Visiting Professor David Sinclair

Contact Details

Phone: (+61) 2 9385 1621
Email: david.sinclair@unsw.edu.au

Supervision

PHD
Masters
Honours

Tabs

Main

David Sinclair, Ph.D. is a Conjoint Professor at the School of Medical Sciences at the University of New South Wales (UNSW), Sydney, a Professor in the Genetics Department at Harvard Medical School, Boston, Co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, and co-founder and co-chief editor of the scientific journal Aging. He obtained a BS and a Ph.D. at UNSW in Molecular Genetics with Ian Dawes, worked as a postdoctoral researcher at M.I.T. with Lenny Guarente, then moved to Harvard Medical School in 1999 as an Assistant Professor. He was promoted to tenured Professor in 2008.

Dr. Sinclair's awards include the Australian Commonwealth Prize, a Helen Hay Whitney Postdoctoral Award, a Special Fellowship from the Leukemia Society, a Ludwig Scholarship, a Harvard-Armenise Fellowship, an American Association for Aging Research Fellowship, the Ellison Medical Foundation Scholarship and Senior Fellowship, the Genzyme Outstanding Achievement in Biomedical Science Award, Teluride Technology Award, Innovator of the Year, a MERIT Award from the NIA, the Nathan Shock Award, the David Murdock-Dole Lectureship, Excellence in Teaching at Harvard Medical School, the Fisher Lectureship, the Denham Harman Research Award, the ASMR Medal (Australian Society for Medical Research). a Knowledge Nation 100 Recipient, an ambassador for business events (Sydney), the Kersten lecturer (USC), a Pioneer Award from the Director of the NIH, Advance Global Australian Award, and the Irving Wright AFAR “Award of Distinction” (2018). In 2014 he was listed by TIME magazine as “one of the 100 most influential people in the world” and in 2018 he was appointed an Officer of the Order of Australia (AO).

David Sinclair is a founder, equity owner, advisor to, director of, consultant to, and/or inventor of patents licensed to Jupiter Orphan Therapeutics, Cohbar, Galilei Biosciences, EdenRoc Sciences (Arc-Bio, Dovetail Genomics, Claret, Revere Biosciences, UpRNA, MetroBiotech, Liberty Biosecurity) and Life Biosciences (Selphagy, InsideTracker, Senolytic Therapeutics, Spotlight Therapeutics, Animal Biosciences, Reprogramming Medicine, Continuum Biosciences, and Jumpstart Fertility). MetroBiotech, Liberty Biosecurity, and Jumpstart are developing NAD boosting molecules/precursors for the treatment of diseases. He is an inventor on an invention filed by Mayo Clinic and Harvard Medical School that has been licensed to Elysium Health. For more information see https://www.linkedin.com/in/sinclairda/

University role:

Conjoint professor

Research

Media

LinkedIn:

http://www.linkedin.com/in/sinclairda

Publications related to this Person

Books

Sinclair D; Mills K; Guarente L, 1998, Aging in Saccharomyces cerevisiae, http://dx.doi.org/10.1146/annurev.micro.52.1.533

Book Chapters

Journal articles

Ross JM; Coppotelli G; Branca RM; Kim KM; Lehtiö J; Sinclair DA; Olson L, 2019, 'Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice', Aging Cell, vol. 18, http://dx.doi.org/10.1111/acel.13029

Palmeira CM; Teodoro JS; Amorim JA; Steegborn C; Sinclair DA; Rolo AP, 2019, 'Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins', Free Radical Biology and Medicine, vol. 141, pp. 483 - 491, http://dx.doi.org/10.1016/j.freeradbiomed.2019.07.017

Youngson NA; Mezbah Uddin G; Das A; Martinez C; Connaughton HS; Whiting S; Yu J; Sinclair DA; John Aitken R; Morris MJ, 2019, 'Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice', Reproduction, vol. 158, pp. 169 - 179, http://dx.doi.org/10.1530/REP-18-0574

Amano H; Chaudhury A; Rodriguez-Aguayo C; Lu L; Akhanov V; Catic A; Popov YV; Verdin E; Johnson H; Stossi F, 2019, 'Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease', Cell Metabolism, vol. 29, pp. 1274 - 1290.e9, http://dx.doi.org/10.1016/j.cmet.2019.03.001

Kane AE; Sinclair DA, 2019, 'Frailty biomarkers in humans and rodents: Current approaches and future advances', Mechanisms of Ageing and Development, vol. 180, pp. 117 - 128, http://dx.doi.org/10.1016/j.mad.2019.03.007

Tarantini S; Valcarcel-Ares MN; Toth P; Yabluchanskiy A; Tucsek Z; Kiss T; Hertelendy P; Kinter M; Ballabh P; Süle Z, 2019, 'Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice', Redox Biology, vol. 24, http://dx.doi.org/10.1016/j.redox.2019.101192

Kane AE; Sinclair DA, 2019, 'Epigenetic changes during aging and their reprogramming potential', Critical Reviews in Biochemistry and Molecular Biology, vol. 54, pp. 61 - 83, http://dx.doi.org/10.1080/10409238.2019.1570075

Feng J; Lachance A; Sinclair DA; Asgari MM, 2019, 'Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1', BMJ Case Reports, vol. 12, http://dx.doi.org/10.1136/bcr-2018-227233

Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y, 2019, 'Erratum: Impairment of an Endothelial NAD⁺-H2S Signaling Network Is a Reversible Cause of Vascular Aging (Cell (2018) 173(1) (74–89.e20), (S0092867418301521) (10.1016/j.cell.2018', Cell, vol. 176, pp. 944 - 945, http://dx.doi.org/10.1016/j.cell.2019.01.026

Bonora M; Wieckowski MR; Sinclair DA; Kroemer G; Pinton P; Galluzzi L, 2019, 'Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles', Nature Reviews Cardiology, vol. 16, pp. 33 - 55, http://dx.doi.org/10.1038/s41569-018-0074-0

Coppotelli G; Ross J; Ling A; Kim K; Sinclair D, 2018, 'CPNE2: A NEW REGULATOR OF LYSOSOMAL-MITOCHONDRIAL FUNCTION INVOLVED IN AGING AND DISEASE.', Innovation in aging, vol. 2, pp. 387 - 388, http://dx.doi.org/10.1093/geroni/igy023.1445

Ross JM; Coppotelli G; Branca R; Lehtiö J; Sinclair D; Olson L, 2018, 'USING PROTEOMICS TO ELUCIDATE HOW VOLUNTARY EXERCISE COMBATS AGING PHENOTYPES IN MTDNA MUTATOR MICE.', Innovation in aging, vol. 2, pp. 334 - 334, http://dx.doi.org/10.1093/geroni/igy023.1223

Bonkowski M; Shawn D; Lu Y; Schultz M; Reyes J; Guarente L; Sinclair D, 2018, 'DIVERGENT REGULATION OF SIRT1 MEDIATES THE ENDOCRINE RESPONSE TO CALORIE RESTRICTION.', Innovation in aging, vol. 2, pp. 88 - 89, http://dx.doi.org/10.1093/geroni/igy023.337

Sinclair DA, 2018, 'UNDERSTANDING WHY WE GROW OLD AS WE GROW OLDER.', Innovation in aging, vol. 2, pp. 592 - 592, http://dx.doi.org/10.1093/geroni/igy023.2199

Ross JM; Coppotelli G; Amorim J; Hillstedt E; Potts E; Sinclair D, 2018, 'DISRUPTING THE EPIGENOME IN NOVEL NICE MICE TO STUDY AGE-RELATED COGNITIVE DECLINE.', Innovation in aging, vol. 2, pp. 626 - 626, http://dx.doi.org/10.1093/geroni/igy023.2333

Schultz MB; Bochaton T; Bonkowski M; Li J; Lokitiyakul D; Colville A; Gomes A; Sinclair D, 2018, 'NAD+ DEPLETION AS A CAUSE OF INFLAMMAGING.', Innovation in aging, vol. 2, pp. 746 - 746, http://dx.doi.org/10.1093/geroni/igy023.2751

Bonkowski MS; Das A; Schultz MB; Lu Y; Mitchell J; Wu L; Guarente L; Sinclair DA, 2018, 'IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING.', Innovation in aging, vol. 2, pp. 799 - 799, http://dx.doi.org/10.1093/geroni/igy023.2966

Bonkowski MS; Das A; Schultz M; Lu Y; Mitchell J; Wu L; Guarente L; Sinclair D, 2018, 'IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING.', Innovation in aging, vol. 2, pp. 388 - 388, http://dx.doi.org/10.1093/geroni/igy023.1446

Pichardo I; Budnik B; Vera D; Kane A; Cooney M; Chwalek K; Rajman L; Sinclair D, 2018, 'DISCOVERY OF A NOVEL CIRCULATING PEPTIDOME IN HUMAN SERUM THAT CORRELATES WITH AGING.', Innovation in aging, vol. 2, pp. 880 - 880, http://dx.doi.org/10.1093/geroni/igy031.3285

Amorim J; Tackur S; Bonkowski M; Rolo A; Palmeira C; Sinclair D, 2018, 'A NEW MOUSE MODEL TO UNRAVEL THE MECHANISM OF SIRT1 ACTIVATION.', Innovation in aging, vol. 2, pp. 878 - 878, http://dx.doi.org/10.1093/geroni/igy031.3277

Cooney M; Pichardo I; Tian X; Choi J; Rajman L; Sinclair D, 2018, 'UNCOVERING THE CONNECTION BETWEEN GENOMIC AND EPIGENOMIC STABILITY DURING AGING WITH EXOGENOUS DNA REPAIR PROTEINS.', Innovation in aging, vol. 2, pp. 889 - 889, http://dx.doi.org/10.1093/geroni/igy031.3315

Yang J; Griffin P; Salfati E; Vera D; Hayano M; Berger S; Pfenning A; Sinclair D, 2018, 'EVIDENCE THAT EPIGENETIC ALTERATIONS DRIVE MAMMALIAN AGING.', Innovation in aging, vol. 2, pp. 881 - 881, http://dx.doi.org/10.1093/geroni/igy031.3288

Griffin P; Yang J; Rajman L; Sinclair D, 2018, 'INVESTIGATING THE DNA DAMAGE RESPONSE AS A DRIVER OF EPIGENETIC CHANGE DURING AGING.', Innovation in aging, vol. 2, pp. 883 - 883, http://dx.doi.org/10.1093/geroni/igy031.3296

Lu Y; Yu D; Bonkowski M; Schultz M; Tian X; Yang J; He Z; Sinclair D, 2018, 'IN VIVO CELLULAR REPROGRAMMING FOR TISSUE REGENERATION AND AGE REVERSAL.', Innovation in aging, vol. 2, pp. 883 - 883, http://dx.doi.org/10.1093/geroni/igy031.3294

Westerman K; Reaver A; Roy C; Ploch M; Sharoni E; Nogal B; Sinclair DA; Katz DL; Blumberg JB; Blander G, 2018, 'Erratum to: Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects (Scientific Reports, (2018), 8, 1, (14685), 10.1038/s41598-018-33008-7)', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-35249-y

Wahl D; Solon-Biet SM; Wang QP; Wali JA; Pulpitel T; Clark X; Raubenheimer D; Senior AM; Sinclair DA; Cooney GJ, 2018, 'Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice', Cell Reports, vol. 25, pp. 2234 - 2243.e6, http://dx.doi.org/10.1016/j.celrep.2018.10.070

Kane AE; Sinclair DA, 2018, 'Sirtuins and NAD⁺ in the development and treatment of metabolic and cardiovascular diseases', Circulation Research, vol. 123, pp. 868 - 885, http://dx.doi.org/10.1161/CIRCRESAHA.118.312498

Westerman K; Reaver A; Roy C; Ploch M; Sharoni E; Nogal B; Sinclair DA; Katz DL; Blumberg JB; Blander G, 2018, 'Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-33008-7

Latorre-Muro P; Baeza J; Armstrong EA; Hurtado-Guerrero R; Corzana F; Wu LE; Sinclair DA; López-Buesa P; Carrodeguas JA; Denu JM, 2018, 'Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions', Molecular Cell, vol. 71, pp. 718 - 732.e9, http://dx.doi.org/10.1016/j.molcel.2018.07.031

Kane AE; Sinclair DA; Mitchell JR; Mitchell SJ, 2018, 'Sex differences in the response to dietary restriction in rodents', Current Opinion in Physiology, vol. 6, pp. 28 - 34, http://dx.doi.org/10.1016/j.cophys.2018.03.008

Vatner DE; Zhang J; Oydanich M; Guers J; Katsyuba E; Yan L; Sinclair D; Auwerx J; Vatner SF, 2018, 'Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14', Aging Cell, vol. 17, http://dx.doi.org/10.1111/acel.12751

Dai H; Sinclair DA; Ellis JL; Steegborn C, 2018, 'Sirtuin activators and inhibitors: Promises, achievements, and challenges', Pharmacology and Therapeutics, vol. 188, pp. 140 - 154, http://dx.doi.org/10.1016/j.pharmthera.2018.03.004

Longchamp A; Mirabella T; Arduini A; MacArthur MR; Das A; Treviño-Villarreal JH; Hine C; Ben-Sahra I; Knudsen NH; Brace LE, 2018, 'Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production', Cell, vol. 173, pp. 117 - 129.e14, http://dx.doi.org/10.1016/j.cell.2018.03.001

Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y, 2018, 'Impairment of an Endothelial NAD⁺-H2S Signaling Network Is a Reversible Cause of Vascular Aging', Cell, vol. 173, pp. 74 - 89.e20, http://dx.doi.org/10.1016/j.cell.2018.02.008

Mitchell SJ; Bernier M; Aon MA; Cortassa S; Kim EY; Fang EF; Palacios HH; Ali A; Navas-Enamorado I; Di Francesco A, 2018, 'Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice', Cell Metabolism, vol. 27, pp. 667 - 676.e4, http://dx.doi.org/10.1016/j.cmet.2018.02.001

Rajman L; Chwalek K; Sinclair DA, 2018, 'Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence', Cell Metabolism, vol. 27, pp. 529 - 547, http://dx.doi.org/10.1016/j.cmet.2018.02.011

Costford SR; Brouwers B; Hopf ME; Sparks LM; Dispagna M; Gomes AP; Cornnell HH; Petucci C; Phelan P; Xie H, 2018, 'Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance', Molecular Metabolism, vol. 7, pp. 1 - 11, http://dx.doi.org/10.1016/j.molmet.2017.10.012

Bustamante S; Jayasena T; Richani D; Gilchrist RB; Wu LE; Sinclair DA; Sachdev PS; Braidy N, 2018, 'Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach', Metabolomics, vol. 14, http://dx.doi.org/10.1007/s11306-017-1310-z

Barzilai NR; Gorbunova V; Sinclair D, 2017, 'LONG-LIVED ANIMAL MODELS AND HEALTH-SPAN EXTENSION IN STUDIES OF AGING.', Innovation in aging, vol. 1, pp. 10 - 10, http://dx.doi.org/10.1093/geroni/igx004.033

