Associate Professor Yann Gambin

McCann AJ; Lou J; Moustaqil M; Graus MS; Blum A; Fontaine F; Liu H; Luu W; Rudolffi-Soto P; Koopman P; Sierecki E; Gambin Y; Meunier FA; Liu Z; Hinde E; Francois M, 2021, 'A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity', Nucleic Acids Research, vol. 49, pp. 10931 - 10955, http://dx.doi.org/10.1093/nar/gkab820

Clabbers MTB; Holmes S; Muusse TW; Vajjhala P; Thygesen SJ; Malde AK; Hunter DJB; Croll TI; Flueckiger L; Nanson JD; Rahaman MH; Aquila A; Hunter MS; Liang M; Yoon CH; Zhao J; Zatsepin NA; Abbey B; Sierecki E; Gambin Y; Stacey KJ; Darmanin C; Kobe B; Xu H; Ve T, 2021, 'MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography', ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, vol. 77, pp. C295 - C295, http://dx.doi.org/10.1107/s0108767321093879

Holmes S; Clabbers MTB; Muusse TW; Vajjhala PR; Thygesen SJ; Malde AK; Hunter DJB; Croll TI; Flueckiger L; Nanson JD; Rahaman MH; Aquila A; Hunter MS; Liang M; Yoon CH; Zhao J; Zatsepin NA; Abbey B; Sierecki E; Gambin Y; Stacey KJ; Darmanin C; Kobe B; Xu H; Ve T, 2021, 'MyD88 TIR domain higher-order assembly interactions revealed by serial femtosecond crystallography', ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, vol. 77, pp. C849 - C849, http://dx.doi.org/10.1107/s0108767321088498

McMahon KA; Stroud DA; Gambin Y; Tillu VA; Bastiani M; Sierecki E; Polinkovsky M; Hall TE; Gomez GA; Wu Y; Parat MO; Martel N; Lo HP; Khanna KK; Alexandrov K; Daly R; Yap AS; Ryan MT; Parton RG, 2021, 'Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response', eLife, vol. 10, http://dx.doi.org/10.7554/eLife.61407

Bhumkar A; Magnan C; Lau D; Jun ESW; Dzamko N; Gambin Y; Sierecki E, 2021, 'Single-Molecule Counting Coupled to Rapid Amplification Enables Detection of α-Synuclein Aggregates in Cerebrospinal Fluid of Parkinson's Disease Patients', Angewandte Chemie - International Edition, vol. 60, pp. 11874 - 11883, http://dx.doi.org/10.1002/anie.202014898

Bhumkar A; Magnan C; Lau D; Jun ESW; Dzamko N; Gambin Y; Sierecki E, 2021, 'Single‐Molecule Counting Coupled to Rapid Amplification Enables Detection of α‐Synuclein Aggregates in Cerebrospinal Fluid of Parkinson's Disease Patients', Angewandte Chemie, vol. 133, pp. 11981 - 11990, http://dx.doi.org/10.1002/ange.202014898

Rae J; Ferguson C; Ariotti N; Webb RI; Cheng HH; Mead JL; Riches JD; Hunter DJB; Martel N; Baltos J; Christopoulos A; Bryce NS; Cagigas ML; Fonseka S; Sayre ME; Hardeman EC; Gunning PW; Gambin Y; Hall TE; Parton RG, 2021, 'A robust method for particulate detection of a genetic tag for 3D electron microscopy', eLife, vol. 10, http://dx.doi.org/10.7554/ELIFE.64630

Böcking T; Jacques DA; Lau D; Walsh JC; Dickson CF; Tuckwell A; Stear JH; Hunter DJB; Bhumkar A; Shah V; Turville SG; Sierecki E; Gambin Y, 2021, 'Rapid HIV-1 capsid interaction screening using fluorescence fluctuation spectroscopy', Analytical Chemistry, vol. 93, pp. 3786 - 3793, http://dx.doi.org/10.1021/acs.analchem.0c04250

Shanmugam N; Baker MODG; Sanz-Hernandez M; Sierecki E; Gambin Y; Steain M; Pham CLL; Sunde M, 2021, 'Herpes simplex virus encoded ICP6 protein forms functional amyloid assemblies with necroptosis-associated host proteins', Biophysical Chemistry, vol. 269, http://dx.doi.org/10.1016/j.bpc.2020.106524

Ariotti N; Wu Y; Okano S; Gambin Y; Follett J; Rae J; Ferguson C; Teasdale RD; Alexandrov K; Meunier FA; Hill MM; Parton RG, 2021, 'An inverted CAV1 (caveolin 1) topology defines novel autophagy-dependent exosome secretion from prostate cancer cells', Autophagy, vol. 17, pp. 2200 - 2216, http://dx.doi.org/10.1080/15548627.2020.1820787

