Dr Vashe Chandrakanthan
Fields of research: Cardiovascular Medicine and Haematology, Animal Developmental and Reproductive Biology, Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
Contact Details
Phone: 50065
Email: v.chandrakanthan@unsw.edu.au
Tabs
Publications related to this Person
Journal articles
Yeola A; Subramanian S; Oliver RA; Lucas CA; Thoms JAI; Yan F; Olivier J; Chacon D; Tursky ML; Srivastava P; Potas JR; Hung T; Power C; Hardy P; Ma DD; Kilian KA; McCarroll J; Kavallaris M; Hesson LB; Beck D; Curtis DJ; Wong JWH; Hardeman EC; Walsh WR; Mobbs R; Chandrakanthan V; Pimanda JE, 2021, 'Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine', Science Advances, vol. 7, pp. eabd1929 - eabd1929, http://dx.doi.org/10.1126/sciadv.abd1929
Tavassoli H; Rorimpandey P; Kang YC; Carnell M; Brownlee C; Pimanda J; Chan PPY; Chandrakanthan V, 2020, 'Label-free Isolation and Single Cell Biophysical Phenotyping Analysis of Primary Cardiomyocytes Using Inertial Microfluidics', , http://dx.doi.org/10.1101/2020.08.31.243592
Tavassoli H; Kang YC; Rorimpandey P; Pimanda J; Chandrakanthan V; Chan PPY, 2020, 'Capturing Neonatal Cardiomyocyte – Endothelial interactions on-a-Chip', , http://dx.doi.org/10.1101/2020.08.10.243600
Tavassoli H; Rorimpandey P; Kang YC; Carnell M; Brownlee C; Pimanda JE; Chan PPY; Chandrakanthan V, 2020, 'Label-Free Isolation and Single Cell Biophysical Phenotyping Analysis of Primary Cardiomyocytes Using Inertial Microfluidics', Small, pp. e2006176, http://dx.doi.org/10.1002/smll.202006176
Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V; Thoms JAI; Tursky ML; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj AG; Tobiasson M; Karimi M; Pellagatti A; Wilson SR; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; Wilkins MR; MacKenzie KL; Wong JWH; Campbell PJ; Pimanda JE, 2017, 'Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes', Cell Reports, vol. 20, pp. 572 - 585, http://dx.doi.org/10.1016/j.celrep.2017.06.067
Huang Y; Thoms JAI; Tursky ML; Knezevic K; Beck D; Chandrakanthan V; Suryani S; Olivier J; Boulton A; Glaros EN; Thomas SR; Lock RB; MacKenzie KL; Bushweller JH; Wong JWH; Pimanda JE, 2016, 'MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation', Leukemia, vol. 30, pp. 1552 - 1561, http://dx.doi.org/10.1038/leu.2016.55
Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'Pdgf-ab and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113
Thoms JAI; Knezevic K; Liu JJ; Glaros EN; Thai T; Qiao Q; Campbell H; Packham D; Huang Y; Papathanasiou P; Tunningley R; Whittle B; Yeung AWS; Chandrakanthan V; Hesson L; Chen V; Wong JWH; Purton LE; Ward RL; Thomas SR; Pimanda JE, 2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, vol. 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15
Rao TN; Marks-Bluth J; Sullivan J; Gupta MK; Chandrakanthan V; Fitch SR; Ottersbach K; Jang YC; Piao X; Kulkarni RN; Serwold T; Pimanda JE; Wagers AJ, 2015, 'High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice', Stem Cell Research, vol. 14, pp. 307 - 322, http://dx.doi.org/10.1016/j.scr.2015.02.001
Marks-Bluth J; Khanna A; Chandrakanthan V; Thoms J; Bee T; Eich C; Kang YC; Knezevic K; Qiao Q; Fitch S; Oxburgh L; Ottersbach K; Dzierzak E; de Bruijn MFTR; Pimanda JE, 2015, 'SMAD1 and SMAD5 expression is coordinately regulated by FLI1 and GATA2 during endothelial development', Molecular and Cellular Biology, vol. 35, pp. 2165 - 2172, http://dx.doi.org/10.1128/MCB.00239-15
