Dr Blake Cochran

Fields of research: Animal Cell and Molecular Biology, Biochemistry and Cell Biology, Endocrinology, Cardiology (incl. Cardiovascular Diseases), Cell Metabolism

Contact Details

Phone: (02) 9385 2910
Email: b.cochran@unsw.edu.au

Tabs

Main

The objective of my research is to characterise the role of cholesterol in the mechanisms of disease development and progression. Whilst cholesterol is a fundamental constituent of animal cells, impaired cholesterol homeostasis plays a critical role in the development and pathogenesis of diabetes, atherosclerosis and obesity. My research utilises novel animal models, in vitro systems and translational research approaches to answer important medical questions

Accepting applications to supervise Honours, PhD, ILP and Undergraduate Internship (eg SOMS3001) students.

Current Students
Bikash Manandhar - PhD
Thomas King - BMedSci Honours
Veronica Turong - BMedSci Honours
Shivam Patel - BMedSci Honours
Angela Li - BMedSci Honours
Wei Jack Ang - Medicine ILP
Bradley Tucker - Medicine ILP

Previous Students
2015 - Praween Senenyake - BMedSci Honours. Currently studying Medicine at Western Sydney University, Masters of Clinical Epidemiology at University of Sydney
2016 - Sumaya Mozumder - B MedSci Honours
2017 - Alexander Dupuy - BMedSci Honours. Currently Research Assistant at Heart Research Institute, Sydney
2017 - Maybelle Ling Hoon - Medicine ILP
2018 - Yong Chang Lai - BMed(Hons)
2018 - Wei Ting Tan - Medicine ILP
2018 - Rebecca Metzger - Medicine ILP
2018 - Ishbel Henderson - Exchange student SOMS3001

University role:

Adjunct Lecturer

Research

Teaching & Supervision

I am available to supervise:

Yes

Areas of supervision:

Undergraduate Intern, ILP, Honours, Masters, PhD

Supervision keywords:

diabetes

atherosclerosis

tissue pathology

Publications related to this Person

Journal articles

Sawant S; Tucker B; Senanayake P; Waters DD; Patel S; Rye K-A; Ong KL; Cochran BJ, 2021, 'The association between lipid levels and leukocyte count: A cross-sectional and longitudinal analysis of three large cohorts', American Heart Journal Plus: Cardiology Research and Practice, vol. 4, pp. 100024 - 100024, http://dx.doi.org/10.1016/j.ahjo.2021.100024

Sawant S; Tucker B; Senenayake P; Waters D; Rye K; Patel S; Ong K; Cochran B, 2021, 'The Association Between Lipid Levels and Leukocyte Count: A Cross-Sectional and Longitudinal Analysis of Three Large Cohorts', Heart, Lung and Circulation, vol. 30, pp. S245 - S245, http://dx.doi.org/10.1016/j.hlc.2021.06.335

Wang H; Leeming MG; Cochran BJ; Hook JM; Ho J; Nguyen GTH; Zhong L; Supuran CT; Donald WA, 2020, 'Nontargeted Identification of Plasma Proteins O-, N-, and S-Transmethylated by O-Methyl Organophosphates', Analytical Chemistry, vol. 92, pp. 15420 - 15428, http://dx.doi.org/10.1021/acs.analchem.0c03077

Manandhar B; Cochran BJ; Rye KA, 2020, 'Role of High-Density Lipoproteins in Cholesterol Homeostasis and Glycemic Control', Journal of the American Heart Association, vol. 9, pp. e013531, http://dx.doi.org/10.1161/JAHA.119.013531

Ho JH; Liu Y; Adam S; Syed AA; Ammori BJ; Donn R; Malik R; Tabet F; Cochran BJ; Rye K-A; Soran H, 2020, 'Changes in the effect of HDL on pancreatic beta-cell insulin secretion following metabolic surgery', Atherosclerosis, vol. 315, pp. e150 - e151, http://dx.doi.org/10.1016/j.atherosclerosis.2020.10.465