Moustaqil M; Ollivier E; Chiu HP; Van Tol S; Rudolffi-Soto P; Stevens C; Bhumkar A; Hunter DJB; Freiberg AN; Jacques D; Lee B; Sierecki E; Gambin Y, 2021, 'SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species', Emerging Microbes and Infections, vol. 10, pp. 178 - 195, http://dx.doi.org/10.1080/22221751.2020.1870414

Rae J; Ferguson C; Ariotti N; Webb R; Cheng H-H; Mead J; Riches J; Hunter DJB; Martel N; Baltos J; Christopoulos A; Bryce N; Cagigas ML; Fonseka S; Hardeman E; Gunning P; Gambin Y; Hall T; Parton R, 2020, 'APEX-Gold: A genetically-encoded particulate marker for robust 3D electron microscopy', , http://dx.doi.org/10.1101/2020.10.06.328831

Steain M; Baker MODG; Pham CLL; Shanmugam N; Gambin Y; Sierecki E; McSharry BP; Avdic S; Slobedman B; Sunde M; Abendroth A, 2020, 'Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death', PLoS Pathogens, vol. 16, pp. e1008473, http://dx.doi.org/10.1371/journal.ppat.1008473

Moustaqil M; Ollivier E; Chiu H-P; Van Tol S; Rudolffi-Soto P; Stevens C; Bhumkar A; Hunter DJB; Freiberg A; Jacques D; Lee B; Sierecki E; Gambin Y, 2020, 'SARS-CoV-2 proteases cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species and the search for reservoir hosts', , http://dx.doi.org/10.1101/2020.06.05.135699

Moustaqil M; Gambin Y; Sierecki E, 2020, 'Biophysical techniques for target validation and drug discovery in transcription-targeted therapy', International Journal of Molecular Sciences, vol. 21, http://dx.doi.org/10.3390/ijms21072301

Sierecki E; Gambin Y, 2020, 'Editorial', Seminars in Cell and Developmental Biology, vol. 99, pp. 1 - 2, http://dx.doi.org/10.1016/j.semcdb.2019.11.007

O'Carroll A; Coyle J; Gambin Y, 2020, 'Prions and Prion-like assemblies in neurodegeneration and immunity: The emergence of universal mechanisms across health and disease', Seminars in Cell and Developmental Biology, vol. 99, pp. 115 - 130, http://dx.doi.org/10.1016/j.semcdb.2019.11.012

McMahon KA; Wu Y; Gambin Y; Sierecki E; Tillu VA; Hall T; Martel N; Okano S; Moradi SV; Ruelcke JE; Ferguson C; Yap AS; Alexandrov K; Hill MM; Parton RG, 2019, 'Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis', Nature Communications, vol. 10, http://dx.doi.org/10.1038/s41467-019-11111-1

Pang SS; Bayly-Jones C; Radjainia M; Spicer BA; Law RHP; Hodel AW; Parsons ES; Ekkel SM; Conroy PJ; Ramm G; Venugopal H; Bird PI; Hoogenboom BW; Voskoboinik I; Gambin Y; Sierecki E; Dunstone MA; Whisstock JC, 2019, 'The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1', Nature Communications, vol. 10, pp. 4288, http://dx.doi.org/10.1038/s41467-019-12279-2

Brown JWP; Bauer A; Polinkovsky ME; Bhumkar A; Hunter DJB; Gaus K; Sierecki E; Gambin Y, 2019, 'Single-molecule detection on a portable 3D-printed microscope', Nature Communications, vol. 10, http://dx.doi.org/10.1038/s41467-019-13617-0

Overman J; Fontaine F; Sears JW; Moustaqil M; Huang L; Meurer M; Chiang IK; Lesieur E; Patel J; Zuegg J; Pasquier E; Sierecki E; Gambin Y; Hamdan M; Khosrotehrani K; Andelfinger G; Bischoff J; Francois M, 2019, 'R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma', eLife, vol. 8, http://dx.doi.org/10.7554/eLife.43026

Monserrat-Martinez A; Gambin Y; Sierecki E, 2019, 'Thinking outside the bug: Molecular targets and strategies to overcome antibiotic resistance', International Journal of Molecular Sciences, vol. 20, http://dx.doi.org/10.3390/ijms20061255

Pham CLL; Shanmugam N; Strange M; O'Carroll A; Brown JWP; Sierecki E; Gambin Y; Steain M; Sunde M, 2019, 'Viral M45 and necroptosis-associated proteins form heteromeric amyloid assemblies', EMBO Reports, vol. 20, http://dx.doi.org/10.15252/embr.201846518

