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Regulation and Heterogeneity of Dormant Hematopoietic Stem Cells

Adult Cancer Program Seminar Series: Special Seminar

Speaker: Dr. Nina Cabezas-Wallscheid, Group Leader: Cellular and Molecular Immunology Max Planck Institute of Immunobiology and Epigenetics.

Abstract: Hematopoiesis is a hierarchically organized process. Hematopoietic Stem Cells (HSCs) reside
at the top of it, are highly quiescent and hold the unique potential to generate multipotent progenitors
which can differentiate into mature blood cells. Our laboratory and others have applied long-term labeling
strategies to identify a sub-population of label-retaining cells within HSCs. These highly quiescent cells,
termed dormant HSCs (dHSCs), harbor the highest long-term reconstitution potential within the
hematopoietic system. Recently, we found that stem cell dormancy is defined by a low biosynthetic state
(low transcription, translation), which gets gradually up-regulated upon commitment. Further, we found
that dietary vitamin A plays an important role in the in vivo regulation of stem cell dormancy. Finally, we
uncovered a novel regulation axis (Neogenin-Netrin) that maintains HSC dormancy.

Bio: Dr. Nina Cabezas-Wallscheid recently started her group at the Max Planck Institute of
Immunobiology and Epigenetics (Germany) where she is investigating the regulation of hematopoietic
stem cell (HSC) dormancy. She conducted her postdoctoral work in the laboratory of Prof. Andreas
Trumpp at the German Cancer Research Center in Heidelberg. During her postdoctoral training she
uncovered molecular and functional properties of hematopoietic stem and progenitor cells by combining
cutting-edge technologies including proteome, DNA methylome (TWGBS) and whole-transcriptome
(RNA-seq) single-cell analysis from very rare populations, combined with in vivo and in vitro functional
approaches. Dr Cabezas-Wallscheid has regularly published in high-impact, broad interest journals
including Cell, Cell Cycle, Stem Cell Reports and Cell Stem Cell. Her success has been recognised by
numerous awards including the Christa Muller Sieburg Award (San Diego, 2016) and the German Stem
Cell Network Young Investigator Award (2018), and an ERC Starting Grant
(2017) to further investigate hematopoietic stem cell dormancy.

To meet with Dr Cabezas-Wallscheid please contact:
Dr Julie Thoms:

Event Date: 
Tuesday, 13 August 2019 - 11:00am
Wallace Wurth Level 6 Seminar Room (Room 638)
Event Type: 
Booking deadline: