN; Hopkins AP; Juergens CP; Khachigian LM, 2000, 'Acute local release of fibroblast growth factor-2, but not transforming growth factor-beta(1), following coronary stenting', CIRCULATION, vol. 102, pp. 732 - 732, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000090072303532&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chong BH; Eisbacher M; Khin TH; Khachigian LM, 2000, 'Inducible expression of GPIX by PMA and TPO in megakaryocytic cells requires an intact Ets site and upstream activation of ERK.', BLOOD, vol. 96, pp. 672A - 672A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000165256102891&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lowe HC; Murray B; Chong BH; Chesterman CN; Khachigian LM, 2000, 'Intracoronary blood sampling using the multifunction probing catheter does not cause platelet activation', Journal of Invasive Cardiology, vol. 12, pp. 144 - 146

Rafty LA; Khachigian LM, 2000, 'Novel negative regulatory element in the platelet-derived growth factor B chain promoter that mediates ERK-dependent transcriptional repression', Journal of Biological Chemistry, vol. 275, pp. 11478 - 11483, http://dx.doi.org/10.1074/jbc.275.15.11478

Sungaran R; Chisholm OT; Markovic B; Khachigian LM; Tanaka Y; Chong BH, 2000, 'The role of platelet α-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells', Blood, vol. 95, pp. 3094 - 3101

Taylor LM; Khachigian LM, 2000, 'Induction of platelet-derived growth factor B-chain expression by transforming growth factor-β involves transactivation by Smads', Journal of Biological Chemistry, vol. 275, pp. 16709 - 16716, http://dx.doi.org/10.1074/jbc.275.22.16709

Larkin L; Khachigian LM; Jessup W, 2000, 'Regulation of apolipoprotein E production in macrophages (review).', International journal of molecular medicine, vol. 6, pp. 253 - 258

Khachigian LM; Takuwa Y; Collins T, 2000, 'Mechanisms of angiotensin II-induced platelet-derived growth factor gene expression', Molecular and Cellular Biochemistry, vol. 212, pp. 183 - 186

Khachigian LM, 2000, 'Catalytic DNAs as potential therapeutic agents and sequence-specific molecular tools to dissect biological function', Journal of Clinical Investigation, vol. 106, pp. 1189 - 1195, http://dx.doi.org/10.1172/JCI11620

Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker A; Atkins DG; Khachigian LM, 1999, 'New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury (vol 5, pg 1264, 1999)', NATURE MEDICINE, vol. 5, pp. 1438 - 1438, http://dx.doi.org/10.1038/71020

Khachigian LM; Santiago FS; Rafty LA; Chan OLW; Delbridge GJ; Bobik A; Collins T; Johnson AC, 1999, 'GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury.', FASEB JOURNAL, vol. 13, pp. A42 - A42, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082033300240&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM, 1999, 'The intimacies of blood vessel injury', Today's Life Science, vol. 11, pp. 74 - 78

Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker A; Atkins DG; Khachigian LM, 1999, 'Erratum: New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury (Nature Medicine (1999) 5 (1264-1269))', Nature Medicine, vol. 5, pp. 1438

Lowe HC; Chesterman CN; Khachigian LM, 1999, 'Left main coronary artery stenosis after percutaneous transluminal coronary angioplasty: Importance of remaining 'minimally invasive'', Catheterization and Cardiovascular Interventions, vol. 46, pp. 254 - 255

Santiago FS; Lowe HC; Day FL; Chesterman CN; Khachigian LM, 1999, 'Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2', American Journal of Pathology, vol. 154, pp. 937 - 944, http://dx.doi.org/10.1016/S0002-9440(10)65341-2

Khachigian LM; Santiago FS; Rafty LA; Chan OLW; Delbridge GJ; Bobik A; Collins T; Johnson AC, 1999, 'GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury', Circulation Research, vol. 84, pp. 1258 - 1267, http://dx.doi.org/10.1161/01.RES.84.11.1258

Day FL; Rafty LA; Chesterman CN; Khachigian LM, 1999, 'Angiotensin II (ATII)-inducible platelet-derived growth factor A-chain gene expression is p42/44 extracellular signal-regulated kinase-1/2 and Egr- 1-dependent and mediated via the ATII type I but not', Journal of Biological Chemistry, vol. 274, pp. 23726 - 23733, http://dx.doi.org/10.1074/jbc.274.34.23726

Santiago FS; Atkins DG; Khachigian LM, 1999, 'Vascular smooth muscle cell proliferation and regrowth after mechanical injury in vitro are Egr-1/NGFI-A-dependent', American Journal of Pathology, vol. 155, pp. 897 - 905, http://dx.doi.org/10.1016/S0002-9440(10)65189-9

Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker A; Atkins DG; Khachigian LM, 1999, 'New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury', Nature Medicine, vol. 5, pp. 1264 - 1269, http://dx.doi.org/10.1038/15215

Silverman ES; Khachigian LM; Santiago FS; Williams AJ; Lindner V; Collins T, 1999, 'Vascular smooth muscle cells express the transcriptional corepressor NAB2 in response to injury', American Journal of Pathology, vol. 155, pp. 1311 - 1317, http://dx.doi.org/10.1016/S0002-9440(10)65233-9

Santiago FS; Atkins D; Khachigian LM, 1998, 'Antisense oligonucleotides directed against Egr-1 inhibit vascular smooth muscle cell proliferation.', FASEB JOURNAL, vol. 12, pp. A189 - A189, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000076006401100&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM; Santiago FS; Delbridge GJ; Chesterman CN, 1998, 'Endothelial injury triggers FGF-2 release and a signaling cascade involving MAPK and Egr-1.', FASEB JOURNAL, vol. 12, pp. A467 - A467, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000076006402706&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Rafty LA; Khachigian LM, 1998, 'Zinc finger transcription factors mediate high constitutive platelet- derived growth factor-B expression in smooth muscle cells derived from aortae of newborn rats', Journal of Biological Chemistry, vol. 273, pp. 5758 - 5764, http://dx.doi.org/10.1074/jbc.273.10.5758

Sumpio BE; Du W; Galagher G; Wang XJ; Khachigian LM; Collins T; Gimbrone MA; Resnick N, 1998, 'Regulation of PDGF-B in endothelial cells exposed to cyclic strain', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 18, pp. 349 - 355, http://dx.doi.org/10.1161/01.ATV.18.3.349

Khachigian LM; Collins T, 1998, 'Early growth response factor 1: A pleiotropic mediator of inducible gene expression', Journal of Molecular Medicine, vol. 76, pp. 613 - 616, http://dx.doi.org/10.1007/s001090050258

Khachigian LM; Santiago FS; Delbridge GJ; Chesterman CN, 1997, 'Endothelial injury and transcriptional activation: bFGF induction of Egr-1 and PDGF-A', ATHEROSCLEROSIS, vol. 134, pp. 265 - 265, http://dx.doi.org/10.1016/S0021-9150(97)89392-6

Gimbrone MA; Resnick N; Nagel T; Khachigian LM; Collins T; Topper JN, 1997, 'Hemodynamics, endothelial gene expression, and atherogenesis', Annals of the New York Academy of Sciences, vol. 811, pp. 1 - 11, http://dx.doi.org/10.1111/j.1749-6632.1997.tb51983.x

Delbridge GJ; Khachigian LM, 1997, 'FGF-1-induced platelet-derived growth factor-A chain gene expression in endothelial cells involves transcriptional activation by early growth response factor-1', Circulation Research, vol. 81, pp. 282 - 288, http://dx.doi.org/10.1161/01.RES.81.2.282

Resnick N; Yahav H; Khachigian LM; Collins T; Anderson KR; Dewey FC; Gimbrone MA, 1997, 'Endothelial gene regulation by laminar shear stress', Advances in Experimental Medicine and Biology, vol. 430, pp. 155 - 164

Khachigian LM; Collins T, 1997, 'Inducible expression of Egr-1-dependent genes: A paradigm of transcriptional activation in vascular endothelium', Circulation Research, vol. 81, pp. 457 - 461, http://dx.doi.org/10.1161/01.RES.81.4.457

Khachigian LM; Collins T; Fries JWU, 1997, 'N-acetyl cysteine blocks mesangial VCAM-1 and NF-κB expression in vivo', American Journal of Pathology, vol. 151, pp. 1225 - 1229

Khachigian LM; Anderson KR; Halnon NJ; Gimbrone J; Resnick N; Collins T, 1997, 'Egr-1 is activated in endothelial cells exposed to fluid shear stress and interacts with a novel shear-stress-response element in the PDGF A-chain promoter', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 17, pp. 2280 - 2286, http://dx.doi.org/10.1161/01.ATV.17.10.2280

Silverman ES; Khachigian LM; Lindner V; Williams AJ; Collins T, 1997, 'Inducible PDGF A-chain transcription in smooth muscle cells is mediated by Egr-1 displacement of Sp1 and Sp3', American Journal of Physiology - Heart and Circulatory Physiology, vol. 273

Lloyd A; Dixon G; Huang XF; Ward P; Catts S; Hickie I; Wakefield D, 1997, 'Molecular biology and the major psychoses', Australian and New Zealand Journal of Psychiatry, vol. 31, pp. 12 - 16, http://dx.doi.org/10.3109/00048679709073794

