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Research InterestsDr Shaun Sandow | | (Position Details) | | Phone Please contact School/Unit | | Qualifications BSc (Hons), PhD |
| | | School/Unit |
| School of Medical Sciences | | http://medicalsciences.med.unsw.edu.au/SOMSWeb.nsf/page/home
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| | Broad Research Areas | |
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Physiology
Cardiology and Vascular Disease
Anatomy
Pharmacology
Neuroscience
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| | | | Specific Research Keywords | |
| Vascular Biology
Endothelial Biology
Obesity
Cell Coupling
Electron Microscopy
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| | | | Research Interests | |
| Working with colleagues in Australia, Canada, Britain, the US and Denmark, our studies aim to determine some of the ways that cells in arteries communicate with one another and specifically, at how cells control the balance between the way that arteries narrow (constrict) and enlarge (dilate). This balance is referred to as vascular tone and is the main determinant of blood pressure and thus cardiovascular disease. Coordination of vascular tone is dependent on signals passing through junctions within and between the cellular layers in arteries. Our studies correlate anatomy and function, to identify the fundamental pathways that underlie blood vessel function.
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| | | | ILP Research Interests (Will supervise ILP students) |
| Cardiovascular Diseases
Cardiovascular System
Diabetes Mellitus
Electron Microscopy
Hypertension
Microscopy
Pharmacology
Physiology
Vascular Diseases
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| | | | Project Topics for current Honours Students |
| Arteries consist of two main cell types; endothelial cells and smooth muscle cells. These cells communicate with each other by release of diffusible factors and by direct contact via gap junctions. The latter junctions are referred to as myoendothelial gap junctions, and recent studies show that a variety of ion channels and receptors are found very close to these junctions, implying that they interact as a functional ‘microdomain’.
Studies will use anatomical (confocal microscopy) and functional methods (myography) to examine whether the proteins at myoendothelial gap junction microdomains are altered in vascular disease, such as in obesity, diabetes and hypertension. Attendance at a confocal microscopy course will be required. | |
| | | | Teaching Interests | |
| Broadly ranging from vascular anatomy, physiology and pharmacology, with an emphasis on mechanisms of coordinating cell coupling. | |
| | | | Society Memberships & Professional Activities | |
| Amercian Heart Association.
Australian and New Zealand Microcirculation Society (ANZMS; President, 2008-2009).
Australian Physiological Society (AuPS).
Australian Society of Clinical and Experimental Pharmacology and Toxicology (ASCEPT)
British Pharmacological Society (BPS).
National Association of Research Fellows (NARF).
Occassional referee for;
American Journal of Physiology: Heart and Circulatory Physiology; Autonomic Neuroscience: Basic and Clinical; Arteriosclerosis, Thrombosis and Vascular Biology; British Journal of Pharmacology; Clinical and Experimental Physiology and Pharmacology; Experimental Eye Research; Journal of Anatomy; Journal of Cellular Physiology; Journal of Hypertension; Journal of Pharmacology and Experimental Therapeutics; Journal of Physiology; Journal of Vascular Research; Microcirculation; Microvascular Research; Regulatory Peptides; Stroke.
National Heart Foundation of Australia, National Health and Medical Research Council of Australia, The Wellcome Trust. | |
| | | | Funding Sources | |
| National Heart Foundation of Australia (NHF)
National Health and Medical Research Council of Australia (NHMRC) | |
| | | | Thesis topics for current UNSW Medicine postgraduate research students |
- Calcium dynamics, innervation and regulation of smooth muscle function
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| | | | Key works/Publications | |
| Recent Journal Articles:
Sandow SL & Grayson TH (2009). An issue of isolation and culture: vascular endothelium and BKCa. American Journal of Physiology. 297:H1-7.
Sandow SL Gzik DJ & Lee RMKW (2009). Holes in the internal elastic lamina: what for? Journal of Anatomy. 214:258-266.
Sandow SL, Haddock RE, Hill CE, Chadha P, Kerr PM, Welsh DG & Plane F (2009). What’s where and why at a vascular myoendothelial microdomain signaling complex? Clinical and Experimental Pharmacology and Physiology. 36:67-76.
Smith P, Brett SE, Luykenaar KD, Sandow SL, Marelli SP, Vigmond EJ & Welsh DG (2008). KIR channels function as electrical amplifiers in vascular smooth muscle. Journal of Physiology 586:1147-1160.
