Professor Patsie Polly

Fields of research: Medical and Health Sciences, Gene Expression (incl. Microarray and other genome-wide approaches), Curriculum and Pedagogy

Contact Details

Phone: +61 2 9385 2924
Fax: +61 2 9385 1389
Email: patsie.polly@unsw.edu.au

Supervision

PHD
Masters
Honours

Tabs

Main

Professor Patsie Polly (SFHEA) is a Scientia Education Fellow who is an Education Focussed Champion and Academic in the Department of Pathology within the School of Medical Sciences (SoMS), Faculty of Medicine, UNSW.

Patsie is recognised nationally as a medical scientist, leading teacher and innovative education researcher. Patsie is a Scientia Education Fellow, Education Focussed Champion and Professor in Pathology, within the School of Medical Sciences, UNSW Medicine. Patsie has infused her extensive medical research experience into the classroom by applying the latest laboratory research practice. Patsie strategically integrates adaptive lessons, ePortfolio pedagogy and collaborative communities of practice to allow her students to learn these career-relevant skills. Her unique method blends virtual and real laboratory experiences to break new ground in engaging her students as researchers. Patsie has led reflective ePortfolio implementation to develop deep learning of teamwork and communication competencies in students, contextualising acquiring these skills for their future as medical researchers and health professionals. Patsie has been recognised with multiple institutional/national teaching awards, funding and invited institutional/national/international presentations and peer-reviewed research outputs in research communication, virtual laboratory lessons and ePortfolio use. Patsie is recognised internationally as a Senior Fellow of the Higher Education Academy-UK. Patsie is a board member and research special interest group chair for the US ePortfolio organisation, AAEEBL.

Patsie has led the Cancer Cachexia Mechanisms Research Group within Mechanisms of Disease and Translational Research unit, SoMS since 2007. She has niche expertise in gene regulatory mechanisms underlying muscle wasting due to cancer cachexia and has developed gene and proteomic approaches for identifying biomarkers in muscle wasting. She is nationally and internationally recognised for molecular mechanisms of transcription factor-mediated gene regulation. Patsie has held three competitive international and national fellowships to conduct her research on gene regulation. She was an Alexander von Humboldt Fellow (Germany, 1997-1999), an NHMRC Howard Fellow (Sydney, 2000-2003) and a Japan Society for Promotion of Science (JSPS) Fellow (Japan, 2002). Patsie’s specific expertise is in unravelling molecular mechanisms that involve DNA-protein interactions and protein-protein interactions. In recognition of this, she is a sought after collaborator (Cancer Cell; JNCI) and PhD supervisor.

Fellowships and Appointments

1997-1999 Alexander von Humboldt Fellow, Heinrich Heine Universitaet, Germany

2000-2002 NHMRC Howard Florey Fellow, Children’s Medical Research Institute, Sydney

2002 JSPS Short Term Visiting Fellow, National Institute of Advanced Industrial Science and Technology (AIST), Institute of Molecular and Cell Biology, Japan

2003-2004 Senior Research Scientist, Children’s Medical Research Institute, Sydney

2004-2009 Lecturer, Department of Pathology, School of Medical Sciences, UNSW

2007- Present Senior Research Fellow Conjoint; USyd, NSW

2007- Present Group Leader, Cancer Cachexia Mechanisms Research Group, Department of Pathology, SoMS, UNSW

2009-2015 Senior Lecturer, Department of Pathology, SoMS UNSW

2012-2015 Associate Professor (Conjoint), School of Medical Science, Griffith University, Queensland

2015-Present Associate Professor, Department of Pathology, SoMS, UNSW Medicine

2014-2016 UNSW Academic Board Member, Faculty of Medicine Representative

2015-2016 Deputy Head, Department of Pathology, School of Medical Sciences, UNSW Medicine, UNSW

2016-2017 UNSW Teaching Fellow

2017-Present Education Focussed Academic Champion, Vice Chancellor’s Strategy Office, UNSW

2017-2021 Scientia Education Fellow

2018-Present Senior Fellow Higher Education Academy UK

2019-Present Professor

Medical Research Expertise

I am a Professor (Department of Pathology) and lead the Cancer Cachexia Mechanisms Research Group, Mechanisms of Disease and Translational Research within SoMS with particular expertise in underlying gene regulatory mechanisms in muscle wasting due to cancer cachexia. I have developed gene and proteomic approaches for identifying biomarkers in skeletal muscle wasting and have extensive experience with molecular and cellular techniques required to study the molecular mechanisms of transcription factor-mediated gene regulation. My specific expertise is in unravelling molecular mechanisms that involve DNA-protein interactions using electrophorectic mobility shift assays and protein-protein interactions using GST-pull down assays. I have previously established research programs on molecular mechanisms of nuclear receptor and myogenic transcription factor action.

Medical Research:

Recognition: 7 awards as a PhD Scholar. 3 international and national fellowships. Alexander von Humboldt Fellow (AvH), Heinrich Heine Universität, Germany 1997-1999, NHMRC Howard Florey Fellow 2000-2003 Children’s Medical Research Institute, NSW and Short-Term Japan Society for Promotion of Science Fellow 2002, National Science Institute, Japan. I have delivered 23 invited presentations.

Publications: Published journal/reviews/book chapters and abstracts: 73 (1993-2019). Of those, 31 peer reviewed Journal articles, 13 peer reviewed review articles and book chapters, 29 peer reviewed published abstracts, 2 patents in 5 countries. I have an H index=19 with >1270 citations (Scopus); H index=21 with >1810 citations (Google Scholar).

Funding: $1.6 million (project grants [1992-2013]). $2.434 million (infrastructure grants, since 2008).