Sinclair D, 2017, 'NAD PRECURSORS AS INTERVENTIONS FOR AGE-RELATED DISEASES AND EXTENDING HUMAN HEALTHSPAN.', Innovation in aging, vol. 1, pp. 11 - 11, http://dx.doi.org/10.1093/geroni/igx004.037

Ferrer CM; Lu TY; Bacigalupa ZA; Katsetos CD; Sinclair DA; Reginato MJ, 2017, 'O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway', Oncogene, vol. 36, pp. 559 - 569, http://dx.doi.org/10.1038/onc.2016.228

Cronise RJ; Sinclair DA; Bremer AA, 2017, 'Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease', Metabolic Syndrome and Related Disorders, vol. 15, pp. 6 - 17, http://dx.doi.org/10.1089/met.2016.0108

Pollack RM; Barzilai N; Anghel V; Kulkarni AS; Golden A; O'Broin P; Sinclair DA; Bonkowski MS; Coleville AJ; Powell D, 2017, 'Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 72, pp. 1703 - 1709, http://dx.doi.org/10.1093/gerona/glx041

Uddin GM; Youngson NA; Doyle BM; Sinclair DA; Morris MJ, 2017, 'Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: Comparison with exercise', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-14866-z

Li J; Bonkowski MS; Moniot S; Zhang D; Hubbard BP; Ling AJY; Rajman LA; Qin B; Lou Z; Gorbunova V, 2017, 'A conserved NAD⁺ binding pocket that regulates protein-protein interactions during aging', Science, vol. 355, pp. 1312 - 1317, http://dx.doi.org/10.1126/science.aad8242

Cronise RJ; Sinclair DA; Bremer AA, 2017, 'Response to: "if the Metabolic Winter Is Coming, When Will It Be Summer?" (Metab Syndr Relat Disord 2017;15:3)', Metabolic Syndrome and Related Disorders, vol. 15, pp. 4 - 5, http://dx.doi.org/10.1089/met.2017.0004

Prola A; Da Silva JP; Guilbert A; Lecru L; Piquereau J; Ribeiro M; Mateo P; Gressette M; Fortin D; Boursier C, 2017, 'SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation', Cell Death and Differentiation, vol. 24, pp. 343 - 356, http://dx.doi.org/10.1038/cdd.2016.138

Schultz MB; Sinclair DA, 2016, 'When stem cells grow old: Phenotypes and mechanisms of stem cell aging', Development (Cambridge), vol. 143, pp. 3 - 14, http://dx.doi.org/10.1242/dev.130633

Anderson EN; Corkins ME; Li JC; Singh K; Parsons S; Tucey TM; Sorkaç A; Huang H; Dimitriadi M; Sinclair DA, 2016, 'C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins', Mechanisms of Ageing and Development, vol. 154, pp. 30 - 42, http://dx.doi.org/10.1016/j.mad.2016.01.004

Mitchell SJ; Madrigal-Matute J; Scheibye-Knudsen M; Fang E; Aon M; González-Reyes JA; Cortassa S; Kaushik S; Gonzalez-Freire M; Patel B, 2016, 'Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice', Cell Metabolism, vol. 23, pp. 1093 - 1112, http://dx.doi.org/10.1016/j.cmet.2016.05.027

Van Meter M; Simon M; Tombline G; May A; Morello TD; Hubbard BP; Bredbenner K; Park R; Sinclair DA; Bohr VA, 2016, 'JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks', Cell Reports, vol. 16, pp. 2641 - 2650, http://dx.doi.org/10.1016/j.celrep.2016.08.006

Abdesselem H; Madani A; Hani A; Al-Noubi M; Goswami N; Ben Hamidane H; Billing AM; Pasquier J; Bonkowski MS; Halabi N, 2016, 'SIRT1 limits adipocyte hyperplasia through c-Myc inhibition', Journal of Biological Chemistry, vol. 291, pp. 2119 - 2135, http://dx.doi.org/10.1074/jbc.M115.675645

Bonkowski MS; Sinclair DA, 2016, 'Slowing ageing by design: The rise of NAD⁺ and sirtuin-activating compounds', Nature Reviews Molecular Cell Biology, vol. 17, pp. 679 - 690, http://dx.doi.org/10.1038/nrm.2016.93

Fang EF; Kassahun H; Croteau DL; Scheibye-Knudsen M; Marosi K; Lu H; Shamanna RA; Kalyanasundaram S; Bollineni RC; Wilson MA, 2016, 'NAD⁺ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair', Cell Metabolism, vol. 24, pp. 566 - 581, http://dx.doi.org/10.1016/j.cmet.2016.09.004

Uddin GM; Youngson NA; Sinclair DA; Morris MJ, 2016, 'Head to head comparison of short-term treatment with the NAD⁺ precursor nicotinamide mononucleotide (NMN) and 6 weeks of exercise in obese female mice', Frontiers in Pharmacology, vol. 7, http://dx.doi.org/10.3389/fphar.2016.00258

Mohamad M; Mitchell SJ; Wu LE; White MY; Cordwell SJ; Mach J; Solon-Biet SM; Boyer D; Nines D; Das A, 2016, 'Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance', Aging Cell, vol. 15, pp. 706 - 715, http://dx.doi.org/10.1111/acel.12481

Schultz MB; Sinclair DA, 2016, 'Why NAD⁺ Declines during Aging: It's Destroyed', Cell Metabolism, vol. 23, pp. 965 - 966, http://dx.doi.org/10.1016/j.cmet.2016.05.022

Wu LE; Sinclair DA, 2016, 'Restoring stem cells-all you need is NAD⁺', Cell Research, vol. 26, pp. 971 - 972, http://dx.doi.org/10.1038/cr.2016.80

Cagnone GLM; Tsai TS; Makanji Y; Matthews P; Gould J; Bonkowski MS; Elgass KD; Wong ASA; Wu LE; McKenzie M, 2016, 'Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep23229

Shannon Weickert C; Webster MJ; Boerrigter D; Sinclair D, 2016, 'FKBP5 Messenger RNA Increases After Adolescence in Human Dorsolateral Prefrontal Cortex', Biological Psychiatry, vol. 80, pp. e29 - e31, http://dx.doi.org/10.1016/j.biopsych.2015.11.005

Gomes AP; Sinclair DA, 2015, 'Measuring PGC-1α and its acetylation status in mouse primary myotubes', Methods in Molecular Biology, vol. 1241, pp. 49 - 57, http://dx.doi.org/10.1007/978-1-4939-1875-1_5

Rumpf T; Schiedel M; Karaman B; Roessler C; North BJ; Lehotzky A; Oláh J; Ladwein KI; Schmidtkunz K; Gajer M, 2015, 'Selective Sirt2 inhibition by ligand-induced rearrangement of the active site', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms7263

Winnik S; Auwerx J; Sinclair DA; Matter CM, 2015, 'Protective effects of sirtuins in cardiovascular diseases: From bench to bedside', European Heart Journal, vol. 36, pp. 3404 - 3412, http://dx.doi.org/10.1093/eurheartj/ehv290

Miranda MX; Van Tits LJ; Lohmann C; Arsiwala T; Winnik S; Tailleux A; Stein S; Gomes AP; Suri V; Ellis JL, 2015, 'The Sirt1 activator SRT3025 provides atheroprotection in Apoe^-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression', European Heart Journal, vol. 36, pp. 51 - 59, http://dx.doi.org/10.1093/eurheartj/ehu095

Kim J; Sturgill D; Tran AD; Sinclair DA; Oberdoerffer P, 2015, 'Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability', Nucleic Acids Research, vol. 44, http://dx.doi.org/10.1093/nar/gkv1482

Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair D; Homer H, 2015, 'Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0130058

