Professor Christopher Heeschen

Contact Details

Phone: +61 (0) 2 9385 1004
Fax: +61 (2) 9385 1510
Email: c.heeschen@unsw.edu.au

Tabs

Main

Prof Heeschen obtained his Medical Degree in 1997 from the Free University of Berlin (Germany). His clinical training in Internal Medicine ran from 1996 – 2004 at the University of Hamburg and the University of Frankfurt. During this time, he also spent 2.5 years at the Falk Cardiovascular Research Center at Stanford University (USA) where he worked on basic and translational aspects of angiogenesis and vasculogenic stem cells and subsequently obtained his PhD in 2001.

Prof Heeschen became an independent investigator in 2004 as Professor of Experimental Oncology and Transplantation and Head of the Department Experimental at Ludwig-Maximilian-University in Munich (Germany). In 2008 he moved to the Spanish National Cancer Research Centre (CNIO) as a founding member of the Clinical Research Programme. In 2013, he became the lead of the new Centre for Stem Cells in Cancer & Ageing at Barts Cancer Institute, London, UK. In March 2018, Prof Heeschen was recruited to UNSW under the SHARP program to establish his translational research programme at the Lowy Cancer Research Institute (Randwick Campus) and the Ingham Institute (Liverpool Campus). Building on his original discovery of pancreatic cancer stem cells and the heterogeneity therein, his lab is now working on newly identified key epigenetic and metabolic regulators of the stemness signalling network in cancer stem cells. Please Stem Cells & Cancer Group for more details on his lab-based work.

Prof Heeschen also has a strong track record in innovative, investigator-initiated clinical trials and has developed numerous biomarkers that have been successfully applied for precision medicine and implemented into clinical guidelines. Making use of his extensive international network of clinical investigators, industry partners and funding agencies, several innovative clinical trials have just been opened (SU2C and EU funded).

Prof Heeschen has published more than 150 articles in prestigious scientific journals such as the New England Journal of Medicine, Nature Medicine, The Lancet, Cancer Cell, Cell Stem Cell, the Journal of Experimental Medicine, and PNAS, among others. His work has been cited more than 26,000 times (GoogleScholar). Prof Heeschen has made major original contributions to the field of stem and vascular cell biology that have advanced our understanding of the basic processes of stem cell function and trafficking. His research has been recognised through numerous international awards and has earned him an ERC Advanced Investigator Grant for pancreatic cancer research.

University role:

Professor for Stem Cell Biology

Grants:

Funded by the UNSW Strategic Hires and Retention Pathways (SHARP), which supports recruitment in carefully selected areas of research. Significant funding have been invested to bring Prof Heeschen and his team of highly successful research to UNSW Sydney. The package enables recruitment of several skilled technical, professionals and academic personal to UNSW under PRfl Heeschen's leadership. The SHARP program is also funding the purchase of intestines suites of equipment, including core facilities for the isolation, handling and propagation of rare (circulating) cancer stem cells, and their subsequent multiplex phenotypic profiling of cancer stem cells for precision medicine.

Interested in joining? We are currently looking for

Research Officer – Job ID 494884
PostDoc – please inquire
Senior PostDoc – please inquire
PhD students – please check available projects below
Honour students – Search here for suitable projects.

Awards:

1999 Research Fellowship, German Research Association (DFG)
2000 Young Investigator Award, American Heart Association
2001 Young Investigator Award, American College of Cardiology
2002 Paul-Martini-Award, Paul Martini Foundation
2003 Hermann-Rein-Award, German Society for Microcirculation & Vascular Biology
2004 Merit Award from the American Heart Association’s Council on ATVB
2004 SERVIER Award for Microcirculation
2006 DIGEST-Innovation Award 2006
2008 Chaire d’Excellence, Agence Nationale Recherche, France
2009 ERC Advanced Investigator Award, European Research Council
2009 Richtzenhain Award, German Cancer Research Institute (DKFZ)
2012 PlanE Innovation Award, Ministry of Science & Innovation, Spain

Keywords:

personalised medicine

pancreas

pancreatic cancer

chronic pancreatitis

stem cells

adult stem cells

circulating tumour cells

Groups:

Stem Cells and Cancer

Research

Research activities:

Prof Heeschen's laboratory is committed to developing more effective therapies for patients with pancreatic cancer, a disease with clear unmet medical need. Their main objective is to make a true impact on the outcome of these patients through various means - earlier diagnosis, tracking of treatment response, precision medicine, and prevention of relapse by targeting cancer stem cells. For this purpose, Prof Heeschen is running an integrated basic and translational research program, with a particular focus on pancreatic cancer. His Stem Cells & Cancer Group is hosted in the Adult Cancer Programme of the Lowy Cancer Research Institute.

His group is dissecting the cellular heterogeneity and hierarchy of pancreatic cancer down to single cells and determining the underlying molecular mechanisms. Tumours are heterogeneous, but not only because of diverse subclones that arise during tumour development, but also because they are driven by functional heterogeneity within each subclone. So-called cancer stem cells (CSCs) are responsible for intraclonal heterogeneity.

His group and others have provided conclusive evidence down to the single cell that they represent the root of the disease by giving rise to all differentiated progenies within each cancer subclone. These cells are also seeding metastases from primary tumour dissemination and represent an important cause of disease relapse following treatment.

Building on these findings and newly developed technologies in Prof Heeschen's lab, his team is now systematically determining which common key regulators control the process of stemness in pancreatic cancer. Our studies are directly relevant to improving therapy in pancreatic cancer and will provide vital and novel information on how to target cancer stem cells for preventing relapse.

The ultimate goal of our research relies on the identification of new multimodal treatment regimens, including CAR T-cell immunotherapies, that generate rapid and significant impact on pancreatic cancer progression (i.e. doubling or greater in the median survival for Stage IV pancreatic cancer patients) based on the additional targeting of the highly tumourigenic CSC compartment.

In order to advance our understanding of the regulatory machinery of cancer stem cells, we are running a combined basic and translation research programme, which synergistically promotes studies on the biology of mouse and human cancer stem cells, including their in vivo microenvironment.

Please also see "How embryos and cancer are connected – UNSW's Chris Heeschen shares lessons over lunch"

Teaching & Supervision

I am available to supervise:

Yes

Areas of supervision:

We are developing novel approaches to efficiently eliminate cancer stem cells as the root of the tumour, and bear the potential to finally improve long-term outcomes for patients with pancreatic cancer, one of the most devastating human cancers.

Determining how cancer stem cells actually regulate self-renewal and in vivo tumourigenesis will significantly advance our understanding of cancer stem cell biology. This represents an essential step towards the development of strategies for eliminating cancer stem cells as a prerequisite for improving long-term therapeutic response in pancreatic cancer patients. We are looking for

Honour students. Search here for suitable projects.
Master Students. Search here for suitable projects.
PhD students.