Learning and Teaching Expertise

I am the Convenor of 3^rd yr Pathology (PATH3205), SoMS Research Internship Co-ordinator (SOMS3001) and Co-convenor of 2nd yr Pathology (PATH2201/PATH2202) courses.

I have a national and international profile as an inspirational teacher who is an innovator in higher education. I have championed scholarly activities by creating multiple collaborative communities of practice that engage colleagues, tutors and students to enhance the learning and teaching experience at UNSW and beyond.

Education Research Projects:

Adaptive e-learning: Virtual Laboratories (v-Labs)

Microcredentialing Professional Skills and Graduate Attributes

Higher Education:

Recognition: 11 awards: 5 school, 2 faculty, 3 institutional, 1 national award and 4 nominations for national awards. UNSW Teaching Fellow (2016-2017). Scientia Education Fellow (2017-2021). I have delivered 80 invited institutional, national and international presentations.

Publications: Since 2008, I have generated 54 peer-reviewed journal articles, book chapters, international and national abstracts, and online resources on my scholarly approaches and education research. I have produced 6 course manuals, with ISBNs or ISSNs.

Funding: $5.16 million in higher education project grant funding, 2012-2019 to support development of eLearning resources.

International funding: 2019 Bavarian State Funding, Germany. P. Polly lead CI (Australia; UNSW), O.Friedrich lead CI (Germany; FAU); 2019 QuiS – FAU – International Collaborator; 2019-2020 DAAD Australian-German Exchange : ‘MyoRobot automated Biomechatronics Technology for Research, Higher Education and Teaching Using Virtual Skills Labs.’ P. Polly lead CI (Australia; UNSW), O.Friedrich lead CI (Germany; FAU)

Social Engagement, Global Impact, Leadership:

International: Chair, AAEEBL ePortfolio Research special interest group and AAEEBL Projects and Initiatives Standing Committee (both July 2017-present). Invited International Board Member, AAEEBL (March 2019-present). ePortfolios Australia, national conference organiser (2016 - present [Sydney host]-2018).

National: BEST Network lead (2012-2014); Alexander von Humboldt National Mentor (since 2014). ASMR Student Career Forum, Invited Speaker, 2014-2015; ASMR ‘Politics of Promotion’, Invited interview narrator and facilitator, 2017. ePortfolios Australia Committee member (since 2015).

UNSW: EF Academic Champion, (since 2017), Scientia Education Fellow (2017-2021), UNSW Teaching Fellow (2016-2017), UNSW Gene Technology Regulation Committee member (since 2008), UNSW Recognition of Education Excellence (2020-ongoing).

Faculty: Membership of multiple cross faculty promotion committees, as well as invited speaker of UNSW and Faculty of Medicine workshop activities for women. SoMS representative, cross-faculty BMedSci committee (since 2006), AWCAP Mentor (April 2020-ongoing).

SoMS: Honours co-ordinator and committee chair (2010-2013), Department of Pathology representative SoMS Honours committee (2008-2014) and SoMS teaching committee (2004-2016).

Deputy Head of Department Pathology, (2015-2016)

Committees

SoMS Teaching Committee, Faculty of Medicine, 2004-Aug 2017
BMedSc Committee, Faculty of Medicine/Faculty of Science, 2006-Present
Developmental Cell Biology Group, NSW, 2007-2009
Gene Technology Regulation Committee, UNSW, 2008-Present
Department of Pathology Representative, SoMS Honours Committee, Faculty of Medicine, 2008-2013
SoMS Research Committee, Faculty of Medicine, 2010-2013
SoMS Honours Committee, Faculty of Medicine, Chair 2010-2013
Department of Pathology Representative, SoMS OHS Committee, Faculty of Medicine, June 2011-2015
UNSW Academic Board, Faculty of Medicine Representative, Dec 2014-Dec 2016
SoMS Research Committee, Faculty of Medicine, 2010-2013
SoMS Higher Degree Research Committee-2011-Present, Panel D Deputy Chair
L&T May Forum, 2012 Working Party
L&T May Forum, 2012 Table Facilitator
Adaptive eLearning Forum, Organiser, Presenter and Panel Mediator, July 2012
TCRN Education Working Group-Invited member, June 2013-Feb 2014
ePortfolios Australia National Conference Organising Committee, 2016, 2017
International AAEEBL Projects and Initiative Standing Committee, July 2017-present
International AAEEBL Research Special Interest Group, Invited Chair, July 2017-present
International AAEEBL Board Member, 2019-present

University role:

Professor, Scientia Education Fellow, SFHEA

Grants:

Higher Education:

Funding: $5.16 million in higher education project grant funding, 2012-2019 to support development of eLearning resources.

Medical Research:

Funding: $1.6 million (project grants [1992-2013]). $2.434 million (infrastructure grants, since 2008).

Awards:

Institution and National Awards:

Dec 2005: SoMS Teaching Award ‘Innovations in Course Convening’

Dec 2007: SoMS Teaching Award ‘Outstanding Contributions to Student Learning’

Dec 2007: Faculty of Medicine Teaching Award, Outstanding Contributions to Student Learning

Dec 2010: SoMS Teaching Award ‘Enhancing the Student Experience’

Sept 2012: OLT Citation: ‘Outstanding Contributions to Student Learning’

Dec 2012: SoMS Teaching Award ‘Community Engagement’

Dec 2012: UNSW Vice-Chancellor’s Award for Initiatives that Enhance Learning

Dec 2013: SoMS Teaching Award ‘Teacher of the Year'

Dec 2014: Faculty of Medicine Teaching Award, ‘Teaching Excellence’

Dec 2015: UNSW Vice-Chancellor’s Award for Teaching Excellence

2016-2017: UNSW Teaching Fellowship

2020: FULT Good Practice Award

Groups:

