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‘HIF-1 HIF-1 Hooray! Hypoxia inducible-1 (HIF-1) as a target for brain repair after stroke’ - Dr Nicole Jones, School of Medical Sciences, UNSW Sydney

SoMS Neuroscience & Non-Communicable Diseases WEBINAR

Speaker: Dr Nicole Jones, School of Medical Sciences, UNSW Sydney

Nicole Jones is a Senior Lecturer in Pharmacology at UNSW Sydney. She completed a PhD in Pharmacology at Monash University (1998) and Postdoctoral fellowships at Eli Lilly UK and USA (1998-2002) and the Howard Florey Institute (2002-2008).

Hypoxia-inducible factor-1 (HIF-1) is the key transcription factor regulating the expression of many hypoxia-responsive genes. Hypoxia-inducible changes allow the body to adapt to a low oxygen environment. Under normoxia, HIF-1α is degraded due to HIF-1 prolyl hydroxylase enzymes (PHDs) thus, constitutive levels of HIF-1α are low. Previous studies have shown that mild hypoxia and PHD inhibitors can increase HIF-1 and HIF-1 target gene expression in the brain. We have employed this strategy in a model of brain injury in rats to examine whether enhancing HIF-1 can promote brain repair. Our studies have shown that postconditioning with mild hypoxia can protect against endothelin-1 induced stroke in adult rats by reducing the extent of brain damage and promoting functional recovery. Similarly, treatment with two PHD inhibitors can reduce injury and promote recovery after stroke. Our findings indicate that modulation of HIF-1 and its target genes after a stroke is an effective strategy to promote brain repair.

Friday 1st May, 3pm

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Event Date: 
Friday, 1 May 2020 - 3:00pm
Location: 
WEBINAR
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All
Event Type: 
Seminar
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