Pelekanos RA; Li J; Gongora M; Chandrakanthan V; Scown J; Suhaimi N; Brooke G; Christensen ME; Doan T; Rice AM; Osborne GW; Grimmond SM; Harvey RP; Atkinson K; Little MH, 2012, 'Corrigendum to "Comprehensive transcriptome and immunophenotype analysis of renal and cardiac MSC-like populations supports strong congruence with bone marrow MSC despite maintenance of distinct identities" [Stem Cell. 8 (2012) 58-73]', Stem Cell Research, vol. 9, pp. 58, http://dx.doi.org/10.1016/j.scr.2012.02.003
Pelecanos A; Li J; Gongora M; Chandrakanthan V; Scown J; Suhaimi M; Brooke G; Christensen ME; Doan T; Rice AM; Osborne GW; Grimmond S; Harvey RP; Atkinson K; Little MH, 2011, 'Comprehensive transcriptome and immunophenotype analysis of renal and cardiac MSC-like populations supports strong congruence with bone marrow MSC despite maintenance of distinct identities', Cell Stem Cell, vol. 8, pp. 58 - 73, http://dx.doi.org/10.1016/j.scr.2011.08.003
Chong J; Chandrakanthan V; Xaymardan M; Asli NS; Li J; Ahmed I; Heffernan C; Menon M; Scarlett C; Rashidianfar A; Biben C; Zoellner H; Colvin EK; Pimanda JE; Biankin AV; Zhou B; Pu WT; Prall OWJ; Harvey RP, 2011, 'Adult cardiac-resident MSC-like stem cells with a proepicardial origin', Cell Stem Cell, vol. 9, pp. 527 - 540, http://dx.doi.org/10.1016/j.stem.2011.10.002
Jin XL; Chandrakanthan V; Morgan HD; O'Neill C, 2009, 'Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway (Biology of Reproduction (2009) 80, (286-294) DOI: 10.1095/biolreprod.108.070102)', Biology of Reproduction, vol. 81, pp. 233 - 242, http://dx.doi.org/10.1095/biolreprod.109.078444
Jin XL; Chandrakanthan V; Morgan HD; O'Neill C, 2009, 'Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway.', Biology of reproduction, vol. 81, pp. 234 - 242
Jin XL; Chandrakanthan V; Morgan HD; O'Neill C, 2009, 'Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway', Biology of Reproduction, vol. 80, pp. 286 - 294, http://dx.doi.org/10.1095/biolreprod.108.070102
Li Y; Chandrakanthan V; Day ML; O'Neill C, 2007, 'Direct evidence for the action of phosphatidylinositol (3,4,5)- trisphosphate-mediated signal transduction in the 2-cell mouse embryo', Biology of Reproduction, vol. 77, pp. 813 - 821, http://dx.doi.org/10.1095/biolreprod.107.060129
Chandrakanthan V; Chami O; Stojanov T; O'Neill C, 2007, 'Variable expressivity of the tumour suppressor protein TRP53 in cryopreserved human blastocysts', Reproductive Biology and Endocrinology, vol. 5, http://dx.doi.org/10.1186/1477-7827-5-39
Li A; Chandrakanthan V; Chami O; O'Neill C, 2007, 'Erratum: Culture of zygotes increases TRP53 expression in B6 mouse embryos, which reduces embryo viability (Biology of Reproduction (2007) 76, (362-367) DOI: 10.1095/biolreprod.106.056838)', Biology of Reproduction, vol. 76, pp. 924, http://dx.doi.org/10.1095/biolreprod.107.061853
Li A; Chandrakanthan V; Chami O; O'Neill C, 2007, 'Culture of zygotes increases p53 expression in B6 mouse embryos, which reduces embryo viability', Biology of Reproduction, vol. 76, pp. 362 - 367, http://dx.doi.org/10.1095/biolreprod.106.056838
Chandrakanthan V; Li A; Chami O; O'Neill C, 2006, 'Effects of in vitro fertilization and embryo culture on TRP53 and Bax expression in B6 mouse embryos', Reproductive Biology and Endocrinology, vol. 4, http://dx.doi.org/10.1186/1477-7827-4-4
Lu DP; Chandrakanthan V; Cahana A; Ishii S; O'Neill C, 2004, 'Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development', Journal of Cell Science, vol. 117, pp. 1567 - 1576, http://dx.doi.org/10.1242/jcs.00991
