Dr Blake Cochran

Fields of research: Animal Cell and Molecular Biology, Biochemistry and Cell Biology, Endocrinology, Cardiology (incl. Cardiovascular Diseases), Cell Metabolism

Contact Details

Phone: (02) 9385 1253
Email: b.cochran@unsw.edu.au

Tabs

Main

The objective of my research is to characterise the role of cholesterol in the mechanisms of disease development and progression. Whilst cholesterol is a fundamental constituent of animal cells, impaired cholesterol homeostasis plays a critical role in the development and pathogenesis of diabetes, atherosclerosis and obesity. My research utilises novel animal models, in vitro systems and translational research approaches to answer important medical questions

Accepting applications to supervise Honours, PhD, ILP and Undergraduate Internship (eg SOMS3001) students.

Current Students
Bikash Manandhar - PhD
Thomas King - BMedSci Honours
Veronica Turong - BMedSci Honours
Shivam Patel - BMedSci Honours
Angela Li - BMedSci Honours
Wei Jack Ang - Medicine ILP
Bradley Tucker - Medicine ILP

Previous Students
2015 - Praween Senenyake - BMedSci Honours. Currently studying Medicine at Western Sydney University, Masters of Clinical Epidemiology at University of Sydney
2016 - Sumaya Mozumder - B MedSci Honours
2017 - Alexander Dupuy - BMedSci Honours. Currently Research Assistant at Heart Research Institute, Sydney
2017 - Maybelle Ling Hoon - Medicine ILP
2018 - Yong Chang Lai - BMed(Hons)
2018 - Wei Ting Tan - Medicine ILP
2018 - Rebecca Metzger - Medicine ILP
2018 - Ishbel Henderson - Exchange student SOMS3001

University role:

Lecturer

Research

Teaching & Supervision

I am available to supervise:

Yes

Areas of supervision:

Undergraduate Intern, ILP, Honours, Masters, PhD

Supervision keywords:

diabetes

atherosclerosis

tissue pathology

Publications related to this Person

Journal articles

Tang S; Tabet F; Cochran BJ; Cuesta Torres LF; Wu BJ; Barter PJ; Rye K-A, 2019, 'Apolipoprotein A-I enhances insulin-dependent and insulin-independent glucose uptake by skeletal muscle', Scientific Reports, vol. 9, http://dx.doi.org/10.1038/s41598-018-38014-3

Barter PJ; Cochran BJ; Rye KA, 2018, 'CETP inhibition, statins and diabetes', Atherosclerosis, vol. 278, pp. 143 - 146, http://dx.doi.org/10.1016/j.atherosclerosis.2018.09.033

Jones B; Buenaventura T; Kanda N; Chabosseau P; Owen BM; Scott R; Goldin R; Angkathunyakul N; Corrêa IR; Bosco D, 2018, 'Targeting GLP-1 receptor trafficking to improve agonist efficacy', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-03941-2

Aleidi SM; Yang A; Sharpe LJ; Rao G; Cochran BJ; Rye KA; Kockx M; Brown AJ; Gelissen IC, 2018, 'The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1863, pp. 359 - 368, http://dx.doi.org/10.1016/j.bbalip.2017.12.011

Cochran BJ; Hou L; Manavalan APC; Moore BM; Tabet F; Sultana A; Cuesta Torres L; Tang S; Shrestha S; Senanayake P, 2017, 'Erratum. Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism. Diabetes 2016;65:3610-3620.', Diabetes, vol. 66, pp. 560, http://dx.doi.org/10.2337/db17-er02b

Cochran BJ; Ryder WJ; Parmar A; Klaeser K; Reilhac A; Angelis GI; Meikle SR; Barter PJ; Rye KA, 2017, 'Determining glucose metabolism kinetics using ¹⁸F-FDG micro-PET/CT', Journal of Visualized Experiments, vol. 2017, http://dx.doi.org/10.3791/55184

