
Visiting Professor David Sinclair
Contact Details
Phone: (+61) 2 9385 1621
Email: david.sinclair@unsw.edu.au
Supervision
- PHD
- Masters
- Honours
Tabs
Publications related to this Person
Books
Sinclair D; Mills K; Guarente L, 1998, Aging in Saccharomyces cerevisiae, http://dx.doi.org/10.1146/annurev.micro.52.1.533
Book Chapters
Schultz MB; Lu Y; Braidy N; Sinclair DA, 2018, 'Assays for NAD+-Dependent reactions and NAD+ metabolites', in Methods in Molecular Biology, pp. 77 - 90, http://dx.doi.org/10.1007/978-1-4939-8588-3_6
Dai H; Ellis JL; Sinclair DA; Hubbard BP, 2016, 'Synthesis and Assay of SIRT1-Activating Compounds', in Methods in Enzymology, pp. 213 - 244, http://dx.doi.org/10.1016/bs.mie.2016.01.012
Gomes AP; Sinclair DA, 2014, 'Measuring PGC-1α and its acetylation status in mouse primary myotubes', in Mitochondrial Regulation: Methods and Protocols, pp. 49 - 57, http://dx.doi.org/10.1007/978-1-4939-1875-1-5
Haigis MC; Sinclair DA, 2011, 'Sirtuins in aging and age-related diseases', in Handbook of the Biology of Aging, pp. 243 - 274, http://dx.doi.org/10.1016/B978-0-12-378638-8.00011-7
Le Couteur DG; Sinclair DA; Cogger VC; McMahon AC; Warren A; Everitt AV; Lebel M; De Cabo R, 2010, 'The aging liver and the effects of long term caloric restriction', in Calorie Restriction, Aging and Longevity, pp. 191 - 216, http://dx.doi.org/10.1007/978-90-481-8556-6_11
Sinclair DA; Howitz KT, 2005, 'Dietary Restriction, Hormesis, and Small Molecule Mimetics', in Handbook of the Biology of Aging, pp. 63 - 104, http://dx.doi.org/10.1016/B978-012088387-5/50006-6
Journal articles
Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y, 2019, 'Impairment of an Endothelial NAD+-H
Bonora M; Wieckowski MR; Sinclair DA; Kroemer G; Pinton P; Galluzzi L, 2019, 'Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles', Nature Reviews Cardiology, vol. 16, pp. 33 - 55, http://dx.doi.org/10.1038/s41569-018-0074-0
Wahl D; Solon-Biet SM; Wang QP; Wali JA; Pulpitel T; Clark X; Raubenheimer D; Senior AM; Sinclair DA; Cooney GJ, 2018, 'Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice', Cell Reports, vol. 25, pp. 2234 - 2243.e6, http://dx.doi.org/10.1016/j.celrep.2018.10.070
Kane AE; Sinclair DA, 2018, 'Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases', Circulation research, vol. 123, pp. 868 - 885, http://dx.doi.org/10.1161/CIRCRESAHA.118.312498
Latorre-Muro P; Baeza J; Armstrong EA; Hurtado-Guerrero R; Corzana F; Wu LE; Sinclair DA; López-Buesa P; Carrodeguas JA; Denu JM, 2018, 'Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions', Molecular Cell, vol. 71, pp. 718 - 732.e9, http://dx.doi.org/10.1016/j.molcel.2018.07.031
Kane AE; Sinclair DA; Mitchell JR; Mitchell SJ, 2018, 'Sex differences in the response to dietary restriction in rodents', Current Opinion in Physiology, vol. 6, pp. 28 - 34, http://dx.doi.org/10.1016/j.cophys.2018.03.008
Vatner DE; Zhang J; Oydanich M; Guers J; Katsyuba E; Yan L; Sinclair D; Auwerx J; Vatner SF, 2018, 'Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14', Aging Cell, vol. 17, http://dx.doi.org/10.1111/acel.12751
Dai H; Sinclair DA; Ellis JL; Steegborn C, 2018, 'Sirtuin activators and inhibitors: Promises, achievements, and challenges', Pharmacology and Therapeutics, vol. 188, pp. 140 - 154, http://dx.doi.org/10.1016/j.pharmthera.2018.03.004
Longchamp A; Mirabella T; Arduini A; MacArthur MR; Das A; Treviño-Villarreal JH; Hine C; Ben-Sahra I; Knudsen NH; Brace LE, 2018, 'Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H
Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y, 2018, 'Impairment of an Endothelial NAD+-H
Mitchell SJ; Bernier M; Aon MA; Cortassa S; Kim EY; Fang EF; Palacios HH; Ali A; Navas-Enamorado I; Di Francesco A, 2018, 'Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice', Cell Metabolism, vol. 27, pp. 667 - 676.e4, http://dx.doi.org/10.1016/j.cmet.2018.02.001
Rajman L; Chwalek K; Sinclair DA, 2018, 'Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence', Cell Metabolism, vol. 27, pp. 529 - 547, http://dx.doi.org/10.1016/j.cmet.2018.02.011
Costford SR; Brouwers B; Hopf ME; Sparks LM; Dispagna M; Gomes AP; Cornnell HH; Petucci C; Phelan P; Xie H, 2018, 'Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance', Molecular Metabolism, vol. 7, pp. 1 - 11, http://dx.doi.org/10.1016/j.molmet.2017.10.012
Bustamante S; Jayasena T; Richani D; Gilchrist RB; Wu LE; Sinclair DA; Sachdev PS; Braidy N, 2018, 'Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach', Metabolomics, vol. 14, http://dx.doi.org/10.1007/s11306-017-1310-z
Ferrer CM; Lu TY; Bacigalupa ZA; Katsetos CD; Sinclair DA; Reginato MJ, 2017, 'O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway', Oncogene, vol. 36, pp. 559 - 569, http://dx.doi.org/10.1038/onc.2016.228
Cronise RJ; Sinclair DA; Bremer AA, 2017, 'Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease', Metabolic Syndrome and Related Disorders, vol. 15, pp. 6 - 17, http://dx.doi.org/10.1089/met.2016.0108
