Neuromuscular and Regenerative Medicine Unit

About us

The Neuromuscular and Regenerative Medicine Unit (NRMU) is engaged in a range of research activities that span basic mechanisms in cell biology to cell-based therapies to the cellular basis for aspects of human cognition and behaviour. Our disease foci are neuromuscular disorders, regenerative medicine, childhood cancer, cancer metabolic syndrome, and the neurodevelomental disorder William Beurens Syndrome. Our research aims are to understand muscle cytoarchitecture, muscle regeneration and develop stem cell-based therapy, to understand how radiation therapy for childhood cancers impacts the epigenome of muscle stem cells, to analyse anti-cytoarchitecture/anti-cancer drugs, and to understand how one gene, discovered by us, GTF2IRD1, can profoundly affect skeletal muscle and yet also play a role in human cognition and behaviour. Current research projects are:

  • Novel approach and insights into muscle stem cell transplantation
  • The role of transient DNA methylation in muscular adaptation
  • The role of epigenetic modifications in longterm memory of irradiation in cancer survivors
  • Development of anti-tropomyosin drugs, anti-cancer drugs
  • Regulation of cell proliferation by the actin cytoskeleton
  • Regulation of glucose uptake by tropomyosins and myosins
  • Gtf2ird1 and the molecular and cellular basis of human behaviour
  • The genetic control of skin proliferation in the face

 

Team

Collaborators

  • Judy Anderson (Department of Biological Sciences, University of Manitoba, Canada)
  • Marie-Louise Bang (Istituto Tecnologie Biomediche-Consiglio Nazionale delle Ricerche (ITB-CNR), Milan, Italy)
  • Romain Barrès (The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark)
  • Greg Cooney (Diabetes & Obesity Research Program, Garvan Institute of Medical Research, Sydney)
  • Thomas Fath (Neurodegeneration and Repair Laboratory, School of Medical Sciences, UNSW)
  • Julien Gondin (Centre de Résonance Magnétique Biologique et Médicale (CRMBM) UMR CNRS, Marseille, France)
  • Peter Gunning (Oncology Research Unit, School of Medical Sciences, UNSW)
  • Weiping Han (Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, Singapore)
  • Anthony Hannan (Florey Neuroscience Institutes, Melbourne Brain Centre, University of Melbourne)
  • Gary Housley (Translational Neuroscience Facility, School of Medical Sciences, UNSW)
  • Will Hughes (Diabetes & Obesity Research Program, Director Molecular Imaging Facility, Garvan Institute of Medical Research, Sydney)
  • David James (Diabetes & Obesity Research Program, Garvan Institute of Medical Research, Sydney)
  • Julien Ochala (Institutionen för Neurovetenskap, Akademiska Sjukhuset, Uppsala, Sweden)
  • David Sassoon & Giovanna Marazzi(Université de Pierre et Marie Curie-Sorbonne Universités, Paris, France)
  • Shahragim Tajbakhsh (Pasteur Institute, Paris, France)

Grants & Funding

  • NHMRC Project Grant (E Hardeman, P Gunning) Novel approach and insights into muscle stem cell transplantation
  • Association Francaise contre les Myopathies (E Hardeman) Novel therapy for muscular dystrophy
  • NHMRC Project Grant (P Gunning, G Schevzov, E Hardeman) Regulation of cell proliferation by the actin cytoskeleton
  • NHMRC Project Grant (P Gunning, E Hardeman, A Kee) Regulation of glucose uptake by tropomyosin and myosins
  • The Kids Cancer Project (E Hardeman, Anthony Kee) Development of anti-tropomyosin, anti-cancer drugs
  • The Kids' Cancer Project (E Hardeman) The role of epigenetic modifications in longterm memory of irradiation in cancer survivors
  • ARC Discovery Project (R Barres, P Gunning, E Hardeman) The role of transient DNA methylation in muscular adaptation

Students

  • Mark Appaduray (PhD)
  • Nadia Amorim (PhD)
  • Anita Chitsaz (PhD)