Professor Nick Di Girolamo

Fields of research: Ophthalmology, Regenerative Medicine (incl. Stem Cells and Tissue Engineering)

Contact Details

Phone: + 61 2 9385 2538
Fax: +61 2 9835 1389
Email: n.digirolamo@unsw.edu.au

Supervision

PHD
Masters
Honours

Tabs

Main

Research Interests:
Ultraviolet Radiation and Tumours of the Human Cornea

1. Our research program focuses on understanding how excessive solar ultraviolet radiation and viral infections are potential triggers for diseases that develop on the surface of the human eye including benign pterygia, and invasive neoplasias. We study the role inflammatory mediators including cytokines, growth factors and matrix metalloproteinases in the pathogenesis of these lesions using cell culture models and fresh human tissue specimens. In collaboration with Professor Gary Halliday (USyd) we have been developing animal models of ocular cancer.

Corneal Stem Cell Transplantation

2. The second arm of our research program focuses on identifying, isolating and cultivating human corneal stem cells to help us understand how the ocular surface is replenished and maintained in a healthy transparent state under normal physiological conditions and following trauma. We also hope to identify better culture conditions and better markers for these rare cells with the ultimate aim of generating better quality grafts to treat patients with severe corneal diseases.

Corneal Wound Healing

3. The third arm of our research program focuses on devising therapies to treat patients with persistent corneal epithelial defects. Patients with these conditions do not require a cell or tissue replacement strategy and we are devising methods to dispense wound-healing factors to the cornea in order to prevent infection and other complications

Broad Research Areas:
Stem Cells, Ophthalmology, Transplantation, Pathology, Inflammation

Qualifications:
PhD

Society Memberships & Professional Activities:
1. Association for Research in Vision and Ophthalmology (ARV0), 2. International Ocular Inflammation Society (IOIS), 3. Sydney Tissue Engineering and Matrix group (STEAM), 4. Australian Society for Medical Research (ASMR), 5. Australian Protease Network, 6. Mutagenesis and Experimental Pathology Society of Australasia (MEPSA), 7. Member, NHMRC GRP Panels(Autonomic/Peripheral & Sensory Nervous System; Surgery/Dental/Medical & Related Technologies), 8. Member, ORIA Research Advisory Committee, 9. Editorial board Member, J Biomed Biotechnol, 10. Section Editor, Clin Exp Ophthalmol

Specific Research Keywords:
Corneal Stem Cell Biology, Stem Cell Therapy, Ocular Surface Cancer, Pterygia, Ultraviolet Radiation

University role:

Professor

Groups:

Ocular Diseases Research Group

Research

Media

Media Video Collection:

http://tv.unsw.edu.au/video/sight-for-sore-eyes

Publications related to this Person

Book Chapters

Bobba S; Di Girolamo N; Watson S, 2016, 'Contact lens delivery of stem cells for restoring the ocular surface', in Biomaterials and Regenerative Medicine in Ophthalmology: Second Edition, pp. 219 - 239, http://dx.doi.org/10.1016/B978-0-08-100147-9.00009-2

Journal articles

Wilkinson A; Kawaguchi N; Geczy C; Di Girolamo N, 2016, 'S100A8 and S100A9 proteins are expressed by human corneal stromal dendritic cells', British Journal of Ophthalmology, vol. 100, pp. 1304 - 1308, http://dx.doi.org/10.1136/bjophthalmol-2016-308827

Eghtedari Y; Richardson A; Mai K; Heng B; Guillemin GJ; Wakefield D; Di Girolamo N, 2016, 'Keratin 14 expression in epithelial progenitor cells of the developing human cornea', Stem Cells and Development, vol. 25, pp. 699 - 711, http://dx.doi.org/10.1089/scd.2016.0039

Richardson A; Wakefield D; Di Girolamo N, 2016, 'Fate Mapping Mammalian Corneal Epithelia', Ocular Surface, vol. 14, pp. 82 - 99, http://dx.doi.org/10.1016/j.jtos.2015.11.007

Di Girolamo N; Chow S; Richardson A; Wakefield D, 2016, 'Contamination of primary human corneal epithelial cells with an SV40-transformed human corneal epithelial cell line: A lesson for cell biologists in good laboratory practice', Investigative Ophthalmology and Visual Science, vol. 57, pp. 611 - 616, http://dx.doi.org/10.1167/iovs.15-18783

Bobba S; Di Girolamo N, 2016, 'Contact lenses: A delivery device for stem cells to treat corneal blindness', Optometry and Vision Science, vol. 93, pp. 412 - 418, http://dx.doi.org/10.1097/OPX.0000000000000699

Jones LW; Chauhan A; Di Girolamo N; Sheedy J; Smith E, 2016, 'Expert views on innovative future uses for contact lenses', Optometry and Vision Science, vol. 93, pp. 328 - 335, http://dx.doi.org/10.1097/OPX.0000000000000700

Gupta B; Mai K; Lowe SB; Wakefield D; Di Girolamo N; Gaus K; Reece PJ; Gooding JJ, 2015, 'Ultrasensitive and Specific Measurement of Protease Activity Using Functionalized Photonic Crystals', Analytical Chemistry, vol. 87, pp. 9946 - 9953, http://dx.doi.org/10.1021/acs.analchem.5b02529

Di Girolamo N, 2015, 'Moving epithelia: Tracking the fate of mammalian limbal epithelial stem cells', Progress in Retinal and Eye Research, http://dx.doi.org/10.1016/j.preteyeres.2015.04.002

Bobba S; Chow S; Watson S; Di Girolamo N, 2015, 'Clinical outcomes of xeno-free expansion and transplantation of autologous ocular surface epithelial stem cells via contact lens delivery: A prospective case series', Stem Cell Research and Therapy, vol. 6, http://dx.doi.org/10.1186/s13287-015-0009-1

Samarawickrama C; Cherepanoff S; Di Girolamo N; Benger R; Watson S, 2015, 'Unusual Limbal Lesion in Neurofibromatosis Type 1', Cornea, http://dx.doi.org/10.1097/ICO.0000000000000353

Di Girolamo N; Bobba S; Raviraj V; Delic NC; Slapetova I; Nicovich PR; Halliday GM; Wakefield D; Whan R; Lyons JG, 2015, 'Tracing the fate of limbal epithelial progenitor cells in the murine cornea', Stem Cells, vol. 33, pp. 157 - 169, http://dx.doi.org/10.1002/stem.1769

Chow S; Di Girolamo N, 2014, 'Vitronectin: a migration and wound healing factor for human corneal epithelial cells', Investigative ophthalmology & visual science, vol. 55, pp. 6590 - 6600, http://dx.doi.org/10.1167/iovs.14-15054

Hassan NMM; Painter N; Howlett CR; Farrell AW; Di Girolamo N; Lyons JG; Halliday GM, 2014, 'BrmInhibits the proliferative response of keratinocytes and corneal epithelial cells to ultraviolet radiation-induced damage', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0107931

Mai K; Chui JJY; Di Girolamo N; McCluskey PJ; Wakefield D, 2014, 'Role of toll-like receptors in human iris pigment epithelial cells and their response to pathogen-associated molecular patterns', Journal of Inflammation (United Kingdom), vol. 11, http://dx.doi.org/10.1186/1476-9255-11-20

Nicovich PR; Slapetova I; Whan R; Raviraj V; Bobba S; Di Girolamo N; Lyons JG, 2013, 'Imaging and Lineage Segmentation in Homozygous R26R-Confetti Mice', MOLECULAR BIOLOGY OF THE CELL, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348700008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Di Girolamo N; Atik A; McCluskey PJ; Wakefield D, 2013, 'Matrix Metalloproteinases and Their Inhibitors in Squamous Cell Carcinoma of the Conjunctiva', OCULAR SURFACE, vol. 11, pp. 193 - 205, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344216400006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Di Girolamo N; Ordonez P; Chow S, 2013, 'Integrin alphavbeta5 identifies human corneal epithelial stem cells', ACTA OPHTHALMOLOGICA, vol. 91, http://dx.doi.org/10.1111/j.1755-3768.2013.4763.x

Tonthat CV; Di Girolamo N, 2013, 'Nestin expression in pterygia: potential role in angiogenesis', British Journal of Ophthalmology, vol. 98, pp. 801 - 807, http://dx.doi.org/10.1136/bjophthalmol-2013-303919

Leahy K; Sarris M; Di Girolamo N; Watson S; McCluskey P; White A, 2013, 'IMMUNOFLUORESCENT INVESTIGATION OF CORNEAL ENDOTHELIAL CHANGES ASSOCIATED WITH SELECTIVE LASER TRABECULOPLASTY', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol. 41, pp. 15 - 15, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000329507100021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Woods M; Chow S; Heng B; Glenn W; Whitaker N; Waring D; Iwasenko J; Rawlinson W; Coroneo MT; Wakefield D, 2013, 'Detecting human papillomavirus in ocular surface diseases', Investigative Ophthalmology and Visual Science, vol. 54, pp. 8069 - 8078, http://dx.doi.org/10.1167/iovs.13-13140

Wakefield D; Di Girolamo N; Thurau S; Wildner G; McCluskey P, 2013, 'Scleritis: Challenges in immunopathogenesis and treatment', Discovery Medicine, vol. 16, pp. 153 - 157

Demurtas P; Di Girolamo N; Corrias M; Zucca I; Maxia C; Diana A; Piras F; Lai S; Sirigu P; Perra MT, 2013, 'Immunohistochemical analysis of angiotensin converting enzyme in sardinian pterygium', Histology and Histopathology, vol. 28, pp. 759 - 766

Wakefield D; Di Girolamo N; Thurau S; Wildner G; McCluskey P, 2013, 'Scleritis: Immunopathogenesis and molecular basis for therapy', Progress in Retinal and Eye Research, vol. 35, pp. 44 - 62, http://dx.doi.org/10.1016/j.preteyeres.2013.02.004

Di Girolamo N; Atik A; McCluskey PJ; Wakefield D, 2013, 'Matrix Metalloproteinases and Their Inhibitors in Squamous Cell Carcinoma of the Conjunctiva', Ocular Surface, http://dx.doi.org/10.1016/j.jtos.2013.01.006

Ordonez P; Chow S; Wakefield D; Di Girolamo N, 2013, 'Human limbal epithelial progenitor cells express αvβ5-integrin and the interferon-inducible chemokine CXCL10/IP-10', Stem Cell Research, vol. 11, pp. 888 - 901, http://dx.doi.org/10.1016/j.scr.2013.05.013

Harkin DG; Apel AJ; Di Girolamo N; Watson S; Brown K; Daniell MD; McGhee JJ; McGhee CNJ, 2013, 'Current status and future prospects for cultured limbal tissue transplants in Australia and New Zealand', Clinical and Experimental Ophthalmology, vol. 41, pp. 272 - 281, http://dx.doi.org/10.1111/j.1442-9071.2012.02877.x

Di Girolamo N, 2012, 'Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia', Eye, vol. 26, pp. 202 - 211, http://dx.doi.org/10.1038/eye.2011.312

Ordonez P; Di Girolamo N, 2012, 'Concise review: Limbal epithelial stem cells: Role of the niche microenvironment', Stem Cells, vol. 30, pp. 100 - 107, http://dx.doi.org/10.1002/stem.794

Halliday GM; Zhou Y; Sou PW; Huang XXJ; Rana S; Bugeja MJ; Painter N; Scolyer RA; Muchardt C; Di Girolamo N, 2012, 'The absence of Brm exacerbates photocarcinogenesis', Experimental Dermatology, vol. 21, pp. 599 - 604, http://dx.doi.org/10.1111/j.1600-0625.2012.01522.x

Karaconji T; Skippen B; Di Girolamo N; Taylor SF; Francis IC; Coroneo MT, 2012, 'Doxycycline for treatment of blepharochalasis via inhibition of matrix metalloproteinases', Ophthalmic Plastic and Reconstructive Surgery, vol. 28, http://dx.doi.org/10.1097/IOP.0b013e31822ddf6e

Di Girolamo N; Wakefield D; Coroneo MT, 2011, 'Doxycycline's and ocular angiogenesis', Ophthalmology, vol. 118, pp. 789 - 790, http://dx.doi.org/10.1016/j.ophtha.2011.01.009

Echevarria TJ; Di Girolamo N, 2011, 'Tissue-Regenerating, Vision-Restoring Corneal Epithelial Stem Cells', Stem Cell Reviews and Reports, vol. 7, pp. 256 - 268, http://dx.doi.org/10.1007/s12015-010-9199-1

Di Girolamo N, 2011, 'Stem cells of the human cornea', British Medical Bulletin, vol. 100, pp. 191 - 207, http://dx.doi.org/10.1093/bmb/ldr026

Van Nguyen H; Di Girolamo N; Jackson N; Hampartzoumian T; Bullpitt P; Tedla N; Wakefield D, 2011, 'Ultraviolet radiation-induced cytokines promote mast cell accumulation and matrix metalloproteinase production: Potential role in cutaneous lupus erythematosus', Scandinavian Journal of Rheumatology, vol. 40, pp. 197 - 204, http://dx.doi.org/10.3109/03009742.2010.528020

Echevarria TJ; Chow S; Watson S; Wakefield D; Di Girolamo N, 2011, 'Vitronectin: A matrix support factor for human limbal epithelial progenitor cells', Investigative Ophthalmology and Visual Science, vol. 52, pp. 8138 - 8147, http://dx.doi.org/10.1167/iovs.11-8140

Di Girolamo N; Coroneo MT; Wakefield D, 2011, 'Animal model of pterygium.', ophthalmology, vol. 118, pp. 789 - 790

Di Girolamo N, 2010, 'Signalling pathways activated by ultraviolet radiation: Role in ocular and cutaneous health', Current Pharmaceutical Design, vol. 16, pp. 1358 - 1375

Davies SB; Di Girolamo N, 2010, 'Corneal stem cells and their origins: Significance in developmental biology', Stem Cells and Development, vol. 19, pp. 1651 - 1662, http://dx.doi.org/10.1089/scd.2010.0201

Chui JJY; Li MWM; Di Girolamo N; Chang JH; McCluskey PJ; Wakefield D, 2010, 'Iris pigment epithelial cells express a functional lipopolysaccharide receptor complex', Investigative Ophthalmology and Visual Science, vol. 51, pp. 2558 - 2567, http://dx.doi.org/10.1167/iovs.09-3923

Di Girolamo N; Watson SL, 2010, 'Reply to contact lens-based expansion and transplantation of autologous epithelial progenitors for ocular surface reconstruction: Crossover control', Transplantation, vol. 89, pp. 484, http://dx.doi.org/10.1097/01.TP.0000368789.42492.f2

Di Girolamo N; Watson SL, 2010, 'Reply to aniridia-to be or not to be?', Transplantation, vol. 89, pp. 483 - 484, http://dx.doi.org/10.1097/TP.0b013e3181c832a8

Davies SB; Chui J; Madigan MC; Provis JM; Wakefield D; Di Girolamo N, 2009, 'Stem cell activity in the developing human cornea', Stem Cells, vol. 27, pp. 2781 - 2792, http://dx.doi.org/10.1002/stem.209

McCluskey P; Molteno A; Wakefield D; Di Girolamo N, 2009, 'Otago glaucoma surgery outcome study: The pattern of expression of mmps and timps in bleb capsules surrounding molteno implants', Investigative Ophthalmology and Visual Science, vol. 50, pp. 2161 - 2164, http://dx.doi.org/10.1167/iovs.08-2063

Kilian KA; Lai LMH; Magenau A; Cartland S; Bocking T; Girolamo ND; Gal M; Gaus K; Gooding JJ, 2009, 'Smart tissue culture: in situ monitoring of the activity of protease enzymes secreted from live cells using nanostructured photonic crystals', Nano Letters, vol. 9, pp. 2021 - 2025, http://dx.doi.org/10.1021/nl900283j

Goyette J; Yan WX; Yamen E; Chung YM; Lim SY; Hsu K; Rahimi F; Di Girolamo N; Song C; Jessup W, 2009, 'Pleiotropic roles of S100A12 in coronary atherosclerotic plaque formation and rupture', Journal of Immunology, vol. 183, pp. 593 - 603, http://dx.doi.org/10.4049/jimmunol.0900373

