Associate Professor Shane Thomas

Fields of research: Cardiology (incl. Cardiovascular Diseases), Biochemistry and Cell Biology, Cancer and related disorders, Immunology

Contact Details

Phone: +61 2 9385 2582
Fax: 51389
Email: shane.thomas@unsw.edu.au

Supervision

PHD
Masters
Honours

Tabs

Main

Research Interests:
The Redox Cell Signalling Laboratory focuses on two major research areas:

1. Identification of the redox reactions and cell signaling pathways important for endothelial dysfunction during vascular disease

The endothelium is critical for the maintenance of vascular homeostasis. Central to this is endothelium-derived nitric oxide (EDNO), synthesized by the endothelial nitric oxide synthase (eNOS). Vascular diseases including diabetes, atherosclerosis and hypertension are characterized by endothelial dysfunction that is manifested as impaired EDNO bioactivity that contributes to clinical cardiovascular events. Considerable evidence shows that endothelial dysfunction is due to oxidative stress in the blood vessel wall and there is great interest in defining the oxidative processes and cell signalling events involved.

Oxidative stress and endothelial dysfunction
This project aims to define the oxidative reactions promoting endothelial dysfunction during vascular disease. At present we focus on the oxidative enzyme myeloperoxidase (MPO) that during vascular disease accumulates in the sub-endothelium of diseased blood vessels where it is ideally placed to impact on endothelial function. We are currently investigating the oxidative and cell signalling mechanisms by which MPO impacts on EDNO bioactivity and endothelial function in vascular disease and testing novel agents for their ability to selectively remove MPO from the endothelium. These agents may represent potential therapeutics to combat endothelial dysfunction.

Redox control of endothelial cell signalling
Reduction and oxidation (redox) reactions represent important transducers of vascular cell signalling pathways. This project aims to identify the redox responsive cell signalling pathways in endothelial cells stimulated with agonists (e.g., vascular endothelial growth factor, angiotensin II) and to define the nature and intracellular source of the redox-active signalling species.

2. Roles and Regulation of Indoleamine 2, 3-Dioxygenase

Indoleamine 2, 3-dioxygenase (IDO) is an intracellular heme enzyme that catalyses the catabolism of L-tryptophan (L-Trp). IDO represents a central immune regulatory enzyme. Thus, expression of IDO in professional antigen presenting cells or tumor cells and resultant depletion of L-Trp, the least abundant essential amino acid, inhibits T lymphocyte activation to promote immune suppression and tolerance during inflammation, transplantation, auto-immunity and cancer.

IDO and Vascular Disease
Atherosclerosis is a chronic inflammatory disease of the artery in which T lymphocyte-mediated immune reactions play an important role. We have detected increased IDO expression in atherosclerotic lesions and currently testing if IDO activity expressed in immune cells inhibits atherosclerosis by limiting T cell activation and vascular inflammation.

Regulation of IDO activity
In light of the important immune regulatory roles of IDO it is important to understand how the enzyme is controlled. Our previous studies were the first to describe post-translational regulation of IDO and this project aims to characterize the post-translational modifications involved and the extent to which they govern the immune regulatory actions of antigen presenting cells and tumour cells. Identification of how IDO is regulated may facilitate the development of novel drug strategies to modulate IDO activity in vivo.

Broad Research Areas:

Cardiology and Vascular Disease, Immunology, Cell Biology and Gene Regulation, Biochemistry, Cancer

Society Memberships & Professional Activities:
Australasian Society for Free Radical Research, Australian Vascular Biology Society, Australian Society for Medical Research

Specific Research Keywords:
Vascular Biology, Cell Biology and Immunology, Cancer, Inflammation, Nitric oxide

University role:

Associate Professor

Groups:

Redox Cell Signalling Lab

Research

Socio-economic Objective (SEO) tags:

