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| Professor Ken Ashwell
School of Medical Sciences - Department of AnatomyStatement of Interests:
Comparative and Evolutionary Neuroscience. Comparative neuroanatomy of marsupials and monotremes. Brain evolution among marsupials, monotremes and ratites. Sexual dimorphism in the brains of marsupials. Developmental Neuroscience.
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| Emeritus Professor Peter Barry
School of Medical Sciences - Department of PhysiologyStatement of Interests:
These include investigating the relationship between the molecular structure and the physiological function of channels such as those of the inhibitory neurotransmitter receptor glycine and the olfactory cyclic nucleotide-gated channel, investigating the factors that determine their ion selectivity and conductance, together with the mechanisms underlying olfactory transduction and the role different ionic channels in that phenomenon. Other interests include evaluating errors arising from liquid junction potentials in membrane potential measurements (with the development of a software program, JPCalc, to do that; see http://www.med.unsw.edu.au/PHBSoft) and the role of unstirred-layers in biological phenomena
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| Dr Benjamin Barry
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
The broad aim of my research is to understand the physiology of the nervous system involved in the control of movement, and to determine how this system changes with ageing, injury and disease.
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| Associate Professor Paul Bertrand
School of Medical SciencesStatement of Interests:
The goal of my research is to understand the neuronal basis of disease with an emphasis on the compounds ATP & serotonin (5‑HT) and the roles they play in neurotransmission & sensory transduction. My laboratory focuses on the neurophysiology of the gastrointestinal tract using electrophysiological and electrochemical methods.
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| Dr Rebecca Bertrand
School of Medical SciencesStatement of Interests:
The gastrointestinal tract turns out to be quite a complicated organ. You might think it's just absorb this and poop that, but how does that really happen? A lot of it is controlled by a massive network of neurons located within the gut (called the enteric nervous system) - that's right, the brain isn't the only place where a whole bunch of neurons live. We investigate how this network of neurons manages to control the workings of the intestine without any help from the brain. We record from individual neurons (intracellular electrophysiology) to see how they communicate with their neighbours and how the neighbours talk to them (synaptic transmission). We also look at it from the whole organ level.
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| Professor Elizabeth Burcher
School of Medical Sciences - Department of PharmacologyStatement of Interests:
a) neurochemicals in human intestine: alterations in disease. b) neurochemicals in the human bladder: relevance to urinary incontinence. c) urothelium of the pig bladder as a model for human bladder studies.
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| Associate Professor Pascal Carrive
School of Medical Sciences - Department of AnatomyStatement of Interests:
My main research interests are in the field of neuroscience and in the neural substrate of emotions. More specifically, my research investigates the neural network responsible for the autonomic, particularly cardiovascular and thermogenic changes associated with psychological stress (anxiety, fear).
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| Dr Hui Chen
School of Medical Sciences - Department of PharmacologyStatement of Interests:
The effects of maternal nutrition interventions on appetite, body weight, hormones (plasma leptin, insulin), lipids, and brain peptide expression invovled in appetite and glucose metabolism in offspring are of interest. A palatable high fat diet (32% fat) is being used to induce maternal obesity. This approach will be used to address the possibility of preventing childhood obesity by drugs and behaviour interventions. A second area of study deals with the effects of cigarette smoking on appetite, body weight, plasma leptin, and hypothalamic peptides expression to address wasting diseases.
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| Dr Thomas Fath
School of Medical SciencesStatement of Interests:
The primary research focus of the lab is on the regulation of the cytoskeleton in neurodegenerative diseases such as Alzheimer's Disease with a particular interest in the microfilament system. For this we employ cell and tissue cultures, prepared from genetically modified mice which express altered levels of the actin dynamics-regulating protein tropomyosin. Other projects in the lab focus on the role of the cytoskeleton in early neuronal development. Recent outcome of these projects demonstrate that tropomyosin isoforms regulate early processes such as neurite formation in an isoform-specific manner.
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| Dr Catherine Gorrie
School of Medical Sciences - Department of AnatomyStatement of Interests:
Repair of the injured spinal cord, investigating both neuroprotective mechanisms to limit tissue damage, and repair strategies to encourage the re-growth of new axons. Two different platforms are currently being trialled, using a) cell transplants and b) a mimetic peptide approach. These target the acute and chronic stages of spinal cord injury. The overall aim is to improve locomotion and demonstrate cellular repair of spinal tissue.
