Dr Sylvie Shen

Dolnikov A; Yang S; Shen S; Xu N; Chaudhry K; Nordon R; O'Brien T, 2016, 'Prolonging CART Cell Persistence Using Conditioning with 5-Azacytidine', Cytotherapy, vol. 18, pp. S98 - S98, http://dx.doi.org/10.1016/j.jcyt.2016.03.201

Shen S; Xu N; Yang S; O'Brien T; Dolnikov A, 2016, 'Stem Cell Approach to Generate Chimeric Antigen Receptor Modified Immune Effector Cells to Treat Cancer', Cytotherapy, vol. 18, pp. S101 - S101, http://dx.doi.org/10.1016/j.jcyt.2016.03.211

Shen S; Dolnikov A; O'Brien T, 2016, 'Use of HDACi and PD-1/PD-L1 Blockade to Enhance Cytolytic Activity of Ex Vivo Expanded NK Cells Against Neuroblastoma', Cytotherapy, vol. 18, pp. S101 - S101, http://dx.doi.org/10.1016/j.jcyt.2016.03.212

Shen S; Xu N; Klamer G; Ko KH; Khoo M; Ma D; Moore J; O'Brien TA; Dolnikov A, 2015, 'Small-molecule inhibitor of glycogen synthase kinase 3β 6-bromoindirubin-3-oxime inhibits hematopoietic regeneration in stem cell recipient mice', Stem Cells and Development, vol. 24, pp. 724 - 736, http://dx.doi.org/10.1089/scd.2014.0230

Dolnikov A; Shen S; Klamer G; Joshi S; Xu N; Yang L; Micklethwaite K; O'Brien TA, 2015, 'Antileukemic potency of CD19-specific T cells against chemoresistant pediatric acute lymphoblastic leukemia', Experimental Hematology, vol. 43, pp. 1001 - 1014.e5, http://dx.doi.org/10.1016/j.exphem.2015.08.006

Komala MG; Gross S; Mudaliar H; Huang C; Pegg K; Mather A; Shen S; Pollock CA; Panchapakesan U, 2014, 'Inhibition of kidney proximal tubular glucose reabsorption does not prevent against diabetic nephropathy in type 1 diabetic enos knockout mice', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0108994

Komala MG; Gross S; Mudaliar H; Huang C; Pegg K; Mather A; Shen S; Pollock CA; Panchapakesan U, 2014, 'Inhibition of kidney proximal tubular glucose reabsorption does not prevent against diabetic nephropathy in type 1 diabetic enos knockout mice', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0108994

Huang C; Shen S; Ma Q; Gill A; Pollock CA; Chen XM, 2014, 'KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis', Nephrology Dialysis Transplantation, vol. 29, pp. 313 - 324, http://dx.doi.org/10.1093/ndt/gft431

Dolnikov A; Xu N; Shen S; Song E; Holmes T; Klamer G; O'Brien TA, 2014, 'GSK-3β inhibition promotes early engraftment of ex vivo-expanded haematopoietic stem cells', Cell Proliferation, vol. 47, pp. 113 - 123, http://dx.doi.org/10.1111/cpr.12092

Huang C; Shen S; Ma Q; Gill A; Pollock CA; Chen X-M, 2014, 'KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis', Nephrology Dialysis Transplantation, vol. 29, pp. 313 - 324

Cheng D; Shen S; Chen XM; Pollock C; Braet F, 2013, 'Application of transmission electron tomography for modeling the renal corpuscle', Pathology Research and Practice, vol. 209, pp. 731 - 734, http://dx.doi.org/10.1016/j.prp.2013.06.013

Yong R; Chen XM; Shen S; Vijayaraj S; Ma Q; Pollock CA; Saad S, 2013, 'Plumbagin Ameliorates Diabetic Nephropathy via Interruption of Pathways that Include NOX4 Signalling', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0073428

Huang C; Shen S; Ma Q; Chen J; Gill A; Pollock CA; Chen XM, 2013, 'Blockade of KCa3.1 ameliorates renal fibrosis through the tgf-β1/smad pathway in diabetic mice', Diabetes, vol. 62, pp. 2923 - 2934, http://dx.doi.org/10.2337/db13-0135