Cancer Cachexia Mechanisms Research Group

Research

Research Activity Links:

Functional variants of RUNX2 related to bone density

Socio-economic Objective (SEO) tags:

Cancer and Related Disorders

Teaching & Supervision

Supervised Students:

Angie Shum

Areas of supervision:

Basic Science Research Projects

Suitable for: Honours, Masters and Postgraduate studies

Overall Muscle Wasting-Cachexia Research Program Outline:

Cancer cachexia occurs in 50-80% of cancer patients involves severe muscle wasting in cancer patients and is directly responsible for 30% of all cancer mortality. At present there is no means of early diagnosis or effective therapy. Research projects on offer include biomarker discovery and assessing transcriptional mechanisms that underlie muscle wasting, and include intervention strategies that target muscle specific transcription factors in addition to nuclear hormone receptors for the purposes of in preventing muscle loss. Study outcomes will provide novel ways of treating muscle wasting in cancer patients.

Research Techniques
Transcription factor analysis: Electrophoretic Mobility Shift, GST-pull down, Reporter Gene assays

Gene expression: qPCR, Affymetrix gene analysis

Protein Expression: Western blotting, iTRAQ Proteomics analysis

Histomorphology: Electron microscopy, Immunohistochemistry, Histochemistry

Models: Mouse models of Cancer Cachexia, Skeletal Muscle, Cardiomyocyte and Bone cell culture models

Publications related to this Person

Books

Dziegielewski M; Polly P, (ed.), 2010, Molecular Basis of Disease PATH3205/3206 Student Manual, Department of Pathology, UNSW, NSW Australia

Lipworth W; Polly P; Kumar RK, (eds.), 2010, Processes in Disease PATH2201 Student Manual, Department of Pathology, University of New South Wales, NSW Australia

Polly P; Velan GM; Champion SA, (eds.), 2010, Processes in Disease for Health and Exercise Science PATH2202 Student Manual, Dept of Pathology, UNSW, Sydney, Australia

Dziegielewski M; Polly P, (ed.), 2009, Molecular Basis of Disease PATH3205/3206 Student Manual, Department of Pathology, UNSW, NSW Australia

Lipworth W; Polly P; Kumar RK, (eds.), 2009, Processes in Disease PATH2201 Student Manual, Department of Pathology, University of New South Wales, NSW Australia

Polly P; Velan GM; Champion SA, (eds.), 2009, Processes in Disease for Health and Exercise Science PATH2202 Student Manual, Department of Pathology , University of New South Wales, Sydney, Australia

Dziegielewski M; Polly P, (ed.), 2008, Molecular Basis of Disease PATH3205/3206 Student Manual, Department of Pathology, UNSW, NSW Australia

Lipworth W; Polly P; Kumar RK, (eds.), 2008, Processes in Disease PATH2201 Student Manual, Department of Pathology, University of New South Wales, NSW Australia

Dziegielewski M; Polly P, (ed.), 2007, Molecular Basis of Disease PATH3205/3206 Student Manual, Department of Pathology, UNSW, NSW Australia

Polly P; Tedla NT, (ed.), 2007, Musculoskeletal Diseases PATH3207 Student Manual, Department of Pathology, University of New South Wales, NSW Australia

Lipworth W; Polly P; Kumar RK, (eds.), 2007, Processes in Disease PATH2201 Student Manual, Department of Pathology, University of New South Wales, NSW Australia

Dziegielewski M; Polly P, (ed.), 2006, Molecular Basis of Disease PATH3205/3206 Student Manual, Department of Pathology, UNSW, NSW Australia

Polly P; Tedla NT, (ed.), 2006, Musculoskeletal Diseases PATH3207 Student Manual, Department of Pathology, University of New South Wales, NSW Australia

Lipworth W; Polly P; Kumar RK, (eds.), 2006, Processes in Disease PATH2201 Student Manual, Department of Pathology, University of New South Wales, NSW Australia

Dziegielewski M; Polly P, (ed.), 2005, Molecular Basis of Disease PATH3205/3206 Student Manual, Department of Pathology, UNSW, NSW Australia

Polly P; Tedla N, (ed.), 2005, Musculoskeletal Diseases PATH3207 Student Manual, Department of Pathology, University of New South Wales, NSW Australia

Lipworth W; Polly P, (ed.), 2005, Processes in Disease PATH2201 Student Manual, Department of Pathology, University of New South Wales, NSW Australia

Book Chapters

Journal articles

Polly P; Thai T; Yang JL; Luo A; Herbert C; Jones N; Lewis T; Vickery R; Richardson A; Schibeci S, 2018, 'The teacher-student journey: Program-wide teamwork skills development and evaluation in the medical sciences', International Journal of Assessment and Evaluation, vol. 24, pp. 1 - 24, http://dx.doi.org/10.18848/2327-7920/CGP/v24i04/1-24

Wong M; Tee AEL; Milazzo G; Bell JL; Poulos RC; Atmadibrata B; Sun Y; Jing D; Ho N; Ling D; Liu PY; Zhang XD; Hüttelmaier S; Wong JWH; Wang J; Polly P; Perini G; Scarlett CJ; Liu T, 2017, 'The histone methyltransferase DOT1L promotes neuroblastoma by regulating gene transcription', Cancer Research, vol. 77, pp. 2522 - 2533, http://dx.doi.org/10.1158/0008-5472.CAN-16-1663

Isaac ST; Tan TC; Polly P, 2016, 'Endoplasmic reticulum stress, calcium dysregulation and altered protein translation: Intersection of processes that contribute to cancer cachexia induced skeletal muscle wasting', Current Drug Targets, vol. 17, pp. 1140 - 1146, http://dx.doi.org/10.2174/1389450116666150416115721