Yang M; Khachigian LM; Hicks C; Chesterman CN; Chong BH, 1997, 'Identification of PDGF receptors on human megakaryocytes and megakaryocytic cell lines', Thrombosis and Haemostasis, vol. 78, pp. 892 - 896

Khachigian LM; Anderson KR; Halnon NJ; Gimbrone MA; Resnick N; Collins T, 1996, 'Shear-induced endothelial pdgf-a chain gene expression involves EGR-1', FASEB Journal, vol. 10

Khachigian LM; Lindner V; Williams AJ; Collins T, 1996, 'Egr-1-induced endothelial gene expression: A common theme in vascular injury', Science, vol. 271, pp. 1427 - 1431, http://dx.doi.org/10.1126/science.271.5254.1427

Field SL; Khachigian LM; Sleigh MJ; Yang G; Vandermark SE; Hogg PJ; Chesterman CN, 1996, 'Extracellular matrix is a source of mitogenically active platelet-derived growth factor', Journal of Cellular Physiology, vol. 168, pp. 322 - 332, http://dx.doi.org/10.1002/(SICI)1097-4652(199608)168:2<322::AID-JCP11>3.0.CO;2-5

Khachigian LM; Williams AJ; Collins T, 1995, 'Interplay of Sp1 and Egr-1 in the PDGF A-chain proximal promoter in cultured vascular endothelial cells.', BLOOD, vol. 86, pp. 1246 - 1246, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TH91001248&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

KHACHIGIAN LM; RESNICK N; GIMBRONE MA; COLLINS T, 1995, 'NUCLEAR FACTOR-KAPPA-B INTERACTS FUNCTIONALLY WITH THE SHEAR-STRESS-RESPONSE-ELEMENT IN THE PLATELET-DERIVED GROWTH-FACTOR B-CHAIN PROMOTER', FASEB JOURNAL, vol. 9, pp. A412 - A412, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QL98702410&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM; Resnick N; Gimbrone MA; Collins T, 1995, 'Nuclear factor-κB interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress', Journal of Clinical Investigation, vol. 96, pp. 1169 - 1175, http://dx.doi.org/10.1172/JCI118106

Khachigian LM; Williams AJ; Collins T, 1995, 'Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells', Journal of Biological Chemistry, vol. 270, pp. 27679 - 27686, http://dx.doi.org/10.1074/jbc.270.46.27679

Neish AS; Khachigian LM; Park A; Baichwal VR; Collins T, 1995, 'Sp1 is a component of the cytokine-inducible enhancer in the promoter of vascular cell adhesion molecule-1', Journal of Biological Chemistry, vol. 270, pp. 28903 - 28909, http://dx.doi.org/10.1074/jbc.270.48.28903

Williams AJ; Khachigian LM; Shows T; Collins T, 1995, 'Isolation and characterization of a novel zinc-finger protein with transcriptional repressor activity', Journal of Biological Chemistry, vol. 270, pp. 22143 - 22152, http://dx.doi.org/10.1074/jbc.270.38.22143

Khachigian LM; Field SL; Crouch R; Chesterman CN, 1995, 'Platelet-derived growth factor A-chain synthetic peptide inhibits human glioma xenograft proliferation in nude mice', Anticancer Research, vol. 15, pp. 337 - 341

Khachigian LM; Collins T; Fries JWU, 1995, 'Nuclear factor-κB mediates induction of vascular cell adhesion molecule-1 in glomerular mesangial cells', Biochemical and Biophysical Research Communications, vol. 206, pp. 462 - 467, http://dx.doi.org/10.1006/bbrc.1995.1065

KHACHIGIAN LM; BENZ MW; NEISH AS; BONTHRON DT; COLLINS T, 1994, 'NOVEL DNA-BINDING ELEMENTS IN THE PROMOTER OF HUMAN PLATELET-DERIVED GROWTH-FACTOR B-CHAIN GENE', FASEB JOURNAL, vol. 8, pp. A392 - A392, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994ND19602268&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM; Fries JWU; Benz MW; Bonthron DT; Collins T, 1994, 'Novel cis-acting elements in the human platelet-derived growth factor B- chain core promoter that mediate gene expression in cultured vascular endothelial cells', Journal of Biological Chemistry, vol. 269, pp. 22647 - 22656

Khachigian LM; Chesterman CN, 1994, 'Structural basis for the extracellular retention of PDGF A-chain using a synthetic peptide corresponding to exon 6', Peptides, vol. 15, pp. 133 - 137, http://dx.doi.org/10.1016/0196-9781(94)90181-3