Currently available projects in our group are related to the following areas:

• Dissecting the heterogeneity of (circulating) cancer stem cells using single cell technologies;
• Identification and validation of novel cancer stem cell targets using functional genomics (siRNA, CRISPR/Cas9);
• Epigenetically defined stemness signalling network
• Cancer and stroma cell metabolism
• Contributions of the tumour microenvironment to promote stemness
• Development of novel cell-based immunotherapies (CAR-T) against cancer (stem) cells

If you find any of the above topics of interest to you, please send me an email (c.heeschen@unsw.edu.au) making a strong case why you are an excellent candidate for this, considering your area of expertise, skill sets, soft skills etc.

Once we have agreed that you are indeed the right candidate for your favourite project, then you can apply via this link:
https://research.unsw.edu.au/submit-application

Supervision keywords:

stem cells

cancer stem cell

pancreatic cancer

cell biology and immunology

translational medical research

biomarker

circulating tumor cell

Publications related to this Person

Book Chapters

Ray D; Khoshchehreh R; Aicher A; Heeschen C, 2015, 'Pancreatic cancer stem cells', in Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology, pp. 247 - 271, http://dx.doi.org/10.1007/978-3-319-21030-8_10

García-Silva S; Heeschen C, 2014, 'Stem Cells and Pancreatic Cancer', in Cancer Stem Cells, pp. 209 - 222, http://dx.doi.org/10.1002/9781118356203.ch16

Dorado J; Serrano AG; Heeschen C, 2011, 'Cancer Stem Cells in Pancreatic Cancer', in Allan AL (ed.), CANCER STEM CELLS IN SOLID TUMORS, edn. Stem Cell Biology and Regenerative Medicine, HUMANA PRESS INC, pp. 79 - 97, http://dx.doi.org/10.1007/978-1-61779-246-5_5

Clausell-Tormos J; Heeschen C, 2011, 'Pancreatic cancer stem cells as new targets for diagnostics and therapy', in Nanomedicine - Basic and Clinical Applications in Diagnostics and Therapy, pp. 116 - 134, http://dx.doi.org/10.1002/9783805598194.ch10

Heeschen C, 2009, 'Circulating Biomarkers for Risk Stratification', in Acute Coronary Syndromes: A Handbook for Clinical Practice, pp. 52 - 62, http://dx.doi.org/10.1002/9781444312850.ch5

Journal articles

Trabulo S; Aires A; Aicher A; Heeschen C; Cortajarena AL, 2017, 'Multifunctionalized iron oxide nanoparticles for selective targeting of pancreatic cancer cells', Biochimica et Biophysica Acta - General Subjects, vol. 1861, pp. 1597 - 1605, http://dx.doi.org/10.1016/j.bbagen.2017.01.035

Cioffi M; Trabulo SM; Vallespinos M; Raj D; Kheir TB; Lin ML; Begum J; Baker AM; Amgheib A; Saif J, 2017, 'The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1', Oncotarget, vol. 8, pp. 21609 - 21625, http://dx.doi.org/10.18632/oncotarget.15450

Heeschen C; Sancho P, 2016, 'More challenges ahead—metabolic heterogeneity of pancreatic cancer stem cells', Molecular and Cellular Oncology, vol. 3, http://dx.doi.org/10.1080/23723556.2015.1105353

Sancho P; Barneda D; Heeschen C, 2016, 'Hallmarks of cancer stem cell metabolism', British Journal of Cancer, vol. 114, pp. 1305 - 1312, http://dx.doi.org/10.1038/bjc.2016.152

Zagorac S; Alcala S; Bayon GF; Kheir TB; Schoenhals M; González-Neira A; Fraga MF; Aicher A; Heeschen C; Sainz B, 2016, 'DNMT1 inhibition reprograms pancreatic cancer stem cells via upregulation of the miR-17-92 cluster', Cancer Research, vol. 76, pp. 4546 - 4558, http://dx.doi.org/10.1158/0008-5472.CAN-15-3268

Cioffi M; Vallespinos-Serrano M; Trabulo SM; Fernandez-Marcos PJ; Firment AN; Vazquez BN; Vieira CR; Mulero F; Camara JA; Cronin UP, 2015, 'MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3', Cell Reports, vol. 12, pp. 1594 - 1605, http://dx.doi.org/10.1016/j.celrep.2015.08.006

Lonardo E; Cioffi M; Sancho P; Crusz S; Heeschen C, 2015, 'Studying pancreatic cancer stem cell characteristics for developing new treatment strategies', Journal of Visualized Experiments, vol. 2015, http://dx.doi.org/10.3791/52801

Cioffi M; Trabulo S; Hidalgo M; Costello E; Greenhalf W; Erkan M; Kleeff J; Sainz B; Heeschen C, 2015, 'Inhibition of CD47 Effectively targets pancreatic cancer stem cells via dual mechanisms', Clinical Cancer Research, vol. 21, pp. 2325 - 2337, http://dx.doi.org/10.1158/1078-0432.CCR-14-1399

Raj D; Aicher A; Heeschen C, 2015, 'Concise Review: Stem Cells in Pancreatic Cancer: From Concept to Translation', Stem Cells, vol. 33, pp. 2893 - 2902, http://dx.doi.org/10.1002/stem.2114

Sancho P; Burgos-Ramos E; Tavera A; Bou Kheir T; Jagust P; Schoenhals M; Barneda D; Sellers K; Campos-Olivas R; Graña O, 2015, 'MYC/PGC-1α balance determines the metabolic phenotype and plasticity of pancreatic cancer stem cells', Cell Metabolism, vol. 22, pp. 590 - 605, http://dx.doi.org/10.1016/j.cmet.2015.08.015

Yang MH; Imrali A; Heeschen C, 2015, 'Circulating cancer stem cells: The importance to select', Chinese Journal of Cancer Research, vol. 27, pp. 437 - 449, http://dx.doi.org/10.3978/j.issn.1000-9604.2015.04.08

Sainz B; Miranda-Lorenzo I; Heeschen C, 2015, 'The fuss over lipo"fuss"cin: not all autofluorescence is the same', European journal of histochemistry : EJH, vol. 59, pp. 2512, http://dx.doi.org/10.4081/ejh.2015.2512

Cioffi M; Trabulo SM; Sanchez-Ripoll Y; Miranda-Lorenzo I; Lonardo E; Dorado J; Vieira CR; Ramirez JC; Hidalgo M; Aicher A, 2015, 'The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells', Gut, vol. 64, pp. 1936 - 1948, http://dx.doi.org/10.1136/gutjnl-2014-308470

Sainz B; Alcala S; Garcia E; Sanchez-Ripoll Y; Azevedo MM; Cioffi M; Tatari M; Miranda-Lorenzo I; Hidalgo M; Gomez-Lopez G, 2015, 'Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment', Gut, vol. 64, pp. 1921 - 1935, http://dx.doi.org/10.1136/gutjnl-2014-308935

Clausell-Tormos J; Azevedo MM; Miranda-Lorenzo I; Vieira CR; Sanchez-Ripoll Y; Megias D; Heeschen C, 2014, 'Nano-volume well array chip for large-scale propagation and high-resolution analysis of individual cancer stem cells', Journal of Nanomedicine and Nanotechnology, vol. 5, http://dx.doi.org/10.4172/2157-7439.1000191

Balic A; Sørensen MD; Trabulo SM; Sainz B; Cioffi M; Vieira CR; Miranda-Lorenzo I; Hidalgo M; Kleeff J; Erkan M, 2014, 'Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling', Molecular Cancer Therapeutics, vol. 13, pp. 1758 - 1771, http://dx.doi.org/10.1158/1535-7163.MCT-13-0948

Hermann PC; Sancho P; Cañamero M; Martinelli P; Madriles F; Michl P; Gress T; De Pascual R; Gandia L; Guerra C, 2014, 'Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via gata6-dependent dedifferentiation of acinar cells in mice', Gastroenterology, vol. 147, pp. 1119 - 1133.e4, http://dx.doi.org/10.1053/j.gastro.2014.08.002

Miranda-Lorenzo I; Dorado J; Lonardo E; Alcala S; Serrano AG; Clausell-Tormos J; Cioffi M; Megias D; Zagorac S; Balic A, 2014, 'Intracellular autofluorescence: A biomarker for epithelial cancer stem cells', Nature Methods, vol. 11, pp. 1161 - 1169, http://dx.doi.org/10.1038/nmeth.3112

Hernández-Porras I; Fabbiano S; Schuhmacher AJ; Aicher A; Cañamero M; Cámara JA; Cussó L; Desco M; Heeschen C; Mulero F, 2014, 'K-Ras^V14Irecapitulates noonan syndrome in mice', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, pp. 16395 - 16400, http://dx.doi.org/10.1073/pnas.1418126111

Sainz B; Martín B; Tatari M; Heeschen C; Guerra S, 2014, 'ISG15 is a critical microenvironmental factor for pancreatic cancer stem cells', Cancer Research, vol. 74, pp. 7309 - 7320, http://dx.doi.org/10.1158/0008-5472.CAN-14-1354

Trakala M; Fernández-Miranda G; De Castro IP; Heeschen C; Malumbres M, 2013, 'Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21^Cip1', Cell Cycle, vol. 12, pp. 1030 - 1041, http://dx.doi.org/10.4161/cc.24004

Sainz B; Heeschen C, 2013, 'Standing out from the crowd: Cancer stem cells in hepatocellular carcinoma', Cancer Cell, vol. 23, pp. 431 - 433, http://dx.doi.org/10.1016/j.ccr.2013.03.023

Hermann PC; Trabulo SM; Sainz B; Balic A; Garcia E; Hahn SA; Vandana M; Sahoo SK; Tunici P; Bakker A, 2013, 'Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0066371

Hermann PC; Heeschen C, 2013, 'Metastatic cancer stem cells-Quo vadis?', Clinical Chemistry, vol. 59, pp. 1268 - 1269, http://dx.doi.org/10.1373/clinchem.2012.197830

Lonardo E; Cioffi M; Sancho P; Sanchez-Ripoll Y; Trabulo SM; Dorado J; Balic A; Hidalgo M; Heeschen C, 2013, 'Metformin Targets the Metabolic Achilles Heel of Human Pancreatic Cancer Stem Cells', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0076518

Milne R; La Vecchia C; Van Steen K; Hahn S; Buchholz M; Costello E; Esposito I; Hoheisel JD; Lange B; Lopez-Bigas N, 2013, 'EU pancreas: An integrated european platform for pancreas cancer research - From basic science to clinical and public health interventions for a rare disease', Public Health Genomics, vol. 16, pp. 305 - 312, http://dx.doi.org/10.1159/000355937

Lonardo E; Frias-Aldeguer J; Hermann PC; Heeschen C, 2012, 'Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness', CELL CYCLE, vol. 11, pp. 1282 - 1290, http://dx.doi.org/10.4161/cc.11.7.19679

Lonardo E; Hermann PC; Mueller MT; Huber S; Balic A; Miranda-Lorenzo I; Zagorac S; Alcala S; Rodriguez-Arabaolaza I; Ramirez JC, 2012, 'Nodal/activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy (Cell Stem Cell (2011) 9, (433-446))', Cell Stem Cell, vol. 10, pp. 104, http://dx.doi.org/10.1016/j.stem.2011.12.001

Schwarz TM; Leicht SF; Radic T; Rodriguez-Araboalaza I; Hermann PC; Berger F; Saif J; Böcker W; Ellwart JW; Aicher A, 2012, 'Vascular incorporation of endothelial colony-forming cells is essential for functional recovery of murine ischemic tissue following cell therapy', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, http://dx.doi.org/10.1161/ATVBAHA.111.239822

Cioffi M; Dorado J; Baeuerle PA; Heeschen C, 2012, 'EpCAM/CD3-bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells', Clinical Cancer Research, vol. 18, pp. 465 - 474, http://dx.doi.org/10.1158/1078-0432.CCR-11-1270

Balic A; Dorado J; Alonso-Gómez M; Heeschen C, 2012, 'Stem cells as the root of pancreatic ductal adenocarcinoma', Experimental Cell Research, vol. 318, pp. 691 - 704, http://dx.doi.org/10.1016/j.yexcr.2011.11.007

Lonardo E; Frias-Aldeguer J; Hermann PC; Heeschen C, 2012, 'Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness', Cell Cycle, vol. 11, pp. 1282 - 1290, http://dx.doi.org/10.4161/cc.19679

Cioffi M; Heeschen C, 2012, 'Immuno-targeting of pancreatic cancer stem cells: A new therapeutic strategy against a devastating disease?', OncoImmunology, vol. 1, pp. 560 - 562, http://dx.doi.org/10.4161/onci.19368

Dorado J; Lonardo E; Miranda-Lorenzo I; Heeschen C, 2011, 'Pancreatic cancer stem cells: New insights and perspectives', Journal of Gastroenterology, vol. 46, pp. 966 - 973, http://dx.doi.org/10.1007/s00535-011-0422-x

