The role of tropomyosin in coordinated neurite branching

Project members:

Project main description:

The complexity of the nervous system is reflected by its smallest building block, the nerve cell. Our work aims to reveal the molecular mechanisms that underlie the generation of highly branched processes of these nerve cells. Previous research has shown that filamentous elements of the cell architecture are instrumental in supporting process elongation and branch formation. Our group has determined the role of a family of proteins, tropomyosins, in defining distinct filament populations which can either enhance or attenuate branching. Revealing the mechanism by which tropomyosin regulates the degree of branching will be a major step in our understanding of the development and function of the nervous system.

Project supporters:

  • Australian Research Council - Discovery Project|DP110102771