Pollack RM; Barzilai N; Anghel V; Kulkarni AS; Golden A; O'Broin P; Sinclair DA; Bonkowski MS; Coleville AJ; Powell D, 2017, 'Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 72, pp. 1703 - 1709, http://dx.doi.org/10.1093/gerona/glx041
Uddin GM; Youngson NA; Doyle BM; Sinclair DA; Morris MJ, 2017, 'Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: Comparison with exercise', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-14866-z
Li J; Bonkowski MS; Moniot S; Zhang D; Hubbard BP; Ling AJY; Rajman LA; Qin B; Lou Z; Gorbunova V, 2017, 'A conserved NAD+binding pocket that regulates protein-protein interactions during aging', Science, vol. 355, pp. 1312 - 1317, http://dx.doi.org/10.1126/science.aad8242
Cronise RJ; Sinclair DA; Bremer AA, 2017, 'Response to: "if the Metabolic Winter Is Coming, When Will It Be Summer?" (Metab Syndr Relat Disord 2017;15:3)', Metabolic Syndrome and Related Disorders, vol. 15, pp. 4 - 5, http://dx.doi.org/10.1089/met.2017.0004
Prola A; Da Silva JP; Guilbert A; Lecru L; Piquereau J; Ribeiro M; Mateo P; Gressette M; Fortin D; Boursier C, 2017, 'SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation', Cell Death and Differentiation, vol. 24, pp. 343 - 356, http://dx.doi.org/10.1038/cdd.2016.138
Schultz MB; Sinclair DA, 2016, 'When stem cells grow old: Phenotypes and mechanisms of stem cell aging', Development (Cambridge), vol. 143, pp. 3 - 14, http://dx.doi.org/10.1242/dev.130633
Anderson EN; Corkins ME; Li JC; Singh K; Parsons S; Tucey TM; Sorkaç A; Huang H; Dimitriadi M; Sinclair DA, 2016, 'C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins', Mechanisms of Ageing and Development, vol. 154, pp. 30 - 42, http://dx.doi.org/10.1016/j.mad.2016.01.004
Mitchell SJ; Madrigal-Matute J; Scheibye-Knudsen M; Fang E; Aon M; González-Reyes JA; Cortassa S; Kaushik S; Gonzalez-Freire M; Patel B, 2016, 'Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice', Cell Metabolism, vol. 23, pp. 1093 - 1112, http://dx.doi.org/10.1016/j.cmet.2016.05.027
Van Meter M; Simon M; Tombline G; May A; Morello TD; Hubbard BP; Bredbenner K; Park R; Sinclair DA; Bohr VA, 2016, 'JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks', Cell Reports, vol. 16, pp. 2641 - 2650, http://dx.doi.org/10.1016/j.celrep.2016.08.006
Abdesselem H; Madani A; Hani A; Al-Noubi M; Goswami N; Ben Hamidane H; Billing AM; Pasquier J; Bonkowski MS; Halabi N, 2016, 'SIRT1 limits adipocyte hyperplasia through c-Myc inhibition', Journal of Biological Chemistry, vol. 291, pp. 2119 - 2135, http://dx.doi.org/10.1074/jbc.M115.675645
Bonkowski MS; Sinclair DA, 2016, 'Slowing ageing by design: The rise of NAD+and sirtuin-activating compounds', Nature Reviews Molecular Cell Biology, vol. 17, pp. 679 - 690, http://dx.doi.org/10.1038/nrm.2016.93
Fang EF; Kassahun H; Croteau DL; Scheibye-Knudsen M; Marosi K; Lu H; Shamanna RA; Kalyanasundaram S; Bollineni RC; Wilson MA, 2016, 'NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair', Cell Metabolism, vol. 24, pp. 566 - 581, http://dx.doi.org/10.1016/j.cmet.2016.09.004
Uddin GM; Youngson NA; Sinclair DA; Morris MJ, 2016, 'Head to head comparison of short-term treatment with the NAD+precursor nicotinamide mononucleotide (NMN) and 6 weeks of exercise in obese female mice', Frontiers in Pharmacology, vol. 7, http://dx.doi.org/10.3389/fphar.2016.00258
Mohamad M; Mitchell SJ; Wu LE; White MY; Cordwell SJ; Mach J; Solon-Biet SM; Boyer D; Nines D; Das A, 2016, 'Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance', Aging Cell, vol. 15, pp. 706 - 715, http://dx.doi.org/10.1111/acel.12481
Schultz MB; Sinclair DA, 2016, 'Why NAD+ Declines during Aging: It's Destroyed', Cell Metabolism, vol. 23, pp. 965 - 966, http://dx.doi.org/10.1016/j.cmet.2016.05.022
Wu LE; Sinclair DA, 2016, 'Restoring stem cells-all you need is NAD+', Cell Research, vol. 26, pp. 971 - 972, http://dx.doi.org/10.1038/cr.2016.80
Cagnone GLM; Tsai TS; Makanji Y; Matthews P; Gould J; Bonkowski MS; Elgass KD; Wong ASA; Wu LE; McKenzie M, 2016, 'Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep23229
Shannon Weickert C; Webster MJ; Boerrigter D; Sinclair D, 2016, 'FKBP5 Messenger RNA Increases After Adolescence in Human Dorsolateral Prefrontal Cortex', Biological Psychiatry, vol. 80, pp. e29 - e31, http://dx.doi.org/10.1016/j.biopsych.2015.11.005
Gomes AP; Sinclair DA, 2015, 'Measuring PGC-1α and its acetylation status in mouse primary myotubes', Methods in Molecular Biology, vol. 1241, pp. 49 - 57, http://dx.doi.org/10.1007/978-1-4939-1875-1_5
Rumpf T; Schiedel M; Karaman B; Roessler C; North BJ; Lehotzky A; Oláh J; Ladwein KI; Schmidtkunz K; Gajer M, 2015, 'Selective Sirt2 inhibition by ligand-induced rearrangement of the active site', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms7263
Winnik S; Auwerx J; Sinclair DA; Matter CM, 2015, 'Protective effects of sirtuins in cardiovascular diseases: From bench to bedside', European Heart Journal, vol. 36, pp. 3404 - 3412, http://dx.doi.org/10.1093/eurheartj/ehv290