O'Carroll A; Chauvin B; Brown JWP; Meagher A; Coyle J; Schill J; Bhumkhar A; Hunter DJB; Ve T; Kobe B; Sierecki E; Gambin Y, 2018, 'Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88', BMC Biology, vol. 16, pp. 149, http://dx.doi.org/10.1186/s12915-018-0611-7

Moustaqil M; Fontaine F; Overman J; McCann A; Bailey TL; Soto PR; Bhumkar A; Giles N; Hunter DJB; Gambin Y; Francois M; Sierecki E, 2018, 'Homodimerization regulates an endothelial specific signature of the SOX18 transcription factor', Nucleic Acids Research, vol. 46, pp. 11381 - 11395, http://dx.doi.org/10.1093/nar/gky897

Steinbeck J; Ross IL; Rothnagel R; Gäbelein P; Schulze S; Giles N; Ali R; Drysdale R; Sierecki E; Gambin Y; Stahlberg H; Takahashi Y; Hippler M; Hankamer B, 2018, 'Structure of a PSI-LHCI-cyt b6f supercomplex in Chlamydomonas reinhardtii promoting cyclic electron flow under anaerobic conditions', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, pp. 10517 - 10522, http://dx.doi.org/10.1073/pnas.1809973115

Hunter DJB; Bhumkar A; Giles N; Sierecki E; Gambin Y, 2018, 'Unexpected instabilities explain batch-to-batch variability in cell-free protein expression systems', Biotechnology and Bioengineering, vol. 115, pp. 1904 - 1914, http://dx.doi.org/10.1002/bit.26604

Jung WR; Sierecki E; Bastiani M; O'Carroll A; Alexandrov K; Rae J; Johnston W; Hunter DJB; Ferguson C; Gambin Y; Ariotti N; Parton RG, 2018, 'Cell-free formation and interactome analysis of caveolae', Journal of Cell Biology, vol. 217, pp. 2141 - 2165, http://dx.doi.org/10.1083/jcb.201707004

Fontaine FR; Goodall S; Prokop JW; Howard CB; Moustaqil M; Kumble S; Rasicci DT; Osborne GW; Gambin Y; Sierecki E; Jones ML; Zuegg J; Mahler S; Francois M, 2018, 'Functional domain analysis of SOX18 transcription factor using a single-chain variable fragment-based approach', mAbs, vol. 10, pp. 596 - 606, http://dx.doi.org/10.1080/19420862.2018.1451288

Gambin Y; Giles N; O'Carroll A; Polinkovsky ME; Hunter DJB; Sierecki E, 2018, 'Corrigendum to “Single-Molecule Fluorescence Reveals the Oligomerisation and Folding Steps Driving the Prion-like Behaviour of ASC” [J. Mol. Biol. 430 (4) (February 16, 2018) 491–508] (S0022283617305946) (10.1016/j.jmb.2017.12.013))', Journal of Molecular Biology, vol. 430, pp. 1263, http://dx.doi.org/10.1016/j.jmb.2018.02.011

Ariotti N; Rae J; Giles N; Martel N; Sierecki E; Gambin Y; Hall TE; Parton RG, 2018, 'Ultrastructural localisation of protein interactions using conditionally stable nanobodies', PLoS Biology, vol. 16, http://dx.doi.org/10.1371/journal.pbio.2005473

Healey RD; Wojciechowski JP; Monserrat-Martinez A; Tan SL; Marquis CP; Sierecki E; Gambin Y; Finch AM; Thordarson P, 2018, 'Design, Synthesis, and Evaluation of N- and C-Terminal Protein Bioconjugates as G Protein-Coupled Receptor Agonists', Bioconjugate Chemistry, vol. 29, pp. 403 - 409, http://dx.doi.org/10.1021/acs.bioconjchem.7b00716

Gambin Y; Giles N; O'Carroll A; Polinkovsky M; Hunter D; Sierecki E, 2018, 'Single-Molecule Fluorescence Reveals the Oligomerization and Folding Steps Driving the Prion-like Behavior of ASC', Journal of Molecular Biology, vol. 430, pp. 491 - 508, http://dx.doi.org/10.1016/j.jmb.2017.12.013

Leitao A; Bhumkar A; Hunter DJB; Gambin Y; Sierecki E, 2018, 'Unveiling a selective mechanism for the inhibition of α-synuclein aggregation by β-synuclein', International Journal of Molecular Sciences, vol. 19, http://dx.doi.org/10.3390/ijms19020334