Garg N; Sinclair DA, 2015, 'Oogonial stem cells as a model to study age-associated infertility in women', Reproduction, Fertility and Development, vol. 27, pp. 969 - 974, http://dx.doi.org/10.1071/RD14461

Zhang QS; Deater M; Schubert K; Marquez-Loza L; Pelz C; Sinclair DA; Grompe M, 2015, 'The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice', Stem Cell Research, vol. 15, pp. 130 - 140, http://dx.doi.org/10.1016/j.scr.2015.05.007

Longo VD; Antebi A; Bartke A; Barzilai N; Brown-Borg HM; Caruso C; Curiel TJ; De Cabo R; Franceschi C; Gems D, 2015, 'Interventions to slow aging in humans: Are we ready?', Aging Cell, vol. 14, pp. 497 - 510, http://dx.doi.org/10.1111/acel.12338

Franco SS; De Falco L; Ghaffari S; Brugnara C; Sinclair DA; Matte A; Iolascon A; Mohandas N; Bertoldi M; An X, 2014, 'Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice', Haematologica, vol. 99, pp. 267 - 275, http://dx.doi.org/10.3324/haematol.2013.090076

Escande C; Nin V; Price NL; Capellini V; Gomes AP; Barbosa MT; O'Neil L; White TA; Sinclair DA; Chini EN, 2014, 'Flavonoid apigenin is an inhibitor of the NAD⁺ase CD38: Implications for cellular NAD⁺ metabolism, protein acetylation, and treatment of metabolic syndrome (Diabetes (2013) 62 (1', Diabetes, vol. 63, pp. 1428, http://dx.doi.org/10.2337/db14-er04

Cucurachi M; Busconi M; Fogher C; Hubbard B; Sinclair DA; Kovacs LG; Oláh R; Winterhagen P; Perl A; Bavaresco L, 2014, 'Preliminary observations on the role of Sirtuin genes in grapevine (Vitis vinifera L.) Physiology', Acta Horticulturae, vol. 1046, pp. 363 - 370

Sinclair D, 2014, 'Turning back time', Chemistry and Industry (London), vol. 78, pp. 32 - 35, http://dx.doi.org/10.1002/cind.7810_10.x

Mercken EM; Mitchell SJ; Martin-Montalvo A; Minor RK; Almeida M; Gomes AP; Scheibye-Knudsen M; Palacios HH; Licata JJ; Zhang Y, 2014, 'SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass', Aging Cell, vol. 13, pp. 787 - 796, http://dx.doi.org/10.1111/acel.12220

Fillman SG; Sinclair D; Fung SJ; Webster MJ; Shannon Weickert C, 2014, 'Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder', Translational Psychiatry, vol. 4, http://dx.doi.org/10.1038/tp.2014.8

Cronise RJ; Sinclair DA; Bremer AA, 2014, 'The "metabolic winter" Hypothesis: A cause of the current epidemics of obesity and cardiometabolic disease', Metabolic Syndrome and Related Disorders, vol. 12, pp. 355 - 361, http://dx.doi.org/10.1089/met.2014.0027

Moroz N; Carmona JJ; Anderson E; Hart AC; Sinclair DA; Blackwell TK, 2014, 'Dietary restriction involves NAD⁺-dependent mechanisms and a shift toward oxidative metabolism', Aging Cell, vol. 13, pp. 1075 - 1085, http://dx.doi.org/10.1111/acel.12273

Rimmelé P; Bigarella CL; Liang R; Izac B; Dieguez-Gonzalez R; Barbet G; Donovan M; Brugnara C; Blander JM; Sinclair DA, 2014, 'Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells', Stem Cell Reports, vol. 3, pp. 44 - 59, http://dx.doi.org/10.1016/j.stemcr.2014.04.015

North BJ; Rosenberg MA; Jeganathan KB; Hafner AV; Michan S; Dai J; Baker DJ; Cen Y; Wu LE; Sauve AA, 2014, 'SIRT2 induces the checkpoint kinase BubR1 to increase lifespan', EMBO Journal, vol. 33, pp. 1438 - 1453, http://dx.doi.org/10.15252/embj.201386907

Mitchell SJ; Martin-Montalvo A; Mercken EM; Palacios HH; Ward TM; Abulwerdi G; Minor RK; Vlasuk GP; Ellis JL; Sinclair DA, 2014, 'The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet', Cell Reports, vol. 6, pp. 836 - 843, http://dx.doi.org/10.1016/j.celrep.2014.01.031

Wu LE; Sinclair DA, 2014, 'SIRT2 controls the pentose phosphate switch', EMBO Journal, vol. 33, pp. 1287 - 1288, http://dx.doi.org/10.15252/embj.201488713

Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG, 2014, 'The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice', Cell Metabolism, vol. 19, pp. 418 - 430, http://dx.doi.org/10.1016/j.cmet.2014.02.009

Michan S; Juan AM; Hurst CG; Cui Z; Evans LP; Hatton CJ; Pei DT; Ju M; Sinclair DA; Smith LEH, 2014, 'Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0085031

Hubbard BP; Sinclair DA, 2014, 'Small molecule SIRT1 activators for the treatment of aging and age-related diseases', Trends in Pharmacological Sciences, vol. 35, pp. 146 - 154, http://dx.doi.org/10.1016/j.tips.2013.12.004

Yoon JC; Ling AJY; Isik M; Donna Lee DY; Steinbaugh MJ; Sack LM; Boduch AN; Blackwell TK; Sinclair DA; Elledge SJ, 2014, 'GLTSCR2/PICT1 links mitochondrial stress and Myc signaling', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, pp. 3781 - 3786, http://dx.doi.org/10.1073/pnas.1400705111

Wu LE; Gomes AP; Sinclair DA, 2014, 'Geroncogenesis: Metabolic changes during aging as a driver of tumorigenesis', Cancer Cell, vol. 25, pp. 12 - 19, http://dx.doi.org/10.1016/j.ccr.2013.12.005

Sinclair DA; Guarente L, 2014, 'Small-molecule allosteric activators of sirtuins', Annual Review of Pharmacology and Toxicology, vol. 54, pp. 363 - 380, http://dx.doi.org/10.1146/annurev-pharmtox-010611-134657

Minor RK; Baur JA; Gomes AP; Ward TM; Csiszar A; Mercken EM; Abdelmohsen K; Shin YK; Canto C; Scheibye-Knudsen M, 2013, 'Erratum: SRT1720 improves survival and healthspan of obese mice (Scientific Reports (2011) 1 (70) DOI: 10.1038/srep00070)', Scientific Reports, vol. 3, http://dx.doi.org/10.1038/srep01131

Biason-Lauber A; Böni-Schnetzler M; Hubbard BP; Bouzakri K; Brunner A; Cavelti-Weder C; Keller C; Meyer-Böni M; Meier DT; Brorsson C, 2013, 'Identification of a SIRT1 mutation in a family with type 1 diabetes', Cell Metabolism, vol. 17, pp. 448 - 455, http://dx.doi.org/10.1016/j.cmet.2013.02.001

Lai L; Yan L; Gao S; Hu CL; Ge H; Davidow A; Park M; Bravo C; Iwatsubo K; Ishikawa Y, 2013, 'Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway', Circulation, vol. 127, pp. 1692 - 1701, http://dx.doi.org/10.1161/CIRCULATIONAHA.112.001212

Anderson RM; Bitterman KJ; Wood JG; Medvedik O; Cohen H; Lin SS; Manchester JK; Gordon JI; Sinclair DA, 2013, 'Erratum: Manipulation of a nuclear NAD⁺ salvage pathway delays aging without altering steady-state NAD⁺ levels (The Journal of Biological Chemistry (2002) 277 (18881-18890))', Journal of Biological Chemistry, vol. 288, pp. 24160, http://dx.doi.org/10.1074/jbc.A113.111773