Oemrawsingh RM; Lenderink T; Akkerhuis KM; Heeschen C; Baldus S; Fichtlscherer S; Hamm CW; Simoons ML; Boersma E, 2011, 'Multimarker risk model containing troponin-T, interleukin 10, myeloperoxidase and placental growth factor predicts long-term cardiovascular risk after non-ST-segment elevation acute coronary syndrome', Heart, vol. 97, pp. 1061 - 1066, http://dx.doi.org/10.1136/hrt.2010.197392

Leicht SF; Schwarz TM; Hermann PC; Seissler J; Aicher A; Heeschen C, 2011, 'Adiponectin pretreatment counteracts the detrimental effect of a diabetic environment on endothelial progenitors', Diabetes, vol. 60, pp. 652 - 661, http://dx.doi.org/10.2337/db10-0240

Lonardo E; Hermann PC; Mueller MT; Huber S; Balic A; Miranda-Lorenzo I; Zagorac S; Alcala S; Rodriguez-Arabaolaza I; Ramirez JC, 2011, 'Nodal/activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy', Cell Stem Cell, vol. 9, pp. 433 - 446, http://dx.doi.org/10.1016/j.stem.2011.10.001

Gallmeier E; Hermann PC; Mueller MT; Machado JG; Ziesch A; De Toni EN; Palagyi A; Eisen C; Ellwart JW; Rivera J, 2011, 'Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133⁺tumor-initiating', Stem Cells, vol. 29, pp. 418 - 429, http://dx.doi.org/10.1002/stem.595

Hermann PC; Bhaskar S; Cioffi M; Heeschen C, 2010, 'Cancer stem cells in solid tumors', Seminars in Cancer Biology, vol. 20, pp. 77 - 84, http://dx.doi.org/10.1016/j.semcancer.2010.03.004

Saif J; Schwarz TM; Chau DYS; Henstock J; Sami P; Leicht SF; Hermann PC; Alcala S; Mulero F; Shakesheff KM, 2010, 'Combination of injectable multiple growth factor-releasing scaffolds and cell therapy as an advanced modality to enhance tissue neovascularization', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, pp. 1897 - 1904, http://dx.doi.org/10.1161/ATVBAHA.110.207928

Mueller MT; Hermann PC; Heeschen C, 2010, 'Cancer stem cells as new therapeutic target to prevent tumour progression and metastasis', Frontiers in Bioscience - Elite, vol. 2 E, pp. 602 - 613

Lonardo E; Hermann PC; Heeschen C, 2010, 'Pancreatic cancer stem cells - update and future perspectives', Molecular Oncology, vol. 4, pp. 431 - 442, http://dx.doi.org/10.1016/j.molonc.2010.06.002

de Boer R; Vrooman HA; Ikram MA; Vernooij MW; Breteler MMB; van der Lugt A; Niessen WJ, 2010, 'Accuracy and reproducibility study of automatic MRI brain tissue segmentation methods', NeuroImage, vol. 51, pp. 1047 - 1056, http://dx.doi.org/10.1016/j.neuroimage.2010.03.012

Aicher A; Heeschen C; Feil S; Hofmann F; Mendelsohn ME; Feil R; Dimmeler S, 2009, 'CGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis', PLoS ONE, vol. 4, http://dx.doi.org/10.1371/journal.pone.0004879

Herrler T; Leicht SF; Huber S; Hermann PC; Schwarz TM; Kopp R; Heeschen C, 2009, 'Prostaglandin e positively modulates endothelial progenitor cell homeostasis: An advanced treatment modality for autologous cell therapy', Journal of Vascular Research, vol. 46, pp. 333 - 346, http://dx.doi.org/10.1159/000189794

Saif J; Heeschen C; Aicher A, 2009, 'Editorial: Add some fat to vascular progenitor cell therapy', Circulation Research, vol. 104, pp. 1330 - 1332, http://dx.doi.org/10.1161/CIRCRESAHA.109.200469

Mueller MT; Hermann PC; Witthauer J; Rubio-Viqueira B; Leicht SF; Huber S; Ellwart JW; Mustafa M; Bartenstein P; D'Haese JG, 2009, 'Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer', Gastroenterology, vol. 137, pp. 1102 - 1113, http://dx.doi.org/10.1053/j.gastro.2009.05.053

Hermann PC; Mueller MT; Heeschen C, 2009, 'Pancreatic cancer stem cells - Insights and perspectives', Expert Opinion on Biological Therapy, vol. 9, pp. 1271 - 1278, http://dx.doi.org/10.1517/14712590903246362

Aicher A; Kollet O; Heeschen C; Liebner S; Urbich C; Ihling C; Orlandi A; Lapidot T; Zeiher AM; Dimmeler S, 2008, 'The wnt antagonist dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche', Circulation Research, vol. 103, pp. 796 - 803, http://dx.doi.org/10.1161/CIRCRESAHA.107.172718

Hermann PC; Huber SL; Heeschen C, 2008, 'Metastatic cancer stem cells: A new target for anti-cancer therapy?', Cell Cycle, vol. 7, pp. 188 - 193, http://dx.doi.org/10.4161/cc.7.2.5326

Herrler T; Böhm M; Heeschen C, 2008, 'More good reasons for adherence to statin therapy during acute coronary syndromes', European Heart Journal, vol. 29, pp. 2061 - 2063, http://dx.doi.org/10.1093/eurheartj/ehn348

Camaj P; Andrassy J; Heeschen C; Jauch KW; Geissler EK; Graeb C, 2008, 'Use of murine mesenchymal stem cells for the expression of donor-specific MHC class I molecules for donor-specific immunosuppression in allogeneic organ transplantation', Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft, vol. 20, pp. 31 - 32

Hermann PC; Huber SL; Herrler T; Von Hesler C; Andrassy J; Kevy SV; Jacobson MS; Heeschen C, 2008, 'Concentration of bone marrow total nucleated cells by a point-of-care device provides a high yield and preserves their functional activity', Cell Transplantation, vol. 16, pp. 1059 - 1069, http://dx.doi.org/10.3727/000000007783472363

Ghanem A; Troatz C; Elhafi N; Dewald O; Heeschen C; Nickenig G; Stypmann J; Tiemann K, 2008, 'Quantitation of Myocardial Borderzone Using Reconstructive 3-D Echocardiography After Chronic Infarction in Rats-Incremental Value of Low-Dose Dobutamine', Ultrasound in Medicine and Biology, vol. 34, pp. 559 - 566, http://dx.doi.org/10.1016/j.ultrasmedbio.2007.09.013

Kissel CK; Lehmann R; Assmus B; Aicher A; Honold J; Fischer-Rasokat U; Heeschen C; Spyridopoulos I; Dimmeler S; Zeiher AM, 2007, 'Selective Functional Exhaustion of Hematopoietic Progenitor Cells in the Bone Marrow of Patients With Postinfarction Heart Failure', Journal of the American College of Cardiology, vol. 49, pp. 2341 - 2349, http://dx.doi.org/10.1016/j.jacc.2007.01.095

