John Power

Fields of research: Cellular Nervous System, Neurosciences, Nervous system and disorders

Contact Details

Phone: +61-2-9065 1809
Email: john.power@unsw.edu.au

Supervision

ILP
PHD
Masters
Honours

Tabs

Main

Dr. John Power is a Senior Lecturer within the Department of Physiology and the Neuroscience Honours Coordinator. He leads Neuroplasticity in Memory and Addiction Group within the Translational Neuroscience Facility. Dr. Power is an expert in the cellular basis of memory formation. His previous research has contributed to our understanding of the biophysical changes that underlie aging and associative learning, the role of the endoplasmic reticulum in neuronal calcium signalling, and amygdala neurophysiology. His group continues to investigate the cellular mechanisms of memory formation using a combination of electrophysiological recordings, live-cell fluorescent calcium imaging and genetic manipulations. The current focus of his research is the identification of novel cellular mechanisms that modulate or preserve neuronal connections that may be translated into treatments for disorders of impaired or aberrant connectivity such as Alzheimer’s disease, stroke, post-traumatic stress disorder, epilepsy and addiction.

Student projects can be found here.

University role:

Senior Lecturer

Memberships:

Society for Neuroscience - USA

Australasian Neuroscience Society

Groups:

Memory & Plasticity Group

Research

Teaching & Supervision

Supervised Students:

Chanchanok Chaichim

I am available to supervise:

Yes

Currently supervising:

Chanchanok Chaichim

Eddie Wise

Sophia Gilchrist

Supervision keywords:

mental health

neurotransmitters

Publications related to this Person

Journal articles

Prasad AA; Xie C; Chaichim C; Nguyen JH; McClusky HE; Killcross S; Power JM; McNally GP, 2020, 'Complementary roles for ventral pallidum cell types and their projections in relapse', Journal of Neuroscience, vol. 40, pp. 880 - 893, http://dx.doi.org/10.1523/JNEUROSCI.0262-19.2019

Moorhouse AJ; Power JM, 2019, 'Making light work of fine-tuning channelrhodopsins', Journal of Biological Chemistry, vol. 294, pp. 3822 - 3823, http://dx.doi.org/10.1074/jbc.H119.007749

Gorlamandala N; Parmar J; Craig AJ; Power JM; Moorhouse AJ; Krishnan AV; Housley GD, 2018, 'Focal Ischaemic Infarcts Expand Faster in Cerebellar Cortex than Cerebral Cortex in a Mouse Photothrombotic Stroke Model', Translational Stroke Research, vol. 9, pp. 643 - 653, http://dx.doi.org/10.1007/s12975-018-0615-1

Gibson GD; Prasad AA; Jean-Richard-dit-Bressel P; Yau JOY; Millan EZ; Liu Y; Campbell EJ; Lim J; Marchant NJ; Power JM; Killcross S; Lawrence AJ; McNally GP, 2018, 'Distinct Accumbens Shell Output Pathways Promote versus Prevent Relapse to Alcohol Seeking', Neuron, vol. 98, pp. 512 - 520.e6, http://dx.doi.org/10.1016/j.neuron.2018.03.033

Weiss C; Procissi D; Power JM; Disterhoft JF, 2018, 'The rabbit as a behavioral model system for magnetic resonance imaging', Journal of Neuroscience Methods, vol. 300, pp. 196 - 205, http://dx.doi.org/10.1016/j.jneumeth.2017.05.021

Sengupta A; Yau JOY; Jean-Richard-dit-Bressel P; Liu Y; Millan EZ; Power JM; McNally GP, 2018, 'Basolateral amygdala neurons maintain aversive emotional salience', Journal of Neuroscience, vol. 38, pp. 3001 - 3012, http://dx.doi.org/10.1523/JNEUROSCI.2460-17.2017

Jhaveri DJ; Tedoldi A; Hunt S; Sullivan R; Watts NR; Power JM; Bartlett PF; Sah P, 2018, 'Evidence for newly generated interneurons in the basolateral amygdala of adult mice', Molecular Psychiatry, vol. 23, pp. 521 - 532, http://dx.doi.org/10.1038/mp.2017.134

Suchowerska AK; Fok S; Stefen H; Gunning PW; Hardeman EC; Power J; Fath T, 2017, 'Developmental profiling of tropomyosin expression in mouse brain reveals Tpm4.2 as the major post-synaptic tropomyosin in the mature brain', Frontiers in Cellular Neuroscience, vol. 11, http://dx.doi.org/10.3389/fncel.2017.00421

