Expression and functions of leukocyte Immunoglobulin-like Receptor (LIR)-6 and LIR-4 in inflammatory arthritis (IA).

Project members:

Project main description:

Rheumatoid arthritis (RA) that affects millions worldwide is characterised by uncontrolled activation of immune cells destroying ones own joints. The reasons for this excessive activation of cells are not known and existing treatments are limited to easing symptoms. We will study the role of new proteins named as Leucocyte Ig-like Receptors in regulating immune cell activation. Understanding mechanisms that control unwanted activation of immune cells is critical in preventing and treating RA.

Project supporters:

  • National Health & Medical Research Council - Project Grant|510236