Hermann PC; Huber SL; Herrler T; Aicher A; Ellwart JW; Guba M; Bruns CJ; Heeschen C, 2007, 'Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer', Cell Stem Cell, vol. 1, pp. 313 - 323, http://dx.doi.org/10.1016/j.stem.2007.06.002

Aicher A; Rentsch M; Sasaki KI; Ellwart JW; Fändrich F; Siebert R; Cooke JP; Dimmeler S; Heeschen C, 2007, 'Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia', Circulation Research, vol. 100, pp. 581 - 589, http://dx.doi.org/10.1161/01.RES.0000259562.63718.35

Aicher A; Dimmeler S; Heeschen C, 2007, 'Nonbone marrow-derived endothelial progenitor cells: What is their exact location?', Circulation Research, vol. 101, http://dx.doi.org/10.1161/CIRCRESAHA.107.162438

Huber S; Bruns CJ; Schmid G; Hermann PC; Conrad C; Niess H; Huss R; Graeb C; Jauch KW; Heeschen C, 2007, 'Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis', Kidney International, vol. 71, pp. 771 - 777, http://dx.doi.org/10.1038/sj.ki.5002112

Schmid G; Guba M; Ischenko I; Papyan A; Joka M; Schrepfer S; Bruns CJ; Jauch KW; Heeschen C; Graeb C, 2007, 'The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1', Journal of Cellular Biochemistry, vol. 101, pp. 259 - 270, http://dx.doi.org/10.1002/jcb.21181

Weber M; Rabenau B; Stanisch M; Nef HM; Möllmann H; Elsässer A; Mitrovic V; Heeschen C; Hamm C, 2007, 'Influence of sample type on soluble CD40 ligand assessment in patients with acute coronary syndromes', Thrombosis Research, vol. 120, pp. 811 - 814, http://dx.doi.org/10.1016/j.thromres.2007.01.014

Conrad C; Gupta R; Mohan H; Niess H; Bruns CJ; Kopp R; von Luettichau I; Guba M; Heeschen C; Jauch KW, 2007, 'Genetically engineered stem cells for therapeutic gene delivery', Current Gene Therapy, vol. 7, pp. 249 - 260, http://dx.doi.org/10.2174/156652307781369119

Heeschen C; Chang E; Aicher A; Cooke JP, 2006, 'Endothelial Progenitor Cells Participate in Nicotine-Mediated Angiogenesis', Journal of the American College of Cardiology, vol. 48, pp. 2553 - 2560, http://dx.doi.org/10.1016/j.jacc.2006.07.066

Honold J; Lehmann R; Heeschen C; Walter DH; Assmus B; Sasaki KI; Martin H; Haendeler J; Zeiher AM; Dimmeler S, 2006, 'Effects of granulocyte colony simulating factor on functional activities of endothelial progenitor cells in patients with chronic ischemic heart disease', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, pp. 2238 - 2243, http://dx.doi.org/10.1161/01.ATV.0000240248.55172.dd

Aicher A; Heeschen C; Sasaki KI; Urbich C; Zeiher AM; Dimmeler S, 2006, 'Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: A new modality to increase efficacy of cell therapy in chronic hind limb ischemia', Circulation, vol. 114, pp. 2823 - 2830, http://dx.doi.org/10.1161/CIRCULATIONAHA.106.628623

Lenderink T; Heeschen C; Fichtlscherer S; Dimmeler S; Hamm CW; Zeiher AM; Simoons ML; Boersma E, 2006, 'Elevated placental growth factor levels are associated with adverse outcomes at four-year follow-up in patients with acute coronary syndromes', Journal of the American College of Cardiology, vol. 47, pp. 307 - 311, http://dx.doi.org/10.1016/j.jacc.2005.08.063

Weber M; Rabenau B; Stanisch M; Elsaesser A; Mitrovic V; Heeschen C; Hamm C, 2006, 'Influence of sample type and storage conditions on soluble CD40 ligand assessment', Clinical Chemistry, vol. 52, pp. 888 - 891, http://dx.doi.org/10.1373/clinchem.2005.062083

Fichtlscherer S; Schmidt-Lucke C; Bojunga S; Rössig L; Heeschen C; Dimmeler S; Zeiher AM, 2006, 'Differential effects of short-term lipid lowering with ezetimibe and statins on endothelial function in patients with CAD: Clinical evidence for 'pleiotropic' functions of statin therapy', European Heart Journal, vol. 27, pp. 1182 - 1190, http://dx.doi.org/10.1093/eurheartj/ehi881

Sasaki KI; Heeschen C; Aicher A; Ziebart T; Honold J; Urbich C; Rossig L; Koehl U; Koyanagi M; Mohamed A, 2006, 'Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 14537 - 14541, http://dx.doi.org/10.1073/pnas.0604144103

Urbich C; Aicher A; Heeschen C; Dernbach E; Hofmann WK; Zeiher AM; Dimmeler S, 2005, 'Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells', Journal of Molecular and Cellular Cardiology, vol. 39, pp. 733 - 742, http://dx.doi.org/10.1016/j.yjmcc.2005.07.003

Chavakis E; Aicher A; Heeschen C; Sasaki KI; Kaiser R; El Makhfi N; Urbich C; Peters T; Scharffetter-Kochanek K; Zeiher AM, 2005, 'Role of β2-integrins for homing and neovascularization capacity of endothelial progenitor cells', Journal of Experimental Medicine, vol. 201, pp. 63 - 72, http://dx.doi.org/10.1084/jem.20041402

Achan V; Ho HK; Heeschen C; Stuehlinger M; Jang JJ; Kimoto M; Vallance P; Cooke JP, 2005, 'ADMA regulates angiogenesis: Genetic and metabolic evidence', Vascular Medicine, vol. 10, pp. 7 - 14, http://dx.doi.org/10.1191/1358863x05vm580oa

Heeschen C, 2005, 'Biomarkers in acute coronary syndromes and their role in diabetic patients', Diabetes and Vascular Disease Research, vol. 2, pp. 122 - 127, http://dx.doi.org/10.3132/dvdr.2005.019

Hartmann B; Schmid G; Graeb C; Bruns CJ; Fischereder M; Jauch KW; Heeschen C; Guba M, 2005, 'Biochemical monitoring of mTOR inhibitor-based immunosuppression following kidney transplantation: A novel approach for tailored immunosuppressive therapy', Kidney International, vol. 68, pp. 2593 - 2598, http://dx.doi.org/10.1111/j.1523-1755.2005.00731.x