Sinclair DA, 2013, 'Studying the replicative life span of yeast cells', Methods in Molecular Biology, vol. 1048, pp. 49 - 63, http://dx.doi.org/10.1007/978-1-62703-556-9_5

Strong R; Miller RA; Astle CM; Baur JA; De Cabo R; Fernandez E; Guo W; Javors M; Kirkland JL; Nelson JF, 2013, 'Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 68, pp. 6 - 16, http://dx.doi.org/10.1093/gerona/gls070

Han J; Hubbard BP; Lee J; Montagna C; Lee HW; Sinclair DA; Suh Y, 2013, 'Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene', Cell Cycle, vol. 12, pp. 263 - 270, http://dx.doi.org/10.4161/cc.23056

Escande C; Nin V; Price NL; Capellini V; Gomes AP; Barbosa MT; O'Neil L; White TA; Sinclair DA; Chini EN, 2013, 'Flavonoid apigenin is an inhibitor of the NAD⁺ase CD38: Implications for cellular NAD⁺ metabolism, protein acetylation, and treatment of metabolic syndrome', Diabetes, vol. 62, pp. 1084 - 1093, http://dx.doi.org/10.2337/db12-1139

Martin-Montalvo A; Mercken EM; Mitchell SJ; Palacios HH; Mote PL; Scheibye-Knudsen M; Gomes AP; Ward TM; Minor RK; Blouin MJ, 2013, 'Metformin improves healthspan and lifespan in mice', Nature Communications, vol. 4, http://dx.doi.org/10.1038/ncomms3192

Hubbard BP; Sinclair DA, 2013, 'Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay', Methods in Molecular Biology, vol. 1077, pp. 167 - 177, http://dx.doi.org/10.1007/978-1-62703-637-5_11

Stottmann RW; Donlin M; Hafner A; Bernard A; Sinclair DA; Beier DR, 2013, 'Amutation in tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse', Human Molecular Genetics, vol. 22, pp. 4053 - 4063, http://dx.doi.org/10.1093/hmg/ddt255

Schmeisser K; Mansfeld J; Kuhlow D; Weimer S; Priebe S; Heiland I; Birringer M; Groth M; Segref A; Kanfi Y, 2013, 'Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide', Nature Chemical Biology, vol. 9, pp. 693 - 700, http://dx.doi.org/10.1038/nchembio.1352

Gomes AP; Price NL; Ling AJY; Moslehi JJ; Montgomery MK; Rajman L; White JP; Teodoro JS; Wrann CD; Hubbard BP, 2013, 'Declining NAD⁺ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging', Cell, vol. 155, pp. 1624 - 1638, http://dx.doi.org/10.1016/j.cell.2013.11.037

Chen J; Michan S; Juan AM; Hurst CG; Hatton CJ; Pei DT; Joyal JS; Evans LP; Cui Z; Stahl A, 2013, 'Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy', Angiogenesis, vol. 16, pp. 985 - 992, http://dx.doi.org/10.1007/s10456-013-9374-5

Tilly JL; Sinclair DA, 2013, 'Germline energetics, aging, and female infertility', Cell Metabolism, vol. 17, pp. 838 - 850, http://dx.doi.org/10.1016/j.cmet.2013.05.007

Armour SM; Bennett EJ; Braun CR; Zhang XY; McMahon SB; Gygi SP; Harper JW; Sinclair DA, 2013, 'A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex', Molecular and Cellular Biology, vol. 33, pp. 1487 - 1502, http://dx.doi.org/10.1128/MCB.00971-12

Hubbard BP; Loh C; Gomes AP; Li J; Lu Q; Doyle TLG; Disch JS; Armour SM; Ellis JL; Vlasuk GP, 2013, 'Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation- independent mechanism', Cell Cycle, vol. 12, pp. 2233 - 2240, http://dx.doi.org/10.4161/cc.25268

Hubbard BP; Gomes AP; Dai H; Li J; Case AW; Considine T; Riera TV; Lee JE; Yen E S; Lamming DW, 2013, 'Evidence for a common mechanism of SIRT1 regulation by allosteric activators', Science, vol. 339, pp. 1216 - 1219, http://dx.doi.org/10.1126/science.1231097

Gomes AP; Duarte FV; Nunes P; Hubbard BP; Teodoro JS; Varela AT; Jones JG; Sinclair DA; Palmeira CM; Rolo AP, 2012, 'Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis', Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1822, pp. 185 - 195, http://dx.doi.org/10.1016/j.bbadis.2011.10.008

North BJ; Sinclair DA, 2012, 'The intersection between aging and cardiovascular disease', Circulation Research, vol. 110, pp. 1097 - 1108, http://dx.doi.org/10.1161/CIRCRESAHA.111.246876

Rascón B; Hubbard BP; Sinclair DA; Amdam GV, 2012, 'The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction', Aging, vol. 4, pp. 499 - 508, http://dx.doi.org/10.18632/aging.100474

Nogueiras R; Habegger KM; Chaudhary N; Finan B; Banks AS; Dietrich MO; Horvath TL; Sinclair DA; Pfluger PT; Tschöp MH, 2012, 'Sirtuin 1 and sirtuin 3: Physiological modulators of metabolism', Physiological Reviews, vol. 92, pp. 1479 - 1514, http://dx.doi.org/10.1152/physrev.00022.2011

Nakamura K; Kosugi I; Lee DY; Hafner A; Sinclair DA; Ryo A; Lu KP, 2012, 'Prolyl isomerase pin1 regulates neuronal differentiation via β-catenin', Molecular and Cellular Biology, vol. 32, pp. 2966 - 2978, http://dx.doi.org/10.1128/MCB.05688-11

Sinclair D; Verdin E, 2012, 'The Longevity of Sirtuins', Cell Reports, vol. 2, pp. 1473 - 1474, http://dx.doi.org/10.1016/j.celrep.2012.12.004

Klionsky DJ; Abdalla FC; Abeliovich H; Abraham RT; Acevedo-Arozena A; Adeli K; Agholme L; Agnello M; Agostinis P; Aguirre-Ghiso JA, 2012, 'Guidelines for the use and interpretation of assays for monitoring autophagy', Autophagy, vol. 8, pp. 445 - 544, http://dx.doi.org/10.4161/auto.19496

Price NL; Gomes AP; Ling AJY; Duarte FV; Martin-Montalvo A; North BJ; Agarwal B; Ye L; Ramadori G; Teodoro JS, 2012, 'SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function', Cell Metabolism, vol. 15, pp. 675 - 690, http://dx.doi.org/10.1016/j.cmet.2012.04.003

Hua J; Guerin KI; Chen J; Michán S; Stahl A; Krah NM; Seaward MR; Dennison RJ; Juan AM; Hatton CJ, 2011, 'Resveratrol inhibits pathologic retinal neovascularization in Vldlr^-/- Mice', Investigative Ophthalmology and Visual Science, vol. 52, pp. 2809 - 2816, http://dx.doi.org/10.1167/iovs.10-6496

Miller RA; Harrison DE; Astle CM; Baur JA; Boyd AR; De Cabo R; Fernandez E; Flurkey K; Javors MA; Nelson JF, 2011, 'Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 66 A, pp. 191 - 201, http://dx.doi.org/10.1093/gerona/glq178

Bernier M; Paul RK; Martin-Montalvo A; Scheibye-Knudsen M; Song S; He HJ; Armour SM; Hubbard BP; Bohr VA; Wang L, 2011, 'Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein', Journal of Biological Chemistry, vol. 286, pp. 19270 - 19279, http://dx.doi.org/10.1074/jbc.M110.200311