Di Girolamo N; Bosch M; Zamora K; Coroneo MT; Wakefield D; Watson SL, 2009, 'A contact lens-based technique for expansion and transplantation of autologous epithelial progenitors for ocular surface reconstruction', Transplantation, vol. 87, pp. 1571 - 1578, http://dx.doi.org/10.1097/TP.0b013e3181a4bbf2

Chui J; di Girolamo N; Wakefield D; Coroneo MT, 2008, 'The pathogenesis of pterygium: Current concepts and their therapeutic implications', Ocular Surface, vol. 6, pp. 24 - 43

Ng J; Coroneo MT; Wakefield D; Di Girolamo N, 2008, 'Ultraviolet radiation and the role of matrix metalloproteinases in the pathogenesis of ocular surface squamous neoplasia', Investigative Ophthalmology and Visual Science, vol. 49, pp. 5295 - 5306, http://dx.doi.org/10.1167/iovs.08-1988

Di Girolamo N; Sarris M; Chui J; Cheema H; Coroneo MT; Wakefield D, 2008, 'Localization of the low-affinity nerve growth factor receptor p75 in human limbal epithelial cells', Journal of Cellular and Molecular Medicine, vol. 12, pp. 2799 - 2811, http://dx.doi.org/10.1111/j.1582-4934.2008.00290.x

Lai K; Girolamo N; Conway RM; Jager MJ; Madigan MC, 2007, 'The effect of ultraviolet radiation on choroidal melanocytes and melanoma cell lines: Cell survival and matrix metalloproteinase production', Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 245, pp. 715 - 724, http://dx.doi.org/10.1007/s00417-006-0444-x

Figueira EC; Di Girolamo N; Coroneo MT; Wakefield D, 2007, 'The phenotype of limbal epithelial stem cells', Investigative Ophthalmology and Visual Science, vol. 48, pp. 144 - 156, http://dx.doi.org/10.1167/iovs.06-0346

Di Girolamo N; Chui J; Wakefield D; Coroneo MT, 2007, 'Cultured human ocular surface epithelium on therapeutic contact lenses', British Journal of Ophthalmology, vol. 91, pp. 459 - 464, http://dx.doi.org/10.1136/bjo.2006.103895

Chui J; Di Girolamo N; Coroneo MT; Wakefield D, 2007, 'The role of substance P in the pathogenesis of pterygia', Investigative Ophthalmology and Visual Science, vol. 48, pp. 4482 - 4489, http://dx.doi.org/10.1167/iovs.07-0123

Endoh I; Di Girolamo N; Hampartzoumian T; Cameron B; Geczy CL; Tedla N, 2007, 'Ultraviolet B irradiation selectively increases the production of interleukin-8 in human cord blood-derived mast cells', Clinical and Experimental Immunology, vol. 148, pp. 161 - 167, http://dx.doi.org/10.1111/j.1365-2249.2007.03332.x

Wu BJ; Di Girolamo N; Beck K; Hanratty CG; Choy K; Hou JY; Ward MR; Stocker R, 2007, 'Probucol [4,4′-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1- dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-defi', Journal of Pharmacology and Experimental Therapeutics, vol. 321, pp. 477 - 484, http://dx.doi.org/10.1124/jpet.106.118612

Yang Z; Yan WX; Cai H; Tedla N; Armishaw C; Di Girolamo N; Wang HW; Hampartzoumian T; Simpson JL; Gibson PG, 2007, 'S100A12 provokes mast cell activation: A potential amplification pathway in asthma and innate immunity', Journal of Allergy and Clinical Immunology, vol. 119, pp. 106 - 114, http://dx.doi.org/10.1016/j.jaci.2006.08.021

Hettiaratchi A; Hawkins NJ; McKenzie G; Ward RL; Hunt JE; Wakefield D; Di Girolamo N, 2007, 'The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer', British Journal of Cancer, vol. 96, pp. 783 - 792, http://dx.doi.org/10.1038/sj.bjc.6603630

Di Girolamo N; Wakefield D; Coroneo MT, 2006, 'UVB-mediated induction of cytokines and growth factors in pterygium epithelial cells involves cell surface receptors and intracellular signaling', Investigative Ophthalmology and Visual Science, vol. 47, pp. 2430 - 2437, http://dx.doi.org/10.1167/iovs.05-1130