Walter DH; Haendeler J; Reinhold J; Rochwalsky U; Seeger F; Honold J; Hoffmann J; Urbich C; Lehmann R; Arenzana-Seisdesdos F, 2005, 'Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endothelial progenitor cells from patients with coronary artery disease', Circulation Research, vol. 97, pp. 1142 - 1151, http://dx.doi.org/10.1161/01.RES.0000193596.94936.2c

Rössig L; Urbich C; Brühl T; Dernbach E; Heeschen C; Chavakis E; Sasaki KI; Aicher D; Diehl F; Seeger F, 2005, 'Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells', Journal of Experimental Medicine, vol. 201, pp. 1825 - 1835, http://dx.doi.org/10.1084/jem.20042097

Conti E; Volpe M; Carrozza C; Marzo F; Zuppi C; Crea F; Andreotti F; Heeschen C; Dimmeler S; Fichtlscherer S, 2005, 'Pregnancy-associated plasma protein-A and acute coronary syndromes: Cause or consequence? [2] (multiple letters)', Journal of the American College of Cardiology, vol. 46, pp. 1583 - 1585, http://dx.doi.org/10.1016/j.jacc.2005.07.033

Urbich C; Heeschen C; Aicher A; Sasaki KI; Bruhl T; Farhadi MR; Vajkoczy P; Hofmann WK; Peters C; Pennacchio LA, 2005, 'Cathepsin L is required for endothelial progenitor cell-induced neovascularization', Nature Medicine, vol. 11, pp. 206 - 213, http://dx.doi.org/10.1038/nm1182

Heeschen C; Dimmeler S; Fichtlscherer S; Zeiher AM, 2005, 'Pregnancy-associated plasma protein-A and acute coronary syndromes: Cause or consequence? - Reply', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 46, pp. 1584 - 1585, http://dx.doi.org/10.1016/j.jacc.2005.07.034

Heeschen C; Dimmeler S; Hamm CW; Fichtscherer S; Simoons ML; Zeiher AM, 2005, 'Pregancy-associated plasma protein-a levels in patients with acute coronary syndromes - Comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 45, pp. 229 - 237, http://dx.doi.org/10.1016/j.jacc.2004.09.064

Potente M; Urbich C; Sasaki KI; Hofmann WK; Heeschen C; Aicher A; Kollipara R; DePinho RA; Zeiher AM; Dimmeler S, 2005, 'Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization', Journal of Clinical Investigation, vol. 115, pp. 2382 - 2392, http://dx.doi.org/10.1172/JCI23126

Heeschen C; Dimmeler S; Hamm CW; Fichtlscherer S; Simoons ML; Zeiher AM, 2005, 'Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: Comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis', Journal of the American College of Cardiology, vol. 45, pp. 229 - 237, http://dx.doi.org/10.1016/j.jacc.2004.09.060

Aicher A; Heeschen C; Mildner-Rihm C; Urbich C; Ihling C; Technau-Ihling K; Zeiher AM; Dimmeler S, 2004, 'Erratum: Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells (Nature Medicine (2003) 9 (1370-1376))', Nature Medicine, vol. 10, pp. 999, http://dx.doi.org/10.1038/nm0904-999

Rössig L; Fichtlscherer S; Heeschen C; Berger J; Dimmeler S; Zeiher AM, 2004, 'The pro-apoptotic serum activity is an independent mortality predictor of patients with heart failure', European Heart Journal, vol. 25, pp. 1620 - 1625, http://dx.doi.org/10.1016/j.ehj.2004.06.036

Aicher A; Heeschen C; Dimmeler S, 2004, 'The role of NOS3 in stem cell mobilization', Trends in Molecular Medicine, vol. 10, pp. 421 - 425, http://dx.doi.org/10.1016/j.molmed.2004.07.007

Miranville A; Heeschen C; Sengenès C; Curat CA; Busse R; Bouloumié A, 2004, 'Improvement of postnatal neovascularization by human adipose tissue-derived stem cells', Circulation, vol. 110, pp. 349 - 355, http://dx.doi.org/10.1161/01.CIR.0000135466.16823.D0

Heeschen C; Hamm CW; Mitrovic V; Lantelme NH; White HD, 2004, 'N-terminal pro-B-type natriuretic peptide levels for dynamic risk stratification of patients with acute coronary syndromes', Circulation, vol. 110, pp. 3206 - 3212, http://dx.doi.org/10.1161/01.CIR.0000147611.92021.2B

Fichtlscherer S; Breuer S; Heeschen C; Dimmeler S; Zeiher AM, 2004, 'Interleukin-10 serum levels and systemic endothelial vasoreactivity in patients with coronary artery disease', Journal of the American College of Cardiology, vol. 44, pp. 44 - 49, http://dx.doi.org/10.1016/j.jacc.2004.02.054

Brenner W; Aicher A; Eckey T; Massoudi S; Zuhayra M; Koehl U; Heeschen C; Kampen WU; Zeiher AM; Dimmeler S, 2004, 'In-111-labeled CD34+ hematopoietic progenitor cells in a rat myocardial infarction model', JOURNAL OF NUCLEAR MEDICINE, vol. 45, pp. 512 - 518, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000220098700032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Heeschen C; Dimmeler S; Fichtlscherer S; Hamm CW; Berger J; Simoons ML; Zeiher AM, 2004, 'Prognostic Value of Placental Growth Factor in Patients with Acute Chest Pain', Journal of the American Medical Association, vol. 291, pp. 435 - 441, http://dx.doi.org/10.1001/jama.291.4.435

Goldmann BU; Langenbrink L; Matschuck G; Heeschen C; Kolbe-Busch S; Niederau C; Katz N; Wenserit C; Lestin HG; Brinker K, 2004, 'Quantitative bedside testing of troponin T: Is it equal to laboratory testing? The cardiac reader troponin T (CARE T) study', Clinical Laboratory, vol. 50, pp. 1 - 10

Laufs U; Wassmann S; Schackmann S; Heeschen C; Böhm M; Nickenig G, 2004, 'Beneficial effects of statins in patients with non-ischemic heart failure', Zeitschrift fur Kardiologie, vol. 93, pp. 103 - 108, http://dx.doi.org/10.1007/s00392-004-1005-0

Brenner W; Aicher A; Eckey T; Massoudi S; Zuhayra M; Koehl U; Heeschen C; Kampen WU; Zeiher AM; Dimmeler S, 2004, '¹¹¹In-labeled CD34+ hematopoietic progenitor cells in a rat myocardial infarction model', Journal of Nuclear Medicine, vol. 45, pp. 512 - 518

Heeschen C; Lehmann R; Honold J; Assmus B; Aicher A; Walter DH; Martin H; Zeiher AM; Dimmeler S, 2004, 'Profoundly Reduced Neovascularization Capacity of Bone Marrow Mononuclear Cells Derived from Patients with Chronic Ischemic Heart Disease', Circulation, vol. 109, pp. 1615 - 1622, http://dx.doi.org/10.1161/01.CIR.0000124476.32871.E3