Tucker B; Vaidya K; Kurup R; Khandkar C; Pandzic E; Barraclough J; Misra A; Kavurma M; Martinez G; Rye K; Cochran B; Patel S, 2020, '461 Colchicine Inhibits Neutrophil Extracellular Trap Formation in Acute Coronary Syndrome Patients Post Percutaneous Coronary Intervention', Heart, Lung and Circulation, vol. 29, pp. S244 - S244, http://dx.doi.org/10.1016/j.hlc.2020.09.468

Tucker B; Vaidya K; Kurup R; Khandkar C; Barraclough J; Misra A; Kavurma M; Martinez G; Rye K-A; Cochran B; Patel S, 2020, 'COLCHICINE INHIBITS NEUTROPHIL EXTRACELLULAR TRAP FORMATION IN ACUTE CORONARY SYNDROME PATIENTS POST PERCUTANEOUS CORONARY INTERVENTION', Journal of the American College of Cardiology, vol. 75, pp. 1346 - 1346, http://dx.doi.org/10.1016/s0735-1097(20)31973-2

Lai YC; Woollard KJ; McClelland RL; Allison MA; Rye KA; Ong KL; Cochran BJ, 2019, 'The association of plasma lipids with white blood cell counts: Results from the Multi-Ethnic Study of Atherosclerosis', Journal of Clinical Lipidology, vol. 13, pp. 812 - 820, http://dx.doi.org/10.1016/j.jacl.2019.07.003

Hou L; Tang S; Wu BJ; Ong KL; Westerterp M; Barter PJ; Cochran BJ; Tabet F; Rye KA, 2019, 'Apolipoprotein A-l improves pancreatic β-cell function independent of the ATP-binding cassette transporters ABCA1 and ABCG1', FASEB Journal, vol. 33, pp. 8479 - 8489, http://dx.doi.org/10.1096/fj.201802512RR

Hackett MJ; Hollings A; Majimbi M; Brook E; Cochran B; Giles C; Lam V; Nesbit M; Rye KA; Mamo JCL; Takechi R, 2019, 'Multimodal Imaging Analyses of Brain Hippocampal Formation Reveal Reduced Cu and Lipid Content and Increased Lactate Content in Non-Insulin-Dependent Diabetic Mice', ACS Chemical Neuroscience, vol. 10, pp. 2533 - 2540, http://dx.doi.org/10.1021/acschemneuro.9b00039

Kopecky C; Pandzic E; Parmar A; Szajer J; Lee V; Dupuy A; Arthur A; Fok S; Whan R; Ryder WJ; Rye KA; Cochran BJ, 2019, 'Translocator protein localises to CD11b ⁺ macrophages in atherosclerosis', Atherosclerosis, vol. 284, pp. 153 - 159, http://dx.doi.org/10.1016/j.atherosclerosis.2019.03.011

Cochran B; Tang S; Tabet F; Cuesta Torres L; Wu B; Barter P; Rye K-A, 2019, 'Apolipoprotein A-I enhances insulin-dependent and insulinindependent glucose uptake by skeletal muscle', Scientific Reports, vol. 9, http://dx.doi.org/10.1038/s41598-018-38014-3

Jones B; Buenaventura T; Kanda N; Chabosseau P; Owen BM; Scott R; Goldin R; Angkathunyakul N; Corrêa IR; Bosco D; Johnson PR; Piemonti L; Marchetti P; Shapiro AMJ; Cochran BJ; Hanyaloglu AC; Inoue A; Tan T; Rutter GA; Tomas A; Bloom SR, 2018, 'Targeting GLP-1 receptor trafficking to improve agonist efficacy', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-03941-2

Barter PJ; Cochran BJ; Rye KA, 2018, 'CETP inhibition, statins and diabetes', Atherosclerosis, vol. 278, pp. 143 - 146, http://dx.doi.org/10.1016/j.atherosclerosis.2018.09.033

Aleidi SM; Yang A; Sharpe LJ; Rao G; Cochran BJ; Rye KA; Kockx M; Brown AJ; Gelissen IC, 2018, 'The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1863, pp. 359 - 368, http://dx.doi.org/10.1016/j.bbalip.2017.12.011