Tang O; Chen XM; Shen S; Hahn M; Pollock CA, 2013, 'MiRNA-200b represses transforming growth factor-β1-induced EMT and fibronectin expression in kidney proximal tubular cells', American Journal of Physiology - Renal Physiology, vol. 304, pp. 1266 - 1273, http://dx.doi.org/10.1152/ajprenal.00302.2012

Shen S; Xu N; Klamer G; O'Brien TA; Dolnikov A, 2013, 'NOVEL APPROACH TO GENERATE CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS USING GENETICALLY MODIFIED T CELL PRECURSORS', CYTOTHERAPY, vol. 15, pp. S54 - S54, http://dx.doi.org/10.1016/j.jcyt.2013.01.211

Klamer G; Shen S; Song E; Rice AM; Knight R; Lindeman R; O'Brien TA; Dolnikov A, 2013, 'GSK3 inhibition prevents lethal GVHD in mice', Experimental Hematology, vol. 41, http://dx.doi.org/10.1016/j.exphem.2012.09.005

Shen S; Xu N; O'Brien TA; Dolnikov A; Klamer G, 2013, 'GSK-3β inhibition preserves naive T cell phenotype in bone marrow reconstituted mice', Experimental Hematology, vol. 41, pp. 1016 - 1027, http://dx.doi.org/10.1016/j.exphem.2013.08.006

Mcintyre GJ; Groneman JL; Yu YH; Jaramillo A; Shen S; Applegate TL, 2009, '96 shRNAs designed for maximal coverage of HIV-1 variants', Retrovirology, vol. 6, http://dx.doi.org/10.1186/1742-4690-6-55

Mcintyre GJ; Yu Y; Tran A; Jaramillo AB; Arndt AJ; Millington ML; Boyd MP; Elliott FA; Shen SW; Murray JM; Applegate TL, 2009, 'Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success', Virology Journal, vol. 6, pp. 184, http://dx.doi.org/10.1186/1743-422X-6-184

Millington ML; Arndt A; Boyd MP; Applegate TL; Shen SW, 2009, 'Towards a clinically relevant lentiviral transduction protocol for primary human CD34 hematopoietic stem/progenitor cells', PLoS One, vol. 4, pp. e6461, http://dx.doi.org/10.1371/journal.pone.0006461

Choo A; Palladinetti P; Holmes TA; Basu S; Shen S; Lock RB; O Brien T; Symonds GP; Dolnikov A, 2008, 'siRNA targeting the IRF2 transcription factor inhibits leukaemic cell growth.', International Journal of Oncology, vol. 33, pp. 175 - 183

Holmes TA; O Brien T; Knight RJ; Lindeman R; Shen S; Song YE; Symonds GP; Dolnikov A, 2008, 'Glycogen synthase kinase-3 beta inhibition preserves hematopoietic stem cell activity and inhibits leukemic cell growth', Stem Cells, vol. 26, pp. 1288 - 1297, http://dx.doi.org/10.1634/stemcells.2007-0600

Shen S; Passioura TJ; Symonds GP; Dolnikov A, 2007, 'N-ras oncogene-induced gene expression in human hematopoietic progenitor cells: Upregulation of p16INK4a and p21CIP1/WAF1 correlates with myeloid differentiation', Experimental Hematology, vol. 35, pp. 908 - 919, http://dx.doi.org/10.1016/j.exphem.2007.02.011

Choo A; Palladinetti P; Passioura TJ; Shen S; Symonds GP; Dolnikov A, 2006, 'The role of IRF1 and IRF2 transcription factors in leukaemogenesis', Current Gene Therapy, vol. 6, pp. 543 - 550, http://dx.doi.org/10.2174/156652306778520683

Passioura TJ; Shen S; Symonds GP; Dolnikov A, 2005, 'A retroviral library genetic screen identitifies IRF-2 as an inhabitor of N-ras induced growth suppervision in leukemai cells', Oncogene, vol. 24, pp. 7327 - 7336, http://dx.doi.org/10.1038/sj.onc.1208877

Passioura TJ; Dolnikov A; Shen S; Symonds GP, 2005, 'N-ras induced growth suppression of myeloid cells is mediated by IRF-1', Cancer research, vol. 65, pp. 797 - 804

