The primary research focus of the lab is on the regulation of the cytoskeleton in injury and diseases of the central nervous system, including brain trauma, Alzheimer's Disease and motor neuron disease. For this, we employ cell and tissue cultures and genetically modified mice, combined with advanced imaging technologies. Recent outcome from our work demonstrates that distinct isoforms of the tropomyosin protein family regulate early processes of neuronal morphogenesis and that these proteins are key regulators of the cellular architecture in sub-cellular compartments of neuronal cells such as the growth cones of extending neurites in the developing and synaptic connections in the mature nervous system. Our research team investigates the actin cytoskeleton as potential drug target to provide protection and promote regeneration in the injured or diseased nervous system.
For current PhD project opportunities and scholarships:
Visit: http://www.2025.unsw.edu.au/apply => UNSW Scientia PhD Scholarship and select 'Mindgardens - Molecular Neuroscience' as Strategic Area; Project: 'Manipulation of the synaptic actin cytoskeleton as novel therapeutic approach'
Broad Research Areas:
Neuroscience, Neurodegenerative Diseases, Motor Neuron Disease, Cell Biology and Gene Regulation, Disease Modelling, Injury
Society Memberships & Professional Activities:
American Society for Cell Biology, Society for Neuroscience, Australasian Neuroscience Society, Australian and New Zealand Society for Cell and Developmental Biology
Specific Research Keywords:
Cytoskeleton, Central nervous system disease injury and repair, Cell Biology, Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Neurodevelopment