Dr Jennie Cederholm

Fields of research: Neurosciences, Animal Physiology - Biophysics, Animal Cell and Molecular Biology

Contact Details

Phone: +61 2 9065 7495
Email: j.cederholm@unsw.edu.au

Tabs

Main

I have a MSc in Medical Biology from Linköping University, Linköping, Sweden, and a PhD in Biomedial Sciences from the University of South Australia, Adelaide. My PhD involved studying the human skeletal muscle chloride ion channel, ClC-1. My main interest was in the gating mechanism of this ion channel, and for this I utilised molecular biology to create mutant channels and investigate their function using whole-cell patch clamping.

My first post-doctoral position was at Neuroscience Research Australia, Sydney, in the laboratory of Professor Peter Schofield. During this time, I also held a conjoint position at UNSW, working with Dr Trevor Lewis in the Membrane Biophysics laboratory. Here I investigated the importance of loop structures in the glycine receptor, again using molecular biology and the whole-cell patch clamp technique. I also created several glycine receptor homology models using molecular modelling.

Between 2011 and 2020 I worked as a Postdoctoral Fellow with Professor Gary Housley, at the Translational Neuroscience Facility (TNF), on hearing adaptation to sustained noise, with focus being on the role of P2X2 receptors in noise-induced hearing loss.

My teaching during this time involved facilitation of Medicine undergraduates in Phase 1, and also lecturing/tutoring/demonstrating of Medicine and Science undergraduates in the subject of Physiology and Neuroscience. I was convenor of the SCIF1121 course for two years, and co-convenor of the NEUR3221 course at SoMS for one year.

I was the inaugural Chair of the UNSW Early Career Academic Network Executive Committee (ECAN-EC), and in my role as Chair, I was a member of the UNSW Academic Board.

I am the co-President of the Australian and New Zealand Purine Club, and the co-Coordinator of the Australian Brain Bee Challenge NSW Finals.

I have extensive experience in organising conferences and smaller meetings, and also Neuroscience-related activities for high-school students.

I have a Graduate Certificate in University Learning and Teaching from UNSW Sydney.

In January 2020 I took up the role as an Education focused Academic in the Department of Physioloyg, SoMS, UNSW Sydney.

University role:

Senior Lecturer

Keywords:

auditory

neuroscience

electrophysiology

Research

Teaching & Supervision

I am available to supervise:

Yes

Areas of supervision:

I am available to supervise ILP, Honours, Masters and PhD students.

Currently supervising:

I am currently supervising a PhD student.

Supervision keywords:

auditory pathways

noise induced hearing loss

purines

microarray analysis of gene expression

real-time pcr

structure & function of ion channels

electrophysiology

Media

LinkedIn:

https://au.linkedin.com/pub/dir/Jennie/Cederholm

Publications related to this Person

Journal articles

Conference Papers

Cederholm JME; Ryan AF; Housley GD, 2018, 'Oral Communication: Purinergic hearing adaptation to sustained sound', in PURINERGIC SIGNALLING, SPRINGER, pp. S62 - S63, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000456281300159&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Housley GD; Ryan AF; Cederholm JME, 2018, 'Transcriptome profile of purinergic hearing adaptation', in PURINERGIC SIGNALLING, SPRINGER, pp. S61 - S61, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000456281300155&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Perera C; Von Jonquieres G; Pinyon J; Parley K; Cederholm J; Julien J-P; Ryan A; Housley G, 2016, 'Phenotyping the differential innervation of the peripherin knockout mouse cochlea', in Proceedings of the Australian Physiological Society, Adelaide, presented at Australian Physiological Society, Adelaide, 04 December 2016 - 07 December 2016

Cederholm J; Froud K; Wong A; Ryan A; Housley G, 2015, 'Assessing cochlear amplifier adaptation to noise', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, pp. 236 - 236, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, 23 August 2015 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300582&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Housley G; Cederholm J; Klugmann M; Ryan A, 2014, 'Purinergic signaling in the cochlea.', in Purinergic Signalling, Springer, Bonn, Germany, pp. 726 - 727, presented at Purines 2014, an International Conference on Nucleotides, Nucleosides and Nucleobases, Bonn, Germany, 23 July 2014, http://dx.doi.org/10.1007/s11302-014-9430-7