Shen S; Passioura TJ; Choo A; Symonds GP; Dolnikov A, 2005, 'Mutant N-ras activation in primary human hemaopoietic progenitor cells: biologic, phenotypic and genetic sequelae', EJC Supplements, vol. 3, pp. 285 - 285, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000247564801146&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Shen S; Passioura ; Choo A; Symonds G; Dolnikov A, 2005, 'Targeting the IRF2 transcription factor to inhibit leukaemic cell growth', Journal of Gene Medicine, vol. 7, pp. 1135 - 1135, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000231477900071&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Shen SC; Dolnikov A; Passioura TJ; Millington M; Wotherspoon S; Rice AM; Mackenzie K; Symonds GP, 2004, 'Mutant N-ras preferentially drives human CD34+ hematopoietic progenitor cells into myeloid proliferation both in vitro and in the NOd/SCID mouse.', Experimental Hematology, vol. 32, pp. 852 - 860, http://dx.doi.org/10.1016/j.exphem.2004.06.001

Dolnikov A; Shen S; Millington M; Passioura T; Pedler M; Rasko JEJ; Symonds G, 2003, 'A sensitive dual-fluorescence reporter system enables positive selection of ras suppressors by suppression of ras-induced apoptosis', Cancer Gene Therapy, vol. 10, pp. 745 - 754, http://dx.doi.org/10.1038/sj.cgt.7700603

Dolnikov A; Shen SC; Passioura TJ; Symonds GP, 2003, 'Bone marrow reconstituiton as a relevant model of genetically programmd leukemia', Current Medicinal Chemistry: Cardiovascular and Hematological Agents, vol. 1, pp. 83 - 97, http://dx.doi.org/10.2174/1568016033477531

Dolnikov A; Shen S; Passioura TJ; Symonds GP, 2003, 'Genetic control of hematopoietic stem cell biology and leukemogenesis', Blood, vol. 102, pp. 332A - 332A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000186536701194&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Dolnikov A; Chitranjan A; Shen S; Klamer G; O'Brien T, 2014, 'TESTING CAR-T CELL ACTIVITY IN HUMAN HEMATOCHIMERIC MOUSE MODEL WITH THE NORMAL RANGE OF ANTIGEN EXPRESSION NOT RESCTRICTED TO THE TUMOUR ONLY', in CYTOTHERAPY, ELSEVIER SCI LTD, pp. S23 - S23, http://dx.doi.org/10.1016/j.jcyt.2014.01.072

Dolnikov A; Xu N; Shen S; O'Brien T, 2014, 'INCREASING STEM CELL DOSE PROMOTES THE LONGEVITY OF THE GRAFT IN MICE TRANSPLANTED WITH HUMAN CORD BLOOD STEM CELLS', in CYTOTHERAPY, ELSEVIER SCI LTD, pp. S57 - S57, http://dx.doi.org/10.1016/j.jcyt.2014.01.206

Dolnikov A; Shen S; Klamer G; Xu N; O'Brien TA, 2013, 'GSK-3 beta INHIBITION PROMOTES T CELL RECONSTITUTION AND PRESERVES NAIVE T CELL PHENOTYPE IN MICE TRANSPLANTED WITH HUMAN HAEMATOPOIETIC STEM CELLS', in CYTOTHERAPY, INFORMA HEALTHCARE, pp. S6 - S6, http://dx.doi.org/10.1016/j.jcyt.2013.01.020

Dolnikov A; Holmes T; Xu N; Shen S; Klamer G; O'Brien TA, 2013, 'TRANSIENT INHIBITION OF GSK-3,beta PROMOTES EARLY AND LATE ENGRAFTMENT OF EX VIVO EXPANDED HAEMATOPOIETIC PROGENITOR CELLS IN IMMUNO-COMPROMISED MICE', in CYTOTHERAPY, INFORMA HEALTHCARE, pp. S22 - S22, http://dx.doi.org/10.1016/j.jcyt.2013.01.081

Dolnikov A; Holmes T; Shen S; Knight R; O'Brien TA, 2006, 'N-ras(m)-transduced fibroblasts facilitate the expansion and engraftment of umbilical cord blood stem cells.', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, pp. 912A - 912A, presented at 48th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 09 December 2006 - 12 December 2006, http://dx.doi.org/10.1182/blood.V108.11.3196.3196