Zhang G; Fahmy RG; diGirolamo N; Khachigian LM, 2006, 'JUN siRNA regulates matrix metalloproteinase-2 expression, microvascular endothelial growth and retinal neovascularisation', Journal of Cell Science, vol. 119, pp. 3219 - 3226, http://dx.doi.org/10.1242/jcs.03059

Di Girolamo N; Indoh I; Jackson N; Wakefield D; McNeil HP; Yan W; Geczy C; Arm JP; Tedla N, 2006, 'Human mast cell-derived gelatinase B (matrix metalloproteinase-9) is regulated by inflammatory cytokines: Role in cell migration', Journal of Immunology, vol. 177, pp. 2638 - 2650

Di Girolamo N; Coroneo M; Wakefield D, 2005, 'Epidermal growth factor receptor signaling is partially responsible for the increased matrix metalloproteinase-1 expression in ocular epithelial cells after UVB radiation', American Journal of Pathology, vol. 167, pp. 489 - 503

Bhindi R; Brieger D; Ishii H; Di Girolamo N; Kumar RK; Khachigian LM; Lowe HC, 2005, 'Fibroblast growth factor 2 and the transcription factor Egr-1 localise to endothelial cell microvascular channels in human coronary artery occlusion', Thrombosis and Haemostasis, vol. 93, pp. 172 - 174

Nolan TM; Di Girolamo N; Coroneo MT; Wakefield D, 2004, 'Proliferative Effects of Heparin-Binding Epidermal Growth Factor-like Growth Factor on Pterygium Epithelial Cells and Fibroblasts', Investigative Ophthalmology and Visual Science, vol. 45, pp. 110 - 113, http://dx.doi.org/10.1167/iovs.03-0046

Di Girolamo N; Chui J; Coroneo MT; Wakefield D, 2004, 'Pathogenesis of pterygia: Role of cytokines, growth factors, and matrix metalloproteinases', Progress in Retinal and Eye Research, vol. 23, pp. 195 - 228, http://dx.doi.org/10.1016/j.preteyeres.2004.02.002

Sachdev NH; Di Girolamo N; Nolan TM; McCluskey PJ; Wakefield D; Coroneo MT, 2004, 'Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in the human lens: Implications for cortical cataract formation', Investigative Ophthalmology and Visual Science, vol. 45, pp. 4075 - 4082, http://dx.doi.org/10.1167/iovs.03-1336

Zhang G; Dass CR; Sumithran E; Di Girolamo N; Sun LQ; Khachigian LM, 2004, 'Effect of deoxyribzymes targeting c-Jun on solid tumor growth and angiogenesis in rodents', Journal of the National Cancer Institute, vol. 96, pp. 683 - 696

Nolan TM; DiGirolamo N; Sachdev NH; Hampartzoumian T; Coroneo MT; Wakefield D, 2003, 'The role of ultraviolet irradiation and heparin-binding epidermal growth factor-like growth factor in the pathogenesis of pterygium', American Journal of Pathology, vol. 162, pp. 567 - 574

Xue ML; Wakefield D; Willcox MDP; Lloyd AR; Di Girolamo N; Cole N; Thakur A, 2003, 'Regulation of MMPs and TIMPs by Il-1β during corneal ulceration and infection', Investigative Ophthalmology and Visual Science, vol. 44, pp. 2020 - 2025, http://dx.doi.org/10.1167/iovs.02-0565

Di Girolamo N; Coroneo MT; Wakefield D, 2003, 'UVB-Elicited Induction of MMP-1 Expression in Human Ocular Surface Epithelial Cells Is Mediated through the ERK1/2 MAPK-Dependent Pathway', Investigative Ophthalmology and Visual Science, vol. 44, pp. 4705 - 4714, http://dx.doi.org/10.1167/iovs.03-0356

Lan J; Kumar RK; Di Girolamo N; McCluskey P; Wakefield D, 2003, 'Expression and distribution of matrix metalloproteinases and their inhibitors in the human iris and ciliary body', British Journal of Ophthalmology, vol. 87, pp. 208 - 211, http://dx.doi.org/10.1136/bjo.87.2.208

