Dr Sylvie Shen
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Publications related to this Person
Book Chapters
Dolnikov A; O'Brien TA; Xu N; Shen S; Klamer G, 2014, 'Strategies to improve immune reconstitution after haematopoeitic stem cell transplantation.', in Rahman A; Anjum S (ed.), Frontiers in Stem Cell and Regenerative Medicine Research, vol. 1, Bentham Science, pp. 30 - 64, http://dx.doi.org/10.2174/97816080599421150101
Journal articles
Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2020, 'Intratumoral copper modulates PD-L1 expression and influences tumor immune evasion', Cancer Research, vol. 80, pp. 4129 - 4144, http://dx.doi.org/10.1158/0008-5472.CAN-20-0471
Xu N; Shen S; Dolnikov A, 2017, 'Increasing Stem Cell Dose Promotes Posttransplant Immune Reconstitution', Stem cells and development, vol. 26, pp. 461 - 470, http://dx.doi.org/10.1089/scd.2016.0186
Shen S; Xu N; Klamer G; Ko KH; Khoo M; Ma D; Moore J; O'Brien TA; Dolnikov A, 2015, 'Small-molecule inhibitor of glycogen synthase kinase 3β 6-bromoindirubin-3-oxime inhibits hematopoietic regeneration in stem cell recipient mice', Stem Cells and Development, vol. 24, pp. 724 - 736, http://dx.doi.org/10.1089/scd.2014.0230
Dolnikov A; Shen S; Klamer G; Joshi S; Xu N; Yang L; Micklethwaite K; O'Brien TA, 2015, 'Antileukemic potency of CD19-specific T cells against chemoresistant pediatric acute lymphoblastic leukemia', Experimental Hematology, vol. 43, pp. 1001 - 1014.e5, http://dx.doi.org/10.1016/j.exphem.2015.08.006
Komala MG; Gross S; Mudaliar H; Huang C; Pegg K; Mather A; Shen S; Pollock CA; Panchapakesan U, 2014, 'Inhibition of kidney proximal tubular glucose reabsorption does not prevent against diabetic nephropathy in type 1 diabetic enos knockout mice', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0108994
Komala MG; Gross S; Mudaliar H; Huang C; Pegg K; Mather A; Shen S; Pollock CA; Panchapakesan U, 2014, 'Inhibition of kidney proximal tubular glucose reabsorption does not prevent against diabetic nephropathy in type 1 diabetic enos knockout mice', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0108994
Huang C; Shen S; Ma Q; Gill A; Pollock CA; Chen XM, 2014, 'KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis', Nephrology Dialysis Transplantation, vol. 29, pp. 313 - 324, http://dx.doi.org/10.1093/ndt/gft431
Dolnikov A; Xu N; Shen S; Song E; Holmes T; Klamer G; O'Brien TA, 2014, 'GSK-3β inhibition promotes early engraftment of ex vivo-expanded haematopoietic stem cells', Cell Proliferation, vol. 47, pp. 113 - 123, http://dx.doi.org/10.1111/cpr.12092
Huang C; Shen S; Ma Q; Gill A; Pollock CA; Chen X-M, 2014, 'KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis', Nephrology Dialysis Transplantation, vol. 29, pp. 313 - 324
Cheng D; Shen S; Chen XM; Pollock C; Braet F, 2013, 'Application of transmission electron tomography for modeling the renal corpuscle', Pathology Research and Practice, vol. 209, pp. 731 - 734, http://dx.doi.org/10.1016/j.prp.2013.06.013
Yong R; Chen XM; Shen S; Vijayaraj S; Ma Q; Pollock CA; Saad S, 2013, 'Plumbagin Ameliorates Diabetic Nephropathy via Interruption of Pathways that Include NOX4 Signalling', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0073428
Huang C; Shen S; Ma Q; Chen J; Gill A; Pollock CA; Chen XM, 2013, 'Blockade of KCa3.1 ameliorates renal fibrosis through the tgf-β1/smad pathway in diabetic mice', Diabetes, vol. 62, pp. 2923 - 2934, http://dx.doi.org/10.2337/db13-0135
Tang O; Chen XM; Shen S; Hahn M; Pollock CA, 2013, 'MiRNA-200b represses transforming growth factor-β1-induced EMT and fibronectin expression in kidney proximal tubular cells', American Journal of Physiology - Renal Physiology, vol. 304, pp. 1266 - 1273, http://dx.doi.org/10.1152/ajprenal.00302.2012
Klamer G; Shen S; Song E; Rice AM; Knight R; Lindeman R; O'Brien TA; Dolnikov A, 2013, 'GSK3 inhibition prevents lethal GVHD in mice', Experimental Hematology, vol. 41, http://dx.doi.org/10.1016/j.exphem.2012.09.005
Shen S; Xu N; O'Brien TA; Dolnikov A; Klamer G, 2013, 'GSK-3β inhibition preserves naive T cell phenotype in bone marrow reconstituted mice', Experimental Hematology, vol. 41, pp. 1016 - 1027, http://dx.doi.org/10.1016/j.exphem.2013.08.006
Mcintyre GJ; Groneman JL; Yu YH; Jaramillo A; Shen S; Applegate TL, 2009, '96 shRNAs designed for maximal coverage of HIV-1 variants', Retrovirology, vol. 6, http://dx.doi.org/10.1186/1742-4690-6-55
Mcintyre GJ; Yu Y; Tran A; Jaramillo AB; Arndt AJ; Millington ML; Boyd MP; Elliott FA; Shen SW; Murray JM; Applegate TL, 2009, 'Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success', Virology Journal, vol. 6, pp. 184, http://dx.doi.org/10.1186/1743-422X-6-184
Millington ML; Arndt A; Boyd MP; Applegate TL; Shen SW, 2009, 'Towards a clinically relevant lentiviral transduction protocol for primary human CD34 hematopoietic stem/progenitor cells', PLoS One, vol. 4, pp. e6461, http://dx.doi.org/10.1371/journal.pone.0006461
Choo A; Palladinetti P; Holmes TA; Basu S; Shen S; Lock RB; O Brien T; Symonds GP; Dolnikov A, 2008, 'siRNA targeting the IRF2 transcription factor inhibits leukaemic cell growth.', International Journal of Oncology, vol. 33, pp. 175 - 183
Holmes TA; O Brien T; Knight RJ; Lindeman R; Shen S; Song YE; Symonds GP; Dolnikov A, 2008, 'Glycogen synthase kinase-3 beta inhibition preserves hematopoietic stem cell activity and inhibits leukemic cell growth', Stem Cells, vol. 26, pp. 1288 - 1297, http://dx.doi.org/10.1634/stemcells.2007-0600
Shen S; Passioura TJ; Symonds GP; Dolnikov A, 2007, 'N-ras oncogene-induced gene expression in human hematopoietic progenitor cells: Upregulation of p16INK4a and p21CIP1/WAF1 correlates with myeloid differentiation', Experimental Hematology, vol. 35, pp. 908 - 919, http://dx.doi.org/10.1016/j.exphem.2007.02.011
Choo A; Palladinetti P; Passioura TJ; Shen S; Symonds GP; Dolnikov A, 2006, 'The role of IRF1 and IRF2 transcription factors in leukaemogenesis', Current Gene Therapy, vol. 6, pp. 543 - 550, http://dx.doi.org/10.2174/156652306778520683
Passioura TJ; Shen S; Symonds GP; Dolnikov A, 2005, 'A retroviral library genetic screen identitifies IRF-2 as an inhabitor of N-ras induced growth suppervision in leukemai cells', Oncogene, vol. 24, pp. 7327 - 7336, http://dx.doi.org/10.1038/sj.onc.1208877
Passioura TJ; Dolnikov A; Shen S; Symonds GP, 2005, 'N-ras induced growth suppression of myeloid cells is mediated by IRF-1', Cancer research, vol. 65, pp. 797 - 804
Shen S; Passioura TJ; Choo A; Symonds GP; Dolnikov A, 2005, 'Mutant N-ras activation in primary human hemaopoietic progenitor cells: biologic, phenotypic and genetic sequelae', EJC Supplements, vol. 3, pp. 285 - 285, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000247564801146&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Shen S; Passioura ; Choo A; Symonds G; Dolnikov A, 2005, 'Targeting the IRF2 transcription factor to inhibit leukaemic cell growth', Journal of Gene Medicine, vol. 7, pp. 1135 - 1135, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000231477900071&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Shen SC; Dolnikov A; Passioura TJ; Millington M; Wotherspoon S; Rice AM; Mackenzie K; Symonds GP, 2004, 'Mutant N-ras preferentially drives human CD34+ hematopoietic progenitor cells into myeloid proliferation both in vitro and in the NOd/SCID mouse.', Experimental Hematology, vol. 32, pp. 852 - 860, http://dx.doi.org/10.1016/j.exphem.2004.06.001
Dolnikov A; Shen S; Millington M; Passioura T; Pedler M; Rasko JEJ; Symonds G, 2003, 'A sensitive dual-fluorescence reporter system enables positive selection of ras suppressors by suppression of ras-induced apoptosis', Cancer Gene Therapy, vol. 10, pp. 745 - 754, http://dx.doi.org/10.1038/sj.cgt.7700603
Dolnikov A; Shen SC; Passioura TJ; Symonds GP, 2003, 'Bone marrow reconstituiton as a relevant model of genetically programmd leukemia', Current Medicinal Chemistry: Cardiovascular and Hematological Agents, vol. 1, pp. 83 - 97, http://dx.doi.org/10.2174/1568016033477531
