Dr Sophie Pageon

Contact Details

Phone: 52012

Tabs

Main

Sophie is interested in the strategies that immune cells, in particular T cells and Natural Killer cells, use in order to hunt down and efficiently destroy cancer cells. She was awarded a PhD in Cell and Molecular Biology on the topic of ligand recognition by Natural Killer (NK) cell receptors investigated using super-resolution microscopy (Imperial College London, 2012). She then relocated to Australia and joined the group of Prof. Katharina Gaus (UNSW) as a postdoctoral fellow, where I expanded my knowledge of advanced microscopy and immune cell biology (2013-2016).

Since January 2017, she has been working with Dr. Maté Biro, head of the Cell Motility and Mechanobiology Group within the EMBL Australia Node for Single Molecule Science (SMS, UNSW). She employs a combination of super-resolution microscopy, live cell imaging and flow cytometry techniques to decipher the molecular mechanisms underlying the migratory behaviour of immune cells and their decision to kill or not to kill a target cell they encounter. She is currently investigating the molecular cues that direct T cell migration in a tumour microenvironment.

University role:

Postdoctoral Fellow

Research

Publications related to this Person

Journal articles

Conference Papers

Pageon S; Tabarin T; Yamamoto Y; Gaus K, 2016, 'Nanoscale clustering of the T cell receptor regulates T cell signalling efficiency', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, pp. 1198 - 1198, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402809&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Nicovich PR; Tabarin T; Stiegler J; Pageon SV; Gaus K, 2015, 'Analysis of Nanoscale Protein Clustering with Quantitative Localization Microscopy', in BIOPHYSICAL JOURNAL, CELL PRESS, Baltimore, MD, pp. 475A - 475A, presented at 59th Annual Meeting of the Biophysical-Society, Baltimore, MD, 07 - 11 February 2015, http://dx.doi.org/10.1016/j.bpj.2014.11.2598

Purbhoo MA; Liu H; Oddos S; Owen DM; Neil MAA; Pageon SV; French PMW; Rudd CE; Davis DM, 2010, 'Dynamics of sub-synaptic vesicles and surface microclusters at the T cell immunological synapse', in IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING, INC, Liverpool, ENGLAND, pp. 175 - 175, presented at Annual Congress of the British-Society-for-Immunology, Liverpool, ENGLAND, 06 - 10 December 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000284964100589&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a