Wei XM; Heywood GJ; Di Girolamo N; Thomas PS, 2003, 'Nicorandil inhibits the release of TNFα from a lymphocyte cell line and peripheral blood lymphocytes', International Immunopharmacology, vol. 3, pp. 1581 - 1588, http://dx.doi.org/10.1016/S1567-5769(03)00176-0

Cuello C; Wakefield D; Di Girolamo N, 2002, 'Neutrophil accumulation correlates with type IV collagenase/gelatinase activity in endotoxin induced uveitis', British Journal of Ophthalmology, vol. 86, pp. 290 - 295, http://dx.doi.org/10.1136/bjo.86.3.290

Sachdev NH; Di Girolamo N; McCluskey PJ; Jennings AV; McGuinness R; Wakefield D; Coroneo MT, 2002, 'Lens dislocation in marfan syndrome: Potential role of matrix metalloproteinases in fibrillin degradation', Archives of Ophthalmology, vol. 120, pp. 833 - 835

Di Girolamo N; Kumar RK; Coroneo MT; Wakefield D, 2002, 'UVB-mediated induction of interleukin-6 and -8 in pterygia and cultured human pterygium epithelial cells', Investigative Ophthalmology and Visual Science, vol. 43, pp. 3430 - 3437

Di Girolamo N; Coroneo MT; Wakefield D, 2001, 'Active matrilysin (MMP-7) in human pterygia: Potential role in angiogenesis', Investigative Ophthalmology and Visual Science, vol. 42, pp. 1963 - 1968

Yang Z; Tao T; Raftery MJ; Youssef P; Di Girolamo N; Geczy CL, 2001, 'Proinflammatory properties of the human S100 protein S100A12', Journal of Leukocyte Biology, vol. 69, pp. 986 - 994

Di Girolamo N; Wakefield D; Coroneo MT, 2000, 'Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases at the invading pterygium head', INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 41, pp. S451 - S451, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000086246702387&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Di Girolamo N; McCluskey P; Lloyd A; Coroneo MT; Wakefield D, 2000, 'Expression of MMPs and TIMPs in human pterygia and cultured pterygium epithelial cells', Investigative Ophthalmology and Visual Science, vol. 41, pp. 671 - 679

Di Girolamo N; Wakefield D, 2000, 'In vitro and in vivo expression of interstitial collagenase/MMP-1 by human mast cells', Developmental Immunology, vol. 7, pp. 131 - 142

Di Girolamo N; Wakefield D; Coroneo MT, 2000, 'Differential expression of matrix metalloproteinases and their tissue inhibitors at the advancing pterygium head', Investigative Ophthalmology and Visual Science, vol. 41, pp. 4142 - 4149

Coroneo MT; Di Girolamo N; Wakefield D, 1999, 'The pathogenesis of pterygia', Current Opinion in Ophthalmology, vol. 10, pp. 282 - 288, http://dx.doi.org/10.1097/00055735-199908000-00011

Wakefield D; Cuello C; Di Girolamo N; Lloyd A, 1999, 'The role of cytokines and chemokines in uveitis.', Developments in ophthalmology, vol. 31, pp. 53 - 66

Di Girolamo N; Tedla N; Kumar RK; McCluskey P; Lloyd A; Coroneo MT; Wakefield D, 1999, 'Culture and characterisation of epithelial cells from human pterygia', British Journal of Ophthalmology, vol. 83, pp. 1077 - 1082

Di Girolamo N; Tedla N; Lloyd A; Wakefield D, 1998, 'Expression of matrix metalloproteinases by human plasma cells and B lymphocytes', European Journal of Immunology, vol. 28, pp. 1773 - 1784, http://dx.doi.org/10.1002/(SICI)1521-4141(199806)28:06<1773::AID-IMMU1773>3.0.CO;2-B

Cuello C; Palladinetti P; Tedla N; Di Girolamo N; Lloyd AR; McCluskey PJ; Wakefield D, 1998, 'Chemokine expression and leucocyte infiltration in Sjogren's syndrome', British Journal of Rheumatology, vol. 37, pp. 779 - 783

Tedla N; Wang HW; McNeil HP; Di Girolamo N; Hampartzoumian T; Wakefield D; Lloyd A, 1998, 'Regulation of T lymphocyte trafficking into lymph nodes during an immune response by the chemokines macrophage inflammatory protein (MIP)-1α and MIP- 1β', Journal of Immunology, vol. 161, pp. 5663 - 5672

Wakefield D, 1997, 'Expression of tumor necrosis factor-alpha by human plasma cells in scllritis', Investigative Ophthalmology and Visual Science, vol. 38

Di Girolamo N; Lloyd A; McCluskey P; Filipic M; Wakefield D, 1997, 'Increased expression of matrix metalloproteinases in vivo in scleritis tissue and in vitro in cultured human scleral fibroblasts', American Journal of Pathology, vol. 150, pp. 653 - 666

Di Girolamo N; Visvanathan K; Lloyd A; Wakefield D, 1997, 'Expression of TNF-α by human plasma cells in chronic inflammation', Journal of Leukocyte Biology, vol. 61, pp. 667 - 678

Di Girolamo N; Verma MJ; McCluskey PJ; Lloyd A; Wakefield D, 1996, 'Increased matrix metalloproteinases in the aqueous humor of patients and experimental animals with uveitis', Current Eye Research, vol. 15, pp. 1060 - 1068

Girolamo ND; McCluskey PJ; Lloyd A; Wakefield D, 1995, 'Stromelysin (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase (TIMP-1) mRNA expression in scleritis', Ocular Immunology and Inflammation, vol. 3, pp. 181 - 194, http://dx.doi.org/10.3109/09273949509069111

Conference Papers

Goyette J; Yan W; Lim SY; Di Girolamo N; Geczy CL, 2008, 'Does S100A12 activate mast cells and monocytes/macrophages via rage?', in CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Montreal, CANADA, pp. 293 - 294, presented at 7th Joint Conference of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytoklin-Research, Montreal, CANADA, 12 - 16 October 2008, http://dx.doi.org/10.1016/j.cyto.2008.07.293

Nguyen HV; Di Girolamo N; Tedla N; Jackson N; Geczy C; Hampartzoumian T; Bullpitt P; Wakefield D, 2007, 'Roles of mast cells and ultraviolet radiation in the pathogenesis of systemic lupus erythematosus', in ANNALS OF THE RHEUMATIC DISEASES, B M J PUBLISHING GROUP, Barcelona, SPAIN, pp. 312 - 312, presented at Annual European Congress of Rheumatology (EULAR 2007), Barcelona, SPAIN, 13 - 16 June 2007, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000253101101276&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Lan JX; Kumar RK; Di Girolamo N; McCluskey P; Wakefield D, 2003, 'Expression and distribution of matrix metalloproteinases and their inhibitors in the human iris and ciliary body', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, FT LAUDERDALE, FLORIDA, pp. U209 - U209, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, FT LAUDERDALE, FLORIDA, 01 May 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000184606800666&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Nolan TM; Di Girolamo N; Coroneo MT; Wakefield D, 2003, 'The effects of ultraviolet irradiation on growth factor expression in pterygium', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, FT LAUDERDALE, FLORIDA, pp. U315 - U315, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, FT LAUDERDALE, FLORIDA, 01 May 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000184606801272&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Di Girolamo N; Coroneo MT; Wakefield D, 2003, 'The UVB-elicited induction of MMP-1 in pterygium epithelial cells is mediated through a MAPK-dependent pathway', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, FT LAUDERDALE, FLORIDA, pp. U315 - U315, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, FT LAUDERDALE, FLORIDA, 01 May 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000184606801273&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Posters

Bobba S; Di Girolamo N; Watson SL, 2016, 'AN AUSTRALIAN AND NEW ZEALAND OPHTHALMIC SURVEILLANCE UNIT STUDY OF THE INCIDENCE AND NATURE OF SEVERE LIMBAL STEM CELL DEFICIENCY', in CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, WILEY-BLACKWELL, Vol. 44, pp. 88 - 88, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000387788100119&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Mechanisms of Disease and Translational Research