Associate Professor Orin Chisholm

Fields of research: Pharmaceutical Sciences, Education Assessment and Evaluation, Vocational Education and Training Curriculum and Pedagogy, Higher Education, Health Economics, Pharmacology and Pharmaceutical Sciences, Clinical Pharmacology and Therapeutics, Clinical Pharmacology and Therapeutics, Clinical Pharmacology and Therapeutics, Pharmaceutical Sciences, Medical Biotechnology not elsewhere classified, Medicine, Nursing and Health Curriculum and Pedagogy, Clinical Sciences, Cancer Therapy (excl. Chemotherapy and Radiation Therapy)

Contact Details

Phone: 0293852552
Email: o.chisholm@unsw.edu.au

Supervision

ILP
PHD
Masters

Tabs

Main

Orin Chisholm is the Program Director and Associate Professor in Pharmaceutical Medicine in the School of Medical Sciences at UNSW. She is a Senior Fellow of the Higher Education Academy.

In 2017 she received the Award for Excellence in Regulatory Affairs Education from the international Organisation for Professionals in Regulatory Affairs (TOPRA).

TOPRA award banner

She has extensive experience in the pharmaceutical industry, which has equipped her to embed practical, current and innovative education in pharmaceutical medicine in her role as program director. She has significant expertise in regulatory affairs in both large multinational pharmaceutical and small biotechnology companies in Australia. She has particular success in the registration of biotechnology products for oncology indications. She has contributed her expertise in global regulatory affairs to an important textbook on international regulatory affairs published by the Regulatory Affairs Professional Society (RAPS).

Orin is a member of the Gene Technology Technical Advisory Committee (GTTAC) which provides advice to the Gene Technology Regulator, the federal Office of the Gene Technology Regulator (OGTR) and the Legislative Governance Forum on Gene Technology on all matters relating to gene technology, genetically-modified organisms (GMOs) and genetically modified (GM) products, including applications made to the Regulator under the Gene Technology Act, the biosafety aspects of gene technology and the need for and content of policy principles, guidelines, codes of practice and technical and procedural guidelines in relation to GMOs and GM products in Australia.

Orin also has a strong academic background in the molecular biology of haemopoiesis and oncology and she has teaching qualifications in higher education. In 2016, she received a Faculty of Medicine teaching award for outstanding contributions to student learning.

Orin is a member of the Australia-wide CRITERIA (Clinical-Research-Industry’s-Talent-Expansion-Retention-Investment & Advancement) Consortium, led by ARCS Ltd., which has received $250,000 funding from MTPConnect for Building clinical trial capability and capacity to grow the MTP Sector.

Orin is a member of ARCS, ASCEPT, DIA, RAPS, TOPRA and HERDSA.

Current Teaching

Postgraduate: Pharmaceutical Medicine Program

https://med.unsw.edu.au/pharmaceutical-medicine

Undergraduate: Drug Discovery, Design and Development

Past teaching

Personalised Medicine MOOC

https://www.futurelearn.com/courses/personalised-medicine

https://www.coursera.org/course/personalisedmed

Current Research Interests

1. Regulatory science and Pharmaceutical Medicine

2. The scholarship of learning and teaching in pharmaceutical medicine, personalised medicine and cancer therapeutics

Students interested in ILP, Honours, DrPH or PhD projects in these areas, please contact Orin directly to discuss.

Journal Reviewer

Therapeutic Innovation and Regulatory Science

International Presentations

2015: Online Training for Medical Affairs Professionals in China, presented at The China Medical Affairs Summit, Shanghai, China

International Education Programs

2017: Pharmaceutical Medicine Training Program for delegation of pharmacists from Department of Health, Shandong Province, China

2015: Pharmaceutical Medicine Training Program for Ministry of Health officials and leading Pharmacology Professors from several universities in Kazakhstan

Committees

International:

DIA Regional Advisory Committee-Australia/NZ (Chair), 2018-present
RAPS Editorial Advisory Committee, 2018-present

Australian:

Gene Technology Technical Advisory Committee, 2017-present

Local/UNSW:

SOMS Teaching Committee 2012-present
MedTELT Committee 2012-2018
Medicine Faculty Education Committee 2015-present
Cancer Clinical Academic Group (SPHERE) 2018-present
TCRN 2025 Cancer Workforce and Capacity Building Flagship 2017-present

University role:

Associate Professor

Grants:

Australian

Member of Australia-wide CRITERIA (Clinical-Research-Industry’s-Talent-Expansion-Retention-Investment & Advancement) Consortium, led by ARCS Ltd, $250,000 funding received from MTPConnect for Building clinical trial capability and capacity to grow the MTP Sector.

UNSW

Member of SEIF grant for “UNSW Micro-Credentialing Ecosystem for Recognising Learning and Skills Attainment in Capstone Courses and Internships” ($170,000).

Member of Education-focussed foundation funding grant for “Infrastructure enabling design, implementation and evaluation of innovations, ensuring excellence in student learning and experience” ($123,000).

Memberships:

ARCS

DIA

RAPS

ASCEPT

HERDSA

Awards:

2016: Faculty of Medicine teaching award for outstanding contributions to student learning.

2017: The Organisation for Professionals in Regulatory Affairs (TOPRA) Award for Regulatory Excellence in Education (international award).

Groups:

Educational Research and Development Group

My Notes:

LinkedIn: au.linkedin.com/pub/orin-chisholm/18/17/728

Research

Research activities:

Regulatory Science

Pharmaceutical Medicine

Pharmaceutical Medicine Education

Socio-economic Objective (SEO) tags:

Human Pharmaceutical Products

Expanding Knowledge in the Medical and Health Sciences

Learner and Learning

Teaching & Supervision

I am available to supervise:

Yes

Areas of supervision:

ILP, Honours, Masters, PhD, DrPH

Regulatory Science, Pharmaceutical Medicine, Pharmaceutical Medicine Education, Medical Education

Currently supervising:

Mr Matthew Britland - Professional Doctorate in Public Health (DrPH); co-supervisors are Dr Anita Heywood and Dr Lois Meyer, SPHCM. Project: The role of the medical science liaison in contributing to the Quality Use of Medicines in Australia.

Ms Alina Yoffe - Masters by Research; joint supervisor Dr Greg Smith, co-supervisor Dr Johnson Liu. Project: Analysis of the impact of the new accelerated regulatory approval pathways on access to new medicines in Australia.

Completed students

Ms Eesha Bhargava - Honours student in Bachelor of Advanced Science and Arts program. Project: Innovative education in personalised medicine: analysis of engagement in a massive open online course.

Supervision keywords:

regulatory affairs

pharmacology

evidence-based medicine

biotechnology

adverse effects

pharmaceutical medicine education

Media

LinkedIn:

https://au.linkedin.com/in/orin-chisholm-72801718

Twitter Account:

https://twitter.com/OrinChisholm

Publications related to this Person

Book Chapters

Chisholm O; Carter M, 2018, 'Authorization Procedures for Pharmaceutical Products', in Jones P (ed.), Fundamentals of International Regulatory Affairs, edn. 4, Regulatory Affairs Professional Society, USA, pp. 91 - 108

Chisholm OT, 2017, 'Authorisation procedures for pharmaceutical products', in Jones P (ed.), Fundamentals of international regulatory affairs, edn. 3, RAPS, MD, USA, pp. 69 - 80, https://www.raps.org/ProductDetail.aspx?ProductId=131091030

Journal articles

Badolato J; Chisholm OT; Holmes M, 2013, 'ARCS Australia University Partnerships.', The Source Document, pp. 34 - 34

Marsh IB; Whittington RJ; ORourke B; Hyatt AD; Chisholm O, 2002, 'Rapid differentiation of Australian, European and American ranaviruses based on variation in major capsid protein gene sequence', Molecular and Cellular Probes, vol. 16, pp. 137 - 151, http://dx.doi.org/10.1006/mcpr.2001.0400

Ryan GR; Dai XM; Dominguez MG; Tong W; Chuan F; Chisholm O; Russell RG; Pollard JW; Richard Stanley E, 2001, 'Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1 ^op /Csf1 ^op ) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis', Blood, vol. 98, pp. 74 - 84, http://dx.doi.org/10.1182/blood.V98.1.74

Sungaran R; Chisholm O, 2001, 'Thrombopoietin gene regulation - A review', Hematology, vol. 6, pp. 41 - 46, http://dx.doi.org/10.1080/10245332.2001.11746551

Sungaran R; Chisholm OT; Markovic B; Khachigian LM; Tanaka Y; Chong BH, 2000, 'The role of platelet alpha-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells', BLOOD, vol. 95, pp. 3094 - 3101, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000086951000014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Holmes M; Turner J; Fox A; Chisholm O; Crossley M; Chong B, 1999, 'hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, pp. 23491 - 23498, http://dx.doi.org/10.1074/jbc.274.33.23491

Cohen PE; Chisholm O; Arceci RJ; Stanley ER; Pollard JW, 1996, 'Absence of colony-stimulating factor-1 in osteopetrotic (csfm(op)/csfm(op)) mice results in male fertility defects', Biology of Reproduction, vol. 55, pp. 310 - 317, http://dx.doi.org/10.1095/biolreprod55.2.310