Ramadori G; Fujikawa T; Anderson J; Berglund ED; Frazao R; Michán S; Vianna CR; Sinclair DA; Elias CF; Coppari R, 2011, 'SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance', Cell Metabolism, vol. 14, pp. 301 - 312, http://dx.doi.org/10.1016/j.cmet.2011.06.014

Vendrell A; Martánez-Pastor M; González-Novo A; Pascual-Ahuir A; Sinclair DA; Proft M; Posas F, 2011, 'Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase', EMBO Reports, vol. 12, pp. 1062 - 1068, http://dx.doi.org/10.1038/embor.2011.154

Beirowski B; Gustin J; Armour SM; Yamamoto H; Viader A; North BJ; Michán S; Baloh RH; Golden JP; Schmidt RE, 2011, 'Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling', Proceedings of the National Academy of Sciences of the United States of America, vol. 108, http://dx.doi.org/10.1073/pnas.1104969108

Minor RK; Baur JA; Gomes AP; Ward TM; Csiszar A; Mercken EM; Abdelmohsen K; Shin YK; Canto C; Scheibye-Knudsen M, 2011, 'SRT1720 improves survival and healthspan of obese mice', Scientific Reports, vol. 1, http://dx.doi.org/10.1038/srep00070

Haigis MC; Sinclair DA, 2010, 'Mammalian sirtuins: Biological insights and disease relevance', Annual Review of Pathology: Mechanisms of Disease, vol. 5, pp. 253 - 295, http://dx.doi.org/10.1146/annurev.pathol.4.110807.092250

Blagosklonny MV; Campisi J; Sinclair DA; Bartke A; Blasco MA; Bonner WM; Bohr VA; Brosh RM; Brunet A; DePinho RA, 2010, 'Impact papers on aging in 2009', Aging, vol. 2, pp. 111 - 121, http://dx.doi.org/10.18632/aging.100132

Rutanen J; Yaluri N; Modi S; Pihlajamäki J; Vänttinen M; Itkonen P; Kainulainen S; Yamamoto H; Lagouge M; Sinclair DA, 2010, 'SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity', Diabetes, vol. 59, pp. 829 - 835, http://dx.doi.org/10.2337/db09-1191

Le Couteur DG; Sinclair DA, 2010, 'A blueprint for developing therapeutic approaches that increase healthspan and delay death', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 65 A, pp. 693 - 694, http://dx.doi.org/10.1093/gerona/glq048

Michán S; Li Y; Chou MMH; Parrella E; Ge H; Long JM; Allard JS; Lewis K; Miller M; Xu W, 2010, 'SIRT1 is essential for normal cognitive function and synaptic plasticity', Journal of Neuroscience, vol. 30, pp. 9695 - 9707, http://dx.doi.org/10.1523/JNEUROSCI.0027-10.2010

Baur JA; Chen D; Chini EN; Chua K; Cohen HY; De Cabo R; Deng C; Dimmeler S; Gius D; Guarente LP, 2010, 'Dietary restriction: Standing up for sirtuins', Science, vol. 329, pp. 1012 - 1013, http://dx.doi.org/10.1126/science.329.5995.1012

Yang Y; Hubbard BP; Sinclair DA; Tong Q, 2010, 'Characterization of murine SIRT3 transcript variants and corresponding protein products', Journal of Cellular Biochemistry, vol. 111, pp. 1051 - 1058, http://dx.doi.org/10.1002/jcb.22795

Hafner AV; Dai J; Gomes AP; Xiao CY; Palmeira KCM; Rosenzweig A; Sinclair DA, 2010, 'Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy', Aging, vol. 2, pp. 914 - 923, http://dx.doi.org/10.18632/aging.100252

Blagosklonny MV; Campisi J; Sinclair DA, 2009, 'Aging: past, present and future.', Aging, vol. 1, pp. 1 - 5

Jin L; Galonek H; Israelian K; Choy W; Morrison M; Xia Y; Wang X; Xu Y; Yang Y; Smith JJ, 2009, 'Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3', Protein Science, vol. 18, pp. 514 - 525, http://dx.doi.org/10.1002/pro.50

Jiménez-Hidalgo M; Santos-Ocaña C; Padilla S; Villalba JM; López-Lluch G; Martín-Montalvo A; Minor RK; Sinclair DA; De Cabo R; Navas P, 2009, 'NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast', Aging Cell, vol. 8, pp. 140 - 151, http://dx.doi.org/10.1111/j.1474-9726.2009.00461.x

Armour SM; Baur JA; Hsieh SN; Land-Bracha A; Thomas SM; Sinclair DA, 2009, 'Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy.', Aging, vol. 1, pp. 515 - 528

Sinclair DA; Oberdoerffer P, 2009, 'The ageing epigenome: Damaged beyond repair?', Ageing Research Reviews, vol. 8, pp. 189 - 198, http://dx.doi.org/10.1016/j.arr.2009.04.004

Baur JA; Sinclair DA, 2008, 'What is xenohormesis?', American Journal of Pharmacology and Toxicology, vol. 3, pp. 149 - 156

Sinclair DA, 2008, 'David A. Sinclair, Ph.D is interviewed by Vicki Glaser.', Rejuvenation research, vol. 11, pp. 265 - 268, http://dx.doi.org/10.1089/rej.2008.0694

Howitz KT; Sinclair DA, 2008, 'Xenohormesis: Sensing the Chemical Cues of Other Species', Cell, vol. 133, pp. 387 - 391, http://dx.doi.org/10.1016/j.cell.2008.04.019

Firestein R; Blander G; Michan S; Oberdoerffer P; Ogino S; Campbell J; Bhimavarapu A; Luikenhuis S; de Cabo R; Fuchs C, 2008, 'The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth', PLoS ONE, vol. 3, http://dx.doi.org/10.1371/journal.pone.0002020

Pearson KJ; Baur JA; Lewis KN; Peshkin L; Price NL; Labinskyy N; Swindell WR; Kamara D; Minor RK; Perez E, 2008, 'Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span', Cell Metabolism, vol. 8, pp. 157 - 168, http://dx.doi.org/10.1016/j.cmet.2008.06.011

Oberdoerffer P; Michan S; McVay M; Mostoslavsky R; Vann J; Park SK; Hartlerode A; Stegmuller J; Hafner A; Loerch P, 2008, 'SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging', Cell, vol. 135, pp. 907 - 918, http://dx.doi.org/10.1016/j.cell.2008.10.025

Calabrese EJ; Bachmann KA; Bailer AJ; Bolger PM; Borak J; Cai L; Cedergreen N; Cherian MG; Chiueh CC; Clarkson TW, 2007, 'Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework', Toxicology and Applied Pharmacology, vol. 222, pp. 122 - 128, http://dx.doi.org/10.1016/j.taap.2007.02.015

Medvedik O; Sinclair DA, 2007, 'Caloric restriction and life span determination of yeast cells', Methods in Molecular Biology, vol. 371, pp. 97 - 109, http://dx.doi.org/10.1385/1-59745-361-7:97

Li Y; Yokota T; Gama V; Yoshida T; Gomez JA; Ishikawa K; Sasaguri H; Cohen HY; Sinclair DA; Mizusawa H, 2007, 'Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation', Cell Death and Differentiation, vol. 14, pp. 2058 - 2067, http://dx.doi.org/10.1038/sj.cdd.4402219

Yang H; Baur JA; Chen A; Miller C; Adams JK; Kisielewski A; Howitz KT; Zipkin RE; Sinclair DA, 2007, 'Erratum: (Aging Cell (2007) vol. 7 10.1111/j.1474-9726.2007.00317.x)', Aging Cell, vol. 6, pp. 593, http://dx.doi.org/10.1111/j.1474-9726.2007.00317.x