Yang J-L; Polly P; Fath T; Jones NM; Power J, 2016, 'ISA model and integrative career development learning in year three science courses', Int J Science Math Tech Learning, vol. 23, pp. 33 - 46

Naumann F; Yang J-L; Thai T; Ford C; Polly P, 2016, 'Virtual patient consultations and the use of an ePortfolio assessment to support student learning of integrated professional skills', FOCUS ON HEALTH PROFESSIONAL EDUCATION-A MULTIDISCIPLINARY JOURNAL, vol. 17, pp. 69 - 81, http://dx.doi.org/10.11157/fohpe.v17i3.178

McGill M; Shum A; Mahendradatta T; Bentley N; Chan E; Chen Z; Wilkins M; Tan T; Polly P, 2016, 'Expression Patterns of APLN and OSMR, Potential Novel Modulators of Cancer-induced Cardiac Cachexia, are Altered due to Elevated Inflammatory Cytokines', Heart, Lung and Circulation, vol. 25, pp. S108 - S109, http://dx.doi.org/10.1016/j.hlc.2016.06.257

McGill M; Shum A; Mahendradatta T; Bentley N; Chan E; Chen Z; Wilkins M; Tan T; Polly P, 2016, 'Expression Patterns of APLN and OSMR, Potential Novel Regulators of Cancer-Induced Cardiac Cachexia, are Altered due to Elevated Inflammatory Cytokines', Heart, Lung and Circulation, vol. 25, pp. S109 - S109, http://dx.doi.org/10.1016/j.hlc.2016.06.258

McGill M; Shum A; Poljak A; Tan T; Polly P, 2016, 'Cancer Cachexia Induced Changes in Sarcomeric and Energy Homeostasis: Proteomic Signatures in the Heart', Heart, Lung and Circulation, vol. 25, pp. S99 - S100, http://dx.doi.org/10.1016/j.hlc.2016.06.236

Shum AMY; Fung DCY; Corley SM; McGill MC; Bentley NL; Tan TC; Wilkins MR; Polly P, 2015, 'Cardiac and skeletal muscles show molecularly distinct responses to cancer cachexia', Physiological Genomics, vol. 47, pp. 588 - 599, http://dx.doi.org/10.1152/physiolgenomics.00128.2014

Polly P; Velan GM; Hawkins N, 2015, 'Development of Online Science Practical Lesson Resources to Enhance Student Learning in Phases 1 and 2 Medicine at UNSW Australia.', Proceedings of E-Learn: World Conference on E-Learning in Corporate, Government, Healthcare, and Higher Education 2015, pp. 1452 - 1458, http://www.editlib.org/pv/152202/

Liu PY; Erriquez D; Marshall GM; Tee AE; Polly P; Wong M; Liu B; Bell JL; Zhang XD; Milazzo G; Cheung BB; Fox A; Swarbrick A; Hüttelmaier S; Kavallaris M; Perini G; Mattick JS; Dinger ME; Liu T, 2015, 'Erratum: Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression (Journal of the National Cancer Institute (2014) 106:7 (dju113) DOI: 10.1093/jnci/dju113)', Journal of the National Cancer Institute, vol. 107, http://dx.doi.org/10.1093/jnci/dju359

Wong M; Polly P; Liu T, 2015, 'The histone methyltransferase DOT1L: Regulatory functions and a cancer therapy target', American Journal of Cancer Research, vol. 5, pp. 2823 - 2837

Tan T; McGill M; Falconer R; Bradd A; Bentley N; Polly P, 2015, 'Altered myogenic transcription factors and clinical markers in early stage cardiac hypertrophy due to cancer cachexia', Heart, Lung and Circulation, vol. 24, pp. S194 - S195, http://dx.doi.org/10.1016/j.hlc.2015.06.197

Tan T; Falconer R; Polly P, 2015, 'An in vitro cardiomyocyte model for assessing altered autophagic marker expression due to elevated cytokines', Heart, Lung and Circulation, vol. 24, pp. S196 - S196, http://dx.doi.org/10.1016/j.hlc.2015.06.200

Isaac ST; Tan TC; Polly P, 2015, 'The effects of cytokines involved in cancer cachexia on skeletal muscle cells', Pathology, vol. 47, pp. S64 - S64, http://dx.doi.org/10.1097/01.pat.0000461488.17493.bf

Polly P; Marcus N; Maguire D; Belinson Z; Velan GM, 2014, 'Evaluation of an adaptive virtual laboratory environment using Western Blotting for diagnosis of disease', BMC Medical Education, vol. 14, pp. 222 - 230, http://dx.doi.org/10.1186/1472-6920-14-222

Liu PY; Erriquez D; Marshall GM; Tee AE; Polly P; Wong M; Liu B; Bell JL; Zhang XD; Milazzo G; Cheung BB; Fox A; Swarbrick A; Hüttelmaier S; Kavallaris M; Perini G; Mattick JS; Dinger ME; Liu T, 2014, 'Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression', Journal of the National Cancer Institute, vol. 106, http://dx.doi.org/10.1093/jnci/dju113

Polly P; Tan TC, 2014, 'The role of vitamin D in skeletal and cardiac muscle function', FRONTIERS IN PHYSIOLOGY, vol. 5, http://dx.doi.org/10.3389/fphys.2014.00145

Ittner AA; Bertz J; Chan TYB; Van Eersel J; Polly P; Ittner LM, 2014, 'The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo', Diabetologia, vol. 57, pp. 1410 - 1419, http://dx.doi.org/10.1007/s00125-014-3230-z