Dolnikov A; Shen S; Passioura TJ; Symonds GP, 2003, 'Genetic control of hematopoietic stem cell biology and leukemogenesis', Blood, vol. 102, pp. 332A - 332A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000186536701194&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Conference Papers
Bishop D; Xu N; Shen S; O'Brien T; Gottlieb D; Dolnikov A; Micklethwaite K, 2017, 'Preclinical optimization of a low cost PiggyBac transposase (PB) generated CD19-specific chimeric antigen receptor T cell (CART19) product for a first in man trial using local hospital cell manufacture', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Washington, DC, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington, DC, 01 April 2017 - 05 April 2017, http://dx.doi.org/10.1158/1538-7445.AM2017-3760
Dolnikov A; Rossi S; Xu N; Klamer G; Shen S; Micklethwaite KP; Lock RB; O'Brien T, 2014, '5-Aza-2 '-Deoxycytidine Promotes Cytotoxic Effect of CART-Cells on Leukaemia Cells', in BLOOD, AMER SOC HEMATOLOGY, San Francisco, CA, presented at 56th Annual Meeting of the American-Society-of-Hematology, San Francisco, CA, 06 December 2014 - 09 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349233806021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Dolnikov A; Chitranjan A; Shen S; Klamer G; O'Brien T, 2014, 'TESTING CAR-T CELL ACTIVITY IN HUMAN HEMATOCHIMERIC MOUSE MODEL WITH THE NORMAL RANGE OF ANTIGEN EXPRESSION NOT RESCTRICTED TO THE TUMOUR ONLY', in CYTOTHERAPY, ELSEVIER SCI LTD, pp. S23 - S23, http://dx.doi.org/10.1016/j.jcyt.2014.01.072
Dolnikov A; Holmes T; Shen S; Knight R; O'Brien TA, 2006, 'N-ras(m)-transduced fibroblasts facilitate the expansion and engraftment of umbilical cord blood stem cells.', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, pp. 912A - 912A, presented at 48th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 09 December 2006 - 12 December 2006, http://dx.doi.org/10.1182/blood.V108.11.3196.3196
O'Brien TA; Holmes T; Vowels M; Shen S; Symonds G; Dolnikov A, 2006, 'Novel approaches for the ex vivo expansion of the engraftable cord blood derived haematopoietic progenitor cells.', in CYTOTHERAPY, TAYLOR & FRANCIS AS, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239337600043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Dolnikov A; Shen S; Holmes T; Symonds G; Brien TA, 2006, 'Molecular profile and functional analysis of the molecular factors derived from ras-transduced cells that regulate hematopoiesis.', in CYTOTHERAPY, TAYLOR & FRANCIS AS, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239337600259&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Dolnikov A; Shen S; Symonds G; Holmes TA; O'Brien TA, 2006, 'Stroma cells support ex vivo expansion of retrovirally transduced haematopoietic progenitor cells.', in CYTOTHERAPY, INFORMA HEALTHCARE, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239337600010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Holmes T; O'Brien TA; Shen S; Choo A; Symonds G; Vowels M; Dolnikov A, 2006, 'Glycogen synthase kinase-3 regulates ex vivo expansion of human umbilical cord blood progenitor cells.', in CYTOTHERAPY, TAYLOR & FRANCIS AS, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239337600054&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Dolnikov A; Shen S; Symonds G, 2005, 'Using a novel inhibitor of GSK-3 beta to activate the Wnt pathway in human haematopoietic stem cells: Impact on stem cell parameters', in CYTOMETRY PART A, WILEY-LISS, Queensland, AUSTRIA, pp. 415 - 416, presented at 7th Samuel A Latt Conference on Stem Cells in the Age of Fluorescence Technology, Queensland, AUSTRIA, 06 November 2005 - 09 November 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000237187700065&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Dolnikov A; Shen S; Symonds G, 2005, 'Ras promotes engraftment of human haematopoietic stem cells through