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“Disease mechanisms and therapies for neuromuscular disease”.

Neuroscience & Non-Communicable Diseases Seminar Series

Speaker: Professor Robert Bryson-Richardson, Monash University

Biography:

Prof Bryson-Richardson studied Human Genetics at the University of Nottingham before moving to the Medical Research Council’s Human Genetics Unit in Edinburgh to complete his PhD and begin his work using the zebrafish model system to investigate muscle development and disease. He completed his PhD in 2003 and continued his research at the Victor Chang Cardiac Research Institute before moving to the Australian Regenerative Medicine Institute at Monash University in 2009. He joined the School of Biological Sciences at Monash University in 2010 where his lab investigates neuromuscular disease, spanning the spectrum from identification of new disease genes, to determination of the underlying biological mechanism, and subsequently evaluation of potential therapies. His focus is on the identification of clinically translatable findings, aiding in the diagnosis and treatments of these conditions. His team uses the zebrafish model to achieve these goals.

Abstract:

My team determines the biology underlying neuromuscular disease and uses this information to develop therapeutic approaches. To achieve these goals we use the advantages of the zebrafish model. I will present our work investigating the loss of UBA5, which results in epileptic encephalopathy and cerebellar ataxia, and the loss of BAG3 function, resulting in myofibrillar myopathy, and how in each case our improved understanding has suggested potential treatment approaches. I will also present a large-scale drug screen to identify treatments for nemaline myopathy and a new approach to improve the generation of disease models.

Enquiries: Lindsay Wu  lindsay.wu@unsw.edu.au  

Event Date: 
Friday, 5 November 2021 - 3:00pm
Location: 
Online via Microsoft Teams Meeting
Event Type: 
Seminar
Booking deadline: