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Research InterestsProfessor Margaret J Morris | | (Position Details) | | Phone 02 9385 1560 | | Email | | Qualifications BSc, PhD |
| | | School/Unit |
| School of Medical Sciences | |
| | Broad Research Areas | |
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Obesity
Diabetes
Neuroscience
Pharmacology
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| | | | Specific Research Keywords | |
| Obesity
Epilepsy
Diabetes and Endocrinology
Neuropeptides
Neuropharmacology
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| | | | Research Interests | |
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Obesity - Alterations to brain Neuropeptide Y (NPY) causes increase food intake. Our laboratory is exploring the brain mechanisms involved in appetite. Obesity is a world-wide problem. The brain regulates appetite throught the actions of a complex array of neurotransmitters that either increase or decrease feeding. Professor Morris and her team use animal models of obesity to explore the brain mechanisms involved in appetite, and the changes that occur in these systems during the development of obesity. Their work aims to improve our understanding of how the brain regulates feeding and to provide new insight into potential treatments for obesity and other feeding disorders. Diabetes - The effect of diabetes on how the brain senses hypoglycemia Epilesy - Collaboration with Royal Melbourne Hospital, examining the involvement of NPY on absence seizures. Further work examines the mechanisms by which some anti-epilepy drugs make seizures worse.
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| | | | Teaching Interests | |
| Pharmacology with a focus on neuropharmacology | |
| | | | Society Memberships & Professional Activities | |
| Society for Neuroscience (USA)
Australasian Society for the Study of Obesity
Australian Neuroscience Society
International Society of Hypertension
Australian High Blood Pressure Research Council
Council Member 1999-2004
Australian Society of Clinical and Experimental Pharmacology
Australian Society for Medical Research | |
| | | | Funding Sources | |
| National Health & Medical Research Council
Diabetes Australia Research Trust
Australian Research Council | |
| | | | Key works/Publications | |
| Chen H, Jones JE, Hansen MJ, Vlahos R, Bozinovski,S, Anderson GA & Morris MJ (2006) Cigarette smoke exposure reprograms the hypothalamic neuropeptide Y axis to promote weight loss. American Journal of Respiratory and Critical Care Medicine. 173(11): 1248-1254.
Morris MJ, Velkoska E, Cole TJ. (2005) Central and peripheral contributions to obesity associated hypertension: impact of early overnourishment. Exp. Physiol 90(5):697-702.
Lohman R-J, Liu L, Morris M & O’Brien TJ (2005) Validation of a method for localised microinjection of Drugs into thalamic subregions in rats for pharmacological epilepsy studies. J Neuroscience Methods, 146, 191-197.
Taher TR, Salzberg M, Morris MJ, Rees S, O’Brien TJ. (2005) Chronic low-dose corticosterone supplementation enhances acquired epileptogenesis in the rat amygdala kindling model of TLE. Neuropsychopharmacology 30, 1610-1616
Bedoui S, Velkoska E, Bozinovski S, Jones JE, Anderson GP, Morris MJ. TNF-alpha production by macrophages and monocytes is preserved in diet-induced obesity (2005) J Inflammation (Lond), 2(1):2.
Wallengren C Li S, Morris MJ, Jupp B, O’Brien TJ. Aggravation of absence seizures by carbamazepine in a genetic rat model does not induce neuronal c-Fos activation (2005) Clinical Neuropharmacology, 28, 60-65.
Hansen MJ, Schiöth HB, Morris MJ. Feeding responses to a melanocortin agonist and antagonist in obesity induced by a palatable high-fat diet (2005) Brain Research, 1039, 137-145.
Velkoska E, Cole TJ & Morris MJ. Early dietary intervention: long term effects on blood pressure, brain neuropeptide Y and adiposity markers (2005) Am J Physiology, Endocrinol Metab 288 (6), E1236-E1243
Tan HM, Gundlach A & Morris MJ. Exaggerated feeding response to central galanin-like peptide administration in diet-induced obese rats (2005) Neuropeptides, 39, 333-336.
Stroud S, Jupp, B, Wallengren C, O’Brien T, Morris MJ. Neuropeptide Y suppresses absence seizures in a genetic rat model (2005) Brain Research, 1033, 151-156.
Chen H, Vlahos R, Jones J, Anderson GP & Morris MJ The effect of short term cigarette smoke exposure on body weight, appetite and brain neuropeptide Y in mice (2005) Neuropsychopharmacology 30, 713-719.
Van den Buuse M, Morris M, Chavez C, Martin S, Wang J (2004) Effect of adrenalectomy and corticosterone replacement on prepulse inhibition and locomotor activity in mice. Br J Pharmacol. 142 (3), 543-550.
Lax CJ, Domenighetti AA, Pavia JM, Di Nicolantonio, Curl CL, Morris MJ, Delbridge LMD. Transitory reduction in angiotensin AT2 receptor expression level in post-infarct remodelling in rat myocardium. Clin Exp Pharmacol Physiol (2004) 31 (8), 512-517.
Morris MJ, Tortelli CF, Hart DP, Delbridge LMD. Vascular and brain neuropeptide Y in banded and spontaneously hypertensive rats (2004) Peptides 25 (8), 1313-1319.
Hastings JA, Morris MJ, Lambert G, Lambert E and Esler M. (2004) NPY and NPY Y1 receptor effects on noradrenaline overflow from the rat brain in vitro. Regulatory Peptides 120, 107-112.
Morris MJ and Pavia JM (2004) Increased endogenous noradrenaline and neuropeptide Y release from the hypothalamus of streptozotocin diabetic rats Brain Res 1006 (1), 100-106.
Eikelis N, Lambert G, Wiesner G, Kaye D, Schlaich M, Morris M, Hastings J, Socratous F and Esler M. (2004) Extra-adipocyte leptin release in human obesity and its relation to sympathoadrenal function Am J Physiol Endocrinol Metab 286 (5) E744-752.
Lee J, Albiston AL, Allen AM, Mendelsohn FA, Ping SE, Barrett GL, Murphy M, Morris MJ, McDowall SG, Chai SY (2004) Effect of I.C.V. injection of AT4 receptor ligands, NLE1-angiotensin IV and LVV-hemorphin 7, on spatial learning in rats. Neuroscience 124 (2), 341-349.
Hansen MJ, Jovanovska V and Morris MJ (2004) Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high fat feeding in the rat J Neurochem 88, 909-916.
Morris MJ (2004) Neuropeptide Y and cardiovascular function. In Handbook Exp Pharmacology Vol 162, 327-359. ED: M Michel Springer; Berlin, Germany ISBN 3-540-40581-x
Esler M, Alvarenga M, Lambert G, Kaye D, Hastings J, Jennings G, Morris M, Schwarz R, Richards J. (2004) Cardiac sympathetic nerve biology and brain monoamine turnover in panic disorder. Ann N Y Acad Sci. 1018, 505-514. Review | |
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