Cochran BJ; Pinheiro D; Prendecki M; Jones B; Cegla J; Lee V; Barter PJ; Murphy AJ; Rye K-A; Woollard KJ, 2018, 'Abstract 609: Pro-atherosclerotic Low-density Neutrophils Are Present in Hypercholesterolemia', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 38, http://dx.doi.org/10.1161/atvb.38.suppl_1.609

Cochran BJ; Ryder W; parmar A; Meikle S; Barter P; Rye K, 2017, 'Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT', Journal of Visualized Experiments, vol. 2017, http://dx.doi.org/10.3791/55184

Pandzic E; Gelissen IC; Whan R; Barter PJ; Sviridov D; Gaus K; Rye KA; Cochran BJ, 2017, 'The ATP binding cassette transporter, ABCG1, localizes to cortical actin filaments', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep42025

Cochran BJ; Hou L; Manavalan APC; Moore BM; Tabet F; Sultana A; Torres LC; Tang S; Shrestha S; Senanayake P; Patel M; Ryder WJ; Bongers A; Maraninchi M; Wasinger VC; Westerterp M; Tall AR; Barter PJ; Rye K-A, 2017, 'Impact of Perturbed Pancreatic beta-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism (vol 65, pg 3610, 2016)', DIABETES, vol. 66, pp. 560 - 560, http://dx.doi.org/10.2337/db17-er02b

Cochran BJ; Hou L; Manavalan APC; Moore BM; Tabet F; Sultana A; Torres LC; Tang S; Shrestha S; Senanayake P; Patel M; Ryder WJ; Bongers A; Maraninchi M; Wasinger VC; Westerterp M; Tall AR; Barter PJ; Rye KA, 2016, 'Impact of perturbed pancreatic β-cell cholesterol homeostasis on adipose tissue and skeletal muscle metabolism', Diabetes, vol. 65, pp. 3610 - 3620, http://dx.doi.org/10.2337/db16-0668

Cochran BJ; Ryder WJ; Parmar A; Tang S; Reilhac A; Arthur A; Charil A; Hamze H; Barter PJ; Kritharides L; Meikle SR; Gregoire MC; Rye KA, 2016, 'In vivo PET imaging with [¹⁸F]FDG to explain improved glucose uptake in an apolipoprotein A-I treated mouse model of diabetes', Diabetologia, vol. 59, pp. 1977 - 1984, http://dx.doi.org/10.1007/s00125-016-3993-5

Sultana A; Cochran BJ; Tabet F; Patel M; Cuesta Torres L; Barter PJ; Rye K, 2016, 'Inhibition of inflammatory signaling pathways in 3T3-L1 adipocytes by apolipoprotein A-I', The FASEB Journal, vol. 30, pp. 2324 - 2335, http://dx.doi.org/10.1096/fj.201500026R

Rye KA; Barter PJ; Cochran BJ, 2016, 'Apolipoprotein A-I interactions with insulin secretion and production', Current Opinion in Lipidology, vol. 27, pp. 8 - 13, http://dx.doi.org/10.1097/MOL.0000000000000253

Cochran BJ; Bisoendial RJ; Hou L; Glaros E; Rossy J; Thomas SR; Barter PJ; Rye KA, 2014, 'Apolipoprotein a-I increases insulin secretion and production from pancreatic β-cells via a g-protein-camp-PKA-FOXO1-dependent mechanism', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, pp. 2261 - 2267, http://dx.doi.org/10.1161/ATVBAHA.114.304131

Cochran BJ; Rye K-A, 2012, 'Abstract 34: Apolipoprotein A-I Increases Insulin Secretion from β-cells via a Protein Kinase A Dependent Mechanism', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, http://dx.doi.org/10.1161/atvb.32.suppl_1.a34

Lee JA; Cochran BJ; Lobov S; Ranson M, 2011, 'Forty years later and the role of plasminogen activator inhibitor type 2/SERPINB2 is still an enigma', Seminars in Thrombosis and Hemostasis, vol. 37, pp. 395 - 407, http://dx.doi.org/10.1055/s-0031-1276589