KHACHIGIAN LM; SLEIGH MJ; CHESTERMAN CN, 1993, 'PLATELET-DERIVED GROWTH FACTOR-A-CHAIN EXON-6 PRODUCT ASSOCIATES WITH EXTRACELLULAR HEPARIN-LIKE GLYCOSAMINOGLYCANS', THROMBOSIS AND HAEMOSTASIS, vol. 69, pp. 972 - 972, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993LT57701547&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM; Chesterman CN, 1993, 'Platelet-derived growth factor and its receptor: Structure and roles in normal growth and pathology', Platelets, vol. 4, pp. 304 - 315, http://dx.doi.org/10.3109/09537109309013233

KHACHIGIAN LM, 1992, 'CORRECTION', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, pp. 6449 - 6449, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992HK31800110&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM; Owensby DA; Chesterman CN, 1992, 'Erratum: A tyrosinated peptide representing the alternatively spliced exon of the platelet-derived growth factor A-chain binds specifically to cultured cells and interferes with binding of several gro', Journal of Biological Chemistry, vol. 267, pp. 6449

Khachigian LM; Chesterman CN, 1992, 'Synthetic peptides representing the alternatively spliced exon of the platelet-derived growth factor A-chain modulate mitogenesis stimulated by normal human serum and several growth factors', Journal of Biological Chemistry, vol. 267, pp. 7478 - 7482

Khachigian LM; Owensby DA; Chesterman CN, 1992, 'A tyrosinated peptide representing the alternatively spliced exon of the platelet-derived growth factor A-chain binds specifically to cultured cells and interferes with binding of several growth facto', Journal of Biological Chemistry, vol. 267, pp. 1660 - 1666

Khachigian LM; Evin G; Morgan FJ; Owensby DA; Chesterman CN, 1992, 'A crossreactive antipeptide monoclonal antibody with specificity for lysyl-lysine (J. Immunol. Methods 140 (1991) 249-258)', Journal of Immunological Methods, vol. 149, pp. 267

Khachigian LM; Chesterman CN, 1992, 'Platelet-derived growth factor and alternative splicing: A review', Pathology, vol. 24, pp. 280 - 290, http://dx.doi.org/10.3109/00313029209068882

Khachigian LM; Evin G; Morgan FJ; Owensby DA; Chesterman CN, 1991, 'A crossreactive antipeptide monoclonal antibody with specificity for lysyl-lysine', Journal of Immunological Methods, vol. 140, pp. 249 - 258, http://dx.doi.org/10.1016/0022-1759(91)90378-S

Conference Papers

Khachigian LM, 2003, 'Control of immediate-early transcription factor expression in injured arteries', in CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, BLACKWELL PUBLISHING ASIA, MELBOURNE, AUSTRALIA, pp. A12 - A12, presented at Joint Symposium of the Australian-Athersclerosis-Society/Australian-Vascular-Biology-Society, MELBOURNE, AUSTRALIA, 27 December 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183582000041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Murrell MJ; Khachigian LM; Tsao P; Ward MR, 2003, 'The effect of oxidant stress, injury and flow on c-jun and egr-1 expression', in ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, WASHINGTON, D.C., pp. A20 - A20, presented at 4th Annual Conference on Arteriosclerosis Thrombosisand Vascular Biology, WASHINGTON, D.C., 08 - 10 May 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000182742500140&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM, 2003, 'Insulin and vascular growth regulation by transcription', in CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, BLACKWELL PUBLISHING ASIA, MELBOURNE, AUSTRALIA, pp. A27 - A27, presented at Joint Symposium of the Australian-Athersclerosis-Society/Australian-Vascular-Biology-Society, MELBOURNE, AUSTRALIA, 27 December 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183582000071&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Eisbacher M; Holmes ML; Hogg PJ; Newton A; Khachigian LM; Crossley M; Chong BH, 2003, 'Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA-binding', in Journal of Thrombosis and Haemostasis, Blackwell Publishing Ltd, Birmingham, England, pp. 357 - 357, presented at XIXth Congress of the International Society on Thrombosis and Haematosis, Birmingham, England, 12 - 18 July 2003

Khachigian LM; Resnick N; Gimbrone MA; Collins TF, 1995, 'Nuclear factor-kB interacts functionally with the platelet-derived growth factor B-chain promoter', in Journal of Clinical Investigation, American Society Clinical Investigation Inc, Atlanta, Georgia USA, presented at Experimental Biology Meeting 1995, Atlanta, Georgia USA, 08 - 12 April 1995

Conference Abstracts

Khachigian LM, 2016, 'New insights on the regulatory roles of early growth response-1 in the reparative response to vascular injury', in INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, SPANDIDOS PUBL LTD, Vol. 38, pp. S79 - S79, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383733000298&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Patents

Khachigian LM, 1999, Treatment of cancer, Patent No. , Patent Agent:

Khachigian LM, 1999, Treatment of asthma, Patent No. , Patent Agent:

Khachigian LM; Atkins D; Baker AT, 1999, Catalytic molecules, Patent No. , Patent Agent: