Associate Professor David Simar

Fields of research: Cancer and related disorders, Metabolic Medicine, Cellular Immunology, Exercise Physiology, Paediatrics

Contact Details

Phone: +61 2 9065 1046
Email: d.simar@unsw.edu.au

Supervision

PHD
Masters
Honours

Tabs

Main

I obtained a PhD from the University of Montpellier in France in 2004, before moving to Australia to take a Postdoctoral position at the University of Sydney in 2005 supported by the Bourse Lavoisier from the French Ministry of Science and Research. In 2006, I accepted a position of Lecturer in the Department of Exercise Physiology, School of Medical Sciences, Faculty of Medicine, UNSW Sydney. In 2012, I was offered a Research Affiliate position at the Centre for Basic Metabolic Research, Faculty of Health Science at the University of Copenhagen in Denmark and spent 6 months in this Center supported by a Nordea Foundation Fellowship in 2015 to develop novel collaborations and gain access to world leading experts in the fields of Epigenetic and Metabolism.

I am the Head of the Immunometabolism Research Group (Head) at the Mechanisms of Disease and Translational Research.

I have over 15 years of experience in the fields of metabolism, exercise physiology and oncology and I have developed a research program with a special interest in the investigation of long-term complications in cancer survivors.

My research group is composed of PhD and Masters candidates and supported by national and international collaborators. My research program has been funded by the Cancer Council New South Wales, Cancer Institute New South Wales, National Health and Medical Research Council and Diabetes Australia.

My research project investigating the role of irradiation in long-term metabolic complications in cancer survivors was selected as the Flagship project by the Cancer Council New South Wales in 2013.

I am the Associate Dean of Postgraduate Research Training for the Faculty of Medicine and Health. In that position I lead the implementation of the Faculty's strategy regarding Postgraduate Research training across the 13 Schools and Institutes in the Faculty.

University role:

Associate Dean Postgraduate Research Training UNSW Medicine

Grants:

2019-23: Fotsing JM,..., Simar D, et al. Family farming, lifestyle and health in the Pacific. Marie Sklodowska-Curie Actions H2020-MSCA-RISE 2019, AU$2,065,000.

2019-20: Goldstein D, Park S, McCrary MJ, Simar D, Ward R. The effect of exercise training on neurophysiologic, functional, and quality of life deficits in cancer survivors with chemotherapy-induced peripheral neuropathy. World Cancer Research Fund International, AU$99,958.

2018-19: Goldstein D, Park S, McCrary MJ, Menant J, Harris C, Simar D. Exercise rehabilitation for cancer survivors with chemotherapy-induced peripheral neuropathy: Impact and mechanisms.Cancer Clinical Academic Group seed grant scheme, AU$200,000.

2014: Zekry A, Simar D, Lloyd A. T-cell metabolic pathways as a predictor of anti-HCV T-cell immune response and outcomes after primary HCV infection.Australian Centre for HIV and Hepatitis Virology Research, AU$ 95,000.

2013-15: Hardeman E, Barres R, Simar D, Cohn R. The role of epigenetic modifications in longterm memory of irradiation in cancer survivors. Cancer Council New South Wales, AU$ 360,000.

2010: Cohn R, Simar D.Metabolic complications in childhood leukaemia survivors. Cancer Institute New South Wales, AU$ 46,000.

2009: Chen H, Morris MJ, Simar D. Activation of brain glucose sensing mTOR pathway to improve glucose tolerance and reduce adiposity in offspring from obese dams.DARTResearchGrant, AU$ 59,400.

2008: Simar D. Impaired metabolism in peripheral blood mononuclear cells condition the antiviral response in hepatitis C virus infection,Faculty of Medicine: UNSW Sydney, AU$ 11,800.

2008: Chen H, Morris MJ, Simar D. Impact of maternal smoking and high fat diet feeding on pathways involved in central and peripheral glucose metabolism. DART Research Grant, AU$ 50,000.

2008-12: Fiatarone Singh M, Blair S, Singh N, O’Sullivan A, Simar D, Baune B. A randomised controlled trial of progressive resistance training in older type 2 diabetics at cardiovascular risk.NHMRC Research Grant, AU$ 806,250.

2008:Fiatarone Singh M, Blair S, Singh N, O’Sullivan A, Simar D, Baune B. Australian Diabetes Society – Servier National Diabetes Strategy Grant, AU$ 19,532.

2008: Simar D, Tzar C, Tejani N, Metabolic alterations in Polycistic Ovary Syndrome: protective effect of resistance training,Faculty of Medicine,UNSW Sydney:Early Career Research Grant, AU$ 30,000.

2008:Ruell P, Caillaud C, Thompson M, Simar D. Can plasma HSP70 be used to screen athletes at risk of injury from heatstroke?New South Wales Government, Research and Injury Prevention Scheme, AU$ 19,600.

2007:Caillaud C, Thompson M, Simar D, Kazlauskas R, Trout G, Howe C. Does exercise in hot environmental condition impair detection of EPO doping?Australian Government, Department of Communication, Information, Technology and the Arts, AU$ 125,358.

2007: Simar D, A new model to study insulin-stimulated glucose transport in type 2 diabetes,Faculty of Medicine,UNSW Sydney: Early Career Research Grant, AU$ 36,000.

Awards:

2015: Nordea-Fonden’s Residence Program at Heerings Gaard, Denmark.

2015: Quality and Innovation Award in Preventive Health, The Sydney Children’s Hospital Network.

2013: Selected Flagship project by Cancer Council New South Wales

2008: School of Medical Sciences, Faculty of Medicine, UNSW Sydney. New Researcher of the year

Keywords:

Cancer Survivorship

immunology

inflammation

endocrinology & metabolism

exercise physiology

child health

Groups:

Immunometabolism Research Group

Research

Research activities:

I am an active member of the Translational Cancer Research Network and member of the Cancer Clinical Academic Group for Maridulu Budyari Gumal/Sydney Partnership for Health, Education, Research and Enterprise (SPHERE).

My research program investigates and targets the mechanisms responsible for long-term complications in cancer survivors, using a translational approach ranging from cellular models to animal and human studies. My research group is also interested in the role of exercise in the promotion of child health.

Current projects on offer (suitable for Honours, Masters and PhD) include: Long-term complications in cancer survivors, Physical activity in cancer survivors, Role of exercise in Child Health.

Socio-economic Objective (SEO) tags:

Cancer and Related Disorders

Diabetes

Immune System and Allergy

Teaching & Supervision

I am available to supervise:

Yes

Areas of supervision:

I supervise ILP, honours, Masters and PhD students on the following projects:

- Metabolic complications in cancer survivors

- Physical activity in cancer survivors

- Child health

Currently supervising:

PhD: A new digital and human-centred educational program to foster healthy behaviours and reduce cardiometabolic complications in children who survived cancer

PhD: The effect of the gut microbiome on adaptation to exercise

PhD: Discovery of serum biomarkers for the diagnosis of sport-related concussion in children

MRes: Investigating the impact of a dance intervention on the physical and psychological health of breast cancer survivors. The dance intervention will be designed and delivered in consideration of movement limitations experienced following cancer

Supervision keywords:

cancer

endocrinology & metabolism

inflammation

exercise physiology

child health

Teaching:

As a member of the School of Health Sciences, I convene the course Clinical Exercise Physiology offered to third year students enrolled in the Program of Exercise Physiology. This course focuses on the epidemiology and the pathophysiology of respiratory, metabolic, cardiovascular and immune diseases. It develops knowledge of how to set up and implement exercise testing and programming in these special populations in order to provide symptomatic relief and to improve the management of the underlying disease.

Media

LinkedIn:

https://www.linkedin.com/profile/view?id=254603902&trk=nav_responsive_tab_profile

Publications related to this Person

Book Chapters

Simar D; Caillaud C, 2014, 'Antioxidant supplementation in the elderly and leukocytes', in Preedy VR (ed.), Aging: oxidative stress and dietary antioxidants, Academic Press, pp. 277 - 286, http://dx.doi.org/10.1016/B978-0-12-405933-7.00026-3

Simar D; Caillaud C, 2014, 'Chapter 26 Antioxidant Supplementation in the Elderly and Leukocytes', in Aging, pp. 277 - 287, http://dx.doi.org/10.1016/b978-0-12-405933-7.00026-3

Simar D; Malatesta D; Caillaud C, 2010, 'Ageing', in Connes P; Hue O; Perrey S (ed.), Exercise Physiology: from a cellular to an integrative approach, edn. Biomedical and Health Research, IOS Press, Amsterdam, The Netherlands, pp. 654 - 670, http://dx.doi.org/10.3233/978-1-60750-497-9-654

Simar D; Malatesta D, 2004, 'Mesure de l'aptitude physique aerobie chez les sujets ages', in Seynnes O; Jeandel C; Bernard PL (ed.), Aptitude physique, sante et vieillissement, edn. 1st, Sauramps Medical, Montpellier, France, pp. 65 - 71

Caillaud C; Simar D, 2004, 'Aptitude physique aerobie et age', in Jeandel C; Bernard PL; Seynnes O (ed.), Aptitude physique, sante et vieillissement, edn. 1st, Sauramps Medical, Montpellier, France, pp. 57 - 63

Journal articles

Mizrahi D; Wakefield CE; Simar D; Ha L; McBride J; Field P; Cohn RJ; Fardell JE, 2020, 'Barriers and enablers to physical activity and aerobic fitness deficits among childhood cancer survivors', Pediatric Blood and Cancer, vol. 67, pp. e28339, http://dx.doi.org/10.1002/pbc.28339

Amorim NML; Kee A; Coster ACF; Lucas C; Bould S; Daniel S; Weir JM; Mellett NA; Barbour J; Meikle PJ; Cohn RJ; Turner N; Hardeman EC; Simar D, 2020, 'Irradiation impairs mitochondrial function and skeletal muscle oxidative capacity: significance for metabolic complications in cancer survivors', Metabolism: clinical and experimental, vol. 103, pp. 154025, http://dx.doi.org/10.1016/j.metabol.2019.154025

Bellamy J; Broderick C; Hardy LL; Simar D; Puusepp-Benazzouz H; Ong N; Silove N, 2020, 'Feasibility of a school-based exercise intervention for children with intellectual disability to reduce cardio-metabolic risk', Journal of Intellectual Disability Research, vol. 64, pp. 7 - 17, http://dx.doi.org/10.1111/jir.12690

Hiam D; Simar D; Laker R; Altintas A; Gibson-Helm M; Fletcher E; Moreno-Asso A; Trewin AJ; Barres R; Stepto NK, 2019, 'Epigenetic reprogramming of immune cells in women with PCOS impact genes controlling reproductive function', The Journal of Clinical Endocrinology & Metabolism, vol. 104, http://dx.doi.org/10.1210/jc.2019-01015

Alzahrani J; Hussain T; Simar D; Palchaudhuri R; Abdel-Mohsen M; Crowe SM; Mbogo GW; Palmer CS, 2019, 'Inflammatory and immunometabolic consequences of gut dysfunction in HIV: Parallels with IBD and implications for reservoir persistence and non-AIDS comorbidities', EBioMedicine, vol. 46, pp. 522 - 531, http://dx.doi.org/10.1016/j.ebiom.2019.07.027

Mizrahi D; Fardell JE; Wakefield CE; Simar D; Maguire AM; Hubbard G; Cohn RJ, 2019, 'How physically active do Australian and New Zealander childhood cancer survivors perceive themselves? A report from the ANZCHOG survivorship study', Complementary Therapies in Medicine, vol. 44, pp. 196 - 203, http://dx.doi.org/10.1016/j.ctim.2019.04.020

Hiam D; Patten R; Gibson-Helm M; Moreno-Asso A; McIlvenna L; Levinger I; Harrison C; Moran LJ; Joham A; Parker A; Shorakae S; Simar D; Stepto N, 2019, 'The effectiveness of high intensity intermittent training on metabolic, reproductive and mental health in women with polycystic ovary syndrome: Study protocol for the iHIT- randomised controlled trial', Trials, vol. 20, pp. 221, http://dx.doi.org/10.1186/s13063-019-3313-8

Poupeau A; Garde C; Sulek K; Citirikkaya K; Treebak JT; Arumugam M; Simar D; Olofsson LE; Bäckhed F; Barres R, 2019, 'Genes controlling the activation of natural killer lymphocytes are epigenetically remodeled in intestinal cells from germ-free mice', The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 33, pp. 2719 - 2731, http://dx.doi.org/10.1096/fj.201800787R

Mizrahi D; Wakefield C; Ha L; Cohn R; Simar D; Fardell J, 2019, 'Satisfaction with an exercise physiology consultation after treatment for childhood cancer: An opportunity for healthy lifestyle education', Heart and Mind, vol. 3, pp. 77 - 77, http://dx.doi.org/10.4103/hm.hm_47_19

Daniel S; Nylander V; Ingerslev LR; Zhong L; Fabre O; Clifford B; Johnston K; Cohn R; Barres R; Simar D, 2018, 'T-cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors', Clinical Epigenetics, vol. 10, pp. 138 - 138, http://dx.doi.org/10.1186/s13148-018-0561-5

Fabre O; Ingerslev LR; Garde C; Donkin I; Simar D; Barres R, 2018, 'Exercise training alters the genomic response to acute exercise in human adipose tissue', Epigenomics, vol. 10, pp. 1033 - 1050, http://dx.doi.org/10.2217/epi-2018-0039

Clifford BK; Mizrahi D; Sandler CX; Barry BK; Simar D; Wakefield CE; Goldstein D, 2018, 'Barriers and facilitators of exercise experienced by cancer survivors: a mixed methods systematic review', Supportive Care in Cancer, vol. 26, pp. 685 - 700, http://dx.doi.org/10.1007/s00520-017-3964-5

Andersen E; Ingerslev LR; Fabre O; Donkin I; Altintas A; Versteyhe S; Kristiansen VB; Bisgaard T; Simar D; Barres R, 2018, 'Preadipocytes from obese humans with type 2 diabetes are epigenetically reprogrammed at genes controlling adipose tissue function', International Journal of Obesity, vol. 43, pp. 306 - 318, http://dx.doi.org/10.1038/s41366-018-0031-3

Mizrahi D; Wakefield CE; Fardell JE; Quinn VF; Lim Q; Clifford BK; Simar D; Ness KK; Cohn RJ, 2017, 'Distance-delivered physical activity interventions for childhood cancer survivors: A systematic review and meta-analysis', Critical Reviews in Oncology/Hematology, vol. 118, pp. 27 - 41, http://dx.doi.org/10.1016/j.critrevonc.2017.08.008

Palmer CS; Duette GA; Wagner MCE; Henstridge DC; Saleh S; Pereira C; Zhou J; Simar D; Lewin SR; Febbraio MA; Ostrowski M; McCune JM; Crowe SM, 2017, 'Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection', FEBS Letters, vol. 591, pp. 3319 - 3332, http://dx.doi.org/10.1002/1873-3468.12843

Luo A; Leach ST; Barres R; Hesson LB; Grimm MC; Simar D, 2017, 'The microbiota and epigenetic regulation of t helper 17/regulatory T cells: In search of a balanced immune system', Frontiers in Immunology, vol. 8, pp. 417, http://dx.doi.org/10.3389/fimmu.2017.00417

Ying Lim M; Simar D; Chow S; Hsu K; R. Lewis C; L. Geczy C; S. Thomas P, 2017, 'S100A8, S100A9 and S100A12 Expression in Myeloid Cells from Whole Blood from Patients with Common Lung Diseases', Pulmonary and Critical Care Medicine, vol. 1, pp. 1 - 10, http://dx.doi.org/10.15761/PCCM.1000123

Nylander V; Ingerslev LR; Andersen E; Fabre O; Garde C; Rasmussen M; Citirikkaya K; Bæk J; Christensen GL; Aznar M; Specht L; Simar D; Barrès R, 2016, 'Ionizing radiation potentiates high-fat diet-induced insulin resistance and reprograms skeletal muscle and adipose progenitor cells', Diabetes, vol. 65, pp. 3573 - 3584, http://dx.doi.org/10.2337/db16-0364

Raghuraman S; Donkin I; Versteyhe S; Barres R; Simar D, 2016, 'The Emerging Role of Epigenetics in Inflammation and Immunometabolism', Trends in Endocrinology and Metabolism, vol. 27, pp. 782 - 795, http://dx.doi.org/10.1016/j.tem.2016.06.008

Simpson KA; Mavros Y; Kay S; Meiklejohn J; de Vos N; Wang Y; Guo Q; Zhao R; Climstein M; Baune BT; Blair S; O'Sullivan AJ; Simar D; Singh N; Fiatarone Singh MA, 2015, 'Graded Resistance Exercise And Type 2 Diabetes in Older adults (The GREAT2DO study): methods and baseline cohort characteristics of a randomized controlled trial', Trials, vol. 16, pp. 512 - 512, http://dx.doi.org/10.1186/s13063-015-1037-y

Chan YL; Saad S; Simar D; Oliver B; McGrath K; Reyk DV; Bertrand PP; Gorrie C; Pollock C; Chen H, 2015, 'Short term exendin-4 treatment reduces markers of metabolic disorders in female offspring of obese rat dams', International Journal of Developmental Neuroscience, vol. 46, pp. 67 - 75, http://dx.doi.org/10.1016/j.ijdevneu.2015.05.009

Jacobsen MJ; Mentzel CMJ; Olesen AS; Huby T; Jorgensen CB; Barres R; Fredholm M; Simar D, 2015, 'Altered methylation profile of lymphocytes is concordant with perturbation of lipids metabolism and inflammatory response in obesity', Journal of Diabetes Research, vol. 2016, pp. 8539057 - 8539057, http://dx.doi.org/10.1155/2016/8539057

Caillaud C; Mechta M; Ainge H; Madsen AN; Ruell P; Mas E; Bisbal C; Mercier J; Twigg S; Mori TA; Simar D; Barres R, 2015, 'Chronic erythropoietin treatment improves diet-induced glucose intolerance in rats', Journal of Endocrinology, vol. 225, pp. 77 - 88, http://dx.doi.org/10.1530/JOE-15-0010

Simar D; Versteyhe S; Donkin I; Liu J; Hesson L; Nylander V; Fossum A; Barres R, 2014, 'DNA Methylation Is Altered In B And NK Lymphocytes In Obese And Type 2 Diabetic Human', Metabolism: clinical and experimental, vol. 63, pp. 1188 - 1197, http://dx.doi.org/10.1016/j.metabol.2014.05.014

Ruell, PA ; Simar D; Periard, JD ; Best, S ; Caillaud, C ; Thompson, MW , 2014, 'Plasma and lymphocyte Hsp72 responses to exercise in athletes with prior exertional heat illness', Amino Acids, vol. 46, pp. 1491 - 1499, http://dx.doi.org/10.1007/s00726-014-1721-3

Martinez D; Palmer C; Simar D; Cameron B; Nguyen N; Aggarwal V; Lloyd A; Zekry A, 2014, 'Characterization of the cytokine milieu associated with the upregulation of IL-6 and suppressor of cytokine 3 in chronic hepatitis C treatment non-responders', Liver International, vol. 35, pp. 463 - 472, http://dx.doi.org/10.1111/liv.12473

Chen H; Simar D; Morris MJ, 2014, 'Maternal obesity impairs brain glucose metabolism and neural response to hyperglycemia in male rat offspring', Journal of Neurochemistry, vol. 129, pp. 297 - 303, http://dx.doi.org/10.1111/jnc.12623

Mavros Y; Kay S; Simpson KA; Baker MK; Wang Y; Zhao RR; Meiklejohn J; Climstein M; O'Sullivan AJ; de Vos N; Baune BT; Blair SN; Simar D; Rooney K; Singh NA; Fiatarone Singh MA, 2014, 'Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training', Journal of Cachexia, Sarcopenia and Muscle, vol. 5, pp. 111 - 120, http://dx.doi.org/10.1007/s13539-014-0134-1

Chen H; Simar D; Pegg K; Saad S; Palmer C; Morris MJ, 2014, 'Exendin-4 is effective against metabolic disorders induced by intrauterine and postnatal overnutrition in rodents', Diabetologia, vol. 57, pp. 614 - 622, http://dx.doi.org/10.1007/s00125-013-3132-5

Mavros Y; Anderberg K; Baker M; Wang Y; Zhao R; Meiklejohn J; Climstein M; O Sullivan AJ; De Vos N; Baune B; Simar D; Rooney K; Singh N; Fiatarone Singh M; Kay S, 2013, 'Changes in Insulin Resistance and HbA1c Are Related to Exercise-Mediated Changes in Body Composition in Older Adults With Type 2 Diabetes', Diabetes Care, vol. 36, pp. 2372 - 2379, http://dx.doi.org/10.2337/dc12-2196

Simar D; Chen H; Lambert K; Mercier J; Morris MJ, 2012, 'Interaction between maternal obesity and post-natal over-nutrition on skeletal muscle metabolism', Nutrition Metabolism and Cardiovascular Diseases, vol. 22, pp. 269 - 276, http://dx.doi.org/10.1016/j.numecd.2010.11.007

Chen H; Simar D; Ting JH; Erkelens RS; Morris MJ, 2012, 'Leucine improves glucose and lipid status in offspring from obese dams, dependent on diet type, but not caloric intake', Journal of Neuroendocrinology, vol. 24, pp. 1356 - 1364, http://dx.doi.org/10.1111/j.1365-2826.2012.02339.x

