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Human Genetics and Dyslipidemia: From Non-synonymous Variants to Non-coding Variants

Neuroscience & Non-Communicable Diseases WEBINAR Series

Speaker: Professor Yan Wang, College of Life Science, Wuhan University, China. 


Dyslipidemia is a major risk factor for cardiovascular diseases. Genetic evidence suggests that the heritability for dyslipidemia is high, with about 50% of dyslipidemia is caused by genetic risk factors. We are interested in identifying those genetic risk factors and uncovering their pathological and physiological functions and the underline molecular mechanisms, aiming to pave the road for translational research. Our previous studies reviewed the pathological functions of non-synonymous variants in PCSK9, ANGPTL3, ANGPTL8 in dyslipidemia, which have become new generation of therapeutic targets for dyslipidemia. Recently we identified a non-coding variants that upregulates the expression level of an orphan receptor GPR146, who plays critical role in regulating cholesterol hemostasis. GPR146 is the first reported GPCR that directly regulates blood cholesterol levels and holds great promise for treating hypercholesterolemia. In this presentation, I will quickly summarize our previous work in non-synonymous variants in dyslipidemia and then mainly focus on the newly identified orphan receptor GPR146. 

All welcome!

Enquiries: Lindsay Wu,    Vita Birzniece

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Friday, 25 September 2020 - 3:00pm
Online via Microsoft Teams
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