Hussein WM; Choi PM; Zhang C; Sierecki E; Johnston W; Jia Z; Monteiro MJ; Skwarczynski M; Gambin Y; Toth I, 2018, 'Investigating the affinity of poly tert-butyl acrylate toward Toll-Like Receptor 2', AIMS ALLERGY AND IMMUNOLOGY, vol. 2, pp. 141 - 147, http://dx.doi.org/10.3934/Allergy.2018.3.141

Moustaqil M; Bhumkar A; Gonzalez L; Raoul L; Hunter DJB; Carrive P; Sierecki E; Gambin Y, 2017, 'A split-luciferase reporter recognizing GFP and mCherry tags to facilitate studies of protein–protein interactions', International Journal of Molecular Sciences, vol. 18, http://dx.doi.org/10.3390/ijms18122681

Ve T; Vajjhala PR; Hedger A; Croll T; Dimaio F; Horsefield S; Yu X; Lavrencic P; Hassan Z; Morgan GP; Mansell A; Mobli M; O'Carroll A; Chauvin B; Gambin Y; Sierecki E; Landsberg MJ; Stacey KJ; Egelman EH; Kobe B, 2017, 'Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling', Nature Structural and Molecular Biology, vol. 24, pp. 743 - 751, http://dx.doi.org/10.1038/nsmb.3444

Fontaine F; Overman J; Moustaqil M; Mamidyala S; Salim A; Narasimhan K; Prokoph N; Robertson AAB; Lua L; Alexandrov K; Koopman P; Capon RJ; Sierecki E; Gambin Y; Jauch R; Cooper MA; Zuegg J; Francois M, 2017, 'Small-Molecule Inhibitors of the SOX18 Transcription Factor', Cell Chemical Biology, vol. 24, pp. 346 - 359, http://dx.doi.org/10.1016/j.chembiol.2017.01.003

Overman J; Fontaine F; Moustaqil M; Mittal D; Sierecki E; Sacilotto N; Zuegg J; Robertson AAB; Holmes K; Salim AA; Mamidyala S; Butler MS; Robinson AS; Lesieur E; Johnston W; Alexandrov K; Black BL; Hogan BM; De Val S; Capon RJ; Carroll JS; Bailey TL; Koopman P; Jauch R; Smyth MJ; Cooper MA; Gambin Y; Francois M, 2017, 'Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice', eLife, vol. 6, http://dx.doi.org/10.7554/eLife.21221

Sierecki E; Giles N; Bowden Q; Polinkovsky ME; Steinbeck J; Arrioti N; Rahman D; Bhumkar A; Nicovich PR; Ross I; Parton RG; Böcking T; Gambin Y, 2016, 'Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep37630

Gambin Y; Polinkovsky M; Francois B; Giles N; Bhumkar A; Sierecki E, 2016, 'Confocal Spectroscopy to Study Dimerization, Oligomerization and Aggregation of Proteins: A Practical Guide', International journal of molecular sciences, vol. 17, http://dx.doi.org/10.3390/ijms17050655

Gagoski D; Polinkovsky ME; Mureev S; Kunert A; Johnston W; Gambin Y; Alexandrov K, 2016, 'Performance benchmarking of four cell-free protein expression systems', Biotechnology and Bioengineering, vol. 113, pp. 292 - 300, http://dx.doi.org/10.1002/bit.25814

Chai YJ; Sierecki E; Tomatis VM; Gormal RS; Giles N; Morrow IC; Xia D; Götz J; Parton RG; Collins BM; Gambin Y; Meunier FA, 2016, 'Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation', Journal of Cell Biology, vol. 214, http://dx.doi.org/10.1083/jcb.201512016

Hussein WM; Choi PM; Zhang C; Su M; Sierecki E; Johnston W; Fagan V; Alexandrov K; Skwarczynski M; Gambin Y; Toth I; Simerska P, 2016, 'Evaluation of lipopeptides as toll-like receptor 2 ligands', Current Drug Delivery, vol. 13, http://dx.doi.org/10.2174/1567201813666160804114107

Gagoski D; Polinkovsky ME; Mureev S; Kunert A; Johnston W; Gambin Y; Alexandrov K, 2015, 'Performance benchmarking of four cell-free protein expression systems', Biotechnology and Bioengineering, http://dx.doi.org/10.1002/bit.25814

Martin S; Papadopulos A; Tomatis VM; Sierecki E; Malintan NT; Gormal RS; Giles N; Johnston WA; Alexandrov K; Gambin Y; Collins BM; Meunier FA, 2014, 'Increased polyubiquitination and proteasomal degradation of a Munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis', Cell Reports, vol. 9, pp. 206 - 218, http://dx.doi.org/10.1016/j.celrep.2014.08.059