North BJ; Sinclair DA, 2007, 'Sirtuins: a conserved key unlocking AceCS activity', Trends in Biochemical Sciences, vol. 32, pp. 1 - 4, http://dx.doi.org/10.1016/j.tibs.2006.11.002

Yang H; Baur JA; Chen A; Miller C; Sinclair DA, 2007, 'Design and synthesis of compounds that extend yeast replicative lifespan', Aging Cell, vol. 6, pp. 35 - 43, http://dx.doi.org/10.1111/j.1474-9726.2006.00259.x

Michan S; Sinclair D, 2007, 'Sirtuins in mammals: Insights into their biological function', Biochemical Journal, vol. 404, pp. 1 - 13, http://dx.doi.org/10.1042/BJ20070140

Kim D; Nguyen MD; Dobbin MM; Fischer A; Sananbenesi F; Rodgers JT; Delalle I; Baur JA; Sui G; Armour SM, 2007, 'SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis', EMBO Journal, vol. 26, pp. 3169 - 3179, http://dx.doi.org/10.1038/sj.emboj.7601758

Oberdoerffer P; Sinclair DA, 2007, 'The role of nuclear architecture in genomic instability and ageing', Nature Reviews Molecular Cell Biology, vol. 8, pp. 692 - 702, http://dx.doi.org/10.1038/nrm2238

Yang H; Yang T; Baur JA; Perez E; Matsui T; Carmona JJ; Lamming DW; Souza-Pinto NC; Bohr VA; Rosenzweig A, 2007, 'Nutrient-Sensitive Mitochondrial NAD⁺ Levels Dictate Cell Survival', Cell, vol. 130, pp. 1095 - 1107, http://dx.doi.org/10.1016/j.cell.2007.07.035

Medvedik O; Lamming DW; Kim KD; Sinclair DA, 2007, 'MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae', PLoS Biology, vol. 5, pp. 2330 - 2341, http://dx.doi.org/10.1371/journal.pbio.0050261

Barbosa MTP; Soares SM; Novak CM; Sinclair D; Levine JA; Aksoy P; Chini EN, 2007, 'The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity', FASEB Journal, vol. 21, pp. 3629 - 3639, http://dx.doi.org/10.1096/fj.07-8290com

Milne JC; Lambert PD; Schenk S; Carney DP; Smith JJ; Gagne DJ; Jin L; Boss O; Perni RB; Vu CB, 2007, 'Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes', Nature, vol. 450, pp. 712 - 716, http://dx.doi.org/10.1038/nature06261

Sinclair DA; Guarente L, 2006, 'Unlocking the secrets of longevity genes', Scientific American, vol. 294, pp. 48 - 57, http://dx.doi.org/10.1038/scientificamerican0306-48

Sinclair DA; Lin SJ; Guarente L, 2006, 'Life-span extension in yeast [2]', Science, vol. 312, pp. 195 - 196

Baur JA; Sinclair DA, 2006, 'Therapeutic potential of resveratrol: The in vivo evidence', Nature Reviews Drug Discovery, vol. 5, pp. 493 - 506, http://dx.doi.org/10.1038/nrd2060

Yang H; Lavu S; Sinclair DA, 2006, 'Nampt/PBEF/Visfatin: A regulator of mammalian health and longevity?', Experimental Gerontology, vol. 41, pp. 718 - 726, http://dx.doi.org/10.1016/j.exger.2006.06.003

Baur JA; Pearson KJ; Price NL; Jamieson HA; Lerin C; Kalra A; Prabhu VV; Allard JS; Lopez-Lluch G; Lewis K, 2006, 'Resveratrol improves health and survival of mice on a high-calorie diet', Nature, vol. 444, pp. 337 - 342, http://dx.doi.org/10.1038/nature05354

Yu MC; Lamming DW; Eskin JA; Sinclair DA; Silver PA, 2006, 'The role of protein arginine methylation in the formation of silent chromatin', Genes and Development, vol. 20, pp. 3249 - 3254, http://dx.doi.org/10.1101/gad.1495206

Sinclair D, 2005, 'Sirtuins for healthy neurons', Nature Genetics, vol. 37, pp. 339 - 340, http://dx.doi.org/10.1038/ng0405-339

Sinclair DA, 2005, 'Toward a unified theory of caloric restriction and longevity regulation', Mechanisms of Ageing and Development, vol. 126, pp. 987 - 1002, http://dx.doi.org/10.1016/j.mad.2005.03.019

Lamming DW; Latorre-Esteves M; Medvedik O; Wong SN; Tsang FA; Wang C; Lin SJ; Sinclair DA, 2005, 'Cell biology: HST2 mediates SIR2-independent life-span extension by calorie restriction', Science, vol. 309, pp. 1861 - 1864, http://dx.doi.org/10.1126/science.1113611

Mai A; Massa S; Lavu S; Pezzi R; Simeoni S; Ragno R; Mariotti FR; Chiani F; Camilloni G; Sinclair DA, 2005, 'Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors', Journal of Medicinal Chemistry, vol. 48, pp. 7789 - 7795, http://dx.doi.org/10.1021/jm050100l

Wood JG; Rogina B; Lavu S; Ilowitz K; Helfand SL; Tatar M; Sinclair D, 2004, 'Erratum: Sirtuin activators mimic caloric restriction and delay ageing in metazoans (Nature (2004) 430 (686-689))', Nature, vol. 430, pp. 107

Cohen HY; Lavu S; Bitterman KJ; Hekking B; Imahiyerobo TA; Miller C; Frye R; Ploegh H; Kessler BM; Sinclair DA, 2004, 'Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis', Molecular Cell, vol. 13, pp. 627 - 638, http://dx.doi.org/10.1016/S1097-2765(04)00094-2

Brunet A; Sweeney LB; Sturgill JF; Chua KF; Greer PL; Lin Y; Tran H; Ross SE; Mostoslavsy R; Cohen HY, 2004, 'Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase', Science, vol. 303, pp. 2011 - 2015, http://dx.doi.org/10.1126/science.1094637

Cohen HY; Miller C; Bitterman KJ; Wall NR; Hekking B; Kessler B; Howitz KT; Gorospe M; De Cabo R; Sinclair DA, 2004, 'Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase', Science, vol. 305, pp. 390 - 392, http://dx.doi.org/10.1126/science.1099196

Mizuno T; Kishimoto T; Shinzato T; Haw R; Chambers A; Wood J; Sinclair D; Uemura H, 2004, 'Role of the N-terminal region of Rap1p in the transcriptional activation of glycolytic genes in Saccharomyces cerevisiae', Yeast, vol. 21, pp. 851 - 866, http://dx.doi.org/10.1002/yea.1123

Lamming DW; Wood JG; Sinclair DA, 2004, 'Small molecules that regulate lifespan: Evidence for xenohormesis', Molecular Microbiology, vol. 53, pp. 1003 - 1009, http://dx.doi.org/10.1111/j.1365-2958.2004.04209.x

Wood JG; Regina B; Lavu S; Hewitz K; Helfand SL; Tatar M; Sinclair D, 2004, 'Sirtuin activators mimic caloric restriction and delay ageing in metazoans', Nature, vol. 430, pp. 686 - 689, http://dx.doi.org/10.1038/nature02789

Sinclair D, 2003, 'Is DNA cut out for a long life?', Science of aging knowledge environment : SAGE KE, vol. 2003

