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Harnessing molecular insights into glutamate receptor activity for neuroscience drug discovery

Neuroscience & Non-Communicable Diseases Seminar Series

Speaker: Dr Karen Gregory, Monash University


Dr Gregory is an Australian Research Council Future Fellow (2017) who co-leads the Endocrine and Neuropharmacology lab at Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences (MIPS). Dr. Gregory is an internationally recognised expert in analytical and molecular pharmacology of G protein-coupled receptors (GPCRs), with a particular focus on promising therapeutic targets for neuropsychiatric and neurological disorders. She returned to Australia in 2013 to establish her independent program at MIPS, following a successful 4-year postdoctoral period under the mentorship of Prof. Jeff Conn at Vanderbilt Center for Neuroscience Drug Discovery in Nashville, TN. 

Dr. Gregory's research focuses on understanding novel paradigms of allosteric drug action at GPCRs such as allosteric and biased pharmacology with the goal of using these insights to facilitate rational drug discovery efforts. To date, she has published 47 original research papers and 10 invited reviews in this area. The overarching goal of her research program is to harness molecular insights into allosteric dug action to elucidate fundamental insights into how glutamate receptor activation modulates brain cell function for therapeutic gain. Her research program probes the functional consequences of allosteric ligand-receptor interactions from the atomic level through to in vitro signalling in native brain cell cultures and efficacy in preclinical models.

Enquiries: Lindsay Wu

Event Date: 
Friday, 24 September 2021 - 3:00pm
Online via Microsoft Teams
Event Type: 
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