Yang J-L; Polly P; Fath T; Jones NM; Power J, 2016, 'ISA model and integrative career development learning in year three science courses', Int J Science Math Tech Learning, vol. 23, pp. 33 - 46

Stefen H; Chaichim C; Power J; Fath T, 2016, 'Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease', Neural Plasticity, vol. 2016, http://dx.doi.org/10.1155/2016/2371970

Keshavarzi S; Power JM; Albers EHH; Sullivan RKS; Sah P, 2015, 'Dendritic Organization of Olfactory Inputs to Medial Amygdala Neurons', The Journal of Neuroscience, vol. 35, pp. 13020 - 13028, http://dx.doi.org/10.1523/JNEUROSCI.0627-15.2015

Keshavarzi S; Power JM; Albers EHH; Sullivan RKS; Sah P, 2015, 'Dendritic organization of olfactory inputs to medial amygdala neurons', Journal of Neuroscience, vol. 35, pp. 13020 - 13028, http://dx.doi.org/10.1523/JNEUROSCI.0627-15.2015

Harasta AE; Power JM; Von Jonquieres G; Karl T; Drucker DJ; Housley GD; Schneider M; Klugmann M, 2015, 'Septal glucagon-like peptide 1 receptor expression determines suppression of cocaine-induced behavior', Neuropsychopharmacology, vol. 40, pp. 1969 - 1978, http://dx.doi.org/10.1038/npp.2015.47

Power JM; Sah P, 2014, 'Dendritic spine heterogeneity and calcium dynamics in basolateral amygdala principal neurons', Journal of Neurophysiology, vol. 112, pp. 1616 - 1627, http://dx.doi.org/10.1152/jn.00770.2013

Cheng D; Meintjes EM; Stanton ME; Desmond J; Pienaar M; Dodge N; Power J; Molteno CD; Disterhoft JF; Jacobson JL; Jacobson SW, 2013, 'Functional MRI of cerebellar activity during eyeblink classical conditioning in children and adults.', Human Brain Mapping, vol. 35, pp. 1 - 14, http://dx.doi.org/10.1002/hbm.22261

Delaney A; Sedlak PL; Autuori E; Power J; Sah P, 2013, 'Synaptic NMDA receptors in basolateral amygdala principal neurons are triheteromeric proteins: physiological role of GluN2B subunits', Journal of Neurophysiology, vol. 109, pp. 1391 - 1402, http://dx.doi.org/10.1152/jn.00176.2012

Kim YS; Wong AC; Power J; Tadros SF; Klugmann M; Moorhouse AJ; Bertrand PP; Housley GD, 2012, 'Alternative Splicing of the TRPC3 Ion Channel Calmodulin/ IP3 Receptor-Binding Domain in the Hindbrain Enhances Cation Flux', The Journal of Neuroscience, vol. 32, pp. 11414 - 11423, http://dx.doi.org/10.1523/JNEUROSCI.6446-11.2012

Delaney A; Power J; Pankaj S, 2012, 'Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels', Journal of Neurophysiology, vol. 107, pp. 1571 - 1575, http://dx.doi.org/10.1152/jn.01066.2011

Power J; Bocklisch C; Curby P; Pankaj S, 2011, 'Location and function of the slow afterhyperpolarization channels in the basolateral amygdala', The Journal of Neuroscience, vol. 31, pp. 526 - 537, http://dx.doi.org/10.1523/JNEUROSCI.1045-10.2011

Oh MM; McKay BM; Power J; Disterhoft JF, 2009, 'Learning-related postburst afterhyperpolarization reduction in CA1 pyramidal neurons is mediated by protein kinase A', Proceedings of the National Academy of Sciences, vol. 106, pp. 1620 - 1625, http://dx.doi.org/10.1073/pnas.0807708106

Power J; Pankaj S, 2008, 'Competition between calcium-activated K+ channels determines cholinergic action on firing properties of basolateral amygdala projection neurons', The Journal of Neuroscience, vol. 28, pp. 3209 - 3220, http://dx.doi.org/10.1523/JNEUROSCI.4310-07.2008

Cheng D; Disterhoft JF; Power J; Ellis DA; Desmond J, 2008, 'Neural substrates underlying human delay and trace eyeblink conditioning', Proceedings of the National Academy of Sciences, vol. 105, pp. 8108 - 8113, http://dx.doi.org/10.1073/pnas.0800374105

