Dr Gila Moalem-Taylor

Fields of research: Neurosciences, Peripheral Nervous System, Central Nervous System, Cellular Immunology

Contact Details

Phone: +61 2 9385 2478
Fax: +61 2 9385 0023
Email: gila@unsw.edu.au

Supervision

PHD
Masters
Honours

Tabs

Main

Research Interests:
Damage to the nervous system is often associated with chronic neuropathic pain symptoms including spontaneous pain, increased sensitivity to painful stimuli (hyperalgesia), and pain perceived in response to normally non-painful stimuli (allodynia). Such pain is extremely debilitating and difficult to treat. My current research focuses on the mechanisms underlying neuropathic pain, with particular emphasis on how immune cells and inflammatory mediators influence chronic pain following peripheral nerve injury or autoimmune inflammation in the nervous system.

Broad Research Areas:
Pain, Neuroscience, Inflammation

Qualifications:
PhD

Society Memberships & Professional Activities:
Member of the Australian Neuroscience Society, Member of the Australian Pain Society, Member of the International Association for the Study of Pain, Member of the International Society of Neuroimmunology

Specific Research Keywords:
Pain Research, Nerve Injury Pain, T Cells

University role:

Senior Lecturer

Groups:

Neuropathic Pain Research

Research

Research activities:

Socio-economic Objective (SEO) tags:

Nervous System and Disorders

Immune System and Allergy

Media

Facebook:

http://www.facebook.com/people/Gila-Moalem-Taylor/1055188103#!/profile.php?id=1055188103

LinkedIn:

http://www.linkedin.com/pub/gila-moalem-taylor/6/786/a6

Publications related to this Person

Book Chapters

Austin PJ; Moalem-Taylor G, 2013, 'Pathophysiology of neuropathic pain: inflammatory mediators', in Toth C; Moulin DE (ed.), NEUROPATHIC PAIN: CAUSES, MANAGEMENT, AND UNDERSTANDING, Cambridge University Press, Cambridge, UK, pp. 77 - 89, http://www.cambridge.org/mx/academic/subjects/medicine/neurology-and-clinical-neuroscience/neuropathic-pain-causes-management-and-understanding

Austin P; Moalem-Taylor G, 2013, 'Animal Models of Neuropathic Pain Due to Nerve Injury', in Pilowsky PM; Farnham MM; Fong AY (ed.), Stimulation and Inhibition of Neurons Series: Neuromethods, edn. Volume: 78, Springer Protocols, pp. 239 - 260, http://dx.doi.org/10.1007/978-1-62703-233-9_14

Journal articles

Lees JG; Fivelman B; Duffy SS; Makker PGS; Perera CJ; Moalem-Taylor G, 2015, 'Cytokines in neuropathic pain and associated depression', Modern Trends in Pharmacopsychiatry, vol. 30, pp. 51 - 66, http://dx.doi.org/10.1159/000435932

Perera CJ; Lees JG; Duffy SS; Makker PGS; Fivelman B; Apostolopoulos V; Moalem-Taylor G, 2015, 'Effects of active immunisation with myelin basic protein and myelin-derived altered peptide ligand on pain hypersensitivity and neuroinflammation', Journal of Neuroimmunology, vol. 286, pp. 59 - 70, http://dx.doi.org/10.1016/j.jneuroim.2015.07.004

Perera CJ; Duffy SS; Lees JG; Kim CF; Cameron B; Apostolopoulos V; Moalem-Taylor G, 2015, 'Active immunization with myelin-derived altered peptide ligand reduces mechanical pain hypersensitivity following peripheral nerve injury', Journal of Neuroinflammation, vol. 12, http://dx.doi.org/10.1186/s12974-015-0253-4

Tonkin RS; Mao Y; O'carroll SJ; Nicholson LFB; Green CR; Gorrie CA; Moalem-Taylor G, 2015, 'Gap junction proteins and their role in spinal cord injury', Frontiers in Molecular Neuroscience, vol. 7, http://dx.doi.org/10.3389/fnmol.2014.00102

Lees JG; Duffy SS; Perera CJ; Moalem-Taylor G, 2015, 'Depletion of Foxp3+ regulatory T cells increases severity of mechanical allodynia and significantly alters systemic cytokine levels following peripheral nerve injury', Cytokine, vol. 71, pp. 207 - 214, http://dx.doi.org/10.1016/j.cyto.2014.10.028

Duffy SS; Lees JG; Moalem-Taylor G, 2014, 'The contribution of immune and glial cell types in experimental autoimmune encephalomyelitis and multiple sclerosis.', Mult Scler Int, vol. 2014, pp. 285245, http://dx.doi.org/10.1155/2014/285245

Tian DH; Perera CJ; Apostolopoulos V; Moalem-Taylor G, 2013, 'Effects of vaccination with altered peptide ligand on chronic pain in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis', Frontiers in Neurology, http://dx.doi.org/10.3389/fneur.2013.00168

Lees JG; Duffy SS; Moalem-Taylor G, 2013, 'Immunotherapy targeting cytokines in neuropathic pain', Frontiers in Pharmacology, vol. 4 NOV, http://dx.doi.org/10.3389/fphar.2013.00142

Tian DH; Perera CJ; Moalem-Taylor G, 2013, 'Neuropathic pain in animal models of nervous system autoimmune diseases', Mediators of Inflammation, vol. 2013, http://dx.doi.org/10.1155/2013/298326

Wu A; Green CR; Rupenthal ID; Moalem-Taylor G, 2012, 'Role of gap junctions in chronic pain', Journal of Neuroscience Research, vol. 90, pp. 337 - 345, http://dx.doi.org/10.1002/jnr.22764

Austin PJ; Wu A; Moalem-Taylor G, 2012, 'Chronic constriction of the sciatic nerve and pain hypersensitivity testing in rats.', Journal of visualized experiments : JoVE

Austin PJ; Kim CF; Perera CJ; Moalem-Taylor G, 2012, 'Regulatory T cells attenuate neuropathic pain following peripheral nerve injury and experimental autoimmune neuritis', Pain, vol. 153, pp. 1916 - 1931, http://dx.doi.org/10.1016/j.pain.2012.06.005

Moalem-Taylor G; Li M; Allbutt HN; Wu A; Tracey DJ, 2011, 'A Preconditioning Nerve Lesion Inhibits Mechanical Pain Hypersensitivity following Subsequent Neuropathic Injury', Molecular Pain, vol. 7, pp. 1744-8069-7-1 - 1744-8069-7-1, http://dx.doi.org/10.1186/1744-8069-7-1

Hill F; Kim CF; Gorrie CA; Moalem-Taylor G, 2011, 'Interleukin-17 deficiency improves locomotor recovery and tissue sparing after spinal cord contusion injury in mice', Neuroscience Letters, vol. 487, pp. 363 - 367, http://dx.doi.org/10.1016/j.neulet.2010.10.057

Kim CF; Moalem-Taylor G, 2011, 'Interleukin-17 contributes to neuroinflammation and neuropathic pain following peripheral nerve injury in mice', Journal of Pain, vol. 12, pp. 370 - 383, http://dx.doi.org/10.1016/j.jpain.2010.08.003

Kim CF; Moalem-Taylor G, 2011, 'Detailed characterization of neuro-immune responses following neuropathic injury in mice', Brain Research, vol. 1405, pp. 95 - 108, http://dx.doi.org/10.1016/j.brainres.2011.06.022

Austin PJ; Moalem-Taylor G, 2010, 'The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines', Journal of Neuroimmunology, vol. 229, pp. 26 - 50, http://dx.doi.org/10.1016/j.jneuroim.2010.08.013

Moalem-Taylor G; Allbutt HN; Iordanova MD; Tracey DJ, 2007, 'Pain hypersensitivity in rats with experimental autoimmune neuritis, an animal model of human inflammatory demyelinating neuropathy', Brain, Behavior, and Immunity, vol. 21, pp. 699 - 710, http://dx.doi.org/10.1016/j.bbi.2006.07.007

Moalem-Taylor G; Lang PM; Tracey DJ; Grafe P, 2007, 'Post-spike excitability indicates changes in membrane potential of isolated C-fibers', Muscle and Nerve, vol. 36, pp. 172 - 182, http://dx.doi.org/10.1002/mus.20793

Smith FM; Haskelberg H; Tracey DJ; Moalem-Taylor G, 2007, 'Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury.', Neuroimmunomodulation, vol. 14, pp. 317 - 325, http://dx.doi.org/10.1159/000125048

Li M; Peake PW; Charlesworth JA; Tracey DJ; Moalem-Taylor G, 2007, 'Complement activation contributes to leukocyte recruitment and neuropathic pain following peripheral nerve injury in rats', European Journal of Neuroscience, vol. 26, pp. 3486 - 3500, http://dx.doi.org/10.1111/j.1460-9568.2007.05971.x

Evans S; Moalem-Taylor G; Tracey DJ, 2007, 'Pain and endometriosis', Pain, vol. 132, http://dx.doi.org/10.1016/j.pain.2007.07.006

Moalem G; Tracey DJ, 2006, 'Immune and inflammatory mechanisms in neuropathic pain', Brain Research Reviews, vol. 51, pp. 240 - 264, http://dx.doi.org/10.1016/j.brainresrev.2005.11.004

Lang PM; Moalem-Taylor G; Tracey DJ; Bostock H; Grafe P, 2006, 'Activity-dependent modulation of axonal excitability in unmyelinated peripheral rat nerve fibers by the 5-HT(3) serotonin receptor', Journal of Neurophysiology, vol. 96, pp. 2963 - 2971, http://dx.doi.org/10.1152/jn.00716.2006

Moalem G; Grafe P; Tracey DJ, 2005, 'Chemical mediators enhance the excitability of unmyelinated sensory axons in normal and injured peripheral nerve of the rat', Neuroscience, vol. 134, pp. 1399 - 1411, http://dx.doi.org/10.1016/j.neuroscience.2005.05.046

Moalem G; Xu K; Yu L, 2004, 'T lymphocytes play a role in neuropathic pain following peripheral nerve injury in rats', Neuroscience, vol. 129, pp. 767 - 777, http://dx.doi.org/10.1016/j.neuroscience.2004.08.035

Schwartz M; Moalem G, 2001, 'Beneficial immune activity after CNS injury: Prospects for vaccination', Journal of Neuroimmunology, vol. 113, pp. 185 - 192, http://dx.doi.org/10.1016/S0165-5728(00)00447-1

Schwartz M; Moalem G; Fisher J; Yoles E, 2000, 'Neuroprotection of the injured optic nerve by vaccination to self-myelin peptides', INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 41, pp. S827 - S827, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000086246704461&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Hauben E; Nevo U; Yoles E; Moalem G; Agranov E; Mor F; Akselrod S; Neeman M; Cohen IR; Schwartz M, 2000, 'Autoimmune T cells as potential neuroprotective therapy for spinal cord injury', Lancet, vol. 355, pp. 286 - 287, http://dx.doi.org/10.1016/S0140-6736(99)05140-5

Moalem G; Yoles E; Leibowitz-Amit R; Muller-Gilor S; Mor F; Cohen IR; Schwartz M, 2000, 'Autoimmune T cells retard the loss of function in injured rat optic nerves', Journal of Neuroimmunology, vol. 106, pp. 189 - 197, http://dx.doi.org/10.1016/S0165-5728(00)00240-X

Hauben E; Butovsky O; Nevo U; Yoles E; Moalem G; Agranov E; Mor F; Leibowitz-Amit R; Pevsner E; Akselrod S, 2000, 'Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion', Journal of Neuroscience, vol. 20, pp. 6421 - 6430

Moalem G; Gdalyahu A; Shani Y; Otten U; Lazarovici P; Cohen IR; Schwartz M, 2000, 'Production of neurotrophins by activated T cells: Implications for neuroprotective autoimmunity', Journal of Autoimmunity, vol. 15, pp. 331 - 345, http://dx.doi.org/10.1006/jaut.2000.0441