Simar D; Jacques A; Caillaud C, 2012, 'Heat shock proteins induction reduces stress kinases activation, potentially improving insulin signaling in monocytes from obese subjects', Cell Stress and Chaperones, vol. 17, pp. 615 - 621, http://dx.doi.org/10.1007/s12192-012-0336-4

Simar D; Malatesta D; Mas E; Delage M; Caillaud C, 2012, 'Effect of an 8-weeks aerobic training program in elderly on oxidative stress and HSP72 expression in leukocytes during antioxidant supplementation', The Journal of Nutrition, Health and Aging (JNHA), vol. 16, pp. 155 - 161, http://dx.doi.org/10.1007/s12603-011-0106-5

Wang Y; Simar D; Anderberg K; Mavros Y; Kay S; Zhao R; Baune B; O'sullivan A; Singh N; Fiatarone singh M, 2011, 'Muscle and Adipose Tissue Biopsy in Older Adults with Type 2 Diabetes', Journal of Diabetes Mellitus, vol. 1, pp. 27 - 35, http://dx.doi.org/10.4236/Jdm.2011.13005

Maimoun L; Simar D; Caillaud C; Coste O; Puech AM; Jaussent A; Mariano-Goulart D; Sultan C, 2011, 'Basal plasma leptin in healthy elderly males are related to physical fitness without impact on bone metabolism', Journal of Sports Medicine and Physical Fitness, vol. 51, pp. 160 - 168, https://www.ncbi.nlm.nih.gov/pubmed/21297576

Malatesta D; Simar D; Ben Saad H; Prefaut C; Caillaud C, 2010, 'Effect of an overground walking training on gait performance in healthy 65- to 80-year-olds', Experimental Gerontology, vol. 45, pp. 427 - 434, http://dx.doi.org/10.1016/j.exger.2010.03.009

Chen H; Simar D; Morris MJ, 2009, 'Hypothalamic neuroendocrine circuitry is programmed by maternal obesity: interaction with postnatal nutritional environment', PLoS One, vol. 4, pp. 1 - 10, http://dx.doi.org/10.1371/journal.pone.0006259

Mavros Y; Simar D; Singh M, 2009, 'Glucose tranporter-4 expression in monocytes: a systematic review', Diabetes Research and Clinical Practice, vol. 84, pp. 123 - 131, http://dx.doi.org/10.1016/j.diabres.2009.02.014

Wang Y; Simar D; Singh M, 2009, 'Adaptations to exercise training within skeletal muscle in adults with type 2 diabetes or impaired glucose tolerance: a systematic review', Diabetes - Metabolism Research and Reviews, vol. 25, pp. 13 - 40, http://dx.doi.org/10.1002/dmrr.928

Maimoun L; Simar D; Caillaud C; Coste O; Barbotte E; Peruchon E; Rossi M; Mariano-Goulart D, 2009, 'Response of calciotripic hormones and bone turnover to brisk walking according to age and fitness level', Journal of Science and Medicine in Sport, vol. 12, pp. 463 - 467, http://dx.doi.org/10.1016/j.jsams.2008.05.004

Chen H; Simar D; Lambert K; Mercier J; Morris MJ, 2008, 'Maternal and Postnatal Overnutrition Differentially Impact Appetite Regulators and Fuel Metabolism', Endocrinology, vol. 149, pp. 5348 - 5356, http://dx.doi.org/10.1210/en.2008-0582

Maimoun L; Simar D; Caillaud C; Peruchon E; Sultan C; Rossi M; Mariano-Goulart D, 2008, 'Effect of antioxidants and exercise on bone metabolism', Journal of Sports Sciences, vol. 26, pp. 251 - 258, http://dx.doi.org/10.1080/02640410701501689

Simar D; Malatesta D; Badiou S; Dupuy AM; Caillaud C, 2007, 'Physical activity modulates heat shock protein-72 expression and limits oxidative damage accumulation in a healthy elderly population aged 60-90 years', Journals of Gerontology, Series A : Biological Sciences and Medical Sciences, vol. 62A, pp. 1413 - 1419, http://dx.doi.org/10.1093/gerona/62.12.1413

Maimoun L; Simar D; Malatesta D; Caillaud C; Peruchon E; Couret I; Rossi M; Mariano-Goulart D, 2005, 'Response of bone metabolism related hormones to a single session of strenuous exercise in active elderly subjects', British Journal of Sports Medicine, vol. 39, pp. 497 - 502, http://dx.doi.org/10.1136/bjsm.2004.013151

Simar D; Malatesta D; Dauvilliers Y; Prefaut C; Varray A; Caillaud C, 2005, 'Aerobic and Functional Capacities in a Selected Active Population of European Octogenarians', International Journal of Sports Medicine, vol. 26, pp. 128 - 133, http://dx.doi.org/10.1055/s-2004-817860

Simar D; Malatesta D; Koechlin C; Cristol JP; Vendrell JP; Caillaud C, 2004, 'Effect of age on Hsp72 expression in leukocytes of healthy active people', Experimental Gerontology, vol. 39, pp. 1467 - 1474, http://dx.doi.org/10.1016/j.exger.2004.08.002

Connes P; Caillaud C; Simar D; Villard S; Sicart MT; Audran M, 2004, 'Strengths and weaknesses of established indirect models to detect recombinant human erythropoietin abuse on blood samples collected 48-hr post administration', Haematologica - the Hematology Journal, vol. 89, pp. 891 - 892, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15257956

Koechlin C; Couillard A; Simar D; Cristol JP; Bellet H; Hayot M; Prefaut C, 2004, 'Does oxidative stress alter quadriceps endurance in chronic obstructive pulmonary disease?', American Journal of Respiratory and Critical Care Medicine, vol. 169, pp. 1022 - 1027, http://dx.doi.org/10.1164/rccm.200310-1465OC

Malatesta D; Simar D; Dauvilliers Y; Candau R; Ben Saad H; Prefaut C; Caillaud C, 2004, 'Aerobic determinants of the decline in preferred walking speed in healthy, active 65- and 80-year-olds', Pflugers Archiv - European Journal of Physiology, vol. 447, pp. 915 - 921, http://dx.doi.org/10.1007/s00424-003-1212-y

Malatesta D; Simar D; Dauvilliers Y; Candau R; Borrani F; Prefaut C; Caillaud C, 2004, 'Energy Cost of Walking and Gait Instability in Healthy 65- And 80-Yr-Olds.', Cardiopulmonary Physical Therapy Journal, vol. 15, pp. 29 - 30, http://dx.doi.org/10.1097/01823246-200415010-00013

Malatesta D; Simar D; Dauvilliers Y; Candau R; Borrani F; Prefaut C; Caillaud C, 2003, 'Energy cost of walking and gait instability in healthy 65- and 80-yr-olds', Journal of Applied Physiology, vol. 95, pp. 2248 - 2256, http://dx.doi.org/10.1152/japplphysiol.01106.2002

Conference Papers

Conference Abstracts

McBride J; Plush L; Field P; Ha L; Simar D; Cohn R; Mizrahi D, 2021, 'EVALUATION OF CARDIOPULMONARY DYSFUNCTION IN CHILDHOOD CANCER SURVIVORS', in RESPIROLOGY, WILEY, Vol. 26, pp. 17 - 17, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000644657800031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mcbride J; Plush L; Field P; Ha L; Simar D; Cohn R; Mizrahi D, 2020, 'EXERCISE INTOLERANCE IN CHILDHOOD CANCER SURVIVORS', in RESPIROLOGY, WILEY, Vol. 25, pp. 17 - 17, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000538684200030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

McBride J; Plush L; Field P; Ha L; Simar D; Cohn R; Mizrahi D, 2020, 'AP 011: EXERCISE INTOLERANCE IN CHILDHOOD CANCER SURVIVORS', in Respirology, Wiley, Melbourne Convention and Exhibition Centre, VIC, Australia, Vol. 25, presented at Conference: TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne Convention and Exhibition Centre, VIC, Australia, 27 March 2020 - 31 March 2020, http://dx.doi.org/10.1111/resp.13776

Singh MF; Sharma P; Hollings M; Mavros Y; Kay S; Anderberg KA; Baker MK; Wang Y; Zhao RR; Meiklejohn J; Climstein M; O'Sullivan A; De Vos N; Baune BT; Simar D; Singh N; Blair SN, 2020, 'Effect Of High Intensity Power Training On Blood Pressure In Type 2 Diabetes: Great2Do Trial', in MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, LIPPINCOTT WILLIAMS & WILKINS, ELECTR NETWORK, Vol. 52, pp. 524 - 524, presented at American-College-of-Sports-Medicine (ACSM) Virtual Conference, ELECTR NETWORK, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000590026302078&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Haghighi MM; Mavros Y; Kay S; Anderberg KA; Baker MK; Wang Y; Zhao RR; Meiklejohn J; Climstein M; O'Sullivan A; De Vos N; Baune BT; Blair SN; Simar D; Singh N; Schlicht J; Singh MF, 2020, 'Six-year Effects Of Power Training On Physical Activity In Older Adults With Type 2 Diabetes', in MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, LIPPINCOTT WILLIAMS & WILKINS, ELECTR NETWORK, Vol. 52, pp. 526 - 526, presented at American-College-of-Sports-Medicine (ACSM) Virtual Conference, ELECTR NETWORK, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000590026302083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mizrahi D; Wakefield CE; Fardell JE; Simar D; Maguire A; Hubbard G; McBride J; Field P; Cohn RJ, 2018, 'An Investigation Of Physical Activity And Cardiorespiratory Fitness In Childhood Cancer Survivors.', in MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, LIPPINCOTT WILLIAMS & WILKINS, Minneapolis, MN, Vol. 50, pp. 705 - 705, presented at Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Minneapolis, MN, 29 May 2018 - 02 June 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000456870503102&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mizrahi D; Wakefield C; Simar D; Maguire A; Hubbard G; Fardell J; McBride J; Field P; Cohn RJ, 2018, 'Is physical activity and cardiorespiratory fitness reduced among childhood cancer survivors?', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Vol. 36, http://dx.doi.org/10.1200/JCO.2018.36.15_suppl.10569

Mizrahi D; Wakefield CE; Fardell JE; Simar D; Maguire A; Hubbard G; McBride J; Field P; Cohn RJ, 2018, 'An Investigation Of Physical Activity And Cardiorespiratory Fitness In Childhood Cancer Survivors.', in Medicine & Science in Sports & Exercise, Ovid Technologies (Wolters Kluwer Health), Vol. 50, pp. 705 - 705, http://dx.doi.org/10.1249/01.mss.0000538323.14277.a2

Mizrahi D; Wakefield CE; Simar D; Maguire AM; Osborn M; Hubbard G; Cohn RJ; Fardell JE, 2017, 'Do Childhood Cancer Survivors Achieve Recommended Physical Activity Levels? A Report from the Anzchog Survivorship Study', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 13, pp. 86 - 86, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000413954500073&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Eslami S; Nylander V; Ingerslev L; Fabre O; Johnston K; Cohn R; Barres R; Simar D, 2016, 'Accelerated epigenetic aging in childhood cancer survivors', in Accelerated epigenetic aging in childhood cancer survivors, Sydney Cancer Conference 2016, Sydney, Australia, presented at Sydney Cancer Conference 2016, Sydney, Australia, 22 September 2016 - 23 September 2016

Eslami S; Boysen L; Amorim N; Bould S; Kee A; Lucas C; Johnston K; Hardeman E; Cohn RJ; Barres R; Simar D, 2015, 'Radiation-induced metabolic complications: potential role for the microbiota', in Radiation-induced metabolic complications: potential role for the microbiota, Nutrient & Metabolite Sensing, Copenhagen, Denmark, presented at Nutrient & Metabolite Sensing, Copenhagen, Denmark, 01 November 2015 - 05 November 2015

Eslami S; Boysen L; Amorim N; Bould S; Kee A; Lucas C; Johnston K; Cohn R; Hardeman E; Barres R; Simar D, (eds.), 2015, 'Metabolic complications in cancer survivors: role of adipose tissue dysfunction', in Metabolic complications in cancer survivors: role of adipose tissue dysfunction, Keystone Symposia: Systems Biology of Lipid Metabolism, Breckenridge, Colorado, USA, presented at Keystone Symposia: Systems Biology of Lipid Metabolism, Breckenridge, Colorado, USA, 09 February 2015 - 13 February 2015

Nylander V; Simar D; Aznar M; Specht L; Zierath JR; Barres R, 2014, 'Cancer therapy alters whole body metabolism later in life: a potential role for epigenetic mechanisms', in DIABETOLOGIA, SPRINGER, Vol. 57, pp. S111 - S111, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344386100248&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lim M; Chow S; Hsu K; Lewis C; Simar D; Geczy C; Thomas P, (ed.), 2014, 'Serum and exhaled breath condensate (EBC) levels of S100A9, nitrite/nitrate (NOX) and Interleukin-10 (IL-10) in non-small cell lung (NSCLC)', in Proceedings of the Annual Scientific Meeting of the Thoracic Society of Australia and New Zealand Aril 4-9 2014, WILEY-BLACKWELL, Adelaide, Australia, Vol. 19, pp. 68 - 68, presented at Annual Scientific Meeting of the Thoracic Society of Australia and New Zealand, Adelaide, Australia, 04 April 2014 - 09 April 2014, http://dx.doi.org/10.1111/resp.12263_3

Lim M; Chow S; Hsu K; Lewis C; Geczy C; Thomas P; Simar D, 2014, 'S100A8, A9 and A12 expression by myeloid-derived suppressor cells (MDSC) in non-small cell lung cancer (NSCLC)', in Respirology, John Wiley & Sons Inc, Adelaide, Australia, Vol. 19, pp. 1 - 1, presented at Annual Scientific Meeting of the Thoracic Society of Australia and New Zealand, Adelaide, Australia, 04 April 2014 - 09 April 2014, http://dx.doi.org/10.1111/resp.12263_3

Eslami S; Johnston K; Cohn RJ; Simar D, (eds.), 2013, 'Systemic inflammation in childhood cancer survivors treated with irradiation', in Systemic inflammation in childhood cancer survivors treated with irradiation, 2nd International Conference on ImmunoMetabolism: Molecular and Cellular Immunology of Metabolism, Rhodes, Greece, presented at 2nd International Conference on ImmunoMetabolism: Molecular and Cellular Immunology of Metabolism, Rhodes, Greece, 15 September 2013 - 20 September 2013

Simar D; Eslami S; Cohn RJ; Johnston K; Barres R, (ed.), 2013, 'Effect of epigenetic changes on metabolic complications in childhood cancer survivors', in Keystone Symposia, Metabolic Control of Inflammation and Immunity, USA, presented at Metabolic Control of Inflammation and Immunity, Beaver Run Resort, Breckenridge, Colorado, USA, 21 January 2013 - 24 January 2013

Ainge H; Madsen A; Simar D; Ruell P; Barres R; Caillaud C, (eds.), 2012, 'ERYTHROPIETIN INCREASES FAT OXIDATION IN LEAN RATS AND IMPROVES GLUCOSE REGULATION IN HIGH FAT FED ANIMALS', in 14th Annual Congress of the European College of Sport Science, Book of Abstracts, European College of Sport Science, Oslo, Norway, presented at 17th Annual Congress of the European College of Sport Science, Bruges, Belgium, 04 July 2012 - 07 July 2012

Ruell P; Simar D; Pierrard J; Best S; Caillaud C; Thompson MW, (eds.), 2012, 'Exercise does not increase serum Hsp70B', in 14th Annual Congress of the European College of Sport Science, Book of Abstracts, European College of Sport Science, Oslo, Norway, presented at 17th Annual Congress of the European College of Sport Science, Bruges, Belgium, 04 July 2012 - 07 July 2012