Miranda MX; Van Tits LJ; Lohmann C; Arsiwala T; Winnik S; Tailleux A; Stein S; Gomes AP; Suri V; Ellis JL, 2015, 'The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression', European Heart Journal, vol. 36, pp. 51 - 59, http://dx.doi.org/10.1093/eurheartj/ehu095
Kim J; Sturgill D; Tran AD; Sinclair DA; Oberdoerffer P, 2015, 'Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability', Nucleic Acids Research, vol. 44, http://dx.doi.org/10.1093/nar/gkv1482
Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair D; Homer H, 2015, 'Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0130058
Garg N; Sinclair DA, 2015, 'Oogonial stem cells as a model to study age-associated infertility in women', Reproduction, Fertility and Development, vol. 27, pp. 969 - 974, http://dx.doi.org/10.1071/RD14461
Zhang QS; Deater M; Schubert K; Marquez-Loza L; Pelz C; Sinclair DA; Grompe M, 2015, 'The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice', Stem Cell Research, vol. 15, pp. 130 - 140, http://dx.doi.org/10.1016/j.scr.2015.05.007
Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair D; Homer H, 2015, 'Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0126194
Longo VD; Antebi A; Bartke A; Barzilai N; Brown-Borg HM; Caruso C; Curiel TJ; De Cabo R; Franceschi C; Gems D, 2015, 'Interventions to slow aging in humans: Are we ready?', Aging Cell, vol. 14, pp. 497 - 510, http://dx.doi.org/10.1111/acel.12338
Franco SS; De Falco L; Ghaffari S; Brugnara C; Sinclair DA; Matte A; Iolascon A; Mohandas N; Bertoldi M; An X, 2014, 'Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice', Haematologica, vol. 99, pp. 267 - 275, http://dx.doi.org/10.3324/haematol.2013.090076
Escande C; Nin V; Price NL; Capellini V; Gomes AP; Barbosa MT; O'Neil L; White TA; Sinclair DA; Chini EN, 2014, 'Flavonoid apigenin is an inhibitor of the NAD+ase CD38: Implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome (Diabetes (2013) 62 (1', Diabetes, vol. 63, pp. 1428, http://dx.doi.org/10.2337/db14-er04
Cucurachi M; Busconi M; Fogher C; Hubbard B; Sinclair DA; Kovacs LG; Oláh R; Winterhagen P; Perl A; Bavaresco L, 2014, 'Preliminary observations on the role of Sirtuin genes in grapevine (Vitis vinifera L.) Physiology', Acta Horticulturae, vol. 1046, pp. 363 - 370
Sinclair D, 2014, 'Turning back time', Chemistry and Industry (London), vol. 78, pp. 32 - 35, http://dx.doi.org/10.1002/cind.7810_10.x
Mercken EM; Mitchell SJ; Martin-Montalvo A; Minor RK; Almeida M; Gomes AP; Scheibye-Knudsen M; Palacios HH; Licata JJ; Zhang Y, 2014, 'SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass', Aging Cell, vol. 13, pp. 787 - 796, http://dx.doi.org/10.1111/acel.12220
Fillman SG; Sinclair D; Fung SJ; Webster MJ; Shannon Weickert C, 2014, 'Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder', Translational Psychiatry, vol. 4, http://dx.doi.org/10.1038/tp.2014.8
Cronise RJ; Sinclair DA; Bremer AA, 2014, 'The "metabolic winter" Hypothesis: A cause of the current epidemics of obesity and cardiometabolic disease', Metabolic Syndrome and Related Disorders, vol. 12, pp. 355 - 361, http://dx.doi.org/10.1089/met.2014.0027
Moroz N; Carmona JJ; Anderson E; Hart AC; Sinclair DA; Blackwell TK, 2014, 'Dietary restriction involves NAD+-dependent mechanisms and a shift toward oxidative metabolism', Aging Cell, vol. 13, pp. 1075 - 1085, http://dx.doi.org/10.1111/acel.12273
Rimmelé P; Bigarella CL; Liang R; Izac B; Dieguez-Gonzalez R; Barbet G; Donovan M; Brugnara C; Blander JM; Sinclair DA, 2014, 'Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells', Stem Cell Reports, vol. 3, pp. 44 - 59, http://dx.doi.org/10.1016/j.stemcr.2014.04.015
North BJ; Rosenberg MA; Jeganathan KB; Hafner AV; Michan S; Dai J; Baker DJ; Cen Y; Wu LE; Sauve AA, 2014, 'SIRT2 induces the checkpoint kinase BubR1 to increase lifespan', EMBO Journal, vol. 33, pp. 1438 - 1453, http://dx.doi.org/10.15252/embj.201386907
Mitchell SJ; Martin-Montalvo A; Mercken EM; Palacios HH; Ward TM; Abulwerdi G; Minor RK; Vlasuk GP; Ellis JL; Sinclair DA, 2014, 'The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet', Cell Reports, vol. 6, pp. 836 - 843, http://dx.doi.org/10.1016/j.celrep.2014.01.031
Wu LE; Sinclair DA, 2014, 'SIRT2 controls the pentose phosphate switch', EMBO Journal, vol. 33, pp. 1287 - 1288, http://dx.doi.org/10.15252/embj.201488713
Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG, 2014, 'The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice', Cell Metabolism, vol. 19, pp. 418 - 430, http://dx.doi.org/10.1016/j.cmet.2014.02.009
Michan S; Juan AM; Hurst CG; Cui Z; Evans LP; Hatton CJ; Pei DT; Ju M; Sinclair DA; Smith LEH, 2014, 'Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0085031
Hubbard BP; Sinclair DA, 2014, 'Small molecule SIRT1 activators for the treatment of aging and age-related diseases', Trends in Pharmacological Sciences, vol. 35, pp. 146 - 154, http://dx.doi.org/10.1016/j.tips.2013.12.004
Yoon JC; Ling AJY; Isik M; Donna Lee DY; Steinbaugh MJ; Sack LM; Boduch AN; Blackwell TK; Sinclair DA; Elledge SJ, 2014, 'GLTSCR2/PICT1 links mitochondrial stress and Myc signaling', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, pp. 3781 - 3786, http://dx.doi.org/10.1073/pnas.1400705111
Wu LE; Gomes AP; Sinclair DA, 2014, 'Geroncogenesis: Metabolic changes during aging as a driver of tumorigenesis', Cancer Cell, vol. 25, pp. 12 - 19, http://dx.doi.org/10.1016/j.ccr.2013.12.005
Sinclair DA; Guarente L, 2014, 'Small-molecule allosteric activators of sirtuins', Annual Review of Pharmacology and Toxicology, vol. 54, pp. 363 - 380, http://dx.doi.org/10.1146/annurev-pharmtox-010611-134657
Minor RK; Baur JA; Gomes AP; Ward TM; Csiszar A; Mercken EM; Abdelmohsen K; Shin YK; Canto C; Scheibye-Knudsen M, 2013, 'Erratum: SRT1720 improves survival and healthspan of obese mice (Scientific Reports (2011) 1 (70) DOI: 10.1038/srep00070)', Scientific Reports, vol. 3, http://dx.doi.org/10.1038/srep01131
Biason-Lauber A; Böni-Schnetzler M; Hubbard BP; Bouzakri K; Brunner A; Cavelti-Weder C; Keller C; Meyer-Böni M; Meier DT; Brorsson C, 2013, 'Identification of a SIRT1 mutation in a family with type 1 diabetes', Cell Metabolism, vol. 17, pp. 448 - 455, http://dx.doi.org/10.1016/j.cmet.2013.02.001
Lai L; Yan L; Gao S; Hu CL; Ge H; Davidow A; Park M; Bravo C; Iwatsubo K; Ishikawa Y, 2013, 'Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway', Circulation, vol. 127, pp. 1692 - 1701, http://dx.doi.org/10.1161/CIRCULATIONAHA.112.001212
Anderson RM; Bitterman KJ; Wood JG; Medvedik O; Cohen H; Lin SS; Manchester JK; Gordon JI; Sinclair DA, 2013, 'Erratum: Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels (The Journal of Biological Chemistry (2002) 277 (18881-18890))', Journal of Biological Chemistry, vol. 288, pp. 24160, http://dx.doi.org/10.1074/jbc.A113.111773
Sinclair DA, 2013, 'Studying the replicative life span of yeast cells', Methods in Molecular Biology, vol. 1048, pp. 49 - 63, http://dx.doi.org/10.1007/978-1-62703-556-9_5
Strong R; Miller RA; Astle CM; Baur JA; De Cabo R; Fernandez E; Guo W; Javors M; Kirkland JL; Nelson JF, 2013, 'Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 68, pp. 6 - 16, http://dx.doi.org/10.1093/gerona/gls070
Han J; Hubbard BP; Lee J; Montagna C; Lee HW; Sinclair DA; Suh Y, 2013, 'Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene', Cell Cycle, vol. 12, pp. 263 - 270, http://dx.doi.org/10.4161/cc.23056
Escande C; Nin V; Price NL; Capellini V; Gomes AP; Barbosa MT; O'Neil L; White TA; Sinclair DA; Chini EN, 2013, 'Flavonoid apigenin is an inhibitor of the NAD+ase CD38: Implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome', Diabetes, vol. 62, pp. 1084 - 1093, http://dx.doi.org/10.2337/db12-1139
Martin-Montalvo A; Mercken EM; Mitchell SJ; Palacios HH; Mote PL; Scheibye-Knudsen M; Gomes AP; Ward TM; Minor RK; Blouin MJ, 2013, 'Metformin improves healthspan and lifespan in mice', Nature Communications, vol. 4, http://dx.doi.org/10.1038/ncomms3192
Hubbard BP; Sinclair DA, 2013, 'Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay', Methods in Molecular Biology, vol. 1077, pp. 167 - 177, http://dx.doi.org/10.1007/978-1-62703-637-5_11
Stottmann RW; Donlin M; Hafner A; Bernard A; Sinclair DA; Beier DR, 2013, 'Amutation in tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse', Human Molecular Genetics, vol. 22, pp. 4053 - 4063, http://dx.doi.org/10.1093/hmg/ddt255
Schmeisser K; Mansfeld J; Kuhlow D; Weimer S; Priebe S; Heiland I; Birringer M; Groth M; Segref A; Kanfi Y, 2013, 'Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide', Nature Chemical Biology, vol. 9, pp. 693 - 700, http://dx.doi.org/10.1038/nchembio.1352
Gomes AP; Price NL; Ling AJY; Moslehi JJ; Montgomery MK; Rajman L; White JP; Teodoro JS; Wrann CD; Hubbard BP, 2013, 'Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging', Cell, vol. 155, pp. 1624 - 1638, http://dx.doi.org/10.1016/j.cell.2013.11.037
Chen J; Michan S; Juan AM; Hurst CG; Hatton CJ; Pei DT; Joyal JS; Evans LP; Cui Z; Stahl A, 2013, 'Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy', Angiogenesis, vol. 16, pp. 985 - 992, http://dx.doi.org/10.1007/s10456-013-9374-5
Tilly JL; Sinclair DA, 2013, 'Germline energetics, aging, and female infertility', Cell Metabolism, vol. 17, pp. 838 - 850, http://dx.doi.org/10.1016/j.cmet.2013.05.007
Armour SM; Bennett EJ; Braun CR; Zhang XY; McMahon SB; Gygi SP; Harper JW; Sinclair DA, 2013, 'A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex', Molecular and Cellular Biology, vol. 33, pp. 1487 - 1502, http://dx.doi.org/10.1128/MCB.00971-12
Hubbard BP; Loh C; Gomes AP; Li J; Lu Q; Doyle TLG; Disch JS; Armour SM; Ellis JL; Vlasuk GP, 2013, 'Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation- independent mechanism', Cell Cycle, vol. 12, pp. 2233 - 2240, http://dx.doi.org/10.4161/cc.25268
Hubbard BP; Gomes AP; Dai H; Li J; Case AW; Considine T; Riera TV; Lee JE; Yen E S; Lamming DW, 2013, 'Evidence for a common mechanism of SIRT1 regulation by allosteric activators', Science, vol. 339, pp. 1216 - 1219, http://dx.doi.org/10.1126/science.1231097
