Dr Fernando Santiago
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Journal articles
Li Y; Alhendi AMN; Yeh M-C; Elahy M; Santiago FS; Deshpande NP; Wu B; Chan E; Inam S; Prado-Lourenco L; Marchand J; Joyce RD; Wilkinson-White LE; Raftery MJ; Zhu M; Adamson SJ; Barnat F; Viaud-Quentric K; Sockler J; Mackay JP; Chang A; Mitchell P; Marcuccio SM; Khachigian LM, 2020, 'Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/Delta FosB-VCAM-1 axis', SCIENCE ADVANCES, vol. 6, http://dx.doi.org/10.1126/sciadv.aaz7815
Santiago FS; Sanchez-Guerrero E; Zhang G; Zhong L; Raftery MJ; Khachigian LM, 2019, 'Extracellular signal-regulated kinase-1 phosphorylates early growth response-1 at serine 26', Biochemical and Biophysical Research Communications, vol. 510, pp. 345 - 351, http://dx.doi.org/10.1016/j.bbrc.2019.01.019
Buckler JN; Banwell MG; Kordbacheh F; Parish CR; Santiago FS; Khachigian LM, 2017, 'Developing neolignans as proangiogenic agents: Stereoselective total syntheses and preliminary biological evaluations of the four guaiacylglycerol 8-O-4'-coniferyl ethers', ACS Omega, vol. 2, pp. 7375 - 7388, http://dx.doi.org/10.1021/acsomega.7b01459
Ishii H; Hulett M; Li J; Santiago FS; Parish CR; Khachigian LM, 2012, 'Yin Yang-1 inhibits tumor cell growth and inhibits p21 WAF1/Cip1complex formation with cdk4 and cyclin D1', International Journal of Oncology, vol. 40, pp. 1575 - 1580, http://dx.doi.org/10.3892/ijo.2012.1362
Cai H; Santiago FS; Prado-lourenco L; Wang B; Patrikakis M; Davenport MP; Maghzal GJ; Stocker R; Parish CR; Chong BH; Lieschke GJ; Wong TW; Chesterman CN; Francis DJ; Moloney F; Barnetson R; Halliday GM; Khachigian LM, 2012, 'DNAzyme Targeting c-jun Suppresses Skin Cancer Growth.', Science Translational Medicine, vol. 4, pp. p. 139ra82, http://dx.doi.org/10.1126/scitranslmed.3003960
Cheng Q; McKeown SJ; Santos L; Santiago FS; Khachigian LM; Morand EF; Hickey MJ, 2010, 'Erratum: Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules (Journal of Immunology (2010) 185 (1238-1247))', Journal of Immunology, vol. 185, pp. 4959, http://dx.doi.org/10.4049/jimmunol.1090092
Wang B; Chen J; Santiago FS; Janes ME; Kavurma MM; Chong BH; Pimanda JE; Khachigian LM, 2010, 'Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 30, pp. 536 - 545, http://dx.doi.org/10.1161/ATVBAHA.109.193821
Beck K; Wu B; Ni J; Santiago FS; Malabanan KP; Li C; Wang Y; Khachigian LM; Stocker R, 2010, 'Interplay between heme oxyhenase-1 and the multifunctional transcription factor yin yang 1 in the inhibition of intimal hyperplasia', Circulation Research, vol. 107, pp. 1490 - 1497, http://dx.doi.org/10.1161/CIRCRESAHA.110.231985
Cheng Q; Mckeown S; Santos L; Santiago FS; Khachigian LM; Morand E; Hickey M, 2010, 'Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules.', Journal of Immunology, vol. 185, pp. 1238 - 1247, http://dx.doi.org/10.4049/jimmunol.0904104
Tan N; Midgley VC; Kavurma MM; Santiago FS; Luo X; Peden RS; Fahmy R; Berndt MC; Molloy M; Khachigian LM, 2008, 'Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific ser/thr residues in the second zinc finger region of Sp1', Circulation Research, vol. 102, pp. E38 - E51, http://dx.doi.org/10.1161/CIRCRESAHA.107.167395
Santiago FS; Ishii H; Shafi S; Khurana R; Kanellakis P; Bhindi R; Ramirez M; Bobik A; Martin J; Chesterman CN; Zachary I; Khachigian LM, 2007, 'Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21(WAF1/Cip1) transcription and p21(WAF1/Cip1)-Cdk4-cyclin D1 assembly', Circulation Research, vol. 101, pp. 146 - 155, http://dx.doi.org/10.1161/CIRCRESAHA.106.145235
Khachigian LM; Santiago FS; Ishii H; Shafi S; Khurana R; Kanellakis P; Bhindi R; Ramirez M; Bobik A; Martin JL; Chesterman CN; Zachary I, 2007, 'Yin yang-1 inhibits intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-Cyclin D1 assembly', Federation of American Societies for Experimantal Biology Journal, vol. 21, pp. A69 - A69, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245708500329&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Liu M; Eyries MM; Zhang C; Santiago FS; Khachigian LM, 2006, 'Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1', Blood, vol. 107, pp. 2322 - 2329, http://dx.doi.org/10.1182/blood-2005-06-2377
Santiago FS; Khachigian LM, 2004, 'Ets-1 Stimulates Platelet-Derived Growth Factor A-Chain Gene Transcription and Vascular Smooth Muscle Cell Growth via Cooperative Interactions With Sp1', Circulation Research, vol. 95, pp. 479 - 487, http://dx.doi.org/10.1161/01.RES.0000141135.36279.67
De Mestre AM; Khachigian LM; Santiago FS; Staykova MA; Hulett MD, 2003, 'Regulation of Inducible Heparanase Gene Transcription in Activated T Cells by Early Growth Response 1', Journal of Biological Chemistry, vol. 278, pp. 50377 - 50385, http://dx.doi.org/10.1074/jbc.M310154200
Francis DJ; Parish CR; McGarry M; Santiago FS; Lowe HC; Brown KJ; Bingley JA; Hayward IP; Cowden WB; Campbell JH; Campbell GR; Chesterman CN; Khachigian LM, 2003, 'Blockade of Vascular Smooth Muscle Cell Proliferation and Intimal Thickening After Balloon Injury by the Sulfated Oligosaccharide PI-88', Circulation Research, vol. 92, pp. 70 - 77
Rafty LA; Santiago FS; Khachigian LM, 2002, 'NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter', European Molecular Biology Organization, vol. 21, pp. 334 - 343, http://dx.doi.org/10.1093/emboj/21.3.334
Santiago FS; Khachigian LM, 2001, 'Nucleic acid based strategies as potential therapeutic tools: mechanistic considerations and implications to restenosis.', Molecular Medicine, vol. 79, pp. 695 - 706, http://dx.doi.org/10.1007/s001090100272
Santiago FS; Lowe HC; Bobryshev YV; Khachigian LM, 2001, 'Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2.', The Journal of Biological Chemistry, vol. 276, pp. 41143 - 41149, http://dx.doi.org/10.1074/jbc.M104913200
Kavurma MM; Santiago FS; Bonfoco E; Khachigian LM, 2001, 'Sp1 Phosphorylation Regulates Apoptosis via Extracellular FasL-Fas Engagement', The Journal of Biological Chemistry, vol. 276, pp. 4964 - 4971, http://dx.doi.org/10.1074/jbc.M009251200
Lowe HC; Santiago FS; Chesterman CN; Khachigian LM, 2000, 'A novel catalytic DNA molecule targeting the transcription factor Egr-1 inhibits neointimal formation following rat carotid angioplasty', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 35, pp. 15A - 15A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000085209700059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Lowe HC; Santiago FS; Chesterman CN; Khachigian LM, 2000, 'Immobilized hyaluronic acid as a thromboresistant coating for cardiovascular devices', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 35, pp. 15A - 15A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000085209700057&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker A; Atkins DG; Khachigian LM, 1999, 'New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury (vol 5, pg 1264, 1999)', NATURE MEDICINE, vol. 5, pp. 1438 - 1438, http://dx.doi.org/10.1038/71020