Conference Papers
Kang YC; Glaros E; Thomas S; Qiao Q; Brownlee C; Pimanda J; Chandrakanthan V, 2017, 'Identification of Novel Embryonic Vascular Stem-like cells and their role in Coronary Vasculature development and repair', in MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, Natil Univ Singapore, Singapore, SINGAPORE, pp. S48 - S49, presented at 18th International Congress of Developmental Biology, Natil Univ Singapore, Singapore, SINGAPORE, 18 June 2017 - 22 June 2017, http://dx.doi.org/10.1016/j.mod.2017.04.088
Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J; Tursky ML; Huang Y; Ali Z; Olivier S; Galbraith S; Kulasekararaj A; Tobiasson M; Karimi M; Pellagatti A; Wilson S; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen S; Mufti G; Hellstrom-Lindberg E; MacKenzie K; Wong J; Campbell P; Pimanda J, 2016, 'Integrative genomics identifies the molecular basis of resistance to Azacitidine therapy in Myelodysplastic Syndromes', in Integrative genomics identifies the molecular basis of resistance to Azacitidine therapy in Myelodysplastic Syndromes, Ferrata Storti Foundation, Copenhagen, Denmark, pp. 157 - 158, presented at 21st Congress Of The European Hematology Association (EHA), Copenhagen, Denmark, 09 June 2016 - 12 June 2016, https://synapse.mskcc.org/synapse/works/97032
Unnikrishnan A; Papaemmanuil E; Beck D; Kumari A, 2015, 'An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML', in An Integrative Genomics Approach Uncovers the Basis of Resistance to, AMER SOC HEMATOLOGY, USA, presented at ASH Annual Meeting, USA, 05 December 2015 - 08 December 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368019002147&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Ahmed I; Chandrakanthan V; Xaymardan M; Prall OW; Nasr-Esfahani S; Harvey RP, 2009, 'A novel endogenous murine adult cardiac stem cell population and its flux after ischaemic injury', in Transplant International, Springer, New York, NY, USA, pp. 256 - 256, presented at Transplant International, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000269392800983&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Ahmed I; Cbandrakantban V; Xaymardan M; Prall OW; Nasr-Esfahani S; Harvey RJ, 2008, 'In vitro characterisation of endogenous adult cardiac progenitors and their flux after ischaemic injury', in Journal of Heart and Lung Transplantation, Elsevier Science Inc, New York, NY, USA, pp. S213 - S213, presented at International-Society-for-Heart-and-Lung-Transplantation, Boston, Massachusetts, 09 April 2008 - 12 April 2008, http://dx.doi.org/10.1016/j.healun.2007.11.435
Conference Abstracts
Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J; Tursky M; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj A; Tobiasson M; Karimi M; Pellagatti A; Wilson S; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen S; Mufti G; Hellstrom-Lindberg E; MacKenzie K; Wong J; Campbell P; Pimanda J, 2016, 'INTEGRATIVE GENOMICS IDENTIFIES THE MOLECULAR BASIS OF RESISTANCE TO AZACITIDINE THERAPY IN MYELODYSPLASTIC SYNDROMES', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, Copenhagen, DENMARK, Vol. 101, pp. 157 - 158, presented at 21st Congress of the European-Hematology-Association, Copenhagen, DENMARK, 09 June 2016 - 12 June 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600349&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113
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