Gomes AP; Duarte FV; Nunes P; Hubbard BP; Teodoro JS; Varela AT; Jones JG; Sinclair DA; Palmeira CM; Rolo AP, 2012, 'Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis', Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1822, pp. 185 - 195, http://dx.doi.org/10.1016/j.bbadis.2011.10.008
North BJ; Sinclair DA, 2012, 'The intersection between aging and cardiovascular disease', Circulation Research, vol. 110, pp. 1097 - 1108, http://dx.doi.org/10.1161/CIRCRESAHA.111.246876
Rascón B; Hubbard BP; Sinclair DA; Amdam GV, 2012, 'The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction', Aging, vol. 4, pp. 499 - 508, http://dx.doi.org/10.18632/aging.100474
Nogueiras R; Habegger KM; Chaudhary N; Finan B; Banks AS; Dietrich MO; Horvath TL; Sinclair DA; Pfluger PT; Tschöp MH, 2012, 'Sirtuin 1 and sirtuin 3: Physiological modulators of metabolism', Physiological Reviews, vol. 92, pp. 1479 - 1514, http://dx.doi.org/10.1152/physrev.00022.2011
Nakamura K; Kosugi I; Lee DY; Hafner A; Sinclair DA; Ryo A; Lu KP, 2012, 'Prolyl isomerase pin1 regulates neuronal differentiation via β-catenin', Molecular and Cellular Biology, vol. 32, pp. 2966 - 2978, http://dx.doi.org/10.1128/MCB.05688-11
Sinclair D; Verdin E, 2012, 'The Longevity of Sirtuins', Cell Reports, vol. 2, pp. 1473 - 1474, http://dx.doi.org/10.1016/j.celrep.2012.12.004
Klionsky DJ; Abdalla FC; Abeliovich H; Abraham RT; Acevedo-Arozena A; Adeli K; Agholme L; Agnello M; Agostinis P; Aguirre-Ghiso JA, 2012, 'Guidelines for the use and interpretation of assays for monitoring autophagy', Autophagy, vol. 8, pp. 445 - 544, http://dx.doi.org/10.4161/auto.19496
Price NL; Gomes AP; Ling AJY; Duarte FV; Martin-Montalvo A; North BJ; Agarwal B; Ye L; Ramadori G; Teodoro JS, 2012, 'SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function', Cell Metabolism, vol. 15, pp. 675 - 690, http://dx.doi.org/10.1016/j.cmet.2012.04.003
Hua J; Guerin KI; Chen J; Michán S; Stahl A; Krah NM; Seaward MR; Dennison RJ; Juan AM; Hatton CJ, 2011, 'Resveratrol inhibits pathologic retinal neovascularization in Vldlr-/- Mice', Investigative Ophthalmology and Visual Science, vol. 52, pp. 2809 - 2816, http://dx.doi.org/10.1167/iovs.10-6496
Miller RA; Harrison DE; Astle CM; Baur JA; Boyd AR; De Cabo R; Fernandez E; Flurkey K; Javors MA; Nelson JF, 2011, 'Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 66 A, pp. 191 - 201, http://dx.doi.org/10.1093/gerona/glq178
Bernier M; Paul RK; Martin-Montalvo A; Scheibye-Knudsen M; Song S; He HJ; Armour SM; Hubbard BP; Bohr VA; Wang L, 2011, 'Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein', Journal of Biological Chemistry, vol. 286, pp. 19270 - 19279, http://dx.doi.org/10.1074/jbc.M110.200311
Ramadori G; Fujikawa T; Anderson J; Berglund ED; Frazao R; Michán S; Vianna CR; Sinclair DA; Elias CF; Coppari R, 2011, 'SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance', Cell Metabolism, vol. 14, pp. 301 - 312, http://dx.doi.org/10.1016/j.cmet.2011.06.014
Vendrell A; Martánez-Pastor M; González-Novo A; Pascual-Ahuir A; Sinclair DA; Proft M; Posas F, 2011, 'Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase', EMBO Reports, vol. 12, pp. 1062 - 1068, http://dx.doi.org/10.1038/embor.2011.154
Beirowski B; Gustin J; Armour SM; Yamamoto H; Viader A; North BJ; Michán S; Baloh RH; Golden JP; Schmidt RE, 2011, 'Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling', Proceedings of the National Academy of Sciences of the United States of America, vol. 108, http://dx.doi.org/10.1073/pnas.1104969108
Minor RK; Baur JA; Gomes AP; Ward TM; Csiszar A; Mercken EM; Abdelmohsen K; Shin YK; Canto C; Scheibye-Knudsen M, 2011, 'SRT1720 improves survival and healthspan of obese mice', Scientific Reports, vol. 1, http://dx.doi.org/10.1038/srep00070
Haigis MC; Sinclair DA, 2010, 'Mammalian sirtuins: Biological insights and disease relevance', Annual Review of Pathology: Mechanisms of Disease, vol. 5, pp. 253 - 295, http://dx.doi.org/10.1146/annurev.pathol.4.110807.092250
Blagosklonny MV; Campisi J; Sinclair DA; Bartke A; Blasco MA; Bonner WM; Bohr VA; Brosh RM; Brunet A; DePinho RA, 2010, 'Impact papers on aging in 2009', Aging, vol. 2, pp. 111 - 121, http://dx.doi.org/10.18632/aging.100132
Rutanen J; Yaluri N; Modi S; Pihlajamäki J; Vänttinen M; Itkonen P; Kainulainen S; Yamamoto H; Lagouge M; Sinclair DA, 2010, 'SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity', Diabetes, vol. 59, pp. 829 - 835, http://dx.doi.org/10.2337/db09-1191
Le Couteur DG; Sinclair DA, 2010, 'A blueprint for developing therapeutic approaches that increase healthspan and delay death', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 65 A, pp. 693 - 694, http://dx.doi.org/10.1093/gerona/glq048
Michán S; Li Y; Chou MMH; Parrella E; Ge H; Long JM; Allard JS; Lewis K; Miller M; Xu W, 2010, 'SIRT1 is essential for normal cognitive function and synaptic plasticity', Journal of Neuroscience, vol. 30, pp. 9695 - 9707, http://dx.doi.org/10.1523/JNEUROSCI.0027-10.2010