Cochran BJ; Saunders D; Croucher DR; Lobov S; Ranson M, 2011, 'Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of serpinE1 and serpinB2 in cancer', The Journal of Biological Chemistry, vol. 286, pp. 24467 - 24475, http://dx.doi.org/10.1074/jbc.M111.225706

Cochran BJ; Gunawardhana LP; Vine KL; Lee JA; Lobov S; Ranson M, 2009, 'The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity', BMC Biotechnology, vol. 9, http://dx.doi.org/10.1186/1472-6750-9-43

Cochran B; Polly P; Jones G; Rowe A, 'eMentoring a Community of Early Career Researchers to Support and Enable Research Integrated Learning and Professional Skills Development for Undergraduate Medical Science Students', , http://dx.doi.org/10.35542/osf.io/wz7s4

Conference Papers

Dunn K; Cochran B; Haeusler M; Cheng T, 2019, 'Design in Paediatric Healthcare: Rethinking 3D models of paediatric orthopaedic data using Design approaches.', in Fairly A (ed.), Real / Material / Etheral, Monash University, Monash University Melbourne, presented at 2nd Annual Design Research Conference, Monash University Melbourne, 03 October 2019 - 04 October 2019, https://www.monash.edu/design-research-conference#links&ampdownloads

Cochran BJ; Trajanovska S; Sunn N; Rye KA; Ryder WJ, 2018, 'Development of 3D printing filaments for bespoke X-Ray phantoms', in 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings, IEEE, presented at 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 10 November 2018 - 17 November 2018, http://dx.doi.org/10.1109/NSSMIC.2018.8824621

Kopecky CM; Ryder WJ; Szajer J; Parmar A; Pandzic E; Rye KA; Cochran BJ, 2018, 'Translocator Protein as Novel Marker for Early Atherosclerosis', in ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, San Francisco, CA, presented at Scientific Sessions of the American-Heart-Association on Vascular Discovery - From Genes to Medicine, San Francisco, CA, 10 May 2018 - 12 May 2018, http://dx.doi.org/10.1161/atvb.38.suppl_1.222

Tabet F; Hou L; Cochran B; Torres LFC; Barter PJ; Rye KA, 2016, 'LIPIDS AND LIPOPROTEINS. BETA CELL-SPECIFIC DELETION OF ABCA1 AND ABCG1 REGULATES THE INCREASE OF SMALL NUCLEOLAR RNAS IN ADIPOCYTES', in ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Innsbruck, AUSTRIA, pp. E199 - E199, presented at Congress of the European-Atherosclerosis-Society (EAS), Innsbruck, AUSTRIA, 29 May 2016 - 01 June 2016, http://dx.doi.org/10.1016/j.atherosclerosis.2016.07.112

Conference Presentations

Rodrigo C; Cochran B; Herbert C; Thomas S; Polly P, 2020, 'Remote delivery of a digitized course; success at time of crisis', UNSW Sydney, presented at Teaching and Learning Forum, UNSW, UNSW Sydney

Manandhar B; Cochran BJ; Rye K, 2019, 'APOLIPOPROTEIN A-I LOCALISES TO MITOCHONDRIA AND INHIBITS ROS GENERATION IN INSULIN PRODUCING CELLS.', Victoria University City Convention Centre, Melbourne, presented at AAS 2019 Annual Scientific meeting, Victoria University City Convention Centre, Melbourne, 16 October 2019 - 19 October 2019

Tucker B; Rehan R; Vaidya K; Rye K; Cochran B; Patel S, 2019, 'Colchicine inhibits neutrophil extracellular trap formation in acute coronary syndrome patients', Melbourne, presented at Australian Atherosclerosis Society Annual Scientific Meeting, Melbourne, 16 October 2019 - 19 October 2019

Tan WT; Kopecky C; Manandhar B; Rye K-A; Cochran B, 2019, 'Skeletal Muscle Specific Deletion Of Abca1 And Abcg1 Impacts Body Composition And Metabolism And Is Age Dependent', presented at 87th European Atherosclerosis Society Congress, 26 May 2019, http://dx.doi.org/10.1016/j.atherosclerosis.2019.06.122