Khachigian LM; Santiago FS; Rafty LA; Chan OLW; Delbridge GJ; Bobik A; Collins T; Johnson AC, 1999, 'GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury.', FASEB JOURNAL, vol. 13, pp. A42 - A42, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082033300240&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker A; Atkins DG; Khachigian LM, 1999, 'Erratum: New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury (Nature Medicine (1999) 5 (1264-1269))', Nature Medicine, vol. 5, pp. 1438, http://dx.doi.org/10.1038/71020
Silverman ES; Khachigian LM; Santiago FS; Williams A; Lindner V; Collins TF, 1999, 'Vascular smooth muscle cells express the transcriptional corepressor NAB2 in response to injury.', American Journal of Pathology, vol. 155, pp. 1311 - 1317, http://dx.doi.org/10.1016/S0002-9440(10)65233-9
Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker AT; Atkins D; Khachigian LM, 1999, 'New DNA enzyme targeting Egr1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury', Nature Medicine, vol. 5, pp. 1264 - 1269, http://dx.doi.org/10.1038/15215
Santiago FS; Atkins D; Khachigian LM, 1999, 'Vascular smooth muscle cell proliferation and regrowth after mechanical injury in vitro are Egr1/NGFIAdependent.', American Journal of Pathology, vol. 155, pp. 897 - 905, http://dx.doi.org/10.1016/S0002-9440(10)65189-9
Khachigian LM; Santiago FS; Rafty LA; Onza CL; Delbridge G; Bobik A; Collins TF; Johnson AG, 1999, 'GC Factor 2 represses plateletderived growth factor Achain gene transcription and is itself induced by arterial injury', Circulation Research, vol. 84, pp. 1258 - 1267, http://dx.doi.org/10.1161/01.RES.84.11.1258
Santiago FS; Lowe HC; Day FL; Chesterman CN; Khachigian LM, 1999, 'Early growth response factor1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor2.', American Journal of Pathology, vol. 154, pp. 937 - 944, http://dx.doi.org/10.1016/S0002-9440(10)65341-2
Khachigian LM; Santiago FS; Delbridge GJ; Chesterman CN, 1998, 'Endothelial injury triggers FGF-2 release and a signaling cascade involving MAPK and Egr-1.', FASEB JOURNAL, vol. 12, pp. A467 - A467, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000076006402706&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Santiago FS; Atkins D; Khachigian LM, 1998, 'Antisense oligonucleotides directed against Egr-1 inhibit vascular smooth muscle cell proliferation.', FASEB JOURNAL, vol. 12, pp. A189 - A189, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000076006401100&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Khachigian LM; Santiago FS; Delbridge GJ; Chesterman CN, 1997, 'Endothelial injury and transcriptional activation: bFGF induction of Egr-1 and PDGF-A', ATHEROSCLEROSIS, vol. 134, pp. 265 - 265, http://dx.doi.org/10.1016/S0021-9150(97)89392-6
Ward RL; Todd AV; Santiago FS; O Connor TW; Hawkins NJ, 1997, 'Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis', Cancer, vol. 79, pp. 1106 - 1113, http://dx.doi.org/10.1002/(SICI)1097-0142(19970315)79:6<1106::AID-CNCR8>3.0.CO;2-D
Santiago FS; Todd AV; Hawkins NJ; Ward RL, 1997, 'Detection of K-ras point mutation by enriched PCR-colorimetric plate assay', Molecular and Cellular Probes, vol. 11, pp. 33 - 38, http://dx.doi.org/10.1006/mcpr.1996.0073
Ward RL; Santiago FS; Hawkins NJ; Coomber DW; O Connor TW; Todd AV, 1995, 'A rapid PCR ELISA for the detection of activates K-ras in colorectal cancer', Journal of Clinical Pathology, vol. 48, pp. 273 - 277, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995RZ58000009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
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