Baur JA; Chen D; Chini EN; Chua K; Cohen HY; De Cabo R; Deng C; Dimmeler S; Gius D; Guarente LP, 2010, 'Dietary restriction: Standing up for sirtuins', Science, vol. 329, pp. 1012 - 1013, http://dx.doi.org/10.1126/science.329.5995.1012
Yang Y; Hubbard BP; Sinclair DA; Tong Q, 2010, 'Characterization of murine SIRT3 transcript variants and corresponding protein products', Journal of Cellular Biochemistry, vol. 111, pp. 1051 - 1058, http://dx.doi.org/10.1002/jcb.22795
Hafner AV; Dai J; Gomes AP; Xiao CY; Palmeira KCM; Rosenzweig A; Sinclair DA, 2010, 'Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy', Aging, vol. 2, pp. 914 - 923, http://dx.doi.org/10.18632/aging.100252
Blagosklonny MV; Campisi J; Sinclair DA, 2009, 'Aging: past, present and future.', Aging, vol. 1, pp. 1 - 5
Jin L; Galonek H; Israelian K; Choy W; Morrison M; Xia Y; Wang X; Xu Y; Yang Y; Smith JJ, 2009, 'Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3', Protein Science, vol. 18, pp. 514 - 525, http://dx.doi.org/10.1002/pro.50
Jiménez-Hidalgo M; Santos-Ocaña C; Padilla S; Villalba JM; López-Lluch G; Martín-Montalvo A; Minor RK; Sinclair DA; De Cabo R; Navas P, 2009, 'NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast', Aging Cell, vol. 8, pp. 140 - 151, http://dx.doi.org/10.1111/j.1474-9726.2009.00461.x
Armour SM; Baur JA; Hsieh SN; Land-Bracha A; Thomas SM; Sinclair DA, 2009, 'Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy.', Aging, vol. 1, pp. 515 - 528
Sinclair DA; Oberdoerffer P, 2009, 'The ageing epigenome: Damaged beyond repair?', Ageing Research Reviews, vol. 8, pp. 189 - 198, http://dx.doi.org/10.1016/j.arr.2009.04.004
Baur JA; Sinclair DA, 2008, 'What is xenohormesis?', American Journal of Pharmacology and Toxicology, vol. 3, pp. 149 - 156
Sinclair DA, 2008, 'David A. Sinclair, Ph.D is interviewed by Vicki Glaser.', Rejuvenation research, vol. 11, pp. 265 - 268, http://dx.doi.org/10.1089/rej.2008.0694
Howitz KT; Sinclair DA, 2008, 'Xenohormesis: Sensing the Chemical Cues of Other Species', Cell, vol. 133, pp. 387 - 391, http://dx.doi.org/10.1016/j.cell.2008.04.019
Firestein R; Blander G; Michan S; Oberdoerffer P; Ogino S; Campbell J; Bhimavarapu A; Luikenhuis S; de Cabo R; Fuchs C, 2008, 'The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth', PLoS ONE, vol. 3, http://dx.doi.org/10.1371/journal.pone.0002020
Pearson KJ; Baur JA; Lewis KN; Peshkin L; Price NL; Labinskyy N; Swindell WR; Kamara D; Minor RK; Perez E, 2008, 'Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span', Cell Metabolism, vol. 8, pp. 157 - 168, http://dx.doi.org/10.1016/j.cmet.2008.06.011
Oberdoerffer P; Michan S; McVay M; Mostoslavsky R; Vann J; Park SK; Hartlerode A; Stegmuller J; Hafner A; Loerch P, 2008, 'SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging', Cell, vol. 135, pp. 907 - 918, http://dx.doi.org/10.1016/j.cell.2008.10.025
Calabrese EJ; Bachmann KA; Bailer AJ; Bolger PM; Borak J; Cai L; Cedergreen N; Cherian MG; Chiueh CC; Clarkson TW, 2007, 'Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework', Toxicology and Applied Pharmacology, vol. 222, pp. 122 - 128, http://dx.doi.org/10.1016/j.taap.2007.02.015
Medvedik O; Sinclair DA, 2007, 'Caloric restriction and life span determination of yeast cells', Methods in Molecular Biology, vol. 371, pp. 97 - 109, http://dx.doi.org/10.1385/1-59745-361-7:97
Li Y; Yokota T; Gama V; Yoshida T; Gomez JA; Ishikawa K; Sasaguri H; Cohen HY; Sinclair DA; Mizusawa H, 2007, 'Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation', Cell Death and Differentiation, vol. 14, pp. 2058 - 2067, http://dx.doi.org/10.1038/sj.cdd.4402219
Yang H; Baur JA; Chen A; Miller C; Adams JK; Kisielewski A; Howitz KT; Zipkin RE; Sinclair DA, 2007, 'Erratum: (Aging Cell (2007) vol. 7 10.1111/j.1474-9726.2007.00317.x)', Aging Cell, vol. 6, pp. 593, http://dx.doi.org/10.1111/j.1474-9726.2007.00317.x
Medvedik O; Lamming DW; Kim KD; Sinclair DA, 2007, 'MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.', PLoS biology, vol. 5, http://dx.doi.org/10.1371/journal.pbio.0050261
North BJ; Sinclair DA, 2007, 'Sirtuins: a conserved key unlocking AceCS activity', Trends in Biochemical Sciences, vol. 32, pp. 1 - 4, http://dx.doi.org/10.1016/j.tibs.2006.11.002
Yang H; Baur JA; Chen A; Miller C; Sinclair DA, 2007, 'Design and synthesis of compounds that extend yeast replicative lifespan', Aging Cell, vol. 6, pp. 35 - 43, http://dx.doi.org/10.1111/j.1474-9726.2006.00259.x
Michan S; Sinclair D, 2007, 'Sirtuins in mammals: Insights into their biological function', Biochemical Journal, vol. 404, pp. 1 - 13, http://dx.doi.org/10.1042/BJ20070140
Kim D; Nguyen MD; Dobbin MM; Fischer A; Sananbenesi F; Rodgers JT; Delalle I; Baur JA; Sui G; Armour SM, 2007, 'SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis', EMBO Journal, vol. 26, pp. 3169 - 3179, http://dx.doi.org/10.1038/sj.emboj.7601758
Oberdoerffer P; Sinclair DA, 2007, 'The role of nuclear architecture in genomic instability and ageing', Nature Reviews Molecular Cell Biology, vol. 8, pp. 692 - 702, http://dx.doi.org/10.1038/nrm2238
