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Research InterestsDr Trudie Binder | | (Position Details) | | Phone Please contact School/Unit | | Qualifications BSc (Hons) (USyd), PhD (UNSW) |
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| School of Medical Sciences | |
| | Broad Research Areas | |
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Pharmacology
Inflammation
Pain
Arthritis / Rheumatology
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| | | | Specific Research Keywords | |
| Opioids
New Therapeutic Strategies
Pain Research
Inflammation
Rheumatoid Arthritis
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| | | | Research Interests | |
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Therapy for inflammatory arthritis, in particular opioid analgesics and bisphosphonates. Rheumatoid arthritis a chronic inflammatory autoimmune disorder, with a world wide distribution and is associated with significant pain and disability. Models of arthritis are used to investigate the immunopharmacological mechanisms by which opioids and bisphosphonates mediate their anti-arthritic actions and the therapeutic potential of combinational therapy.
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| | | | Teaching Interests | |
| Pharmacology, with a focus on opioids, anti-inflammatory drugs, drugs of addiction and the therapeutic application of pharmacology to treat disease. Course co-ordination: Introductory Pharmacology. | |
| | | | Key works/Publications | |
| Zollner, C., Mousa, S.A., Fischer, O., Rittner, H.L., Shaqura, M., Brack, A., Shakibaei, M., Binder, W., Urban, F., Stein, C., Schäfer, M (2008). Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain. J Clin Invest., 118, 1065–73.
Binder, W., Mousa, S.A., Sitte, N., Kaiser, M., Stein C.& Schäfer, M. (2004). Sympathetic activation triggers endogenous opioid release and analgesia within peripheral inflamed tissue. Eur. J. Neurosci., 20, 92-100.
Binder, W., Machelska, H., Mousa, S., Schmitt, T., Riviere, P.J.M., Junien, J.L., Stein, C. & Schäfer, M. (2001). Analgesic and anti-inflammatory effects of two novel kappa opioid peptides. Anesthesiology, 94, 1034-1044.
Binder, W., Carmody, J. & Walker, J. (2000). Effect of Gender on Anti-inflammatory and Analgesic Actions of Two k-Opioids. JPET., 292, 303-309.
Binder, W., Scott, C. & Walker, J.S. (1999). Involvement of substance P in the anti-inflammatory effects of the peripherally selective k-opioid asimadoline and the NK1 antagonist GR205171. Eur. J. Neurosci., 11, 2065-2072.
Binder, W. & Walker, J.S. (1998). The peripherally selective kappa-opioid agonist, asimadoline, attenuates adjuvant arthritis. Br. J. Pharmacol., 124, 647-654. | |
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