Polly P; Tan TC, 2014, 'The role of vitamin D in skeletal and cardiac muscle function', Frontiers in Physiology, vol. 5 APR, http://dx.doi.org/10.3389/fphys.2014.00145

Polly P; Marcus N; Maguire D; Belinson Z; Velan GM, 2014, 'Evaluation of an adaptive virtual laboratory environment using Western Blotting for diagnosis of disease', BMC medical education, vol. 14, pp. 222, http://dx.doi.org/10.1186/1472-6920-14-222

Polly P; Tan T, 2014, 'The Role of Vitamin D in Skeletal and Cardiac Muscle Function', Front Physiol

Falconer R; Tan T; Polly P, 2013, 'Autophagy and Cardiac Dysfunction in Cancer Cachexia', World Journal of Cancer Research, vol. 1, pp. 108 - 117, http://dx.doi.org/10.1166/wjcr.2013.1019

Morrison NA; Stephens AS; Osato M; Pasco JA; Fozzard N; Stein GS; Polly P; Griffiths LR; Nicholson GC, 2013, 'Polyalanine Repeat Polymorphism in RUNX2 Is Associated with Site-Specific Fracture in Post-Menopausal Females', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0072740

Shum AMY; Tan TC; Polly P, 2013, 'A Comparative Study of Gene Expression Changes in Skeletal and Cardiac Muscle from the Colon 26 Carcinoma Mouse Model of Cachexia: Identification of Common Molecular Targets for Future Intervention Studies', World Journal of Cancer Research, vol. 1, pp. 69 - 77, http://dx.doi.org/10.1166/wjcr.2013.1002

Dobson-Stone C; Polly P; Korgaonkar M; Williams LM; Gordon E; Schofield PR; Mather KA; Armstrong N; Wen W; Sachdev PS; Kwok JB, 2013, 'GSK3B and MAPT polymorphisms are associated with grey matter and intracranial volume in healthy individuals', PLoS One, vol. 8, pp. e71750, http://dx.doi.org/10.1371/journal.pone.0071750

Shum A; Theodore M; Taylor R; Painter AB; Moore MM; Tsoli M; Tan TC; Clarke SJ; Robertson GR; Polly P, 2012, 'Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting', Aging, vol. 4, pp. 133 - 143, http://dx.doi.org/10.18632/aging.100436

Morrison NA; Stephens A; Osato M; Polly P; Tan T; Yamashita N; Doecke JD; Pasco J; Fozzard N; Jones G; Ralston SH; Sambrook PN; Prince RL; Nicholson GC, 2012, 'Glutamine repeat variants in human RUNX2 associated with decreased femoral neck BMD, broadband ultrasound attenuation and target gene transactivation', PLoS One, vol. 7, pp. Art. No. e42617, http://dx.doi.org/10.1371/journal.pone.0042617

Shum AMY; Polly P, 2012, 'Cancer Cachexia: Molecular targets and pathways for diagnosis and drug intervention', Endocrine, Metabolic and Immune Disorders - Drug Targets, vol. 12, pp. 247 - 259, http://dx.doi.org/10.2174/187153012802002910

Tan T; Shum A; Mahendradatta T; Sarris M; Clarke S; Polly P, 2011, 'Cancer induced cardiomyopathy: maladaptive responses to inflammation', EUROPEAN HEART JOURNAL, vol. 32, pp. 357 - 357, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208702703162&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hitchins MP; Rapkins R; Kwok C; Srivastava S; Wong JJ; Khachigian LM; Polly P; Goldblatt J; Ward RL, 2011, 'Dominantly Inherited Constitutional Epigenetic Silencing ofMLH1inaCancer-Affected Family IsLinked to a Single Nucleotide Variant within the 5'UTR', Cancer Cell, vol. 20, pp. 200 - 213, http://dx.doi.org/10.1016/J.ccr/2011.07.003

Matic M; Corradin AP; Tsoli M; Clarke SJ; Polly P; Robertson GR, 2010, 'The alternatively spliced murine pregnane X receptor isoform, mPXR 171–211 exhibits a repressive action', International Journal of Biochemistry and Cell Biology, vol. 42, pp. 672 - 682, http://dx.doi.org/10.1016/j.biocel.2010.01.001

Brewer MH; Chaudhry R; McDowall K; Chu S; Kowalski B; Polly P; Nicholson GA; Kennerson M, 2010, 'X-linked CMT: genes and gene loci in an Australian cohort', Neurogenetics, vol. 11, pp. 267 - 269, http://dx.doi.org/10.1007/s10048-010-0238-5

Matic M; Nakhel S; Lehnert AM; Polly P; Clarke SJ; Robertson GR, 2009, 'A novel approach to investigate the subcellular distribution of nuclear receptors in vivo.', Nucl Recept Signal, vol. 7, pp. e004, http://dx.doi.org/10.1621/nrs.07004

Matic M; Nakhel ; Lehnert A; Polly P; Clarke SJ; Robertson GR, 2009, 'A novel approach to investigate the subcellular distribution of nuclear receptors in vivo', Nuclear Receptor Signaling, vol. 7, pp. 1 - 7

Brewer M; Changi F; Antonellis A; Fischbeck K; Polly P; Nicholson GA; Kennerson M, 2008, 'Evidence of a founder haplotype refines the X-linked Charcot-Marie-Tooth (CMTX3) locus to a 2.5 Mb region', Neurogenetics, vol. 9, pp. 191 - 195, http://dx.doi.org/10.1007/s10048-008-0126-4

Kennerson L; Warburton T; Nelis E; Brewer M; Polly P; De Jonghe P; Timmerman V; Nicholson GA, 2007, 'Mutation scanning the GJB1 gene with high-resolution melting analysis: Implications for mutation scanning of genes for Charcot-Marie-Tooth disease', Clinical Chemistry, vol. 53, pp. 349 - 352, http://dx.doi.org/10.1373/clinchem.2006.080010