Cardiovascular System and Diseases

Immune System and Allergy

Cancer and Related Disorders

Teaching & Supervision

Supervision keywords:

cardiovascular diseases

cancer

immunologic diseases

virus diseases

Publications related to this Person

Journal articles

Thoms JAI; Knezevic K; Liu JJ; Glaros EN; Thai T; Qiao Q; Campbell H; Packham D; Huang Y; Papathanasiou P, 2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, vol. 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15

Huang Y; Thoms JAI; Tursky ML; Knezevic K; Beck D; Chandrakanthan V; Suryani S; Olivier J; Boulton A; Glaros EN, 2016, 'MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation', Leukemia, vol. 30, pp. 1552 - 1561, http://dx.doi.org/10.1038/leu.2016.55

Tran J; Magenau A; Rodriguez M; Rentero C; Royo T; Enrich C; Thomas SR; Grewal T; Gaus K, 2016, 'Activation of endothelial nitric oxide (eNOS) occurs through different membrane domains in endothelial cells', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0151556

Liou K; Jepson N; Buckley N; Chen V; Thomas S; Russell EA; Ooi SY, 2016, 'Design and Rationale for the Endothelin-1 Receptor Antagonism in the Prevention of Microvascular Injury in Patients with non-ST Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Inter', Cardiovascular Drugs and Therapy, vol. 30, pp. 169 - 175, http://dx.doi.org/10.1007/s10557-016-6641-x

Di Bartolo BA; Cartland SP; Prado-Lourenco L; Griffith TS; Gentile C; Ravindran J; Azahri NSM; Thai T; Yeung AWS; Thomas SR, 2015, 'Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes angiogenesis and ischemia-induced neovascularization via NADPH oxidase 4 (NOX4) and nitric oxide-dependent mechanisms', Journal of the American Heart Association, vol. 4, http://dx.doi.org/10.1161/JAHA.115.002527

Rees MD; Thomas SR, 2015, 'Using cell-substrate impedance and live cell imaging to measure real-time changes in cellular adhesion and de-adhesion induced by matrix modification', Journal of visualized experiments : JoVE, http://dx.doi.org/10.3791/52423

Nasrallah R; Knezevic K; Thai T; Thomas SR; Göttgens B; Lacaud G; Kouskoff V; Pimanda JE, 2015, 'Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis', Biology Open, vol. 4, pp. 819 - 829, http://dx.doi.org/10.1242/bio.011494

Das T; Kutty SK; Tavallaie R; Ibugo AI; Panchompoo J; Sehar S; Aldous L; Yeung AWS; Thomas SR; Kumar N, 2015, 'Phenazine virulence factor binding to extracellular DNA is important for Pseudomonas aeruginosa biofilm formation', Scientific Reports, vol. 5, http://dx.doi.org/10.1038/srep08398

Yeung AWS; Terentis AC; King NJC; Thomas SR, 2015, 'Role of indoleamine 2,3-dioxygenase in health and disease', Clinical Science, vol. 129, pp. 601 - 672, http://dx.doi.org/10.1042/CS20140392

Rees MD; Thomas SR, 2015, 'Using cell-substrate impedance and live cell imaging to measure real-time changes in cellular adhesion and de-adhesion induced by matrix modification', Journal of Visualized Experiments, http://dx.doi.org/10.3791/52423

Cochran BJ; Bisoendial RJ; Hou L; Glaros E; Rossy J; Thomas SR; Barter PJ; Rye KA, 2014, 'Apolipoprotein a-I increases insulin secretion and production from pancreatic β-cells via a g-protein-camp-PKA-FOXO1-dependent mechanism', Arteriosclerosis, Thrombosis, and Vascular Biology, http://dx.doi.org/10.1161/ATVBAHA.114.304131

Maiocchi SL; Thomas SR; Rees MD, 2014, 'Regulation of the NO Oxidase Activity of Myeloperoxidase by Pharmacological Agents', FREE RADICAL BIOLOGY AND MEDICINE, vol. 76, pp. S17 - S17, http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.497