Mavros Y; Rooney K; Kay S; Simar D; Anderberg K; Baker M; Wang Y; Zhao R; Meiklejohn J; De Vos N; Climstein M; O'Sullivan A; Baune B; Blair S; Singh N; Singh M, 2012, 'Relative Muscle Mass is Inversely Associated with Inflammation in Older Adults with Type 2 Diabetes', in Medicine and Science in Sports and Exercise, Lippincott Williams & Wilkins, Philadelphia, PA, USA, Vol. 44, pp. S116 - S116, presented at ACSM 59th Annual Meeting and 3rd World Congress on Exercise is Medicine, San Francisco, California, USA, 29 May 2012 - 03 June 2012, http://dx.doi.org/10.1249/01.mss.0000417526.38002.a4

Mavros Y; Rooney K; Kay S; Simar D; Anderberg K; Baker M; Wang Y; Zhao R; Meiklejohn J; De Vos N; Climstein M; O''sullivan A; Baune B; Blair S; Singh N; Singh M, 2012, 'Relative Muscle Mass is Inversely Associated with Insulin Resistance in Older Adults with Type 2 Diabetes', in Obesity Facts: the European journal of obesity, European Congress on Obesity, Lyon, France, pp. 227 - 227, presented at European Congress on Obesity, Lyon, France

Guo ; Wang Y; Mavros Y; Simar D; Anderberg K; Kay S; Singh N; Singh M, 2011, 'Skeletal muscle c-Jun N-terminal kinase (JNK) is related to selected cytokines in older adults with type 2 diabetes (T2D): baseline correlations of the GREAT2DO study.', in Gerontologist, Gerontological Society Amer, Washington, DC, USA, Vol. 51, pp. 23 - 23, presented at 64th Annual Scientific meeting of the Gerontological Society of America, Boston, 18 November 2011 - 22 November 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000303602000106&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Wang Y; Simar D; Anderberg K; Mavros Y; Kay S; Baune B; Singh N; Singh M, 2011, 'Skeletal muscle and subcutaneous adipose tissue adaptations to power training in older adults with type 2 diabetes: a double-blind randomized sham-exercise controlled trial.', in Gerontologist, Gerontological Society Amer, Washington, DC, USA, Vol. 51, pp. 585 - 585, presented at 64th Annual Scientific meeting of the Gerontological Society of America, Boston, USA, 18 November 2011 - 22 November 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000303602004068&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Guo ; Wang Y; Anderberg K; Mavros Y; Kay S; Simar D; Singh N; Singh M, 2011, 'Relationship between skeletal muscle c-Jun N-terminal kinase (JNK) and health status indicators in older adults with type 2 diabetes', in Gerontologist, Gerontological Society Amer, Washington, DC, USA, Vol. 51, pp. 584 - 584, presented at 64th Annual Scientific meeting of the Gerontological Society of America, Boston, USA, 18 November 2011 - 22 November 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000303602004067&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Singh M; Mavros Y; Simar D; Anderberg K; Kay S; Wang Y; Singh N; O Sullivan AJ, 2011, 'Glucose transporter-4 expression in monocytes is correlated to indices of insulin resistance in adults with type 2 diabetes.', in Gerontologist, Gerontological Society Amer, Washington, DC, USA, Vol. 51, pp. 584 - 584, presented at 64th Annual Scientific meeting of the Gerontological Society of America, Boston, USA, 18 November 2011 - 22 November 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000303602004066&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Simar D; Andrew J; Caillaud C, 2011, 'Insulin signalling in monocytes: impact of obesity', in Insulin signalling in monocytes: impact of obesity, EMBO workshop 2011: Immunology and Metabolism, Marseille, France, presented at EMBO workshop 2011: Immunology and Metabolism, Marseille, France, 13 January 2011 - 15 January 2011

Ting J; Simar D; Morris MJ; Chen H, 2010, 'Leucine supplement improved glucose metabolism in offspring from obese dams via altering muscle and liver markers', in Obesity Research & Clinical Practice, Elsevier BV, Vol. 4, pp. S66 - S67, http://dx.doi.org/10.1016/j.orcp.2010.09.130

Simar D; Fatseas G; Caillaud C, (eds.), 2009, 'Insulin resistance in obesity: a new cellular model', in 14th Annual Congress of the European College of Sport Science, Book of Abstracts, European College of Sport Science, Oslo, Norway, pp. 502 - 502, presented at 14th Annual Congress of the European College of Sport Science, Oslo, Norway, 24 June 2009 - 27 June 2009

Caillaud C; Trout G; Howe C; Simar D; Fatseas G; Howe C, (eds.), 2009, 'Does exercise in hot environmental condition impair detection of erythropoietin doping?', in 14th Annual Congress of the European College of Sport Science, Book of Abstracts, European College of Sport Science, Oslo, Norway, pp. 536 - 536, presented at 14th Annual Congress of the European College of Sport Science, Oslo, Norway, 24 June 2009 - 27 June 2009

Fatseas G; Simar D; Caillaud C, (eds.), 2009, 'Heat acclimation and activation of a cytoprotective pathway', in 14th Annual Congress of the European College of Sport Science, Book of Abstracts, European College of Sport Science, Oslo, Norway, pp. 252 - 253, presented at 14th Annual Congress of the European College of Sport Science, Oslo, Norway, 24 June 2009 - 27 June 2009

Maimoun L; Simar D; Caillaud C; Coste O; Puechv AA; Peruchon E; Jaussent A; Rossi M; Sultan C; Mariano-Goulart D, 2008, 'In elderly healthy subjects, the physical fitness level plays a crucial role in the leptin secretion and bone turnover', in FUNDAMENTAL & CLINICAL PHARMACOLOGY, BLACKWELL PUBLISHING, Vol. 22, pp. 43 - 43, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000256760500206&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1