Matic M; Mahns A; Tsoli M; Corradin AP; Polly P; Robertson GR, 2007, 'Pregnane X Receptor: Promiscuous regulator of detoxification pathways', International Journal of Biochemistry and Cell Biology, vol. 39, pp. 478 - 483, http://dx.doi.org/10.1016/j.biocel.2006.08.017

Tay ES; Guven KL; Subramaniam N; Polly P; Issa LL; Gunning PW; Hardeman EC, 2003, 'Regulation of alternative splicing of Gtf2ird1 and its impact on slow muscle promoter activity', Biochemical Journal, vol. 374, pp. 359 - 367, http://dx.doi.org/10.1042/BJ20030189

Polly P; Haddadi L; Issa LL; Subramaniam N; Palmer S; Tay ES; Hardeman EC, 2003, 'hMusTRD1α1 Represses MEF2 Activation of the Troponin I Slow Enhancer', The Journal of Biological Chemistry, vol. 278, pp. 36603 - 36610, http://dx.doi.org/10.1074/jbc.M212814200

Carlberg C; Quack M; Herdick M; Bury Y; Polly P; Toell A, 2001, 'Central role of VDR conformations for understanding selective actions of vitamin D3 analogues', Steroids, vol. 66, pp. 213 - 221, http://dx.doi.org/10.1016/S0039-128X(00)00150-1

Herdick M; Bury Y; Quack M; Uskokovic MR; Polly P; Carlberg C, 2000, 'Response element and coactivator-mediated conformational change of the vitamin D3 receptor permits sensitive interaction with agonists', Molecular Pharmacology, vol. 57, pp. 1206 - 1217

Polly P, 2000, 'All natural DR3-type vitamin D response elements show a similar in vitro functionality', Biochemical Journal, vol. 352, pp. 301 - 309, http://dx.doi.org/10.1042/0264-6021:3520301

Polly P, 2000, 'VDR-Alien: A Novel, DNA-selective, Vitamin D3 Receptor-Corepressor Partnership', The FASEB Journal, vol. 14, pp. 1455 - 1463

Polly P, 1999, 'The Nuclear Receptor Superfamily. Retinoids & Lipid Soluble Vitamins in Clinical Practice', The Nuclear Receptor Superfamily. Retinoids & Lipid Soluble Vitamins in Clinical Practice, vol. 15, pp. 71 - 74

Polly P, 1999, 'Cyclin C is a Primary 1α,25-Dihydroxyvitamin D3 Responding Gene. J. Cell', J. Cell. Biochem, vol. 77, pp. 75 - 81, http://dx.doi.org/10.1002/(SICI)1097-4644(20000401)77:1<75::AID-JCB8>3.0.CO;2-Q

Carlberg C; Polly P, 1998, 'Gene regulation by vitamin D3', Critical Reviews in Eukaryotic Gene Expression, vol. 8, pp. 19 - 42, http://dx.doi.org/10.1615/CritRevEukarGeneExpr.v8.i1.20

Polly P, 1998, 'Differential Apoptotic Response of Human Melanoma Cells to 1α,25-dihydroxyvitamin D3 and its Analogues', Cell death and differentiation, vol. 5, pp. 946 - 952, http://dx.doi.org/10.1038/sj.cdd.4400437

Polly P; Carlberg C; Eisman JA; Morrison NA, 1997, 'The 1 alpha, 25-dihydroxyvitamin D3 receptor as a mediator of transrepression of retinoid signalling', Journal of Cellular Biochemistry, vol. 67, pp. 287 - 296, http://dx.doi.org/10.1002/(SICI)1097-4644(19971201)67:3<287::AID-JCB1>3.0.CO;2-S

Mottershead DG; Polly P; Lyons RJ; Sutherland RL; Watts CKW, 1996, 'High activity, soluble, bacterially expressed human vitamin D receptor and its ligand binding domain', Journal of Cellular Biochemistry, vol. 61, pp. 325 - 337, http://dx.doi.org/10.1002/(SICI)1097-4644(19960601)61:3<325::AID-JCB1>3.0.CO;2-V

Goldberg D; Polly P; Eisman JA; Morrison NA, 1996, 'Identification of an osteocalcin gene promoter sequence that binds AP1', Journal of Cellular Biochemistry, vol. 60, pp. 447 - 457, http://dx.doi.org/10.1002/(SICI)1097-4644(19960315)60:4<447::AID-JCB2>3.0.CO;2-S

Polly P; Carlberg C; Eisman JA; Morrison NA, 1996, 'Erratum: Identification of a vitamin D3 response element in the fibronectin gene that is bound by a vitamin D3 receptor homodimer (Journal of Cell Biochemistry (1996) 60 (322-333))', Journal of Cellular Biochemistry, vol. 62, pp. 142, http://dx.doi.org/10.1002/(SICI)1097-4644(199607)62:1<142::AID-JCB15>3.3.CO;2-7

Polly P, 1996, 'Identification of a Vitamin D3 Response Element in the Fibronectin Gene that is Bound by a Vitamin D3 Receptor Homodimer', J. Cell. Biochem, vol. 60, pp. 322 - 332, http://dx.doi.org/10.1002/(SICI)1097-4644(19960301)60:3<322::AID-JCB4>3.0.CO;2-Y

Polly P; Nicholson RC, 1994, 'High levels of c-myc gene expression precede point mutational activation of Ki-ras in mouse lung cancer', Cancer Letters, vol. 76, pp. 87 - 92, http://dx.doi.org/10.1016/0304-3835(94)90382-4