O'Brien TA; Holmes T; Vowels M; Shen S; Symonds G; Dolnikov A, 2006, 'Novel approaches for the ex vivo expansion of the engraftable cord blood derived haematopoietic progenitor cells.', in CYTOTHERAPY, TAYLOR & FRANCIS AS, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239337600043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Shen S; Holmes T; Symonds G; Brien TA, 2006, 'Molecular profile and functional analysis of the molecular factors derived from ras-transduced cells that regulate hematopoiesis.', in CYTOTHERAPY, TAYLOR & FRANCIS AS, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239337600259&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Shen S; Symonds G; Holmes TA; O'Brien TA, 2006, 'Stroma cells support ex vivo expansion of retrovirally transduced haematopoietic progenitor cells.', in CYTOTHERAPY, INFORMA HEALTHCARE, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239337600010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Holmes T; O'Brien TA; Shen S; Choo A; Symonds G; Vowels M; Dolnikov A, 2006, 'Glycogen synthase kinase-3 regulates ex vivo expansion of human umbilical cord blood progenitor cells.', in CYTOTHERAPY, TAYLOR & FRANCIS AS, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239337600054&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Shen S; Symonds G, 2005, 'Using a novel inhibitor of GSK-3 beta to activate the Wnt pathway in human haematopoietic stem cells: Impact on stem cell parameters', in CYTOMETRY PART A, WILEY-LISS, Queensland, AUSTRIA, pp. 415 - 416, presented at 7th Samuel A Latt Conference on Stem Cells in the Age of Fluorescence Technology, Queensland, AUSTRIA, 06 November 2005 - 09 November 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000237187700065&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Shen S; Symonds G, 2005, 'Ras promotes engraftment of human haematopoietic stem cells through the activation of auto/paracrine mechanisms', in CYTOMETRY PART A, WILEY-LISS, Queensland, AUSTRIA, pp. 407 - 407, presented at 7th Samuel A Latt Conference on Stem Cells in the Age of Fluorescence Technology, Queensland, AUSTRIA, 06 November 2005 - 09 November 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000237187700041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Shen S; Symonds G; Dolnikov A, 2005, 'An in vivo assay for retrovirally transduced human haematopoietic stem/progenitor cells (HSC/HPC) using nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice', in JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Melbourne, AUSTRALIA, pp. 1135 - 1135, presented at 4th Meeting of the Australasian-Gene-Therapy-Society, Melbourne, AUSTRALIA, 27 April 2005 - 29 April 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000231477900072&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Shen S; Passioura T; Symonds G, 2003, 'Differential retroviral transduction of primitive hematopoietic progenitors rather than gene silencing accounts for variation in transgene expression', in JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, QUEENSLAND INST MED RES BRISBANE, BRISBANE, AUSTRALIA, pp. S13 - S14, presented at 3rd Meeting of the Australasian-Gene-Therapy-Society, QUEENSLAND INST MED RES BRISBANE, BRISBANE, AUSTRALIA, 30 April 2003 - 02 May 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183493100036&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Shen SW; Dolnikov A; Passioura T; Symonds G; Bradstock KF, 2002, 'Mutant N-ras induces myeloid differentiation in human cord blood CD34+ cells', in BLOOD, AMER SOC HEMATOLOGY, PHILADELPHIA, PENNSYLVANIA, pp. 209B - 209B, presented at 44th Annual Meeting of the American-Society-of-Hematology, PHILADELPHIA, PENNSYLVANIA, 06 December 2002 - 10 December 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179184800888&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Shen S; Dolnikov A; O'Brien T, 2016, 'USE OF HDACI AND PD-1/PD-LI BLOCKADE TO ENHANCE CYTOLYTIC ACTIVITY OF EX VIVO EXPANDED NK CELLS AGAINST NEUROBLASTOMA', in CYTOTHERAPY, ELSEVIER SCI LTD, Vol. 18, pp. S64 - S64, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000376222800173&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Klamer G; Chitranjan A; Xu N; Shen S; Micklethwaite KP; Lock RB; O'Brien T, 2014, 'Identifying the Factors Modulating the Efficacy of CAR-T Cell Therapy', in BLOOD, AMER SOC HEMATOLOGY, Vol. 124, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349242706217&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Klamer G; Shen S; Chitranjan A; Carol H; Lock R; O'Brien T, 2014, 'IDENTIFYING THE FACTORS MODULATING THE EFFICACY OF CAR-T CELL THERAPY', in CYTOTHERAPY, ELSEVIER SCI LTD, Vol. 16, pp. S7 - S7, http://dx.doi.org/10.1016/j.jcyt.2014.01.015