Sierecki E; Stevers LM; Giles N; Polinkovsky ME; Moustaqil M; Mureev S; Johnston WA; Dahmer-Heath M; Skalamera D; Gonda TJ; Gabrielli B; Collins BM; Alexandrov K; Gambin Y, 2014, 'Rapid mapping of interactions between human SNX-BAR proteins measured in vitro by alphascreen and single-molecule spectroscopy', Molecular and Cellular Proteomics, vol. 13, pp. 2233 - 2245, http://dx.doi.org/10.1074/mcp.M113.037275

Han SP; Gambin Y; Gomez GA; Verma S; Giles N; Michael M; Wu SK; Guo Z; Johnston W; Sierecki E; Parton RG; Alexandrov K; Yap AS, 2014, 'Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens', Journal of Biological Chemistry, vol. 289, pp. 7764 - 7775, http://dx.doi.org/10.1074/jbc.M113.544478

Gambin Y; Ariotti N; McMahon KA; Bastiani M; Sierecki E; Kovtun O; Polinkovsky ME; Magenau A; Jung WR; Okano S; Zhou Y; Leneva N; Mureev S; Johnston W; Gaus K; Hancock JF; Collins BM; Alexandrov K; Parton RG, 2014, 'Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae', eLife, vol. 2014, http://dx.doi.org/10.7554/eLife.01434.001

Polinkovsky ME; Gambin Y; Banerjee PR; Erickstad MJ; Groisman A; Deniz AA, 2014, 'Ultrafast cooling reveals microsecond-scale biomolecular dynamics', Nature Communications, vol. 5, http://dx.doi.org/10.1038/ncomms6737

Brooks AJ; Dai W; O'Mara ML; Abankwa D; Chhabra Y; Pelekanos RA; Gardon O; Tunny KA; Blucher KM; Morton CJ; Parker MW; Sierecki E; Gambin Y; Gomez GA; Alexandrov K; Wilson IA; Doxastakis M; Mark AE; Waters MJ, 2014, 'Mechanism of activation of protein kinase JAK2 by the growth hormone receptor', Science, vol. 344, http://dx.doi.org/10.1126/science.1249783

Gambin Y; Ariotti N; McMahon KA; Bastiani M; Sierecki E; Kovtun O; Polinkovsky ME; Magenau A; Jung W; Okano S; Zhou Y; Leneva N; Mureev S; Johnston W; Gaus K; Hancock JF; Collins BM; Alexandrov K; Parton RG, 2014, 'Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae', eLife, vol. 3, pp. e01434, http://dx.doi.org/10.7554/eLife.01434

Gambin Y; Sierecki E; Polinkovsky M; Alexandrov K; Parton R, 2014, 'Single molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae (602.1)', The FASEB Journal, vol. 28, http://dx.doi.org/10.1096/fasebj.28.1_supplement.602.1

Sierecki E; Giles N; Polinkovsky M; Moustaqil M; Alexandrov K; Gambin Y, 2013, 'A cell-free approach to accelerate the study of protein-protein interactions in vitro', Interface Focus, vol. 3, http://dx.doi.org/10.1098/rsfs.2013.0018

Ferreon ACM; Moosa MM; Gambin Y; Deniz AA, 2012, 'Counteracting chemical chaperone effects on the single-molecule α-synuclein structural landscape', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, pp. 17826 - 17831, http://dx.doi.org/10.1073/pnas.1201802109

Tnimov Z; Guo Z; Gambin Y; Nguyen UTT; Wu YW; Abankwa D; Stigter A; Collins BM; Waldmann H; Goody RS; Alexandrov K, 2012, 'Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI', Journal of Biological Chemistry, vol. 287, pp. 26549 - 26562, http://dx.doi.org/10.1074/jbc.M112.371294

Milles S; Koehler C; Gambin Y; Deniz AA; Lemke EA, 2012, 'Intramolecular three-colour single pair FRET of intrinsically disordered proteins with increased dynamic range', Molecular BioSystems, vol. 8, pp. 2531 - 2534, http://dx.doi.org/10.1039/c2mb25135c

Gambin Y; Vandelinder V; Ferreon ACM; Lemke EA; Groisman A; Deniz AA, 2011, 'Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing', Nature Methods, vol. 8, pp. 239 - 241, http://dx.doi.org/10.1038/nmeth.1568

Gambin Y; Deniz AA, 2010, 'Multicolor single-molecule FRET to explore protein folding and binding', Molecular BioSystems, vol. 6, pp. 1540 - 1547, http://dx.doi.org/10.1039/c003024d