Polly P; Nicholson RC, 1993, 'Sequence of the mouse fibronectin-encoding gene promoter region', Gene, vol. 137, pp. 353 - 354, http://dx.doi.org/10.1016/0378-1119(93)90036-3

Conference Papers

Liu PY; Tee A; Marshall G; Polly P; Wong M; Ling D; Kavallaris M; Perini G; Dinger ME; Liu T, 2013, 'Linc367, a novel long intergenic noncoding RNA, up-regulates N-Myc gene expression and neuroblastoma cell proliferation', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Amsterdam, NETHERLANDS, pp. S356 - S356, presented at European Cancer Congress 2013 - 17th ECCO / 38th ESMO / 32nd ESTRO, Amsterdam, NETHERLANDS, 27 September 2013 - 01 October 2013, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000326843602302&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Polly P; Thai T; Flood A; Coleman K; Das M; Yang JL; Cox J, 2013, 'Enhancement of scientific research and communication skills using assessment and ePortfolio in a third year pathology course', in 30th Annual conference on Australian Society for Computers in Learning in Tertiary Education, ASCILITE 2013, pp. 711 - 723

Velan GM; Klein R; Polly P, 2012, 'Impact of integrated adaptive tutorials on learning in pathology', in Tubbs SR (ed.), Abstracts of the 2012 meeting of the Australian and New Zealand association of clinical anatomists. Clinical Anatomy 26: 641–660., Wiley, Sydney, Australia, pp. 641 - 660, presented at 2012 meeting of the Australian and New Zealand association of clinical anatomists, Sydney, Australia, 09 December 2012 - 11 December 2012, http://dx.doi.org/10.1002/ca.22235

Coleman K; Cox J; Das M; Flood A; Polly P; Thai T; Yang JL, 2012, 'Eportfolios in the sciences: The role of reflection as students build professional skills and career readiness', in ASCILITE 2012 - Annual conference of the Australian Society for Computers in Tertiary Education

Shum A; Camilleri P; Clarke SJ; Robertson G; Polly P, 2011, 'MUSCULOSKELETAL BREAKDOWN DUE TO CANCER CACHEXIA: MOLECULAR AND MORPHOLOGICAL EFFECTS', in OSTEOPOROSIS INTERNATIONAL, SPRINGER LONDON LTD, Gold Coast, AUSTRALIA, pp. S596 - S597, presented at IOF Regionals 2nd Asia-Pacific Osteoporosis and Bone Meeting / ANZBMS Annual Scientific Meeting held with the JSBMR, Gold Coast, AUSTRALIA, 04 September 2011 - 08 September 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000309258200195&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Shum A; Mahendradatta ; Clarke S; Tan TC; Polly P, 2011, 'Cardiac and skeletal muscle biomarker profiling in cancer induced cachexia: a comparison', in Heart Lung Circulation

Shum A; Mahendradatta ; Gao J; Ku D; Sarris M; Clarke SJ; Tan TC; Polly P, 2011, 'A Morphological Characterization of Cancer induced Cardiomyopathy Independent of Chemotherapeutic Intervention', in Heart Lung Circulation

Mahendradatta ; Shum A; Clarke SJ; Tan TC; Polly P, 2011, 'Potential novel molecular regulators of cancer cachexia-induced cardiomyopathy.', in Heart Lung Circulation

Tan TC; Shum A; Mahendradatta ; Sarris M; Clarke SJ; Polly P, 2011, 'Cancer-induced cardiomyopathy: A series of maladaptive responses.', in Eur. J. Cardiol. Suppl

Shum A; Camilleri P; Clarke SJ; Robertson GR; Polly P, 2011, 'Musculoskeletal Breakdown due to Cancer Cachexia: Molecular and Morphological Effects.', in Osteoporosis Int., Springer, pp. 22: S596-S597 Suppl. 4,

Shum A; Mahendradatta ; Clarke SJ; Tan TC; Polly P, 2011, 'J. Sarcopenia and Cachexia', in J. Sarcopenia and Cachexia, 6th Cachexia Meeting, Milan, presented at 6th Cachexia Meeting, Milan

Shum A; Clarke S; Robertson G; Polly P, 2010, 'MEF2C: A Novel Regulator of Cancer-Induced Skeletal Muscle Wasting', in MEF2C: A Novel Regulator of Cancer-Induced Skeletal Muscle Wasting, The Lowy Symposium: Discovering Cancer Therapeutics, Sydney, Australia, pp. p68, presented at The Lowy Symposium: Discovering Cancer Therapeutics, Sydney, Australia

Camilleri P; Tsoli M; Clarke SJ; Robertson G; Polly P, 2009, 'Cancer Cachectic effects on bone; an analysis of molecular regulators and morphological changes', in Cancer Cachectic effects on bone; an analysis of molecular regulators and morphological changes, 5th Cachexia Conference, Barcelona, Spain, presented at 5th Cachexia Conference, Barcelona, Spain

Shum A; Tsoli M; Clarke SJ; Clarke G; Polly P, 2009, 'Tumour-mediated Effects on Circadian Rhythm Gene Expression in Skeletal Muscle', in Tumour-mediated Effects on Circadian Rhythm Gene Expression in Skeletal Muscle, 5th Cachexia Conference, Barcelona, Spain, presented at 5th Cachexia Conference, Barcelona, Spain