Conference Presentations

Conference Abstracts

Cederholm J; Perera C; Froud K; Wong A; Klugmann M; Sandow S; Julien J-P; Ryan A; Housley G, 2017, 'Contralateral versus ipsilateral suppression with knockout of a peripherin type III intermediate filament protein', in Australasian Auditory Neuroscience Workshop, Sydney, presented at Australasian Auditory Neuroscience Workshop, Sydney, 02 December 2017 - 02 December 2017

Housley G; Froud K; Cederholm J; Klugmann M; Julien J-P; Ryan A, 2016, 'Type II Spiral Ganglion Afferent Drive of the Medial Olivocochlear Reflex Reduces Hearing Loss from Acoustic Overstimulation', in Abstracts of the ... Midwinter Research Meeting / Association for Research in Otolaryngology. Association for Research in Otolaryngology (U.S.). Midwinter Research Meeting, San Diego, USA, presented at Association for Research in Otolaryngology 39th Annual MidWinter Meeting, San Diego, USA, 20 February 2016 - 24 February 2016, https://www.aro.org/assets/docs/2016_ARO_Abstract_Book_%26_Add.pdf

Froud K; Cederholm J; Klugmann M; Julien J-P; Ryan A; Housley G, 2015, 'Cochlear type II spiral ganglion afferent fibres are essential for medial olivocochlear reflex-mediated otoprotection from noise-induced hearing loss', in Proceedings of the Australian Physiological Society, Hobart, presented at Australian Physiological Society, Hobart, 29 November 2015 - 02 December 2015

Housley G; Froud KE; Wong ACY; Cederholm JME; Klugmann M; Sandow SL; Julien J-P; Ryan AF, 2015, 'Sensory drive for medial olivocochlear efferent control of hearing balance depends upon type II spiral ganglion neuron innervation', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, Vol. 134, pp. 379 - 379, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, 23 August 2015 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300973&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Cederholm J; Froud K; Wong A; Ryan A; Housley G, 2015, 'Assessing cochlear amplifier adaptation to noise.', in Journal of Neurochemistry, Wiley, Cairns, Australia, Vol. 134, pp. 102 - 102, presented at 25th Biennial meeting of the International Society for Neurochemistry (ISN) jointly with the 13th meeting of the Asian-Pacific Society for Neurochemistry (APSN) in conjunction with the 35th meeting of the Australasian Neuroscience Society (ANS), Cairns, Australia, 23 August 2015 - 27 August 2015, http://dx.doi.org/10.1111/jnc.13188

Froud K; Wong A; Cederholm J; Klugmann M; Sandow S; Julien J-P; Ryan A; Housley G, 2015, 'The role of type II spiral ganglion afferent neurons in regulation of the cochlear amplifier.', in Kioloa at Newcastle Neuroscience Colloquium, Lake Macquarie, Newcastle, presented at Kioloa at Newcastle Neuroscience Colloquium, Lake Macquarie, Newcastle

Housley GD; Cederholm JME; Klugmann M; Ryan AF, 2014, 'Purinergic signaling in the cochlea', in PURINERGIC SIGNALLING, SPRINGER, Vol. 10, pp. 726 - 727, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000348578700187&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Cederholm J; Froud K; Kaplan W; Ryan A; Housley G, 2013, 'Analysis of the gene expression response to a temporary reduction in hearing sensitivity', in Proceedings of the Australian Physiological Society, Geelong, presented at Australian Physiological Society, Geelong, 08 December 2013 - 11 December 2013

Cederholm J; Froud K; Ryan A; Housley G, 2013, 'Mouse gene expression analysis following temporary threshold shift', in Proceedings of Society of Neuroscience, San Diego, USA, presented at Society of Neuroscience 2013, San Diego, USA, 09 November 2013 - 13 November 2013, https://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=3236&sKey=2542b0d1-f7c8-4cb3-add6-bed78d6fdb56&cKey=c2caa51f-e648-4943-ac44-f31fa96757eb&mKey=8d2a5bec-4825-4cd6-9439-b42bb151d1cf