Fichtlscherer S; Heeschen C; Zeiher AM, 2004, 'Inflammatory markers and coronary artery disease', Current Opinion in Pharmacology, vol. 4, pp. 124 - 131, http://dx.doi.org/10.1016/j.coph.2004.01.002

Brühl T; Heeschen C; Aicher A; Jadidi AS; Haendeler J; Hoffmann J; Schneider MD; Zeiher AM; Dimmeler S; Rössig L, 2004, 'p21^Cip1Levels Differentially Regulate Turnover of Mature Endothelial Cells, Endothelial Progenitor Cells, and In Vivo Neovascularization', Circulation Research, vol. 94, pp. 686 - 692, http://dx.doi.org/10.1161/01.RES.0000119922.71855.56

Heeschen C; Hamm CW; Zeiher AM, 2003, 'Soluble CD40 ligand in acute coronary syndromes - Reply', NEW ENGLAND JOURNAL OF MEDICINE, vol. 348, pp. 2576 - 2577, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183577200017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Zhu BQ; Heeschen C; Sievers RE; Karliner JS; Parmley WW; Glantz SA; Cooke JP, 2003, 'Second hand smoke stimulates tumor angiogenesis and growth', Cancer Cell, vol. 4, pp. 191 - 196, http://dx.doi.org/10.1016/S1535-6108(03)00219-8

Baldus S; Heeschen C; Meinertz T; Zeiher AM; Eiserich JP; Münzel T; Simoons ML; Hamm CW, 2003, 'Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes', Circulation, vol. 108, pp. 1440 - 1445, http://dx.doi.org/10.1161/01.CIR.0000090690.67322.51

Heeschen C; Weis M; Cooke JP, 2003, 'Nicotine promotes arteriogenesis', Journal of the American College of Cardiology, vol. 41, pp. 489 - 496, http://dx.doi.org/10.1016/S0735-1097(02)02818-8

Aicher A; Heeschen C; Mohaupt M; Cooke JP; Zeiher AM; Dimmeler S, 2003, 'Nicotine strongly activates dendritic cell-mediated adaptive immunity: Potential role for progression of atherosclerotic lesions', Circulation, vol. 107, pp. 604 - 611, http://dx.doi.org/10.1161/01.CIR.0000047279.42427.6D

Heeschen C; Aicher A; Lehmann R; Fichtlscherer S; Vasa M; Urbich C; Mildner-Rihm C; Martin H; Zeiher AM; Dimmeler S, 2003, 'Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization', Blood, vol. 102, pp. 1340 - 1346, http://dx.doi.org/10.1182/blood-2003-01-0223

Heeschen C; Dimmeler S; Hamm CW; Fichtlscherer S; Boersma E; Simoons ML; Zeiher AM, 2003, 'Serum level of the antiinflammatory cytokine interleukin-10 is an important prognostic determinant in patients with acute coronary syndromes', Circulation, vol. 107, pp. 2109 - 2114, http://dx.doi.org/10.1161/01.CIR.0000065232.57371.25

Aicher A; Heeschen C; Mildner-Rihm C; Urbich C; Ihling C; Technau-Ihling K; Zeiher AM; Dimmeler S, 2003, 'Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells', Nature Medicine, vol. 9, pp. 1370 - 1376, http://dx.doi.org/10.1038/nm948

Heeschen C; Dimmeler S; Hamm CW; Boersma E; Zeiher AM; Simoons ML, 2003, 'Prognostic significance of angiogenic growth factor serum levels in patients with acute coronary syndromes', Circulation, vol. 107, pp. 524 - 530, http://dx.doi.org/10.1161/01.CIR.0000048183.37648.1A

Urbich C; Heeschen C; Aicher A; Dernbach E; Zeiher AM; Dimmeler S, 2003, 'Relevance of Monocytic Features for Neovascularization Capacity of Circulating Endothelial Progenitor Cells', Circulation, vol. 108, pp. 2511 - 2516, http://dx.doi.org/10.1161/01.CIR.0000096483.29777.50

Heeschen C; Dimmeler S; Hamm CW; Van den Brand MJ; Boersma E; Zeiher AM; Simoons ML, 2003, 'Soluble CD40 ligand in acute coronary syndromes', New England Journal of Medicine, vol. 348, pp. 1104 - 1111, http://dx.doi.org/10.1056/NEJMoa022600

Heeschen C; Hamm CW; Laufs U; Böhm M; Snapinn S; White HD, 2003, 'Withdrawal of statins in patients with acute coronary syndromes.', Circulation, vol. 107

Kritharides L; Lau GT; Freedman B; Conde ID; Kleiman NS; Heeschen C; Hamm CW; Zeiher AM, 2003, 'Soluble CD40 ligand in acute coronary syndromes [1] (multiple letters)', New England Journal of Medicine, vol. 348, pp. 2575 - 2577, http://dx.doi.org/10.1056/NEJM200306193482516

Cooke JP; Weis M; Glassford AJ; Heeschen C, 2002, 'Biphasic effects of statins on angiogenesis - Response', CIRCULATION, vol. 106, pp. E47 - E47, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000177993100003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Roffi M; Chew DP; Mukherjee D; Bhatt DL; White JA; Moliterno DJ; Heeschen C; Hamm CW; Robbins MA; Kleiman NS, 2002, 'Platelet glycoprotein IIb/IIIa inhibition in acute coronary syndromes: Gradient of benefit related to the revascularization strategy', European Heart Journal, vol. 23, pp. 1441 - 1448, http://dx.doi.org/10.1053/euhj.2002.3160

Heeschen C; Weis M; Aicher A; Dimmeler S; Cooke JP, 2002, 'A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors', Journal of Clinical Investigation, vol. 110, pp. 527 - 536, http://dx.doi.org/10.1172/JCI0214676

Weis M; Heeschen C; Glassford AJ; Cooke JP, 2002, 'Statins have biphasic effects on angiogenesis', Circulation, vol. 105, pp. 739 - 745, http://dx.doi.org/10.1161/hc0602.103393

Heeschen C; Hamm CW; Laufs U; Snapinn S; Böhm M; White HD, 2002, 'Withdrawal of statins increases event rates in patients with acute coronary syndromes', Circulation, vol. 105, pp. 1446 - 1452, http://dx.doi.org/10.1161/01.CIR.0000012530.68333.C8

Heeschen C; Jang JJ; Weis M; Pathak A; Kaji S; Hu RS; Tsao PS; Johnson FL; Cooke JP, 2001, 'Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis', Nature Medicine, vol. 7, pp. 833 - 839, http://dx.doi.org/10.1038/89961