Pandzic E; Gelissen IC; Whan R; Barter PJ; Sviridov D; Gaus K; Rye KA; Cochran BJ, 2017, 'The ATP binding cassette transporter, ABCG1, localizes to cortical actin filaments', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep42025

Cochran BJ; Hou L; Manavalan APC; Moore BM; Tabet F; Sultana A; Torres LC; Tang S; Shrestha S; Senanayake P, 2016, 'Impact of perturbed pancreatic β-cell cholesterol homeostasis on adipose tissue and skeletal muscle metabolism', Diabetes, vol. 65, pp. 3610 - 3620, http://dx.doi.org/10.2337/db16-0668

Cochran BJ; Ryder WJ; Parmar A; Tang S; Reilhac A; Arthur A; Charil A; Hamze H; Barter PJ; Kritharides L, 2016, 'In vivo PET imaging with [¹⁸F]FDG to explain improved glucose uptake in an apolipoprotein A-I treated mouse model of diabetes', Diabetologia, vol. 59, pp. 1977 - 1984, http://dx.doi.org/10.1007/s00125-016-3993-5

Sultana A; Cochran BJ; Tabet F; Patel M; Torres LC; Barter PJ; Rye KA, 2016, 'Inhibition of inflammatory signaling pathways in 3T3-L1 adipocytes by apolipoprotein A-I', FASEB Journal, vol. 30, pp. 2324 - 2335, http://dx.doi.org/10.1096/fj.201500026R

Rye KA; Barter PJ; Cochran BJ, 2015, 'Apolipoprotein A-I interactions with insulin secretion and production', Current Opinion in Lipidology, http://dx.doi.org/10.1097/MOL.0000000000000253

Cochran BJ; Bisoendial RJ; Hou L; Glaros EN; Rossy J; Thomas SR; Barter PJ; Rye KA, 2014, 'Apolipoprotein A-I increases insulin secretion and production from pancreatic β-cells via a G-protein-cAMPPKA-FoxO1-dependent mechanism', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, pp. 2261 - 2267, http://dx.doi.org/10.1161/ATVBAHA.114.304131

Lee JA; Cochran BJ; Lobov S; Ranson M, 2011, 'Forty years later and the role of plasminogen activator inhibitor type 2/SERPINB2 is still an enigma', Seminars in Thrombosis and Hemostasis, vol. 37, pp. 395 - 407, http://dx.doi.org/10.1055/s-0031-1276589

Cochran BJ; Croucher DR; Lobov S; Saunders DN; Ranson M, 2011, 'Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of serpinE1 and serpinB2 in cancer', Journal of Biological Chemistry, vol. 286, pp. 24467 - 24475, http://dx.doi.org/10.1074/jbc.M111.225706

Cochran BJ; Gunawardhana LP; Vine KL; Lee JA; Lobov S; Ranson M, 2009, 'The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity', BMC Biotechnology, vol. 9, http://dx.doi.org/10.1186/1472-6750-9-43

Conference Papers

Haeusler M; Dunn K; Cochran B; Cheng T, 2019, 'Design in Paediatric Healthcare: Rethinking 3D models of paediatric orthopaedic data using Design approaches.', in Real / Material / Etheral, 2nd Annual Design Research Conference, Monash University Melbourne, presented at 2nd Annual Design Research Conference, Monash University Melbourne, 03 - 04 October 2019

Kopecky CM; Ryder WJ; Szajer J; Parmar A; Pandzic E; Rye KA; Cochran BJ, 2018, 'Translocator Protein as Novel Marker for Early Atherosclerosis', in ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, San Francisco, CA, presented at Scientific Sessions of the American-Heart-Association on Vascular Discovery - From Genes to Medicine, San Francisco, CA, 10 - 12 May 2018, http://dx.doi.org/10.1161/atvb.38.suppl_1.222

Cochran BJ; Trajanovska S; Sunn N; Rye KA; Ryder WJ, 2018, 'Development of 3D printing filaments for bespoke X-Ray phantoms', in 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings, http://dx.doi.org/10.1109/NSSMIC.2018.8824621

Conference Presentations

Tucker B; Rehan R; Vaidya K; Rye K; Cochran B; Patel S, 2019, 'Colchicine inhibits neutrophil extracellular trap formation in acute coronary syndrome patients', Australian Atherosclerosis Society Annual Scientific Meeting, Melbourne, presented at Australian Atherosclerosis Society Annual Scientific Meeting, Melbourne, 16 - 19 October 2019

Manandhar B; Cochran BJ; Rye K, 2019, 'APOLIPOPROTEIN A-I LOCALISES TO MITOCHONDRIA AND INHIBITS ROS GENERATION IN INSULIN PRODUCING CELLS.', AAS 2019 Annual Scientific meeting, Victoria University City Convention Centre, Melbourne, presented at AAS 2019 Annual Scientific meeting, Victoria University City Convention Centre, Melbourne, 16 - 19 October 2019

Tan WT; Kopecky C; Manandhar B; Rye KA; Cochran B, 2019, 'SKELETAL MUSCLE SPECIFIC DELETION OF ABCA1 AND ABCG1 IMPACTS BODY COMPOSITION AND METABOLISM AND IS AGE DEPENDENT', in ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Maastricht, NETHERLANDS, Vol. 287, pp. E43 - E43, presented at 87th Congress of the European-Atherosclerosis-Society (EAS), Maastricht, NETHERLANDS, 26 - 29 May 2019, http://dx.doi.org/10.1016/j.atherosclerosis.2019.06.122

Conference Abstracts

Kopecky C; Ryder WJ; Szajer J; Parmar A; Pandzic E; Rye K-A; Cochran BJ, 2018, 'THE TSPO RADIOLIGAND 18F-PBR111 AS A PRE-ATHEROSCLEROTIC LESION DETECTION AGENT', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Toronto, CANADA, Vol. 32, pp. 145 - 146, presented at International Symposium on Atherosclerosis (ISA), Toronto, CANADA, 09 - 12 June 2018, http://dx.doi.org/10.1016/j.atherosclerosissup.2018.04.446

Cochran BJ; Pinheiro D; Prendecki M; Jones B; Cegla J; Lee V; Barter PJ; Murphy AJ; Rye K-A; Woollard KJ, 2018, 'PRO-ATHEROSCLEROTIC LOW-DENSITY NEUTROPHILS ARE PRESENT IN HYPERCHOLESTEROLEMIA', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Toronto, CANADA, Vol. 32, pp. 39 - 40, presented at International Symposium on Atherosclerosis (ISA), Toronto, CANADA, 09 - 12 June 2018, http://dx.doi.org/10.1016/j.atherosclerosissup.2018.04.115

Polly P; Jones G; Cochran B, 2017, 'EMENTORING TO SUPPORT AND ENABLE RESEARCH INTEGRATED LEARNING USING AUTHENTIC ASSESSMENT IN A THIRD YEAR UNDERGRADUATE SCIENCE COURSE IN PATHOLOGY AT A RESEARCH INTENSIVE UNIVERSITY', in EDULEARN17 Proceedings, 9th International Conference on Education and New Learning Technologies, presented at 9th International Conference on Education and New Learning Technologies

Cochran BJ; Hou L; Manavalan APC; Sultana A; Moore BM; Patel M; Tall A; Barter PJ; Rye KA, 2015, 'PANCREATIC BETA-CELL SPECIFIC DELETION OF ABCA1 AND ABCG1 PERTURBS GLUCOSE METABOLISM AND INCREASES ADIPOSITY IN MICE DUE TO SUBOPTIMAL PLASMA INSULIN LEVELS', in ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Glasgow, SCOTLAND, Vol. 241, pp. E3 - E3, presented at 83rd Congress of the European-Atherosclerosis-Society (EAS), Glasgow, SCOTLAND, 22 - 25 March 2015, http://dx.doi.org/10.1016/j.atherosclerosis.2015.04.028