Sherrah AG; Edelman JJB; Thomas SR; Brady PW; Wilson MK; Jeremy RW; Bannon PG; Vallely MP, 2014, 'The freestyle aortic bioprosthesis: A systematic review', Heart Lung and Circulation, vol. 23, pp. 1110 - 1117, http://dx.doi.org/10.1016/j.hlc.2014.04.262

Rees MD; Maiocchi SL; Kettle AJ; Thomas SR, 2014, 'Mechanism and regulation of peroxidase-catalyzed nitric oxide consumption in physiological fluids: Critical protective actions of ascorbate and thiocyanate', Free Radical Biology and Medicine, vol. 72, pp. 91 - 103, http://dx.doi.org/10.1016/j.freeradbiomed.2014.03.037

Stapelberg M; Zobalova R; Nguyen MN; Walker T; Stantic M; Goodwin J; Pasdar EA; Thai T; Prokopova K; Yan B, 2014, 'Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans', Free Radical Biology and Medicine, vol. 67, pp. 41 - 50, http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.003

Sherrah AG; Edelman JJB; Thomas SR; Brady PW; Wilson MK; Jeremy RW; Bannon PG; Vallely MP, 2013, 'The Freestyle Aortic Bioprosthesis: A Systematic Review', Heart Lung and Circulation, http://dx.doi.org/10.1016/j.hlc.2014.04.262

Rivera J; Walduck AK; Thomas SR; Glaros EN; Hooker EU; Guida E; Sobey CG; Drummond GR, 2013, 'Accumulation of serum lipids by vascular smooth muscle cells involves a macropinocytosis-like uptake pathway and is associated with the downregulation of the ATP-binding cassette transporter A1', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 386, pp. 1081 - 1093, http://dx.doi.org/10.1007/s00210-013-0909-5

Freewan M; Rees MD; Sempértegui Plaza TS; Glaros E; Lim YJ; Wang XS; Yeung AWS; Witting PK; Terentis AC; Thomas SR, 2013, 'Human Indoleamine 2,3-dioxygenase is a catalyst of physiological heme peroxidase reactions:implications for the inhibition of dioxygenase activity by hydrogen peroxide', Journal of Biological Chemistry, vol. 288, pp. 1548 - 1567, http://dx.doi.org/10.1074/jbc.M112.410993

Yeung AWS; Wu W; Freewan M; Stocker R; King NJC; Thomas SR, 2012, 'Flavivirus infection induces indoleamine 2,3-dioxygenase in human monocyte-derived macrophages via tumor necrosis factor and NF-κB', Journal of Leukocyte Biology, vol. 91, pp. 657 - 666, http://dx.doi.org/10.1189/jlb.1011532

Getts DR; Terry RL; Getts MT; Müller M; Rana S; Deffrasnes C; Ashhurst TM; Radford J; Hofer M; Thomas S, 2012, 'Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages', Journal of Neuroinflammation, vol. 9, http://dx.doi.org/10.1186/1742-2094-9-246

Li C; Lönn ME; Xu X; Maghzal GJ; Frazer DM; Thomas SR; Halliwell B; Richardson DR; Anderson GJ; Stocker R, 2012, 'Sustained expression of heme oxygenase-1 alters iron homeostasis in nonerythroid cells', Free Radical Biology and Medicine, vol. 53, pp. 366 - 374, http://dx.doi.org/10.1016/j.freeradbiomed.2012.03.007

Munoz-Erazo L; Yeung A; Madigan M; Thomas S; King N, 2011, 'BALANCE OF INDOLEAMINE 2,3 DIOXYGENASE AND INDUCIBLE NITRIC OXIDE SYNTHASE RESPONSES IN WEST NILE VIRUS-INFECTED HUMAN RETINAL PIGMENT EPITHELIUM', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol. 39, pp. 87 - 87, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000296914400169&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Herbert A; Ng H; Jessup W; Kockx M; Cartland S; Thomas SR; Hogg PJ; Wargon O, 2011, 'Hypoxia regulates the production and activity of glucose transporter-1 and indoleamine 2,3-dioxygenase in monocyte-derived endothelial-like cells: possible relevance to infantile haemangioma pathogene', British Journal of Dermatology, vol. 164, pp. 308 - 315, http://dx.doi.org/10.1111/j.1365-2133.2010.10086.x

Meotti FC; Jameson GNL; Turner R; Harwood DT; Stockwell S; Rees MD; Thomas SR; Kettle AJ, 2011, 'Urate as a physiological substrate for myeloperoxidase: Implications for hyperuricemia and inflammation', Journal of Biological Chemistry, vol. 286, pp. 12901 - 12911, http://dx.doi.org/10.1074/jbc.M110.172460

Wang Y; Liu H; McKenzie G; Witting PK; Stasch JP; Hahn M; Changsirivathanathamrong D; Wu BJ; Ball HJ; Thomas SR, 2010, 'Erratum: Kynurenine is an endothelium-derived relaxing factor produced during inflammation (Nature Medicine (2010) 16 (279-285))', Nature Medicine, vol. 16, pp. 607, http://dx.doi.org/10.1038/nm0510-607a

Terentis AC; Freewan M; Sempértegui Plaza TS; Raftery MJ; Stocker R; Thomas SR, 2010, 'The selenazal drug ebselen potently inhibits indoleamine 2,3-dioxygenase by targeting enzyme cysteine residues', Biochemistry, vol. 49, pp. 591 - 600, http://dx.doi.org/10.1021/bi901546e

Wang Y; Liu H; McKenzie G; Witting PK; Stasch JP; Hahn M; Changsirivathanathamrong D; Wu BJ; Ball HJ; Thomas SR, 2010, 'Kynurenine is an endothelium-derived relaxing factor produced during inflammation', Nature Medicine, vol. 16, pp. 279 - 285, http://dx.doi.org/10.1038/nm.2092

Schulz E; Dopheide J; Schuhmacher S; Thomas SR; Chen K; Daiber A; Wenzel P; Münzel T; Keaney JF, 2008, 'Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction', Circulation, vol. 118, pp. 1347 - 1357, http://dx.doi.org/10.1161/CIRCULATIONAHA.108.784298

Maghzal GJ; Thomas SR; Hunt NH; Stocker R, 2008, 'Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells', Journal of Biological Chemistry, vol. 283, pp. 12014 - 12025, http://dx.doi.org/10.1074/jbc.M710266200

Thomas SR; Witting PK; Drummond GR, 2008, 'Redox control of endothelial function and dysfunction: Molecular mechanisms and therapeutic opportunities', Antioxidants and Redox Signaling, vol. 10, pp. 1713 - 1765, http://dx.doi.org/10.1089/ars.2008.2027

Lim SY; Raftery M; Cai H; Hsu K; Yan WX; Hseih HL; Watts RN; Richardson D; Thomas S; Perry M, 2008, 'S-nitrosylated S100A8: Novel anti-inflammatory properties', Journal of Immunology, vol. 181, pp. 5627 - 5636, http://dx.doi.org/10.4049/jimmunol.181.8.5627

Maghzal GJ; Thomas SR; Hunt NH; Stocker R, 2008, 'Cytochrome b5, Not Superoxide Anion Radical, Is a Major Reductant of Indoleamine 2,3-Dioxygenase in Human Cells', The Journal of Biological Chemistry, vol. 285, pp. 12014 - 12025, http://dx.doi.org/10.1074/jbc.M710266200

Thomas SR; Terentis AC; Cai H; Takikawa O; Levina A; Lay PA; Freewan M; Stocker R, 2007, 'Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide', Journal of Biological Chemistry, vol. 282, pp. 23778 - 23787, http://dx.doi.org/10.1074/jbc.M700669200

King NJC; Thomas SR, 2007, 'Molecules in focus: Indoleamine 2,3-dioxygenase', International Journal of Biochemistry and Cell Biology, vol. 39, pp. 2167 - 2172, http://dx.doi.org/10.1016/j.biocel.2007.01.004

Thomas SR; Schulz E; Keaney JF, 2006, 'Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity-Role for iron-dependent oxidative stress', Free Radical Biology and Medicine, vol. 41, pp. 681 - 688, http://dx.doi.org/10.1016/j.freeradbiomed.2006.05.012

Choy K; Beck K; Png FY; Wu BJ; Leichtweis SB; Thomas SR; Hou JY; Croft KD; Mori TA; Stocker R, 2005, 'Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, pp. 1684 - 1690, http://dx.doi.org/10.1161/01.ATV.0000174125.89058.b6

Heydrick SJ; Weiss N; Thomas SR; Cap AP; Pimentel DR; Loscalzo J; Keaney JF, 2004, 'L-Homocysteine and L-homocystine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells', Free Radical Biology and Medicine, vol. 36, pp. 632 - 640, http://dx.doi.org/10.1016/j.freeradbiomed.2003.12.001

Chen K; Thomas SR; Albano A; Murphy MP; Keaney JF, 2004, 'Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling', Journal of Biological Chemistry, vol. 279, pp. 35079 - 35086, http://dx.doi.org/10.1074/jbc.M404859200

Anter E; Thomas SR; Schulz E; Shapira OM; Vita JA; Keaney JF, 2004, 'Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols', Journal of Biological Chemistry, vol. 279, pp. 46637 - 46643, http://dx.doi.org/10.1074/jbc.M405547200

Thomas SR; Keaney JF; Stocker R, 2004, 'Redox regulation of vascular cell function', JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 37, pp. 322 - 323, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000222965000529&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Aitken JB; Thomas SE; Stocker R; Thomas SR; Takikawa O; Armstrong RS; Lay PA, 2004, 'Determination of the Nature of the Heme Environment in Nitrosyl Indoleamine 2,3-Dioxygenase Using Multiple-Scattering Analyses of X-ray Absorption Fine Structure', Biochemistry, vol. 43, pp. 4892 - 4898, http://dx.doi.org/10.1021/bi049645s

Stocker R; Huang A; Jeranian E; Hou JY; Wu TT; Thomas SR; Keaney JF, 2004, 'Hypochlorous acid impairs endothelium-derived nitric oxide bioactivity through a superoxide-dependent mechanism', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, pp. 2028 - 2033, http://dx.doi.org/10.1161/01.ATV.0000143388.20994.fa

Chen K; Thomas SR; Keaney JF, 2003, 'Beyond LDL oxidation: ROS in vascular signal transduction', Free Radical Biology and Medicine, vol. 35, pp. 117 - 132, http://dx.doi.org/10.1016/S0891-5849(03)00239-9

Thomas SR; Chen K; Keaney JF, 2003, 'Oxidative stress and endothelial nitric oxide bioactivity', Antioxidants and Redox Signaling, vol. 5, pp. 181 - 194, http://dx.doi.org/10.1089/152308603764816541

Vita JA; Gokce N; Duffy SJ; Kahn D; Tomasian D; Palmisano J; Thomas S; Holbrook M; Keaney JF, 2003, 'Effect of atorvastatin on endothelium-dependent vasodilation in patients with coronary artery disease', American Journal of Cardiology, vol. 91, pp. 857 - 860, http://dx.doi.org/10.1016/S0002-9149(03)00019-5

Huang A; Thomas SR; Keaney JF, 2002, 'Measurements of redox control of nitric oxide bioavailability', Methods in Enzymology, vol. 359, pp. 209 - 216, http://dx.doi.org/10.1016/S0076-6879(02)59185-0

Thomas SR; Chen K; Keaney JF, 2002, 'Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway', Journal of Biological Chemistry, vol. 277, pp. 6017 - 6024, http://dx.doi.org/10.1074/jbc.M109107200

Kim HS; Skurk C; Thomas SR; Bialik A; Suhara T; Kureishi Y; Birnbaum M; Keaney JF; Kenneth Walsh S, 2002, 'Regulation of angiogenesis by glycogen synthase kinase-3β', Journal of Biological Chemistry, vol. 277, pp. 41888 - 41896, http://dx.doi.org/10.1074/jbc.M206657200

Terentis AC; Thomas SR; Burr JA; Liebler DC; Stocker R, 2002, 'Vitamin E oxidation in human atherosclerotic lesions', Circulation Research, vol. 90, pp. 333 - 339, http://dx.doi.org/10.1161/hh0302.104454

Terentis AC; Thomas SR; Takikawa O; Littlejohn TK; Truscott RJW; Armstrong RS; Stocker SRYR, 2002, 'The heme environment of recombinant human indoleamine 2,3-dioxygenase. Structural properties and substrate-ligand interactions', Journal of Biological Chemistry, vol. 277, pp. 15788 - 15794, http://dx.doi.org/10.1074/jbc.M200457200

Thomas SR; Salahifar H; Mashima R; Hunt NH; Richardson DR; Stocker R, 2001, 'Antioxidants inhibit indoleamine 2,3-dioxygenase in IFN-γ-activated human macrophages: Posttranslational regulation by pyrrolidine dithiocarbamate', Journal of Immunology, vol. 166, pp. 6332 - 6340

Carr AC; Hawkins CL; Thomas SR; Stocker R; Frei B, 2001, 'Relative reactivities of N-chloramines and hypochlorous acid with human plasma constituents', Free Radical Biology and Medicine, vol. 30, pp. 526 - 536, http://dx.doi.org/10.1016/S0891-5849(00)00495-0

Thomas SR; Leichtweis SB; Pettersson K; Croft KD; Mori TA; Brown AJ; Stocker R, 2001, 'Dietary cosupplementation with vitamin E and coenzyme Q10inhibits atherosclerosis in apolipoprotein E gene knockout mice', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 21, pp. 585 - 593, http://dx.doi.org/10.1161/01.ATV.21.4.585

Thomas SR; Stocker R, 2000, 'Molecular action of vitamin E in lipoprotein oxidation: Implications for atherosclerosis', Free Radical Biology and Medicine, vol. 28, pp. 1795 - 1805, http://dx.doi.org/10.1016/S0891-5849(00)00236-7

Thomas SR; Stocker R, 1999, 'Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway', Redox Report, vol. 4, pp. 199 - 220, http://dx.doi.org/10.1179/135100099101534927

Thomas SR; Witting PK; Stocker R, 1999, 'A role for reduced coenzyme Q in atherosclerosis?', BioFactors, vol. 9, pp. 207 - 224, http://dx.doi.org/10.1002/biof.5520090216

Terentis AC; Thomas SR; Burr JA; Liebler DC; Stocker R, 1999, 'Alpha-tocopherol oxidation products in atherosclerotic lesions', FREE RADICAL BIOLOGY AND MEDICINE, vol. 27, pp. S99 - S99, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083598900331&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Thomas SR; Terentis AC; Takikawa O; Hunt NH; Stocker R, 1999, 'Antioxidant activity and redox control of oxidative tryptophan metabolism in IFNG-primed macrophages', FREE RADICAL BIOLOGY AND MEDICINE, vol. 27, pp. S56 - S56, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083598900174&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Sanni LA; Thomas SR; Tattam BN; Moore DE; Chaudhri G; Stocker R; Hunt NH, 1998, 'Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria', American Journal of Pathology, vol. 152, pp. 611 - 619

Thomas SR; Davies MJ; Stocker R, 1998, 'Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite', Chemical Research in Toxicology, vol. 11, pp. 484 - 494, http://dx.doi.org/10.1021/tx970173a

Thomas SR; Davies MJ; Stocker R, 1997, 'Peroxynitrite oxidises LDL lipids via tocopherol-mediated peroxidation', ATHEROSCLEROSIS, vol. 134, pp. 218 - 218, http://dx.doi.org/10.1016/S0021-9150(97)89169-1

Thomas SR; Witting PK; Stocker R, 1997, 'Macrophage-derived 3-hydroxyanthranilate synergises with vitamin E in inhibiting LDL lipid peroxidation', ATHEROSCLEROSIS, vol. 134, pp. 236 - 236, http://dx.doi.org/10.1016/S0021-9150(97)89256-8

Thomas SR; Witting PK; Stocker R, 1996, '3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for α-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidation', Journal of Biological Chemistry, vol. 271, pp. 32714 - 32721, http://dx.doi.org/10.1074/jbc.271.51.32714

Thomas SR; Neužil J; Stocker R, 1996, 'Cosupplementation with Coenzyme Q Prevents the Prpoxidant Effect of α-Tocopherol and Increases the Resistance of LDL to Transition Metal-Dependent Oxidation Initiation', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 16, pp. 687 - 696, http://dx.doi.org/10.1161/01.ATV.16.5.687

Neužil J; Thomas SR; Stocker R, 1996, 'Requirement for, promotion, or inhibition by α-tocopherol of radical- induced initiation of plasma lipoprotein lipid peroxidation', Free Radical Biology and Medicine, vol. 22, pp. 57 - 71, http://dx.doi.org/10.1016/S0891-5849(96)00224-9

Thomas SR; Neuzil J; Mohr D; Stocker R, 1995, 'Coantioxidants make alpha-tocopherol an efficient antioxidant for low-density lipoprotein.', Am J Clin Nutr, vol. 62, pp. 1357S - 1364S, http://dx.doi.org/10.1093/ajcn/62.6.1357S

Christen S; Thomas SR; Garner B; Stocker R, 1994, 'Inhibition by interferon-γ of human mononuclear cell-mediated low density lipoprotein oxidation. Participation of tryptophan metabolism along the kynurenine pathway', Journal of Clinical Investigation, vol. 93, pp. 2149 - 2158, http://dx.doi.org/10.1172/JCI117211

Thomas SR; Mohr D; Stocker R, 1994, 'Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon- γ primed mononuclear phagocytes', Journal of Biological Chemistry, vol. 269, pp. 14457 - 14464

Conference Papers

Munoz-Erazo LE; Natoli R; Yeung AWS; Provis JM; Madigan MC; Thomas SR; King NJC, 2010, 'Microarray Analysis of Human Retinal Pigmented Epithelium Following Infection With West Nile Virus', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000442387300395&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Thai T; Rees M; Dang L; Harwood DT; Winterbourn CC; Kettle AJ; Maghzal G; Stocker R; Keaney JF; Thomas SR, 2009, 'MYELOPEROXIDASE AND ENDOTHELIAL DYSFUNCTION', in JOURNAL OF VASCULAR RESEARCH, KARGER, Queenstown, NEW ZEALAND, pp. 10 - 10, presented at 14th Meeting of the Australian-and-New-Zealand-Microcirculation-Society, Queenstown, NEW ZEALAND, 25 - 27 August 2009, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000268340300011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Wang Y; Liu H; Keaney JF; Stasch JP; Wu BJ; Witting PK; McKenzie G; Ball HJ; Kapoor V; Thomas SR, 2009, 'KYNURENINE IS A NOVEL ENDOTHELIUM-DERIVED VASCULAR RELAXING FACTOR PRODUCED DURING INFLAMMATION', in HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, Melbourne, AUSTRALIA, pp. 1120 - 1120, presented at 30th Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia, Melbourne, AUSTRALIA, 03 - 05 December 2008, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000266239300144&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Wang Y; Keaney JF; Stasch J; Wu BJ; Witting P; McKenzie GL; Ball HJ; Kapoor V; Thomas SR; Mellor A, 2009, 'KYNURENINE IS A NOVEL ENDOTHELIUM-DERIVED VASCULAR RELAXING FACTOR PRODUCED DURING INFLAMMATION', in Hypertension, 4th International Conference of cGMP Generators, Effectors and Therapeutic Implications, Regensburg, Germany, pp. 108 - 109, presented at 4th International Conference of cGMP Generators, Effectors and Therapeutic Implications, Regensburg, Germany, 19 - 21 June 2009