Tay ; Palmer SJ; Subramaniam N; Polly P; Hook J; Gunning P; Jeffrey P; Tam PP; Hardeman EC, 2005, 'The role of MusTRD/GTF2IRD1 in neurodevelopment, Williams-Beuren syndrome and anterior-posterior axis formation', in Mechanisms of Development, Elsevier Science BV, Amsterdam, Netherlands, pp. 122:S117-S117, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207524100439&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Sabramaniam N; Polly P; Tay ESE; Guven KL; Joya J; Nair-Shalliker V; Palmer SJ; Malladi C; Valova V; Robinson PJ; Hardeman EC, 2005, 'PSF and p54nrb/NonO modulate muscle ﬁbre-speciﬁc gene transctiption', in Mechanisms of Development, Elsevier Science BV, Amsterdam, Netherlands, pp. S49 - S49, - , http://dx.doi.org/10.1016/j.mod.2005.06.010

Hardeman E; Tay E; Palmer S; Subramaniam N; Polly P; Hook J; Lemckert F; Gunning P, 2004, 'A GMustrd/Gtf2ird1: Gene that Regulates Behaviour and Body Plan', in Australian Health and Medical Research Congress, Sydney, NSW, pp. 118, Sydney, NSW

Polly P; Herdick M; Carlberg C, 2000, 'VDR-Alien: A Novel, DNA-Selective, Vitamin D3 Receptor-Corepressor Partnership', in Norman AW; Bouillon R; Thomasset M (eds.), Proceedings of the Eleventh Workshop on Vitamin D Vitamin D, Chemistry, Biology and Clinical Applications of the Steroid Hormone,, Nashville, USA, pp. 309 - 312, Nashville, USA

Polly P; Carlberg C; Eisman JA; Morrison NA, 1997, 'Vitamin D Receptor-Mediated Transrepression of Retinoid Signalling Occurs via a Novel Retinoic Acid Response Element Identified in the Human Tumour Necrosis Factor ƒÑ Receptor Type I Gene.', in Norman AW; Bouillon R; Thomasset M (eds.), Proceedings of the Tenth Workshop on Vitamin D Vitamin D, Chemistry, Biology and Clinical Applications of the Steroid Hormone, Strasbourg, France, pp. 326 - 327, Strasbourg, France

Conference Posters

Polly P; de Permentier PJ; Herbert C; Luo A, 2016, 'Reflective practice for enabling future employability skills development in second year science students undertaking Histology and Pathology courses at UNSW', in Reflective practice for enabling future employability skills development in second year science students undertaking Histology and Pathology courses at UNSW, 13th Annual Conference of the Australian and New Zealand Association of Clinical Anatomists (ANZACA 2016), Canberra, Australian Capital Territory, presented at 13th Annual Conference of the Australian and New Zealand Association of Clinical Anatomists (ANZACA 2016), Canberra, Australian Capital Territory, 07 December 2016 - 09 December 2016

Polly P; de Permentier PJ; Mitchell H; Thai T; Hawkins N, 2014, 'Development and deployment of interactive online practical elements from biomedical practical lessons in Phase 1 Medicine at UNSW: What have we learned?', in Development and deployment of interactive online practical elements from biomedical practical lessons in Phase 1 Medicine at UNSW: What have we learned?, UNSW Learning and Teaching Forum, UNSW Australia, presented at UNSW Learning and Teaching Forum, UNSW Australia, 09 May 2014 - 09 May 2014

Conference Presentations

Jones GS; Polly P, 2013, 'Oral Communications: The poor relation in the literacies nexus', in Oral Communications: The poor relation in the literacies nexus, The Eleventh Biennial Conference of the Association for Academic Language and Learning,, Melbourne, presented at The Eleventh Biennial Conference of the Association for Academic Language and Learning,, Melbourne, 13 November 2013 - 15 November 2013

Jones G; Polly P, 2009, 'Collaborative approach to enhancing student learning in a second-year pathology course', in Collaborative approach to enhancing student learning in a second-year pathology course, 9th Biennial Conference of the Association for Academic Language and Learning, Brisbane, presented at 9th Biennial Conference of the Association for Academic Language and Learning, Brisbane, 26 November 2009 - 27 November 2009, http://www.uq.edu.au/aall/docs/Jones-Polly-Handout.pdf

Conference Abstracts

Chen J; Nelson C; Liu P; Tee AE; Atmadibrata B; MacKenzie K; Fletcher J; Trahair T; Polly P; Reddel R; Pickett H; Liu T, 2019, 'Abstract 5209: Efficacious targeting of TERT oncogene rearrangement with BET bromodomain inhibitor and proteasome inhibitor combination therapy', in Molecular and Cellular Biology / Genetics, American Association for Cancer Research, presented at Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA, http://dx.doi.org/10.1158/1538-7445.sabcs18-5209

Chen J; Nelson C; Liu P; Tee AE; Atmadibrata B; MacKenzie K; Fletcher J; Trahair T; Polly P; Reddel R; Pickett H; Liu T, 2019, 'Efficacious targeting of TERT oncogene rearrangement with BET bromodomain inhibitor and proteasome inhibitor combination therapy', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Atlanta, GA, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Atlanta, GA, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.AM2019-5209

Polly P; Jones G; Cochran B, 2017, 'EMENTORING TO SUPPORT AND ENABLE RESEARCH INTEGRATED LEARNING USING AUTHENTIC ASSESSMENT IN A THIRD YEAR UNDERGRADUATE SCIENCE COURSE IN PATHOLOGY AT A RESEARCH INTENSIVE UNIVERSITY', in EDULEARN17 Proceedings, 9th International Conference on Education and New Learning Technologies, presented at 9th International Conference on Education and New Learning Technologies

Wong M; Polly P; Liu T, 2015, 'The role of DOT1L in neuroblastoma', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Vienna, AUSTRIA, Vol. 51, pp. S11 - S12, presented at European Cancer Congress, Vienna, AUSTRIA, http://dx.doi.org/10.1016/S0959-8049(16)30037-5