Chang MDY; Stanley ER; Khalili H; Chisholm O; Pollard JW, 1995, 'Osteopetrotic (op/op) mice deficient in macrophages have the ability to mount a normal T-cell-dependent immune response', Cellular Immunology, vol. 162, pp. 146 - 152, http://dx.doi.org/10.1006/cimm.1995.1062

CHISHOLM O; BERTONCELLO I, 1994, 'ALPHA-4-BETA-1 INTEGRIN EXPRESSION ON SUBSETS OF HEMATOPOIETIC STEM-CELLS', JOURNAL OF CELLULAR BIOCHEMISTRY, pp. 10 - 10, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994MV41200025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Cecchini MG; Dominguez MG; Mocci S; Wetterwald A; Felix R; Fleisch H; Chisholm O; Hofstetter W; Pollard JW; Stanley ER, 1994, 'Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse', Development, vol. 120, pp. 1357 - 1372

CHISHOLM O; BERTONCELLO I, 1993, 'DOES EXPRESSION OF THE ALPHA-4-BETA-1 INTEGRIN CHANGE WITH THE PROLIFERATIVE AND DIFFERENTIATIVE CAPACITY OF MURINE PRIMITIVE HEMATOPOIETIC STEM-CELLS', JOURNAL OF LEUKOCYTE BIOLOGY, pp. 101 - 101, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993ME18500405&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Begg SK; Radley JM; Pollard JW; Chisholm OT; Richard Stanley E; Bertoncello I, 1993, 'Delayed hematopoietic development in osteopetrotic (op/op) mice', Journal of Experimental Medicine, vol. 177, pp. 237 - 242, http://dx.doi.org/10.1084/jem.177.1.237

Stanley ER; Wiktor-Jedrzejczak W; Pollard JW; Hunt JS; Chisholm O; Price LK, 1992, 'Biology and action of colony stimulating factor-1.', Journal of Cellular Biochemistry -Supplement-, vol. 16C, pp. 57 - 57

Pollard JW; Arceci RJ; Chisholm O; Daiter E; Pampfer S; Stanley ER; Wiktor-Jedrzejczak W, 1992, 'Colony-stimulating factor-1 in the regulation of placental development', Journal of Cellular Biochemistry -Supplement-, vol. 16F, pp. 75 - 75

BEGG SK; RADLEY JM; POLLARD JW; CHISHOLM O; STANLEY ER; BERTONCELLO I, 1992, 'MACROPHAGE DEVELOPMENT, AND AGE-RELATED-CHANGES IN HEMATOPOIESIS, IN CSF-1 DEFICIENT OSTEOPETROTIC (OP/OP) MICE', EXPERIMENTAL HEMATOLOGY, vol. 20, pp. 826 - 826, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992JA73400461&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Chisholm O; Stapleton P; Symonds G, 1992, 'Constitutive expression of exogenous myc in myelomonocytic cells: Acquisition of a more transformed phenotype and inhibition of differentiation induction', Oncogene, vol. 7, pp. 1827 - 1836

Chisholm O; Symonds G, 1992, 'An in vitro fibroblast model system to study myc‐driven tumour progression', International Journal of Cancer, vol. 51, pp. 149 - 158, http://dx.doi.org/10.1002/ijc.2910510126

Bonham L; Kwok J; Chisholm O; Symonds G, 1991, 'Inducible transformation of fibroblasts using a metallothionein-v-myc gene construct', Oncogene, vol. 6, pp. 1073 - 1077

Symonds G; Bonham L; Chisholm O; Miller M; Stapleton P; Takayama Y, 1989, 'The use of retroviral vectors to study cell transformation and malignancy', Transplantation Proceedings, vol. 21, pp. 61 - 64

Chisholm O; Symonds G, 1988, 'Transfection of myeloid cell lines using polybrene/DMSO', Nucleic Acids Research, vol. 16, pp. 2352, http://dx.doi.org/10.1093/nar/16.5.2352

Barry RD; Cowley JA; Chisholm OT; Richards SG, 1985, 'Structural and antigenic properties of human parainfluenza viruses', Virus Research, vol. 3, pp. 78 - 78, http://dx.doi.org/10.1016/0168-1702(85)90408-3

Chisholm O, 'Curriculum Transformation: From Didactic to Competency-Based Programs in Pharmaceutical Medicine', Frontiers in Pharmacology, vol. 10, http://dx.doi.org/10.3389/fphar.2019.00278