Yang H; Yang T; Baur JA; Perez E; Matsui T; Carmona JJ; Lamming DW; Souza-Pinto NC; Bohr VA; Rosenzweig A, 2007, 'Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival', Cell, vol. 130, pp. 1095 - 1107, http://dx.doi.org/10.1016/j.cell.2007.07.035
Barbosa MTP; Soares SM; Novak CM; Sinclair D; Levine JA; Aksoy P; Chini EN, 2007, 'The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity', FASEB Journal, vol. 21, pp. 3629 - 3639, http://dx.doi.org/10.1096/fj.07-8290com
Milne JC; Lambert PD; Schenk S; Carney DP; Smith JJ; Gagne DJ; Jin L; Boss O; Perni RB; Vu CB, 2007, 'Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes', Nature, vol. 450, pp. 712 - 716, http://dx.doi.org/10.1038/nature06261
Sinclair DA; Guarente L, 2006, 'Unlocking the secrets of longevity genes', Scientific American, vol. 294, pp. 48 - 57, http://dx.doi.org/10.1038/scientificamerican0306-48
Sinclair DA; Lin SJ; Guarente L, 2006, 'Life-span extension in yeast [2]', Science, vol. 312, pp. 195 - 196
Baur JA; Sinclair DA, 2006, 'Therapeutic potential of resveratrol: The in vivo evidence', Nature Reviews Drug Discovery, vol. 5, pp. 493 - 506, http://dx.doi.org/10.1038/nrd2060
Yang H; Lavu S; Sinclair DA, 2006, 'Nampt/PBEF/Visfatin: A regulator of mammalian health and longevity?', Experimental Gerontology, vol. 41, pp. 718 - 726, http://dx.doi.org/10.1016/j.exger.2006.06.003
Baur JA; Pearson KJ; Price NL; Jamieson HA; Lerin C; Kalra A; Prabhu VV; Allard JS; Lopez-Lluch G; Lewis K, 2006, 'Resveratrol improves health and survival of mice on a high-calorie diet', Nature, vol. 444, pp. 337 - 342, http://dx.doi.org/10.1038/nature05354
Yu MC; Lamming DW; Eskin JA; Sinclair DA; Silver PA, 2006, 'The role of protein arginine methylation in the formation of silent chromatin', Genes and Development, vol. 20, pp. 3249 - 3254, http://dx.doi.org/10.1101/gad.1495206
Sinclair D, 2005, 'Sirtuins for healthy neurons', Nature Genetics, vol. 37, pp. 339 - 340, http://dx.doi.org/10.1038/ng0405-339
Sinclair DA, 2005, 'Toward a unified theory of caloric restriction and longevity regulation', Mechanisms of Ageing and Development, vol. 126, pp. 987 - 1002, http://dx.doi.org/10.1016/j.mad.2005.03.019
Lamming DW; Latorre-Esteves M; Medvedik O; Wong SN; Tsang FA; Wang C; Lin SJ; Sinclair DA, 2005, 'Cell biology: HST2 mediates SIR2-independent life-span extension by calorie restriction', Science, vol. 309, pp. 1861 - 1864, http://dx.doi.org/10.1126/science.1113611
Mai A; Massa S; Lavu S; Pezzi R; Simeoni S; Ragno R; Mariotti FR; Chiani F; Camilloni G; Sinclair DA, 2005, 'Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors', Journal of Medicinal Chemistry, vol. 48, pp. 7789 - 7795, http://dx.doi.org/10.1021/jm050100l
Wood JG; Rogina B; Lavu S; Ilowitz K; Helfand SL; Tatar M; Sinclair D, 2004, 'Erratum: Sirtuin activators mimic caloric restriction and delay ageing in metazoans (Nature (2004) 430 (686-689))', Nature, vol. 430, pp. 107
Cohen HY; Lavu S; Bitterman KJ; Hekking B; Imahiyerobo TA; Miller C; Frye R; Ploegh H; Kessler BM; Sinclair DA, 2004, 'Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis', Molecular Cell, vol. 13, pp. 627 - 638, http://dx.doi.org/10.1016/S1097-2765(04)00094-2
Brunet A; Sweeney LB; Sturgill JF; Chua KF; Greer PL; Lin Y; Tran H; Ross SE; Mostoslavsy R; Cohen HY, 2004, 'Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase', Science, vol. 303, pp. 2011 - 2015, http://dx.doi.org/10.1126/science.1094637
Cohen HY; Miller C; Bitterman KJ; Wall NR; Hekking B; Kessler B; Howitz KT; Gorospe M; De Cabo R; Sinclair DA, 2004, 'Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase', Science, vol. 305, pp. 390 - 392, http://dx.doi.org/10.1126/science.1099196
Mizuno T; Kishimoto T; Shinzato T; Haw R; Chambers A; Wood J; Sinclair D; Uemura H, 2004, 'Role of the N-terminal region of Rap1p in the transcriptional activation of glycolytic genes in Saccharomyces cerevisiae', Yeast, vol. 21, pp. 851 - 866, http://dx.doi.org/10.1002/yea.1123
Lamming DW; Wood JG; Sinclair DA, 2004, 'Small molecules that regulate lifespan: Evidence for xenohormesis', Molecular Microbiology, vol. 53, pp. 1003 - 1009, http://dx.doi.org/10.1111/j.1365-2958.2004.04209.x
Wood JG; Regina B; Lavu S; Hewitz K; Helfand SL; Tatar M; Sinclair D, 2004, 'Sirtuin activators mimic caloric restriction and delay ageing in metazoans', Nature, vol. 430, pp. 686 - 689, http://dx.doi.org/10.1038/nature02789
Sinclair D, 2003, 'Is DNA cut out for a long life?', Science of aging knowledge environment : SAGE KE, vol. 2003
Anderson RM; Bitterman KJ; Wood JG; Medvedik O; Sinclair DA, 2003, 'Nicatinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae', Nature, vol. 423, pp. 181 - 185, http://dx.doi.org/10.1038/nature01578
Bitterman KJ; Medvedik O; Sinclair DA, 2003, 'Longevity regulation in Saccharomyces cerevisiae: Linking metabolism, genome stability, and heterochromatin', Microbiology and Molecular Biology Reviews, vol. 67, pp. 376 - 399, http://dx.doi.org/10.1128/MMBR.67.3.376-399.2003
Howitz KT; Bitterman KJ; Cohen HY; Lamming DW; Lavu S; Wood JG; Zipkin RE; Chung P; Kisielewski A; Zhang LL, 2003, 'Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan', Nature, vol. 425, pp. 191 - 196, http://dx.doi.org/10.1038/nature01960
Sinclair DA, 2003, 'An age of instability', Science, vol. 301, pp. 1859 - 1860, http://dx.doi.org/10.1126/science.1090465
Anderson RM; Latorre-Esteves M; Neves AR; Lavu S; Medvedik O; Taylor C; Howitz KT; Santos H; Sinclair DA, 2003, 'Yeast Life-Span Extension by Calorie Restriction Is Independent of NAD Fluctuation', Science, vol. 302, pp. 2124 - 2126, http://dx.doi.org/10.1126/science.1088697
Wood JG; Sinclair DA, 2002, 'TPE or not TPE? It's no longer a question', Trends in Pharmacological Sciences, vol. 23, pp. 1 - 4, http://dx.doi.org/10.1016/S0165-6147(00)01891-5
Sinclair DA, 2002, 'Paradigms and pitfalls of yeast longevity research', Mechanisms of Ageing and Development, vol. 123, pp. 857 - 867, http://dx.doi.org/10.1016/S0047-6374(02)00023-4
Anderson RM; Bitterman KJ; Wood JG; Medvedik O; Cohen H; Lin SS; Manchester JK; Gordon JI; Sinclair DA, 2002, 'Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels', Journal of Biological Chemistry, vol. 277, pp. 18881 - 18890, http://dx.doi.org/10.1074/jbc.M111773200
Bitterman KJ; Anderson RM; Cohen HY; Latorre-Esteves M; Sinclair DA, 2002, 'Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1', Journal of Biological Chemistry, vol. 277, pp. 45099 - 45107, http://dx.doi.org/10.1074/jbc.M205670200
Cohen H; Sinclair DA, 2001, 'Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase', Proceedings of the National Academy of Sciences of the United States of America, vol. 98, pp. 3174 - 3179, http://dx.doi.org/10.1073/pnas.061579598
Ashrafi K; Sinclair D; Gordon JI; Guarente L, 1999, 'Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae', Proceedings of the National Academy of Sciences of the United States of America, vol. 96, pp. 9100 - 9105, http://dx.doi.org/10.1073/pnas.96.16.9100
Mills KD; Sinclair DA; Guarente L, 1999, 'MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks', Cell, vol. 97, pp. 609 - 620, http://dx.doi.org/10.1016/S0092-8674(00)80772-2
Johnson FB; Sinclair DA; Guarente L, 1999, 'Molecular biology of aging', Cell, vol. 96, pp. 291 - 302, http://dx.doi.org/10.1016/S0092-8674(00)80567-X
Sinclair DA, 1999, 'Yeast aging research: Recent advances and medical relevance', Cellular and Molecular Life Sciences, vol. 56, pp. 807 - 816, http://dx.doi.org/10.1007/s000180050027
Hong SP; Piper MD; Sinclair DA; Dawes IW, 1999, 'Control of expression of one-carbon metabolism genes of Saccharomyces cerevisiae is mediated by a tetrahydrofolate-responsive protein binding to a glycine regulatory region including a core 5'-CTTCTT-', Journal of Biological Chemistry, vol. 274, pp. 10523 - 10532, http://dx.doi.org/10.1074/jbc.274.15.10523
Sinclair DA; Mills K; Guarente L, 1998, 'Molecular mechanisms of yeast aging', Trends in Biochemical Sciences, vol. 23, pp. 131 - 134, http://dx.doi.org/10.1016/S0968-0004(98)01188-8
Sinclair DA; Mills K; Guarente L, 1997, 'Accelerated aging and nucleolar fragmentation in yeast SGS1 mutants', Science, vol. 277, pp. 1313 - 1316, http://dx.doi.org/10.1126/science.277.5330.1313
Kennedy BK; Gotta M; Sinclair DA; Mills K; McNabb DS; Murthy M; Pak SM; Laroche T; Gasser SM; Guarente L, 1997, 'Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae', Cell, vol. 89, pp. 381 - 391, http://dx.doi.org/10.1016/S0092-8674(00)80219-6
Sinclair DA; Guarente L, 1997, 'Extrachromosomal rDNA circles - A cause of aging in yeast', Cell, vol. 91, pp. 1033 - 1042, http://dx.doi.org/10.1016/S0092-8674(00)80493-6
McNeil JB; Zhang FR; Taylor BV; Sinclair DA; Pearlman RE; Bognar AL, 1997, 'Cloning, and molecular characterization of the GCV1 gene encoding the glycine cleavage T-protein from Saccharomyces cerevisiae', Gene, vol. 186, pp. 13 - 20, http://dx.doi.org/10.1016/S0378-1119(96)00670-1
Sinclair DA; Hong SP; Dawes IW, 1996, 'Specific induction by glycine of the gene for the P-subunit of glycine decarboxylase from Saccharomyces cerevisiae', Molecular Microbiology, vol. 19, pp. 611 - 623, http://dx.doi.org/10.1046/j.1365-2958.1996.419947.x
Sinclair DA; Dawes IW, 1995, 'Genetics of the synthesis of serine from glycine and the utilization of glycine as sole nitrogen source by Saccharomyces cerevisiae', Genetics, vol. 140, pp. 1213 - 1222
Sinclair DA; Kornfeld GD; Dawes IW, 1994, 'Yeast intragenic transcriptional control: Activation and repression sites within the coding region of the Saccharomyces cerevisiae LPD1 gene', Molecular and Cellular Biology, vol. 14, pp. 214 - 225, http://dx.doi.org/10.1128/MCB.14.1.214
Sinclair DA; Dawes IW; Dickinson JR, 1993, 'Purification and characterization of the branched chain α-ketoacid dehydrogenase complex from Saccharomyces cerevisiae', Biochemistry and Molecular Biology International, vol. 31, pp. 911 - 922
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