Sandow SL & Tare M (2007). CNP - a new EDHF? Trends in Pharmacological Sciences. 28:61-67.
Chen MX, Sandow SL, Doceul V, Chen YH, Harper H, AD & Clare JJ (2007). Cultivation at reduced growth temperature leads to the accumulation of functional human ether-a-go-go related gene (hERG) K+ channels in heterologously expressing cells. BMC Biotechnology 7:93.
Grayson TH, Ohms SJ, Brackenbury TD, Peng KM, Pittelkow YE, Wilson SR, Sandow SL & Hill CE (2007). Vascular microarray profiling in two models of hypertension identifies Cav-1, RGS2 and RGS5 as antihypertensive targets. BMC Genomics. 8:404.
Welsh DG, Tran CH, Plane F, Sandow SL (2007). Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone? American Journal of Physiology 293:H2007.
Sandow SL, Neylon CB, Chen MX & Garland CJ (2006). Spatial separation of endothelial small- and intermediate-conductance calcium-activated potassium channels (KCa) and connexins: possible relationship to vasodilator function? Journal of Anatomy. 209: 689-698.
Haddock RE, Grayson TH, Brackenbury TD, Meaney KR, Neylon CB, Sandow SL & Hill CE (2006). Endothelial coordination of cerebral vasomotion via myoendothelial gap junctions containing connexins37 and 40. American Journal of Physiology 291: H2047-2056.
McNeish AJ, Sandow SL, Neylon CB, Chen, MX, Dora, KA & Garland CJ (2006). Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery. Stroke 37: 1277-1282.
McSherry I, Sandow SL, Campbell WB, Falck R, Hill MA & Dora KA (2006). EDHF-like responses in rat cremaster muscle arterioles involve SKCa and IKCa channels, and Cyp P450 metabolites. Microcirculation 13: 119-130.
Mather S, Dora KA, Sandow SL, Winter P & Garland CJ. (2005) Rapid endothelial cell-selective loading of connexin 40 antibody blocks EDHF dilation in rat small mesenteric arteries. Circulation Research 97: 399-407.
Sandow SL. (2004) Factors, fiction and endothelium-derived hyperpolarizing factor. Clinical and Experimental Pharmacology and Physiology. 31: 563-570.
Sandow SL, Goto K, Rummery NM & Hill CE. (2004) Developmental dependence of EDHF on myoendothelial gap junctions in the saphenous artery of the WKY rat. Journal of Physiology. 556: 875-886.
Sandow SL, Bramich N, Bandi HP, Rummery N & Hill CE. (2003) Structure, function and EDHF in the caudal artery of the SHR and WKY rat. Arteriosclerosis, Thrombosis and Vascular Biology. 23: 822-828.
Sandow SL, Looft-Wilson R, Grayson TH, Segal SS & Hill CE (2003). Expression of homocellular and heterocellular gap junctions in hamster arterioles and feed arteries. Cardiovascular Research. 60: 643-653.
Dora KA, Sandow SL, Ings NT, Takano H, Rummery N, Hill CE & Garland CJ. (2003). Myoendothelial gap junctions provide the pathway for EDHF in mouse mesenteric artery. Journal of Vascular Research. 40: 480-490.
Sandow SL, Tare M, Coleman HC, Hill CE & Parkington HC. (2002) Involvement of myoendothelial gap junctions in the actions of endothelium-derived hyperpolarizing factor. Circulation Research. 90: 1108-1113.
Hill CE, Rummery N, Hickey H. & Sandow SL. (2002) Heterogeneity in the distribution of vascular gap junctions and connexins: implications for function. Clinical and Experimental Pharmacology and Physiology. 29: 620-625.
Book Chapters
1. Sandow SL, Bramich NJ, Bandi HP, Rummery N & Hill CE. (2003). Endothelium-derived hyperpolarizing factor, myoendothelial gap junctions and hypertension. In: EDHF 2002. Vanhoutte PM (ed.). Taylor and Francis Publishers. UK. p. 108-116.
2. Tare M, Sandow SL, Coleman HA, Wigg SJ, Parkington HC & Hill CE. (2003) Myoendothelial gap junctions - the critical link for endothelium-derived hyperpolarizing factor. In: EDHF 2002. Vanhoutte PM (ed.). Taylor and Francis Publishers. UK. p. 223-233. | |
| | | | Further Information | |
| http://medicalsciences.med.unsw.edu.au/SOMSWeb.nsf/page/Microvascular | |
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