Faber EL; Delaney A; Power J; Sedlak PL; Crane JW; Pankaj S, 2008, 'Modulation of SK channel trafficking by beta adrenoceptors enhances excitatory synaptic transmission and plasticity in the amygdala', The Journal of Neuroscience, vol. 29, pp. 10803 - 10813, http://dx.doi.org/10.1523/JNEUROSCI.1796-08.2008

Morley SN; Power JM; Coulson EJ; Bartlett PF, 2007, 'Zinc-mediated neuronal death is dependent on Trk activation', Experimental Neurology, vol. 205, pp. 360 - 366, http://dx.doi.org/10.1016/j.expneurol.2007.02.006

Power J; Pankaj S, 2007, 'Distribution of IP3-mediated calcium responses and their role in nuclear signalling in rat basolateral amygdala neurons', The Journal of Physiology, vol. 580, pp. 835 - 857, http://dx.doi.org/10.1113/jphysiol.2006.125062

Byrne MJ; Bilney A; Preveolos A; Smolic A; Power JM; Kaye DM, 2007, 'A Comparative Study of AAV2/1/SERCA2a Delivered via the V-Focus Cardiac Delivery System vs. Direct Intra-coronary Infusion in an Ovine Pacing Model of Heart Failure', Heart, Lung and Circulation, vol. 16, pp. S11 - S11, http://dx.doi.org/10.1016/j.hlc.2007.06.029

Oh MM; Wu WW; Power JM; Disterhoft JF, 2006, 'Galantamine increases excitability of CA1 hippocampal pyramidal neurons', Neuroscience, vol. 137, pp. 113 - 123, http://dx.doi.org/10.1016/j.neuroscience.2005.08.063

Power JM; Sah P, 2005, 'Intracellular calcium store filling by an L-type calcium current in the basolateral amygdala at subthreshold membrane potentials', Journal of Physiology, vol. 562, pp. 439 - 453, http://dx.doi.org/10.1113/jphysiol.2004.076711

2005, '91 Atrial fibrillation impairs the cardiac sympathetic response to baroreceptor unloading in congestive heart failure', European Journal of Heart Failure Supplements, vol. 4, pp. 20 - 20, http://dx.doi.org/10.1016/s1567-4215(05)80053-0

Baharvand H; Power JM; Ozsarac N; Matthaei KI, 2004, 'Differentiation of embryonic stem cells into functional neurons in vitro', Neuroscience Research Communications, vol. 35, pp. 130 - 138, http://dx.doi.org/10.1002/nrc.20027

Sah P; Faber ESL; De Armentia ML; Power J, 2003, 'The amygdaloid complex: Anatomy and physiology', Physiological Reviews, vol. 83, pp. 803 - 834, http://dx.doi.org/10.1152/physrev.00002.2003

Power JM; Wu WW; Sametsky E; Oh MM; Disterhoft JF, 2002, 'Age-related enhancement of the slow outward calcium-activated potassium current in hippocampal CA1 pyramidal neurons in vitro', Journal of Neuroscience, vol. 22, pp. 7234 - 7243, http://dx.doi.org/10.1523/jneurosci.22-16-07234.2002

Power JM; Sah P, 2002, 'Nuclear Calcium Signaling Evoked by Cholinergic Stimulation in Hippocampal CA1 Pyramidal Neurons', Journal of Neuroscience, vol. 22, pp. 3454 - 3462, http://dx.doi.org/10.1523/jneurosci.22-09-03454.2002

Knuttinen MG; Parrish TB; Weiss C; LaBar KS; Gitelman DR; Power JM; Mesulam MM; Disterhoft JF, 2002, 'Electromyography as a recording system for eyeblink conditioning with functional magnetic resonance imaging', NeuroImage, vol. 17, pp. 977 - 987, http://dx.doi.org/10.1016/S1053-8119(02)91199-7

Weiss C; Venkatasubramanian PN; Aguado AS; Power JM; Tom BC; Li L; Chen KS; Disterhoft JF; Wyrwicz AM, 2002, 'Impaired eyeblink conditioning and decreased hippocampal volume in PDAPP V717F mice', Neurobiology of Disease, vol. 11, pp. 425 - 433, http://dx.doi.org/10.1006/nbdi.2002.0555

Knuttinen M-G; Parrish TB; Weiss C; LaBar KS; Gitelman DR; Power JM; Mesulam M-M; Disterhoft JF, 2002, 'Electromyography as a Recording System for Eyeblink Conditioning with Functional Magnetic Resonance Imaging', NeuroImage, vol. 17, pp. 977 - 987, http://dx.doi.org/10.1006/nimg.2002.1199