Gambin Y; Reffay M; Sierecki E; Homblé F; Hodges RS; Gov NS; Taulier N; Urbach W, 2010, 'Variation of the lateral mobility of transmembrane peptides with hydrophobic mismatch', Journal of Physical Chemistry B, vol. 114, pp. 3559 - 3566, http://dx.doi.org/10.1021/jp911354y

Ferreon ACM; Moran CR; Gambin Y; Deniz AA, 2010, 'Single-Molecule Fluorescence Studies of Intrinsically Disordered Proteins', Methods in enzymology, vol. 472, pp. 179 - 204, http://dx.doi.org/10.1016/S0076-6879(10)72010-3

Gambin Y; Simonnet C; Vandelinder V; Deniz A; Groisman A, 2010, 'Ultrafast microfluidic mixer with three-dimensional flow focusing for studies of biochemical kinetics', Lab on a Chip, vol. 10, pp. 598 - 609, http://dx.doi.org/10.1039/b914174j

Lemke EA; Gambin Y; Vandelinder V; Brustad EM; Liu HW; Schultz PG; Groisman A; Deniz AA, 2009, 'Microfluidic device for single-molecule experiments with enhanced photostability', Journal of the American Chemical Society, vol. 131, pp. 13610 - 13612, http://dx.doi.org/10.1021/ja9027023

Vandelinder V; Ferreon ACM; Gambin Y; Deniz AA; Groisman A, 2009, 'High-resolution temperature-concentration diagram of α-synuclein conformation obtained from a single Förster resonance energy transfer image in a microfluidic device', Analytical Chemistry, vol. 81, pp. 6929 - 6935, http://dx.doi.org/10.1021/ac901008c

Gambin Y; Schug A; Lemke EA; Lavinder JJ; Ferreon ACM; Magliery TJ; Onuchic JN; Deniz AA, 2009, 'Direct single-molecule observation of a protein living in two opposed native structures', Proceedings of the National Academy of Sciences of the United States of America, vol. 106, pp. 10153 - 10158, http://dx.doi.org/10.1073/pnas.0904461106

Ferreon ACM; Gambin Y; Lemke EA; Deniz AA, 2009, 'Interplay of α-synuclein binding and conformational switching probed by single-molecule fluorescence', Proceedings of the National Academy of Sciences of the United States of America, vol. 106, pp. 5645 - 5650, http://dx.doi.org/10.1073/pnas.0809232106

Reffay M; Gambin Y; Benabdelhak H; Phan G; Taulier N; Ducruix A; Hodges RS; Urbach W, 2009, 'Tracking membrane protein association in model membranes', PLoS ONE, vol. 4, http://dx.doi.org/10.1371/journal.pone.0005035

López-Esparza R; Guedeau-Boudeville MA; Gambin Y; Rodríguez-Beas C; Maldonado A; Urbach W, 2006, 'Interaction between poly(ethylene glycol) and two surfactants investigated by diffusion coefficient measurements', Journal of Colloid and Interface Science, vol. 300, pp. 105 - 110, http://dx.doi.org/10.1016/j.jcis.2006.03.071

Lopez-Esparza R; Guedeau-Boudeville M-A; Gambin Y; Rodriguez-Beas C; Maldonado A; Urbach W, 2006, 'Interaction between poly(ethylene glycol) and two surfactants investigated by diffusion coefficient measurements', JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 300, pp. 105 - 110, http://dx.doi.org/10.1016/j.jcis.2006.03.071

Gambin Y; Legrand O; Quake SR, 2006, 'Microfabricated rubber microscope using soft solid immersion lenses', Applied Physics Letters, vol. 88, http://dx.doi.org/10.1063/1.2194477

Gambin Y; Lopez-Esparza R; Reffay M; Sierecki E; Gov NS; Genest M; Hodges RS; Urbach W, 2006, 'Lateral mobility of proteins in liquid membranes revisited', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 2098 - 2102, http://dx.doi.org/10.1073/pnas.0511026103

Gambin Y; Massiera G; Ramos L; Ligoure C; Urbach W, 2005, 'Bounded step superdiffusion in an oriented hexagonal phase', Physical Review Letters, vol. 94, http://dx.doi.org/10.1103/PhysRevLett.94.110602

Michel E; Cipelletti L; d’Humieres E; Gambin Y; Urbach W; Porte G; Appell J, 2002, 'Self-diffusion and collective diffusion in a model viscoelastic system', Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics, vol. 66, http://dx.doi.org/10.1103/PhysRevE.66.031402