Conference Papers

Yang M; Hogg PJ; Chisholm OT; Li K; Chesterman CN; Chong BH, 1999, 'TSP1 inhibits PEG-rHuMGDF-induced mega karyocytopoiesis via TSP/TSP receptor interaction.', in BLOOD, AMER SOC HEMATOLOGY, pp. 41A - 41A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083790300218&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Sungaran R; Chisholm OT; Chong BH, 1999, 'The regulation of thrombopoietin mRNA expression - An in vitro and in vivo study.', in BLOOD, AMER SOC HEMATOLOGY, pp. 39A - 39A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083790300211&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Yang M; Li K; Lam AC; Chui CMY; Yuen PMP; Chisholm OT; Chesterman CN; Chong BH, 1999, 'PDGF indirectly enhanced granulopoiesis.', in BLOOD, AMER SOC HEMATOLOGY, pp. 46B - 46B, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083790700200&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Chisholm O; Fahmy R; Tao H; Holmes M; Chong B, 1999, 'Transcription factor and cell surface protein expression during megakaryocyte differentiation.', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, pp. 102 - 102, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000081030100250&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Other

Chisholm OT, 2013, Submission on discussion paper “Description of a possible joint regulatory scheme for therapeutic products under ANZTPA”, http://www.anztpa.org/consultation/consult-anztpa-scheme-130108-submissions.htm, http://www.anztpa.org/pdf/submissions/consult-anztpa-scheme-130108-submission-unsw.pdf

Conference Posters

Conference Presentations

Nixdorf S; Chisholm OT; Gomes L; Ford C, 2016, 'Student Engagement in the Personalised Medicine MOOC: Does the Learning Platform Matter?', in Student Engagement in the Personalised Medicine MOOC: Does the Learning Platform Matter?, UNSW Medicine Learning and Teaching Forum, UNSW, Sydney, presented at UNSW Medicine Learning and Teaching Forum, UNSW, Sydney, 07 - 07 December 2016

Ford C; Chisholm O; Gomes L, 2016, 'The Hope and Hype of the Genetic Revolution: Reflections on UNSW Medicine's First MOOC', in The Hope and Hype of the Genetic Revolution: Reflections on UNSW Medicine's First MOOC, Connections Seminar Series, UNSW Australia, UNSW Australia, presented at Connections Seminar Series, UNSW Australia, UNSW Australia, 19 - 19 May 2016

Ford C; Chisholm OT; Gomes L, 2015, 'Hope and Hype: Reflections on UNSW Medicine's First MOOC', in Hope and Hype: Reflections on UNSW Medicine's First MOOC, 2015 UNSW Medicine Learning and Teaching Forum, UNSW, Sydney, NSW, Australia, presented at 2015 UNSW Medicine Learning and Teaching Forum, UNSW, Sydney, NSW, Australia, 02 - 02 December 2015, https://med.unsw.edu.au/annual-learning-and-teaching-forum

Chisholm OT, 2015, 'Career Choices', in Career Choices, APSA-ASCEPT Joint Scientific Meeting 2015, Hobart. Tasmania, Australia, presented at APSA-ASCEPT Joint Scientific Meeting 2015, Hobart. Tasmania, Australia, 29 November - 02 December 2015, http://www.asceptasm.com/

Chisholm OT, 2015, 'Online training for medical affairs professionals in China', in Online training for medical affairs professionals in China, China Medical Affairs Summit, Shanghai, China, presented at China Medical Affairs Summit, Shanghai, China, 17 - 19 June 2015, http://www.chinamedicalaffairs.com/

Chisholm O; Nixdorf S; Williams R; Ford C, 2014, 'Reflections on the development of an open online course', in Reflections on the development of an open online course, UNSW Medicine Learning and Teaching Forum 2014, UNSW Australia, presented at UNSW Medicine Learning and Teaching Forum 2014, UNSW Australia, 10 - 10 December 2014, http://med.unsw.edu.au/annual-learning-and-teaching-forum

Chisholm O; O'Connell P; Bertoncello I; Hapel A, 1995, 'Adhesion-dependent signalling in haematopoietic progenitor cell lines.', in Adhesion-dependent signalling in haematopoietic progenitor cell lines., Postgraduate Committee in Medicine 1995 Scientific Meeting, Canberra, presented at Postgraduate Committee in Medicine 1995 Scientific Meeting, Canberra, 01 - 01 January 1995

Media

Chisholm O, 2016, Time for higher education to play greater pharma role

Ford C; Chisholm O, 2015, Brace yourself genetic testing might give you more than you bargained for., https://theconversation.com/brace-yourself-genetic-testing-might-give-you-more-than-you-bargained-for-40246