Knuttinen MG; Power JM; Preston AR; Disterhoft JF, 2001, 'Awareness in classical differential eyeblink conditioning in young and aging humans', Behavioral Neuroscience, vol. 115, pp. 747 - 757, http://dx.doi.org/10.1037/0735-7044.115.4.747

Geinisman Y; Berry RW; Disterhoft JF; Power JM; Van Der Zee EA, 2001, 'Associative learning elicits the formation of multiple-synapse boutons', Journal of Neuroscience, vol. 21, pp. 5568 - 5573, http://dx.doi.org/10.1523/jneurosci.21-15-05568.2001

Knuttinen MG; Gamelli AE; Weiss C; Power JM; Disterhoft JF, 2001, 'Age-related effects on eyeblink conditioning in the F344 × BN F1 hybrid rat', Neurobiology of Aging, vol. 22, pp. 1 - 8, http://dx.doi.org/10.1016/S0197-4580(00)00194-9

Power JM; Oh MM; Disterhoft JF, 2001, 'Metrifonate decreases sIAHP in CA1 pyramidal neurons in vitro', Journal of Neurophysiology, vol. 85, pp. 319 - 322, http://dx.doi.org/10.1152/jn.2001.85.1.319

Knuttinen M-G; Power JM; Preston AR; Disterhoft JF, 2001, 'Awareness in classical differential eyeblink conditioning in young and aging humans.', Behavioral Neuroscience, vol. 115, pp. 747 - 757, http://dx.doi.org/10.1037//0735-7044.115.4.747

Oh MM; Power JM; Thompson LT; Disterhoft JF, 2000, 'Apamin increases excitability of CA1 hippocampal pyramidal neurons', Neuroscience Research Communications, vol. 27, pp. 135 - 142, http://dx.doi.org/10.1002/1520-6769(200009/10)27:2<135::AID-NRC7>3.0.CO;2-X

Moyer JR; Power JM; Thompson LT; Disterhoft JF, 2000, 'Increased excitability of aged rabbit CA1 neurons after trace eyeblink conditioning', Journal of Neuroscience, vol. 20, pp. 5476 - 5482, http://dx.doi.org/10.1523/jneurosci.20-14-05476.2000

Geinisman Y; Disterhoft JF; Gundersen HJG; Mcechron MD; Persina IS; Power JM; Van Der Zee EA; West MJ, 2000, 'Remodeling of hippocampal synapses after hippocampus-dependent associative learning', Journal of Comparative Neurology, vol. 417, pp. 49 - 59, http://dx.doi.org/10.1002/(SICI)1096-9861(20000131)417:1<49::AID-CNE4>3.0.CO;2-3

Knuttinen M-G; Weiss C; Parrish TB; LaBar KS; Gitelman DR; Power JM; Mesulam M-M; Disterhoft JF, 2000, 'Event-related fMRI of delay eyeblink conditioning', NeuroImage, vol. 11, pp. S416 - S416, http://dx.doi.org/10.1016/s1053-8119(00)91347-8

Weiss C; Bouwmeester H; Power JM; Disterhoft JF, 1999, 'Hippocampal lesions prevent trace eyeblink conditioning in the freely moving rat', Behavioural Brain Research, vol. 99, pp. 123 - 132, http://dx.doi.org/10.1016/S0166-4328(98)00096-5

Oh MM; Power JM; Thompson LT; Moriearty PL; Disterhoft JF, 1999, 'Metrifonate increases neuronal excitability in CA1 pyramidal neurons from both young and aging rabbit hippocampus', Journal of Neuroscience, vol. 19, pp. 1814 - 1823, http://dx.doi.org/10.1523/jneurosci.19-05-01814.1999

Disterhoft JF; Kronforst-Collins M; Oh MM; Power JM; Preston AR; Weiss C, 1999, 'Cholinergic facilitation of trace eyeblink conditioning in aging rabbits', Life Sciences, vol. 64, pp. 541 - 548, http://dx.doi.org/10.1016/S0024-3205(98)00599-2

Weiss C; Knuttinen MG; Power JM; Patel RI; O'Connor MS; Disterhoft JF, 1999, 'Trace eyeblink conditioning in the freely moving rat: Optimizing the conditioning parameters', Behavioral Neuroscience, vol. 113, pp. 1100 - 1105, http://dx.doi.org/10.1037/0735-7044.113.5.1100