Roffi M; Chew DP; Mukherjee D; Bhatt DL; White JA; Heeschen C; Hamm CW; Moliterno DJ; Califf RM; White HD, 2001, 'Platelet glycoprotein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes', Circulation, vol. 104, pp. 2767 - 2771, http://dx.doi.org/10.1161/hc4801.100029

Hamm CW; Heeschen C; Goldmann B; Vahanian A; Aügey J; Mucaya Miguel C; Rutsch W; Beiger J; Kootstni J; Simoons ML, 2000, 'Benefit of abciximab in patients with refractory unstable angina in relation to serum troponm Tlevels capture-study', Herz Kreislauf, vol. 32, pp. 52

Heeschen C; Hamm CW, 2000, 'Erratum: Difficulties with oral glycoprotein IIb/IIIa receptor antagonists (The Lancet (Jan 29 2000) 330)', Lancet, vol. 355, pp. 2000

Heeschen C; Hamm CW, 2000, 'Therapeutic efficiency of tirofiban in acute coronary syndromes - Reply', LANCET, vol. 355, pp. 930 - 931, http://dx.doi.org/10.1016/S0140-6736(05)74134-9

Heeschen C; Hamm CW, 2000, 'Difficulties with oral platelet glycoprotein IIb/IIIa receptor antagonists', Lancet, vol. 355, pp. 330 - 331, http://dx.doi.org/10.1016/S0140-6736(99)00464-X

Heeschen C; Hamm CW; Bruemmer J; Simoons ML, 2000, 'Predictive value of C-reactive protein and troponin T in patients with unstable angina: A comparative analysis', Journal of the American College of Cardiology, vol. 35, pp. 1535 - 1542, http://dx.doi.org/10.1016/S0735-1097(00)00581-7

Heeschen C; Deu A; Langenbrink L; Goldmann BU; Hamm CW, 2000, 'Analytical and diagnostic performance of troponin assays in patients suspicious for acute coronary syndromes', Clinical Biochemistry, vol. 33, pp. 359 - 368, http://dx.doi.org/10.1016/S0009-9120(00)00144-2

Tschentscher P; Heeschen C; Hamm C; Wagener C, 2000, 'High background levels compromise the use of cardiac troponin I RNA detection in peripheral blood as a diagnostic tool in cardiology', International Journal of Clinical and Laboratory Research, vol. 30, pp. 13 - 15, http://dx.doi.org/10.1007/s005990070027

Burnett JR; Blennerhassett J; McConnell W; O'Leary PC; Vasikaran SD; Heeschen C; Hamm CW; Biondi-Zoccai GGL; Agostoni P, 2000, 'Therapeutic efficiency of tirofiban in acute coronary syndromes (multiple letters)', Lancet, vol. 355, pp. 929 - 931

Heeschen C; Hamm CW, 2000, 'Difficulties with oral platelet glycoprotein IIb/IIIa receptor antagonists - Commentary (vol 355, pg 330, 2000)', LANCET, vol. 355, pp. 2000 - 2000, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000087381900058&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Heeschen C; Goldmann BU; Langenbrink L; Matschuck G; Hamm CW, 1999, 'Evaluation of a rapid whole blood ELISA for quantification of troponin I in patients with acute chest pain', Clinical Chemistry, vol. 45, pp. 1789 - 1796

Heeschen C; Schegloff EA, 1999, 'Agrammatism, adaptation theory, conversation analysis: On the role of so-called telegraphic style in talk-in-interaction', Aphasiology, vol. 13, pp. 365 - 405, http://dx.doi.org/10.1080/026870399402145

Heeschen C; Hamm CW; Goldmann B; Deu A; Langenbrink L; White HD, 1999, 'Troponin concentrations for stratification of patients with acute coronary syndromes in relation to therapeutic efficacy of tirofiban', Lancet, vol. 354, pp. 1757 - 1762, http://dx.doi.org/10.1016/S0140-6736(99)10285-X

Hamm CW; Heeschen C; Goldmann B; Vahanian A; Adgey J; Miguel CM; Rutsch W; Berger J; Kootstra J; Simoons ML, 1999, 'Benefit of abciximab in patients with refractory unstable angina in relation to serum troponin T levels', New England Journal of Medicine, vol. 340, pp. 1623 - 1629, http://dx.doi.org/10.1056/NEJM199905273402103

Lev EI; Osende JI; Zaman AG; Hamm CW; Heeschen C, 1999, 'Troponin T levels and abciximab therapy in unstable angina [5] (multiple letters)', New England Journal of Medicine, vol. 341, pp. 1084 - 1085, http://dx.doi.org/10.1056/NEJM199909303411416

Hamm CW; Heeschen C; Meinertz T, 1998, 'Cardiac troponins in patients with chest pain - Reply', NEW ENGLAND JOURNAL OF MEDICINE, vol. 338, pp. 1315 - 1315, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000073335800024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Heeschen C; Goldmann BU; Moeller RH; Hamm CW, 1998, 'Analytical performance and clinical application of a new rapid bedside assay for the detection of serum cardiac troponin I', Clinical Chemistry, vol. 44, pp. 1925 - 1930

Stryer DB; Waxman DA; Katus HA; Frey N; Muller-Bardorff M; Hamm CW; Heeschen C; Meinertz T, 1998, 'Cardiac troponins in patients with chest pain [3] (multiple letters)', New England Journal of Medicine, vol. 338, pp. 1314 - 1315, http://dx.doi.org/10.1056/NEJM199804303381815

Heeschen C; Hamm CW; Goldmann BU; Moeller RH; Meinertz T, 1998, 'Cost-effectiveness of a rapid test for troponin in patients admitted with acute left-chest pain', Deutsche Medizinische Wochenschrift, vol. 123, pp. 1229 - 1234

Hamm CW; Goldmann BU; Heeschen C; Kreymann G; Berger J; Meinertz T, 1997, 'Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or troponin I', New England Journal of Medicine, vol. 337, pp. 1648 - 1653, http://dx.doi.org/10.1056/NEJM199712043372302

Davies E; Gawad Y; Takahashi M; Shi Q; Lam P; Styba G; Lau A; Heeschen C; Usategui M; Jackowski G, 1997, 'Analytical performance and clinical utility of a sensitive immunoassay for determination of human cardiac troponin I', Clinical Biochemistry, vol. 30, pp. 479 - 490, http://dx.doi.org/10.1016/S0009-9120(97)00111-2

Kolk H; Heeschen C, 1996, 'The malleability of agrammatic symptoms: A reply to Hesketh and Bishop', Aphasiology, vol. 10, pp. 81 - 96, http://dx.doi.org/10.1080/02687039608248399

Professor Christopher Heeschen

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