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‘Molecular Pharmacology of Cannabinoid Receptor 2, a Promising Therapeutic Target’.

Neuroscience & Non-Communicable Diseases Seminar Series

Speaker: Natasha Grimsey, University of Auckland, NZ

Bio:  Dr Natasha Grimsey leads the GPCR Molecular Pharmacology lab in the Department of Pharmacology and Clinical Pharmacology at the University of Auckland, NZ.  She holds a Sir Charles Hercus Health Research Fellowship (Health Research Council NZ), is a Principal Investigator of the Centre for Brain Research, and is an Affiliate Investigator of the Maurice Wilkins Centre for Molecular Biodiscovery.  Natasha's research focuses on GPCR signalling and intracellular trafficking, with emphasis on the cannabinoid receptors and how these influence normal physiology and disease.

Abstract: Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as-yet unrealised, therapeutic potential.  Predominantly expressed in the immune system, CB2 is a promising target in a diverse range of disorders.  I will discuss my lab’s current efforts to further our understanding of CB2 molecular pharmacology in a variety of aspects.  In particular, CB2 is observed to be expressed both on the cell surface and intracellularly, and exhibits an unusual trafficking response to orthosteric ligands; we are investigating control of this trafficking, and influences on signalling.

Enquiries: Lindsay Wu  

Event Date: 
Friday, 29 October 2021 - 3:00pm
Online via Microsoft Teams Meeting
Event Type: 
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