Dr Vashe Chandrakanthan
Fields of research: Cardiovascular Medicine and Haematology, Animal Developmental and Reproductive Biology, Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
Contact Details
Phone: 50065
Email: v.chandrakanthan@unsw.edu.au
Tabs
Publications related to this Person
Journal articles
Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V, 2017, 'Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes', Cell Reports, vol. 20, pp. 572 - 585, http://dx.doi.org/10.1016/j.celrep.2017.06.067
Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A, 2016, 'Pdgf-ab and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113
Thoms JAI; Knezevic K; Liu JJ; Glaros EN; Thai T; Qiao Q; Campbell H; Packham D; Huang Y; Papathanasiou P, 2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, vol. 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15
Huang Y; Thoms JAI; Tursky ML; Knezevic K; Beck D; Chandrakanthan V; Suryani S; Olivier J; Boulton A; Glaros EN, 2016, 'MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation', Leukemia, vol. 30, pp. 1552 - 1561, http://dx.doi.org/10.1038/leu.2016.55
Marks-Bluth J; Khanna A; Chandrakanthan V; Thoms J; Bee T; Eich C; Kang YC; Knezevic K; Qiao Q; Fitch S, 2015, 'SMAD1 and SMAD5 expression is coordinately regulated by FLI1 and GATA2 during endothelial development', Molecular and Cellular Biology, vol. 35, pp. 2165 - 2172, http://dx.doi.org/10.1128/MCB.00239-15
Rao TN; Marks-Bluth J; Sullivan J; Gupta MK; Chandrakanthan V; Fitch SR; Ottersbach K; Jang YC; Piao X; Kulkarni RN, 2015, 'High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice', Stem Cell Research, vol. 14, pp. 307 - 322, http://dx.doi.org/10.1016/j.scr.2015.02.001
Pelekanos RA; Li J; Gongora M; Chandrakanthan V; Scown J; Suhaimi N; Brooke G; Christensen ME; Doan T; Rice AM, 2012, 'Comprehensive transcriptome and immunophenotype analysis of renal and cardiac MSC-like populations supports strong congruence with bone marrow MSC despite maintenance of distinct identities', Stem Cell Research, vol. 8, pp. 58 - 73, http://dx.doi.org/10.1016/j.scr.2011.08.003
Chong JJH; Chandrakanthan V; Xaymardan M; Asli NS; Li J; Ahmed I; Heffernan C; Menon MK; Scarlett CJ; Rashidianfar A, 2011, 'Adult cardiac-resident MSC-like stem cells with a proepicardial origin', Cell Stem Cell, vol. 9, pp. 527 - 540, http://dx.doi.org/10.1016/j.stem.2011.10.002
Jin XL; Chandrakanthan V; Morgan HD; O'Neill C, 2009, 'Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway', Biology of Reproduction, vol. 80, pp. 286 - 294, http://dx.doi.org/10.1095/biolreprod.108.070102
Jin XL; Chandrakanthan V; Morgan HD; O'Neill C, 2009, 'Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway.', Biology of reproduction, vol. 81, pp. 234 - 242
Jin XL; Chandrakanthan V; Morgan HD; O'Neill C, 2009, 'Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway (Biology of Reproduction', Biology of Reproduction, vol. 81, pp. 233 - 242, http://dx.doi.org/10.1095/biolreprod.109.078444
Li A; Chandrakanthan V; Chami O; O'Neill C, 2007, 'Culture of zygotes increases p53 expression in B6 mouse embryos, which reduces embryo viability', Biology of Reproduction, vol. 76, pp. 362 - 367, http://dx.doi.org/10.1095/biolreprod.106.056838
Chandrakanthan V; Chami O; Stojanov T; O'Neill C, 2007, 'Variable expressivity of the tumour suppressor protein TRP53 in cryopreserved human blastocysts', Reproductive Biology and Endocrinology, vol. 5, http://dx.doi.org/10.1186/1477-7827-5-39
Li Y; Chandrakanthan V; Day ML; O'Neill C, 2007, 'Direct evidence for the action of phosphatidylinositol (3,4,5)- trisphosphate-mediated signal transduction in the 2-cell mouse embryo', Biology of Reproduction, vol. 77, pp. 813 - 821, http://dx.doi.org/10.1095/biolreprod.107.060129
Chandrakanthan V; Li A; Chami O; O'Neill C, 2006, 'Effects of in vitro fertilization and embryo culture on TRP53 and Bax expression in B6 mouse embryos', Reproductive Biology and Endocrinology, vol. 4, http://dx.doi.org/10.1186/1477-7827-4-4
Lu DP; Chandrakanthan V; Cahana A; Ishii S; O'Neill C, 2004, 'Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development', Journal of Cell Science, vol. 117, pp. 1567 - 1576, http://dx.doi.org/10.1242/jcs.00991
Conference Papers
Kang YC; Glaros E; Thomas S; Qiao Q; Brownlee C; Pimanda J; Chandrakanthan V, 2017, 'Identification of Novel Embryonic Vascular Stem-like cells and their role in Coronary Vasculature development and repair', in MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, Natil Univ Singapore, Singapore, SINGAPORE, pp. S48 - S49, presented at 18th International Congress of Developmental Biology, Natil Univ Singapore, Singapore, SINGAPORE, 18 - 22 June 2017, http://dx.doi.org/10.1016/j.mod.2017.04.088
Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J, 2016, 'Integrative genomics identifies the molecular basis of resistance to Azacitidine therapy in Myelodysplastic Syndromes', Ferrata Storti Foundation, Copenhagen, Denmark, pp. 157 - 158, presented at 21st Congress Of The European Hematology Association (EHA), Copenhagen, Denmark, 09 - 12 June 2016, https://synapse.mskcc.org/synapse/works/97032
Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Richards LA; Knezevic K; Chandrakanthan V; Thoms JAI; Tursky ML, 2015, 'An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, presented at 57th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 05 - 08 December 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368019002147&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Ahmed IM; Chandrakanthan V; Xaymardan M; Prall OWJ; Nasr-Esfahani S; Harvey R, 2009, 'A NOVEL ENDOGENOUS MURINE ADULT CARDIAC STEM CELL POPULATION AND ITS FLUX AFTER ISCHAEMIC INJURY', in TRANSPLANT INTERNATIONAL, WILEY-BLACKWELL PUBLISHING, INC, pp. 256 - 256, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000269392800983&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Ahmed IM; Cbandrakantban V; Xaymardan M; Prall OWJ; Nasr-Esfahani S; Harvey RP, 2008, 'In vitro characterisation of endogenous adult cardiac progenitors and their flux after ischaemic injury', in JOURNAL OF HEART AND LUNG TRANSPLANTATION, ELSEVIER SCIENCE INC, Boston, MA, pp. S213 - S213, presented at 28th Annual Meeting of the International-Society-for-Heart-and-Lung-Transplantation, Boston, MA, 09 - 12 April 2008, http://dx.doi.org/10.1016/j.healun.2007.11.435
Conference Abstracts
Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J, 2016, 'INTEGRATIVE GENOMICS IDENTIFIES THE MOLECULAR BASIS OF RESISTANCE TO AZACITIDINE THERAPY IN MYELODYSPLASTIC SYNDROMES', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, Copenhagen, DENMARK, Vol. 101, pp. 157 - 158, presented at 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, 09 - 12 June 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600349&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A, 2016, 'PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113
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