Cederholm J; Froud K; Housley G, 2013, 'Cochlear gene expression analysis in response to noise stress in mice', in Proceedings of Australasian Neuroscience Society, Melbourne, presented at Australasian Neuroscience Society, Melbourne, 03 February 2013 - 06 February 2013, https://www.ans.org.au/images/pdf/37.pdf

Cederholm J; Froud K; Kaplan W; Housley G, 2013, 'An analysis of noise-induced transcriptional responses in mice.', in Australasian Auditory Neuroscience Workshop, Melbourne, presented at Australasian Auditory Neuroscience Workshop, Melbourne

Housley G; Froud K; Wong ACY; Cederholm J; Ryan A, 2012, 'Neurohumoral mechanisms for regulating sound transduction', in Australian Physiology Society Volume 43, Sydney, presented at Australian Physiology Society, Sydney, 02 December 2012 - 05 December 2012, http://aups.org.au/Proceedings/43/

Cederholm J; Froud K; Kaplan W; Housley G, 2012, 'Transcriptional responses to noise stress in mice', in Proceedings of Australian Physiology Society, Sydney, presented at Australian Physiology Society, Sydney, 02 December 2012 - 05 December 2012, http://aups.org.au/Proceedings/43/

Froud K; Wong ACY; Cederholm J; Klugmann M; Tadros S; Sandow S; Julien J-P; Ryan A; Housley G, 2011, 'The role of type II spiral ganglion neurons in the regulation of hearing sensitivity via the medial olivocochlear efferent pathway', in PROCEEDINGS OF THE AUSTRALIAN PHYSIOLOGICAL SOCIETY Volume 42, Perth, presented at Australian Physiological Society, Perth, 04 December 2011 - 07 December 2011, http://aups.org.au/Proceedings/42/

Housley G; Froud K; Wong A; Cederholm J; Vlajkovic S; Thorne P; Ryan A, 2011, 'Contribution of cochlear P2X2 receptors (ATP-gated ion channels) to hearing adaptation', in Molecular Biology of Hearing and Deafness conference, Cambridge, UK, presented at Molecular Biology of Hearing and Deafness conference, Cambridge, UK

Cederholm J; Sugiharto S; Schofield P; Lewis T, 2011, 'Investigating the role of loop 9 in glycine receptor signal transduction.', in Gage conference, presented at Gage conference

Cederholm J; Absalom N; Sugiharto S; Griffith R; Schofield P; Lewis T, 2009, 'Loop 2 in the extracellular domain of the glycine receptor is involved in signal transduction', in Proceedings of Society for Neuroscience, Chicago, IL, USA., presented at Society for Neuroscience 2009, Chicago, IL, USA.

Cederholm J; Absalom N; Sugiharto S; Kaplan W; Lewis T; Schofield P, 2009, 'Conformational changes in extracellular loop 2 associated with signal transduction in the glycine receptor', in Gage conference, presented at Gage conference

Cederholm J; Absalom N; Sugiharto S; Kaplan W; Lewis T; Schofield P, 2008, 'Conformational changes in extracellular loop 2 associated with signal transduction in the glycine receptor.', in The Australian Society for Biophysics, presented at The Australian Society for Biophysics

Cederholm J; Rychkov G; Bretag A, 2007, 'The effect of mutation E232Q and clofibric acid derivatives on gating in the human skeletal muscle chloride ion channel, ClC-1', in Proceedings of the Australian Physiology Society, Newcastle, presented at Australian Physiology Society, Newcastle, 02 December 2007 - 05 December 2007, http://aups.org.au/Proceedings/38/contents.pdf

Cederholm J; Rychkov G; Duffield M; Bretag A, 2006, 'Effect of mutations on common gating in human ClC-1 chloride channels.', in ComBio conference, Brisbane, presented at ComBio conference, Brisbane

Cederholm J; Rychkov G; Duffield M; Bretag A, 2004, 'The effect of mutations on slow gating in the human ClC-1 chloride channel.', in ComBio conference, Perth, presented at ComBio conference, Perth

Preprints

Cederholm JME; Parley KE; Perera CJ; von Jonquieres G; Pinyon JL; Julien J-P; Ryugo DK; Ryan AF; Housley GD, Association of cochlear outer hair cell - type II spiral ganglion afferents with protection from noise-induced hearing loss, http://dx.doi.org/10.1101/2021.11.06.467554