Weiss C; Knuttinen M-G; Power JM; Patel RI; O'Connor MS; Disterhoft JF, 1999, 'Trace eyeblink conditioning in the freely moving rat: Optimizing the conditioning parameters.', Behavioral Neuroscience, vol. 113, pp. 1100 - 1105, http://dx.doi.org/10.1037//0735-7044.113.5.1100

Disterhoft JF; KronforstCollins MA; McEchron MD; Moyer JR; Power JM; Thompson LT, 1997, 'Mechanisms of associative learning in young and ageing hippocampus', JOURNAL OF PHYSIOLOGY-LONDON, vol. 501P, pp. S6 - S7, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997XD09100236&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Power JM; Thompson LT; Moyer JR; Disterhoft JF, 1997, 'Enhanced synaptic transmission in CA1 hippocampus after eyeblink conditioning', Journal of Neurophysiology, vol. 78, pp. 1184 - 1187, http://dx.doi.org/10.1152/jn.1997.78.2.1184

Power JM; Ringo JM; Dowse HB, 1995, 'The Effects of Period Mutations and Light on the Activity Rhythms of Drosophila melanogaster', Journal of Biological Rhythms, vol. 10, pp. 267 - 280, http://dx.doi.org/10.1177/074873049501000309

Dowse H; Ringo J; Power J; Kinney K; White L, 1995, 'A congenital heart defect in drosophila caused by an action-potential mutation', Journal of Neurogenetics, vol. 10, pp. 153 - 168, http://dx.doi.org/10.3109/01677069509083461

Power J; Ringo J; Dowse H, 1995, 'The role of light in the initiation of circadian activity rhythms of adult drosophila melanogaster', Journal of Neurogenetics, vol. 9, pp. 227 - 238, http://dx.doi.org/10.3109/01677069509084159

Conference Papers

Ong-Palsson E; Munro K; Teng K; Takeshima H; Lichtenthaler S; Power J; Gunnersen J, 2017, 'Seizure-related gene 6 (SEZ6) family proteins and their influence on excitatory synapse function, motor coordination and cognition', in JOURNAL OF NEUROCHEMISTRY, WILEY, Paris, FRANCE, pp. 191 - 191, presented at ISN-ESN Meeting, Paris, FRANCE, 20 August 2017 - 24 August 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000407425300456&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Gorlamandala N; Parmar J; Craig A; Power J; Krishnan A; Housley G, 2015, 'Spatiotemporal delineation of a cerebral photothrombotic infarct in mouse using darkfield microscopy', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, pp. 292 - 292, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, 23 August 2015 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300736&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Disterhoft JF; Thompson LT; Weiss C; Moyer JR; Van der Zee E; Carrillo M; Kronforst-Collins M; Power J, 1995, 'The calcium hypothesis for Alzheimer's disease: Insights from animal and human studies', in Neuroscience Research Communications, pp. 121 - 131

Conference Abstracts

Harasta A; Power JM; von Jonquieres G; Karl T; Drucker DJ; Housley GD; Schneider M; Klugmann M, 2015, 'Septal glucagon-like peptide 1 receptor expression determines suppression of cocaine-induced behaviour', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, Vol. 134, pp. 214 - 214, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, 23 August 2015 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300522&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khoshaba A; Power J; Inada H; Nabekura J; Moorhouse A, 2015, 'Measuring KCC2 function in brain slices using BCECF imaging', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, Vol. 134, pp. 159 - 159, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, 23 August 2015 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300372&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Patents

Kim Y; Bertrand P; Moorhouse A; Wong ACY; Craig A; Power J; Klugmann M; Krishnan A; Morris R, 2018, Methods for inhibiting neuron apoptosis and necrosis, Patent No. 2013286815, Patent Agent:, https://worldwide.espacenet.com/publicationDetails/biblio?CC=AU&NR=2013286815B2&KC=B2&FT=D

Housley GD; Kim YS; Bertrand PP; Moorhouse AJ; Wong AC; Craig A; Power J; Klugmann M; Krishnan AV; Morris R, 2012, Methods for inhibiting neuron apoptosis and necrosis” (filed by New South Innovations – (UNSW) – Au Provisional Patent Application No. 2012902920, 6 July 2012)., AUSTRALIA, 2012, Patent No. 2012902920, Patent Agent:, status:%20Applied%20for%20(Provisional)%20Registered%20in%20names%20of%20(Inventors)