Developmental and Regenerative Dermatology
The Developmental and Regenerative Dermatology Unit
The developmental and regenerative dermatology unit studies the genetic processes that govern development, homeostasis and regeneration of the skin in the mouse. Our research aims at understanding the genetic and molecular basis of developmental and human regenerative skin diseases such as skin cancer, which affects 2 out of 3 Australians in their life time.
The lab recently made the pivotal discovery that Yes-associated protein (YAP) functions as a key molecular switch in epidermal stem/progenitor cell proliferation and differentiation (Beverdam et al., JID 2013). We currently investigate the developmental genetic context in which YAP functions to control skin stem/progenitor cells in normal and in disrupted skin biology. We employ genetically manipulated mouse models, human skin samples, advanced imaging technology such as confocal microscopy and whole mouse in vivo imaging, gene and protein expression analyses and whole genome approaches to address her research questions. Our research will open up exciting new avenues for translational research and the development of treatments for human regenerative skin disease.
Dr Annemiek Beverdam
Dr. Annemiek Beverdam is a developmental geneticist with special interest in epidermal development and regeneration in the mouse, and in the genetic basis of human regenerative skin disease. She obtained her PhD in the lab of Dr Frits Meijlink at the Hubrecht Institute in The Netherlands. Subsequently, she performed her postdoctoral research in the labs of Dr Giovanni Levi in Italy, Professor Peter Koopman at the IMB in Brisbane, and Professor Brian Key at UQ. Currently, she is a Lecturer in Anatomy, with a focus on Developmental Biology, and she is the head of the Developmental and Regenerative Dermatology Unit at the CGMU at the School of Medical Sciences at the University of New South Wales. The primary research focus of her lab is the genetic and molecular context in which Yes-associated protein (YAP) functions to control normal epidermal homeostasis, how these processes go awry in regenerative skin diseases such as skin cancer, and to identify avenues to cure these disorders. Her research is part of a larger, long-term and ambitious goal to identify key genes linking stem cell biology to organ size and growth.
Enthusiastic, bright and hard-working undergraduate and postgraduate students and postdocs who are interested in research projects that concern the developmental and regenerative biology of the skin, should contact Dr. Annemiek Beverdam for further information. (A.Beverdam@unsw.edu.au)
Resources & Tools
Refereed research articles:
James G., Key B., Beverdam A. The E3 ubiquitin ligase Mycbp2 genetically interacts with Robo2 to modulate axon guidance in the mouse olfactory system. Brain Structure and Function. Accepted 8 March 2013. Impact Factor: 7.8. (Link to PubMed)
Beverdam A., Claxton C., James G., Harvey KF, Key B. (2012) . YAP controls stem/progenitor cell proliferation in the mouse postnatal epidermis. Journal of Investigative Dermatology, published on line on 29 November 2012. Impact factor 6.3. (Link to PubMed)
Beverdam A, Svingen T, Bagheri-Fam S, McClive P, Sinclair AH, Harley VR, Koopman P. (2010). Protein tyrosine kinase 2 beta (PTK2B), but not focal adhesion kinase (FAK), is expressed in a sexually dimorphic pattern in developing mouse gonads. Dev Dyn. 239: 2735-41. Impact factor 3.0. (Link to PubMed)
Beverdam A., Svingen T., McClive P., Bernard P., Bagheri-Fam S., Robson M., Banan M., Banan M., Harley V., Sinclair A., and Koopman P. (2009). Gstm6 is a Sox9-responsive gene expressed in Sertoli cells during testis development in mice. Reproduction, 137: 481-486. Impact factor 3.4 (Link to PubMed)
Svingen T., Beverdam A., Bernard P., McClive P., Harley V.R., Sinclair A.H., and Koopman, P. (2007) Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation. Reproduction, 133: 983-9. Impact Factor: 3.4. (Link to PubMed)
Little M.H., Brennan J., Georgas K., Davies J.A., Davidson D.R., Baldock R.A., Beverdam A., et al., (2007) A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expression Patterns, 7, 680-699. Impact Factor: 2.2. (Link to PubMed)
Svingen T., Beverdam A., Verma P., Wilhelm D., and Koopman. P. (2007). Aard is specifically up-regulated in Sertoli cells of the fetal and adult mouse testis. Int. J. Dev. Biol. 51, 255-258. Impact Factor: 3.0. (Link to PubMed)
Beverdam A., and Koopman P. (2006). Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes, Hum Mol Genet. 15: 417-431. Impact Factor: 8.1. (Link to PubMed)
Levi G, Mantero S., Barbieri O., Cantatore D., Paleari L., Beverdam A., Genova F., Robert B., and Merlo G.R. (2006). Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation. Mech Dev. 123: 3-16. Impact Factor: 3.5. (Link to PubMed)
Wilhelm D., Martinson F., Bradford S., Wilson M.J., Combes A.N., Beverdam A., Bowles J., Mizusaki H., and Koopman P. (2005). Sertoli cell differentiation is induced both cell-autonomously and throaugh prostaglandin signaling during mammalian sex determination. Dev Biol. 287: 111-124. Impact Factor: 4.4. (Link to PubMed)
Kuijper S., Beverdam A., Kroon C., Brouwer A., Candille S., Barsh G. and Meijlink F. (2005). Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes. Development 132:1601-1610. Impact Factor: 7.6. (Link to PubMed)
Loffler K. A., Combes A.N., Wilhelm D., Beverdam A., Bowles J. and Koopman P. (2005). Pisrt1, a gene implicated in XX sex reversal, is expressed in gonads of both sexes during mouse development. Mol Genet Metab. 86: 286-292. Impact Factor: 2.6. (Link to PubMed)
Beverdam A., Wilhelm D. and Koopman P. (2003). Molecular characterization of three gonad cell lines. Cytogenet and Genome Res 101: 242-249. Impact Factor: 2.4. (Link to PubMed)
Beverdam A., Merlo G.R., Paleari L., Mantero S., Genova F., Barbieri O., Janvier P. and Levi G. (2002). Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation. Mirror of the past? Genesis 34: 221-227. Impact Factor: 2.5. (Link to PubMed)
Merlo G., Paleari L., Genova F., Mantero S., Beverdam A., Palmisano G.L., Barbieri O. and Levi G. (2002). A mouse model of Split Hand/Foot Malformation Type I. Genesis 33: 97-101. Impact Factor: 2.5. (Link to PubMed)
Beverdam A., Brouwer A., Reijnen M., Korving J. and Meijlink F. (2001). Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice. Development 128, 3975-3986. Impact Factor: 7.6. (Link to PubMed)
Beverdam A. and Meijlink F. (2001). Expression patterns of group-I aristaless-related genes during craniofacial and limb development. Mech. Dev. 107, 163-167. Impact Factor: 3.2. (Link to PubMed)
Meijlink F., Beverdam A., Brouwer A., Oosterveen T.C. and Ten Berge D. (1999). Vertebrate aristaless-related genes. Int. J. Dev. Biol. 43, 651-663. Impact Factor: 2.8. (Link to PubMed)
Books and book chapters:
Merlo G.R., Beverdam A. and Levi G. (2003) Murine Homeobox gene control of embryonic patterning and organogenesis. “Advances in Developmental Biology and Biochemistry”. Chapter 4 (T. Lufkin, ed) Adv. Develop. Biol. Biochem. 13: 107-132.
Beverdam A. (2001). Functions of Alx3, Alx4 and Cart1 during craniofacial development in the mouse. Doctoral thesis.