Anderson RM; Bitterman KJ; Wood JG; Medvedik O; Sinclair DA, 2003, 'Nicatinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae', Nature, vol. 423, pp. 181 - 185, http://dx.doi.org/10.1038/nature01578

Bitterman KJ; Medvedik O; Sinclair DA, 2003, 'Longevity regulation in Saccharomyces cerevisiae: Linking metabolism, genome stability, and heterochromatin', Microbiology and Molecular Biology Reviews, vol. 67, pp. 376 - 399, http://dx.doi.org/10.1128/MMBR.67.3.376-399.2003

Howitz KT; Bitterman KJ; Cohen HY; Lamming DW; Lavu S; Wood JG; Zipkin RE; Chung P; Kisielewski A; Zhang LL, 2003, 'Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan', Nature, vol. 425, pp. 191 - 196, http://dx.doi.org/10.1038/nature01960

Sinclair DA, 2003, 'An age of instability', Science, vol. 301, pp. 1859 - 1860, http://dx.doi.org/10.1126/science.1090465

Anderson RM; Latorre-Esteves M; Neves AR; Lavu S; Medvedik O; Taylor C; Howitz KT; Santos H; Sinclair DA, 2003, 'Yeast Life-Span Extension by Calorie Restriction Is Independent of NAD Fluctuation', Science, vol. 302, pp. 2124 - 2126, http://dx.doi.org/10.1126/science.1088697

Wood JG; Sinclair DA, 2002, 'TPE or not TPE? It's no longer a question', Trends in Pharmacological Sciences, vol. 23, pp. 1 - 4, http://dx.doi.org/10.1016/S0165-6147(00)01891-5

Sinclair DA, 2002, 'Paradigms and pitfalls of yeast longevity research', Mechanisms of Ageing and Development, vol. 123, pp. 857 - 867, http://dx.doi.org/10.1016/S0047-6374(02)00023-4

Anderson RM; Bitterman KJ; Wood JG; Medvedik O; Cohen H; Lin SS; Manchester JK; Gordon JI; Sinclair DA, 2002, 'Manipulation of a nuclear NAD⁺ salvage pathway delays aging without altering steady-state NAD⁺ levels', Journal of Biological Chemistry, vol. 277, pp. 18881 - 18890, http://dx.doi.org/10.1074/jbc.M111773200

Bitterman KJ; Anderson RM; Cohen HY; Latorre-Esteves M; Sinclair DA, 2002, 'Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1', Journal of Biological Chemistry, vol. 277, pp. 45099 - 45107, http://dx.doi.org/10.1074/jbc.M205670200

Cohen H; Sinclair DA, 2001, 'Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase', Proceedings of the National Academy of Sciences of the United States of America, vol. 98, pp. 3174 - 3179, http://dx.doi.org/10.1073/pnas.061579598

Ashrafi K; Sinclair D; Gordon JI; Guarente L, 1999, 'Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae', Proceedings of the National Academy of Sciences of the United States of America, vol. 96, pp. 9100 - 9105, http://dx.doi.org/10.1073/pnas.96.16.9100

Mills KD; Sinclair DA; Guarente L, 1999, 'MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks', Cell, vol. 97, pp. 609 - 620, http://dx.doi.org/10.1016/S0092-8674(00)80772-2

Johnson FB; Sinclair DA; Guarente L, 1999, 'Molecular biology of aging', Cell, vol. 96, pp. 291 - 302, http://dx.doi.org/10.1016/S0092-8674(00)80567-X

Sinclair DA, 1999, 'Yeast aging research: Recent advances and medical relevance', Cellular and Molecular Life Sciences, vol. 56, pp. 807 - 816, http://dx.doi.org/10.1007/s000180050027

Hong SP; Piper MD; Sinclair DA; Dawes IW, 1999, 'Control of expression of one-carbon metabolism genes of Saccharomyces cerevisiae is mediated by a tetrahydrofolate-responsive protein binding to a glycine regulatory region including a core 5'-CTTCTT-', Journal of Biological Chemistry, vol. 274, pp. 10523 - 10532, http://dx.doi.org/10.1074/jbc.274.15.10523

Sinclair DA; Mills K; Guarente L, 1998, 'Molecular mechanisms of yeast aging', Trends in Biochemical Sciences, vol. 23, pp. 131 - 134, http://dx.doi.org/10.1016/S0968-0004(98)01188-8

Sinclair DA; Mills K; Guarente L, 1997, 'Accelerated aging and nucleolar fragmentation in yeast SGS1 mutants', Science, vol. 277, pp. 1313 - 1316, http://dx.doi.org/10.1126/science.277.5330.1313

Kennedy BK; Gotta M; Sinclair DA; Mills K; McNabb DS; Murthy M; Pak SM; Laroche T; Gasser SM; Guarente L, 1997, 'Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae', Cell, vol. 89, pp. 381 - 391, http://dx.doi.org/10.1016/S0092-8674(00)80219-6

Sinclair DA; Guarente L, 1997, 'Extrachromosomal rDNA circles - A cause of aging in yeast', Cell, vol. 91, pp. 1033 - 1042, http://dx.doi.org/10.1016/S0092-8674(00)80493-6

McNeil JB; Zhang FR; Taylor BV; Sinclair DA; Pearlman RE; Bognar AL, 1997, 'Cloning, and molecular characterization of the GCV1 gene encoding the glycine cleavage T-protein from Saccharomyces cerevisiae', Gene, vol. 186, pp. 13 - 20, http://dx.doi.org/10.1016/S0378-1119(96)00670-1

Sinclair DA; Hong SP; Dawes IW, 1996, 'Specific induction by glycine of the gene for the P-subunit of glycine decarboxylase from Saccharomyces cerevisiae', Molecular Microbiology, vol. 19, pp. 611 - 623, http://dx.doi.org/10.1046/j.1365-2958.1996.419947.x

Sinclair DA; Dawes IW, 1995, 'Genetics of the synthesis of serine from glycine and the utilization of glycine as sole nitrogen source by Saccharomyces cerevisiae', Genetics, vol. 140, pp. 1213 - 1222

Sinclair DA; Kornfeld GD; Dawes IW, 1994, 'Yeast intragenic transcriptional control: Activation and repression sites within the coding region of the Saccharomyces cerevisiae LPD1 gene', Molecular and Cellular Biology, vol. 14, pp. 214 - 225, http://dx.doi.org/10.1128/MCB.14.1.214

Sinclair DA; Dawes IW; Dickinson JR, 1993, 'Purification and characterization of the branched chain α-ketoacid dehydrogenase complex from Saccharomyces cerevisiae', Biochemistry and Molecular Biology International, vol. 31, pp. 911 - 922

Patents

Sinclair D; Gomes A; Wu L, 2018, NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation, Patent No. 9877981, Patent Agent:, https://pdfpiw.uspto.gov/.piw?Docid=09877981&homeurl=http:%2F%2Fpatft.uspto.gov%2Fnetacgi%2Fnph-Parser%3FSect1%3DPTO1%2526Sect2%3DHITOFF%2526d%3DPALL%2526p%3D1%2526u%3D%25252Fnetahtml%25252FPTO%25252Fsrchnum.htm%2526r%3D1%2526f%3DG%2526l%3D50%2526s1%3D9877981.PN.%2526OS%3DPN%2F9877981%2526RS%3DPN%2F9877981&PageNum=&Rtype=&SectionNum=&idkey=NONE&Input=View+first+page

Working Papers

Bertoldo M; Listijono D; Ho W-HJ; Riepsamen A; Jin X; Selesniemi K; Goss D; Mahbub S; Campbell J; Habibalahi A, 2019, NAD+ repletion rescues female fertility during reproductive ageing, http://dx.doi.org/10.1101/721985

Metabolic Disease