O'Carroll A; Ve T; Lau D; Giles N; Moustaqil M; Bhumkar A; Hunter D; Kobe B; Boecking T; Sierecki E; Gambin Y, 2016, 'Prion - like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, presented at Experimental Biology Meeting, San Diego, CA, 02 April 2016 - 06 April 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444005435&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Gambin Y; Sierecki E; Jung W; Ariotti N; Giles N; Bastiani M; Parton R, 2016, 'Redefining caveolae as signalling platforms: specificity of interactions on endocytic caveolae in response to stress', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, presented at Experimental Biology Meeting, San Diego, CA, 02 April 2016 - 06 April 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444003550&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Giles N; McCann A; Moustaqil M; Overman J; Fontaine F; Francois M; Sierecki E; Gambin Y, 2016, 'Tracking Dynamics of Vascular Development in Time and Space using Sox18 Dimer split-Fluorescent Protein Biosensors', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, presented at Experimental Biology Meeting, San Diego, CA, 02 April 2016 - 06 April 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444003324&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Moustaqil M; Overman J; Fontaine F; Bailey T; Francois M; Gambin Y; Sierecki E, 2016, 'Establishing a transcription factors protein network for lymphangiogenesis: identification of binding domains, impact of pathological mutations and perturbations by small molecules', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, presented at Experimental Biology Meeting, San Diego, CA, 02 April 2016 - 06 April 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444005311&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Gambin Y; Sierecki E; Jung W; Ariotti N; Giles N; Bastiani M; Parton R, 2016, 'Redefining caveolae as signalling platforms: specificity of interactions on endocytic caveolae in response to stress', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, presented at Experimental Biology Meeting, San Diego, CA, 02 April 2016 - 06 April 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444006522&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Giles N; McCann A; Moustaqil M; Overman J; Fontaine F; Francois M; Sierecki E; Gambin Y, 2016, 'Tracking Dynamics of Vascular Development in Time and Space using Sox18 Dimer split-Fluorescent Protein Biosensors', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, presented at Experimental Biology Meeting, San Diego, CA, 02 April 2016 - 06 April 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444006122&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Moustaqil M; Overman J; Fontaine F; Bailey T; Francois M; Gambin Y; Sierecki E, 2016, 'Establishing a transcription factors protein network for lymphangiogenesis: identification of binding domains, impact of pathological mutations and perturbations by small molecules', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, presented at Experimental Biology Meeting, San Diego, CA, 02 April 2016 - 06 April 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444003094&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Brooks AJ; O'Mara ML; Dai W; Abankwa D; Chhabra Y; Tunny KA; Parker MW; Sierecki E; Gambi Y; Gomez GA; Haxholm GW; Nikolajsen LF; Doxastakis M; Mark AE; Waters MJ, 2016, 'Mechanism of JAK2 Activation by the Archetype Class I Cytokine Receptor, the Growth Hormone Receptor', in BIOPHYSICAL JOURNAL, CELL PRESS, Los Angeles, CA, pp. 31A - 31A, presented at 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA, 27 February 2016 - 02 March 2016, http://dx.doi.org/10.1016/j.bpj.2015.11.233

Brooks A; Dai W; O'Mara ML; Abankwa D; Chhabra Y; Pelekanos RA; Gardon O; Tunny KA; Blucher KM; Morton CJ; Parker MW; Sierecki E; Gambin Y; Gomez GA; Alexandrov K; Wilson IA; Doxastakis M; Mark AE; Waters MJ, 2015, 'Going downstream - how does GH binding activate JAK2', in CLINICAL ENDOCRINOLOGY, WILEY, Adelaide, AUSTRALIA, pp. 16 - 16, presented at Annual Scientific Meeting of the Endocrine-Society-of-Australia, Adelaide, AUSTRALIA, 23 August 2015 - 26 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000372310400043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Brooks AJ; Chhabra Y; Abankwa D; O'Mara M; Dai W; Gardon O; Tunny KA; Blucher KM; Morton CJ; Parker MW; Sierecki E; Gambin Y; Gomez GA; Alexandrov KK; Doxastakis M; Mark AE; Waters MJ, 2014, 'A new cytokine receptor activation paradigm: Activation of JAK2 by the growth hormone receptor', in CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Melbourne, AUSTRALIA, pp. 22 - 22, presented at 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne, AUSTRALIA, 26 October 2014 - 29 October 2014, http://dx.doi.org/10.1016/j.cyto.2014.07.227

Giles N; Sierecki E; Polinkovsky M; Schroder K; Alexandrov K; Gambin Y, 2014, 'A novel approach to investigate the assembly of the NOD-like receptor inflammasomes', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, presented at Experimental Biology Meeting, San Diego, CA, 26 April 2014 - 30 April 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346646700166&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Polinkovsky M; Sierecki E; Giles N; Alexandrov K; Gambin Y, 2014, 'Uncovering transcription factor binding pockets in the tail subdomain of the human mediator complex', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346651004001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Sierecki E; Polinkovsky M; Giles N; Moustaqil M; Alexandrov K; Gambin Y, 2014, 'Probing the architecture of the Mediator complex', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346651003484&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Polinkovsky ME; Gambin Y; Erickstad M; Deniz A; Groisman A, 2012, 'Inverse Temperature Jump System to Study Fast Protein Folding Kinetics', in BIOPHYSICAL JOURNAL, CELL PRESS, San Diego, CA, pp. 448A - 449A, presented at 56th Annual Meeting of the Biophysical-Society, San Diego, CA, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.2460

Gambin Y; Lemke EA; Vandelinder V; Groisman A; Deniz AA, 2010, 'High-Resolution smFRET in a Microfluidic Gas Exchange Platform', in BIOPHYSICAL JOURNAL, CELL PRESS, pp. 622A - 623A, http://dx.doi.org/10.1016/j.bpj.2009.12.3407

Gambin Y; Reffay M; Sierecki E; Homble F; Genest M; Hodges RS; Gov N; Taulier N; Urbach W, 2010, 'Modulation of the Lateral Mobility of Transmembrane Peptides with Hydrophobic Mismatch', in BIOPHYSICAL JOURNAL, CELL PRESS, pp. 224A - 225A, http://dx.doi.org/10.1016/j.bpj.2009.12.1215

Moran CR; Ferreon ACM; Gambin Y; Deniz AA, 2010, 'Single-Molecule FRET Reveals Altered Binding-Induced Folding Landscape of PD-Related Mutant Protein Alpha-Synuclein', in BIOPHYSICAL JOURNAL, CELL PRESS, pp. 258A - 258A, http://dx.doi.org/10.1016/j.bpj.2009.12.1402

Schug A; Gambin Y; Deniz A; Onuchic J, 2009, 'The Rop-Dimer: A Folded Protein Living Between Two Alternate Structures', in BIOPHYSICAL JOURNAL, CELL PRESS, pp. 568A - 568A, http://dx.doi.org/10.1016/j.bpj.2008.12.3722

Meyer B; Chiaravalli J; Gellenoncourt S; Brownridge P; Bryne D; Daly L; Grauslys A; Walter M; Agou F; Chakrabarti L; Chakrabarti L; Craik C; Eyers C; Eyers P; Gambin Y; Jones A; Sierecki E; Verdin E; Vignuzzi M; Emmott E, 2020, Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets with therapeutic potential, http://dx.doi.org/10.1101/2020.09.16.297945

McMahon K-A; Stroud D; Gambin Y; Tillu V; Bastiani M; Sierecki E; Polinkovsky M; Hall T; Gomez G; Wu Y; Parat M-O; Martel N; Lo H; Khanna KK; Alexandrov K; Daly R; Yap A; Ryan M; Parton R, 2020, Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response, http://dx.doi.org/10.1101/2020.07.26.222158

Steain M; Baker MODG; Pham CLL; Gambin Y; Sierecki E; McSharry B; Avdic S; Slobedman B; Sunde M; Abendroth A, 2020, Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death, http://dx.doi.org/10.1101/2020.03.12.988659

Pang SS; Bayly-Jones C; Radjainia M; Spicer B; Law RHP; Hodel A; Ekkel S; Conroy P; Ramm G; Venugopal H; Bird P; Hoogenboom B; Voskoboinik I; Gambin Y; Sierecki E; Dunstone M; Whisstock J, 2019, The structure of Macrophage Expressed Gene-1, a phagolysosome immune effector that is activated upon acidification, http://dx.doi.org/10.1101/580712

O’Carroll A; Chauvin B; Brown J; Meagher A; Coyle J; Hunter D; Bhumkhar A; Ve T; Kobe B; Sierecki E; Gambin Y, 2018, Effects of Pathological Mutations on the Prion-Like Polymerisation of MyD88, http://dx.doi.org/10.1101/351726

Pham C; Strange M; O’ Carroll A; Shanmugam N; Sierecki E; Gambin Y; Steain M; Sunde M, 2018, The RHIM within the M45 protein from murine cytomegalovirus forms heteromeric amyloid fibrils with RIPK1 and RIPK3, http://dx.doi.org/10.1101/324590

Ariotti N; Wu Y; Okano S; Gambin Y; Follett J; Rae J; Ferguson C; Teasdale RD; Alexandrov K; Meunier FA; Hill MM; Parton RG, An inverted Caveolin-1 topology defines a novel exosome secreted from prostate cancer cells, http://dx.doi.org/10.1101/2020.03.19.999441