Moalem G; Gdalyahu A; Leibowitz-Amit R; Yoles E; Muller-Gilor S; Shani Y; Mor F; Otten U; Lazarovici P; Cohen IR, 1999, 'Neuroprotection by autoimmune T cells in injured central nervous system involves T cell-derived neurotrophins', NEUROSCIENCE LETTERS, pp. S30 - S30, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000084100300129&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Hauben E; Butovsky O; Nevo U; Yoles E; Moalem G; Agranov E; Neeman M; Mor F; Cohen I; Schwartz M, 1999, 'Autoimmune T-cells provide neuroprotection following adult spinal cord contusion injury', NEUROSCIENCE LETTERS, pp. S20 - S20, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000084100300085&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Ophir R; Moalem G; Pecht M; Shashoua M; Rashid G; Ben-Efraim S; Trainin N; Burstein Y; Keisari Y, 1999, 'THF-gamma 2-mediated reduction of pulmonary metastases and augmentation of immunocompetence in C57BL/6 mice bearing B16-melanoma.', J Immunother, vol. 22, pp. 103 - 113, http://www.ncbi.nlm.nih.gov/pubmed/10093035

Moalem G; Leibowitz-Amit R; Yoles E; Mor F; Cohen IR; Schwartz M, 1999, 'Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy', Nature Medicine, vol. 5, pp. 49 - 55, http://dx.doi.org/10.1038/4734

Schwartz M; Moalem G; Leibowitz-Amit R; Cohen IR, 1999, 'Innate and adaptive immune responses can be beneficial for CNS repair', Trends in Neurosciences, vol. 22, pp. 295 - 299, http://dx.doi.org/10.1016/S0166-2236(99)01405-8

Moalem G; Monsonego A; Shani Y; Cohen IR; Schwartz M, 1999, 'Differential T cell response in central and peripheral nerve injury: Connection with immune privilege', FASEB Journal, vol. 13, pp. 1207 - 1217

Schwartz M; Cohen I; Lazarov-Spiegler O; Moalem G; Yoles E, 1999, 'The remedy may lie in ourselves: Prospects for immune cell therapy in central nervous system protection and repair', Journal of Molecular Medicine, vol. 77, pp. 713 - 717

Leibowitz-Amit R; Moalem G; Yoles E; Muller S; Cohen IR; Schwartz M, 1998, 'Neuroprotection by T cells specific to CNS self antigens in an axonal injury model implications for autoimmunity in tissue repair', NEUROSCIENCE LETTERS, pp. S25 - S25, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000077512200108&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Gdalyahu A; Moalem G; Cohen IR; Schwartz M, 1998, 'Expression of neurotrophins in activated rat T cell lines', NEUROSCIENCE LETTERS, pp. S13 - S13, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000077512200055&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Moalem G; Leibowitz-Amit R; Yoles E; Muller S; Monsonego A; Mor F; Cohen IR; Schwartz M, 1998, 'T cell accumulation and elimination following axonal injury in the central nervous system of the rat: Implications for neuroprotection', NEUROSCIENCE LETTERS, pp. S30 - S30, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000077512200128&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Hirschberg DL; Moalem G; He J; Mor F; Cohen IR; Schwartz M, 1998, 'Accumulation of passively transferred primed T cells independently of their antigen specificity following central nervous system trauma', Journal of Neuroimmunology, vol. 89, pp. 88 - 96, http://dx.doi.org/10.1016/S0165-5728(98)00118-0

Monsonego A; Mizrahi T; Eitan S; Moalem G; Bárdos H; Ádány R; Schwartz M, 1998, 'Factor XIIIa as a nerve-associated transglutaminase', FASEB Journal, vol. 12, pp. 1163 - 1171

Conference Papers

Moalem-Taylor G; Mao Y; Tonkin R; Nguyen T; O'Carroll S; Nicholson L; Green C; Gorrie C, 2015, 'Systemic delivery of a mimetic peptide against CONNEXIN43 GAP junction protein in rats following spinal cord injury', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, pp. 361 - 361, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australa, Cairns, AUSTRALIA, 23 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300929&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Other

Moalem-Taylor G, 2012, Exploring the Perception of Pain

Conference Abstracts

Sana-Ur-Rehman H; Mansfield K; Moalem-Taylor G; Moore KH; Liu L, 2016, 'EXPRESSION AND LOCALISATION OF CONNEXINS 43 AND 45 AND THEIR INVOLVEMENT IN MEDIATING ATP RELEASE IN PORCINE BLADDER', in NEUROUROLOGY AND URODYNAMICS, WILEY-BLACKWELL, Tokyo, JAPAN, Vol. 35, pp. S60 - S61, presented at Annual Meeting of the International-Continence-Society (ICS), Tokyo, JAPAN, 13 - 16 September 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379907200027&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Translational Neuroscience Facility