Conference Abstracts

Vaidya K; Tucker B; Khandkar C; Pandzic E; Barraclough J; Misra A; Kavurma M; Rye K-A; Patel S; Cochran BJ, 2020, 'Colchicine Inhibits Neutrophil Extracellular Trap Formation in Acute Coronary Syndrome Patients Post Percutaneous Coronary Intervention', in ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, ELECTR NETWORK, Vol. 40, presented at American-Heart-Association's Scientific Sessions on Vascular Discovery - From Genes to Medicine, ELECTR NETWORK, 05 May 2020 - 07 May 2020, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000607042600203&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Cochran BJ; Pinheiro D; Prendecki M; Jones B; Cegla J; Lee V; Barter PJ; Murphy AJ; Rye K-A; Woollard KJ, 2018, 'PRO-ATHEROSCLEROTIC LOW-DENSITY NEUTROPHILS ARE PRESENT IN HYPERCHOLESTEROLEMIA', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Toronto, CANADA, Vol. 32, pp. 39 - 40, presented at International Symposium on Atherosclerosis (ISA), Toronto, CANADA, 09 June 2018 - 12 June 2018, http://dx.doi.org/10.1016/j.atherosclerosissup.2018.04.115

Kopecky C; Ryder WJ; Szajer J; Parmar A; Pandzic E; Rye K-A; Cochran BJ, 2018, 'THE TSPO RADIOLIGAND 18F-PBR111 AS A PRE-ATHEROSCLEROTIC LESION DETECTION AGENT', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, Toronto, CANADA, Vol. 32, pp. 145 - 146, presented at International Symposium on Atherosclerosis (ISA), Toronto, CANADA, 09 June 2018 - 12 June 2018, http://dx.doi.org/10.1016/j.atherosclerosissup.2018.04.446

Polly P; Jones G; Cochran B, 2017, 'EMENTORING TO SUPPORT AND ENABLE RESEARCH INTEGRATED LEARNING USING AUTHENTIC ASSESSMENT IN A THIRD YEAR UNDERGRADUATE SCIENCE COURSE IN PATHOLOGY AT A RESEARCH INTENSIVE UNIVERSITY', in EDULEARN17 Proceedings, 9th International Conference on Education and New Learning Technologies, presented at 9th International Conference on Education and New Learning Technologies

Cochran BJ; Hou L; Manavalan APC; Sultana A; Moore BM; Patel M; Tall A; Barter PJ; Rye KA, 2015, 'PANCREATIC BETA-CELL SPECIFIC DELETION OF ABCA1 AND ABCG1 PERTURBS GLUCOSE METABOLISM AND INCREASES ADIPOSITY IN MICE DUE TO SUBOPTIMAL PLASMA INSULIN LEVELS', in ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, Glasgow, SCOTLAND, Vol. 241, pp. E3 - E3, presented at 83rd Congress of the European-Atherosclerosis-Society (EAS), Glasgow, SCOTLAND, 22 March 2015 - 25 March 2015, http://dx.doi.org/10.1016/j.atherosclerosis.2015.04.028

Working Papers

Yadav S; Dudchenko O; Esvaran M; Rosen B; Field M; Skvortsova K; Gopalakrishnan S; Keilwagen J; Cochran B; Manandhar B; Bucknall M; Bustamante S; Rasmussen J; Melvin R; Omer A; Colaric, Z; Chan E; Minoche A; Smith T; Gilbert T; Bogdanovic O; Zammit R; Thomas T; Aiden E; Ballard B, 2020, Desert Dingo (Canis lupus dingo) genome provides insights into their role in the Australian ecosystem, Cold Spring Harbor, http://dx.doi.org/10.1101/2020.11.15.384057, https://www.biorxiv.org/content/10.1101/2020.11.15.384057v1

Media

Cochran B; Dunn K, 2020, Australia's 3D printing experts are banding together to make masks for at-risk health workers