the activation of auto/paracrine mechanisms', in CYTOMETRY PART A, WILEY-LISS, Queensland, AUSTRIA, pp. 407 - 407, presented at 7th Samuel A Latt Conference on Stem Cells in the Age of Fluorescence Technology, Queensland, AUSTRIA, 06 November 2005 - 09 November 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000237187700041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Shen S; Symonds G; Dolnikov A, 2005, 'An in vivo assay for retrovirally transduced human haematopoietic stem/progenitor cells (HSC/HPC) using nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice', in JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Melbourne, AUSTRALIA, pp. 1135 - 1135, presented at 4th Meeting of the Australasian-Gene-Therapy-Society, Melbourne, AUSTRALIA, 27 April 2005 - 29 April 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000231477900072&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Dolnikov A; Shen S; Passioura T; Symonds G, 2003, 'Differential retroviral transduction of primitive hematopoietic progenitors rather than gene silencing accounts for variation in transgene expression', in JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, QUEENSLAND INST MED RES BRISBANE, BRISBANE, AUSTRALIA, pp. S13 - S14, presented at 3rd Meeting of the Australasian-Gene-Therapy-Society, QUEENSLAND INST MED RES BRISBANE, BRISBANE, AUSTRALIA, 30 April 2003 - 02 May 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183493100036&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Shen SW; Dolnikov A; Passioura T; Symonds G; Bradstock KF, 2002, 'Mutant N-ras induces myeloid differentiation in human cord blood CD34+ cells', in BLOOD, AMER SOC HEMATOLOGY, PHILADELPHIA, PENNSYLVANIA, pp. 209B - 209B, presented at 44th Annual Meeting of the American-Society-of-Hematology, PHILADELPHIA, PENNSYLVANIA, 06 December 2002 - 10 December 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179184800888&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Conference Abstracts
Dolnikov A; Xu N; Tse B; Shen S; O'Brien T, 2018, 'BROMODOMAIN INHIBITOR JQ1 MODULATES IMMUNE SUPPRESSIVE PATHWAYS IN NEUROBLASTOMA AND ENHANCES CARGD2T CELL THERAPY', in CYTOTHERAPY, ELSEVIER SCI LTD, Vol. 20, pp. S97 - S97, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000432441700297&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Dolnikov A; Yang S; Shen S; Xu N; Chaudhry K; Nordon R; O'Brien T, 2016, 'PROLONGING CART CELL PERSISTENCE USING CONDITIONING WITH 5-AZACYTIDINE', in CYTOTHERAPY, ELSEVIER SCI LTD, Vol. 18, pp. S61 - S61, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000376222800163&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Shen S; Xu N; Yang S; O'Brien T; Dolnikov A, 2016, 'STEM CELL APPROACH TO GENERATE CHIMERIC ANTIGEN RECEPTOR MODIFIED IMMUNE EFFECTOR CELLS TO TREAT CANCER', in CYTOTHERAPY, ELSEVIER SCI LTD, Vol. 18, pp. S64 - S64, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000376222800172&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Shen S; Dolnikov A; O'Brien T, 2016, 'USE OF HDACI AND PD-1/PD-LI BLOCKADE TO ENHANCE CYTOLYTIC ACTIVITY OF EX VIVO EXPANDED NK CELLS AGAINST NEUROBLASTOMA', in CYTOTHERAPY, ELSEVIER SCI LTD, Vol. 18, pp. S64 - S64, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000376222800173&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Dolnikov A; Klamer G; Chitranjan A; Xu N; Shen S; Micklethwaite KP; Lock RB; O'Brien T, 2014, 'Identifying the Factors Modulating the Efficacy of CAR-T Cell Therapy', in BLOOD, AMER SOC HEMATOLOGY, Vol. 124, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349242706217&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Dolnikov A; Klamer G; Shen S; Chitranjan A; Carol H; Lock R; O'Brien T, 2014, 'IDENTIFYING THE FACTORS MODULATING THE EFFICACY OF CAR-T CELL THERAPY', in CYTOTHERAPY, ELSEVIER SCI LTD, Vol. 16, pp. S7 - S7, http://dx.doi.org/10.1016/j.jcyt.2014.01.015
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