Lim SY; Raftery M; Cai H; Thomas S; Hsu K; Geczy CL, 2008, 'S-nitrosylated S100A8-novel anti-inflammatory properties', in CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Montreal, CANADA, pp. 263 - 263, presented at 7th Joint Conference of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytoklin-Research, Montreal, CANADA, 12 - 16 October 2008, http://dx.doi.org/10.1016/j.cyto.2008.07.157

Lim SY; Raftery M; Cai H; Thomas S; Geczy C, 2008, 'S-nitrosylated S100A8 suppresses mast cell activation: Novel anti-inflammatory properties', in JOURNAL OF LEUKOCYTE BIOLOGY, FEDERATION AMER SOC EXP BIOL, Pittsburgh, PA, pp. A18 - A18, presented at 3rd International Damage Associated Molecular Pattern Molecules (DAMPs) and Alarmins Symposium, Pittsburgh, PA, 30 August - 02 September 2008, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000258091600049&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Thomas SR; Stocker R, 2000, 'Antioxidant activities and redox regulation of interferon-gamma-induced tryptophan metabolism in human monocytes and macrophages', in Advances in Experimental Medicine and Biology, pp. 541 - 552

Thomas SR; Neuzil J; Stocker R, 1997, 'Inhibition of LDL oxidation by ubiquinol-10. A protective mechanism for coenzyme Q in atherogenesis?', in Molecular Aspects of Medicine, http://dx.doi.org/10.1016/S0098-2997(97)00031-9

Thomas SR; Neuzil J; Mohr D; Stocker R, 1995, 'Coantioxidants make α-tocopherol an efficient antioxidant for low- density lipoprotein', in American Journal of Clinical Nutrition

THOMAS SR; NEUZIL J; MOHR D; STOCKER R, 1995, 'COANTIOXIDANTS MAKE ALPHA-TOCOPHEROL AN EFFICIENT ANTIOXIDANT FOR LOW-DENSITY-LIPOPROTEIN', in AMERICAN JOURNAL OF CLINICAL NUTRITION, AMER SOC NUTRITION-ASN, pp. 1357 - 1364, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TK01900009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Abstracts

Pasalic L; Abeynaike L; Glaros E; Thomas S; Hogg P; Chen V, 2015, 'NEUTROPHILS CONTRIBUTE TO THE GENERATION OF PROCOAGULANT PLATELETS BY A MYELOPEROXIDASE INDEPENDENT MECHANISM', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, Vienna, AUSTRIA, Vol. 100, pp. 144 - 144, presented at 20th Congress of European-Hematology-Association, Vienna, AUSTRIA, 11 - 14 June 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361204901315&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Maiocchi S; Dang L; Morris J; Thomas S; Rees M, 2015, 'Inhibition of Myeloperoxidase-Mediated Endothelial Dysfunction by Nitroxides', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, Stuttgart, GERMANY, Vol. 86, pp. S28 - S29, presented at SFRR-E/SNFS Conference, Stuttgart, GERMANY, 02 - 04 September 2015, http://dx.doi.org/10.1016/j.freeradbiomed.2015.07.103

Maiocchi S; Rees M; Thomas S, 2015, 'Regulation of Myeloperoxidase NO Oxidase Activity by Pharmacological Agents: Novel Biochemical Basis for NO Preservation by Phenolics and Nitroxides (Tempol)', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, Stuttgart, GERMANY, Vol. 86, pp. S29 - S29, presented at SFRR-E/SNFS Conference, Stuttgart, GERMANY, 02 - 04 September 2015, http://dx.doi.org/10.1016/j.freeradbiomed.2015.07.104

Pasalic L; Abeynaike L; Glaros E; Thomas S; Hogg P; Chen V, 2015, 'Neutrophils contribute to the generation of procoagulant platelets by a myeloperoxidase independent mechanism', in JOURNAL OF THROMBOSIS AND HAEMOSTASIS, WILEY-BLACKWELL, Vol. 13, pp. 408 - 408, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000356426903016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a