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‘Immune responses in children with COVID-19 and other respiratory diseases’

Neuroscience & Non-Communicable Diseases WEBINAR

Speaker: Dr Melanie Neeland, Murdoch Children's Research Institute


Dr Melanie Neeland leads an immunology research program investigating early life immune determinants of allergic, respiratory and autoimmune diseases. Dr Neeland completed her PhD in vaccine immunology at Monash University in 2015. She is a recipient of a Melbourne Children's LifeCourse Fellowship, a Thrasher Research Fund Early Career Award and held a Visiting Fellowship at Stanford University in 2017. Melanie was recently awarded an NHMRC project grant and a Chan Zuckerberg Inflammation grant to continue her work in immune profiling of childhood disease.

Talk Abstract:

Children have mild COVID-19 disease compared to adults. The immunological basis for this difference is unclear and data on the cellular immune response in children with SARS-CoV-2 exposure and infection are limited. Here, we report acute and convalescent innate immune responses of 48 children and 70 adults infected with, or exposed to, SARS-CoV-2. We found that clinically mild SARS-CoV-2 infection in children was characterised by activation of multiple aspects of the innate immune system, a feature not observed in adults with COVID-19.  Both children and adults exposed to SARS-CoV-2 but negative on PCR testing had increased proportions showed changes in their immune responses that persisted up to 7 weeks post exposure. This study describes a role for the innate immune response during SARS-CoV-2 infection in children and provides insights to explain differences in disease severity between children and adults.

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All welcome!

Enquiries: Lindsay Wu  

Event Date: 
Friday, 5 March 2021 - 3:00pm
Online via Microsoft Teams meeting
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