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| Dr Ross Grant
School of Medical Sciences - Department of PharmacologyStatement of Interests:
1) Investigation of the role of oxidative stress and NAD metabolism on brain cell death and cellular degeneration.
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| Dr Craig Hardman
School of Medical Sciences - Department of AnatomyStatement of Interests:
In the fields of neuropathology and neurodegeneration, research vocuses on quantitative comparisons across Parkinsonian disorders (e.g. Parkinson's disease and progressive supranuclear palsy). Other areas of interest include comparative neuroanatomy with special interest in quantitative comparison of neuronal populations across primate species and the production of stereotaixc and quantitative atlases of various mammalian brains.
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| Dr Mark Hill
School of Medical Sciences - Department of AnatomyStatement of Interests:
My current research in the Cell Biology Laboratory is looking at the skeleton within each cell and the biological mechanisms use to change and regulate shape. The description of these mechanisms leads to a better understanding of, and perhaps influence on, these changes occurring in disease, development and during cell repair. Analysis in the School employs the powerful tools of molecular biology, tissue culture and image analysis techniques.
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| Professor Gary Housley
School of Medical Sciences - Department of PhysiologyStatement of Interests:
Noise and age-related hearing loss is the most prominent sensory disability in society. Research based in the newly established Translational Neuroscience Facility in the School of Medical Sciences is extending fundamental research on the cellular and molecular processes of cochlear homeostasis to investigate novel ways to preserve hearing. The work focuses on both peripheral sensory and central brain function.
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| Dr Nicole Jones
School of Medical Sciences - Department of PharmacologyStatement of Interests:
The broad research focus of the lab is to examine cellular and molecular mechanisms that may cause or prevent brain cell death resulting from an acute brain injury (ie perinatal asphyxia, stroke, trauma). Drugs with neuroprotective potential are routinely investigated in cell lines, brain tissue cultures and in vivo rat injury models as part of a search for new therapeutic strategies for acute brain injuries. Because tissue hypoxia often occurs after a brain insult, we are interested in learning how hypoxia-inducible proteins (hypoxia-inducible factor-1 (HIF-1), erythropoietin, vascular endothelial growth factor, glucose transporters) are involved in injury and repair processes of the brain.
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| Dr Arun Krishnan
School of Medical SciencesStatement of Interests:
My major area of interest is in the area of clinical neurophysiology, particularly in the use of nerve excitability techniques as a means of investigating the pathophysiology of neuropathic processes. Measurements of excitability are cutting-edge techniques that provide information related to the activity of a variety of ion channels, energy-dependent pumps and ion exchange processes activated during impulse conduction. These are novel techniques which our group has applied to the study of mechanisms underlying the development of neuropathy and nerve injury. Specifically, we have applied these techniques to the study of metabolic and toxic neuropathies including those that occur secondary to diabetes, end-stage kidney disease (ESKD) and chemotherapy. Other studies have explored the responses of nerves to ischaemia, natural activity and altered electrolyte balance. Recently, excitability techniques have been applied to the assessment of cortical excitability using transcranial magnetic stimulation and we propose to apply these techniques to the study of neurodegenerative processes and central channelopathies.
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| Dr Michael Lee
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
The broad aim of my research is to provide useful information regarding the adaptability of the human motor system and the nature of neural adaptation in response to exercise and motor learning. Other research interests include the mechanism of chronic pain, effects of pain on the control of movements and neurophysiological effects of various manual therapies commonly used in rehabilitation medicine, physiotherapy and chiropractic.
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| Dr Trevor Lewis
School of Medical Sciences - Department of PhysiologyStatement of Interests:
Ligand-gated ion channels are one of the fundamental building blocks for a functioning nervous system. They are responsible for the fast transmission of signals between nerve cells at specialised junctions called synapses. Research is undertaken on the human glycine receptor as a model system of ligand-gated channels in general. The overall aim is to relate the functional characteristics of the glycine receptor to what is know about its protein structure. Two strands are currently being investigated. The first is the conformational changes that follow ligand binding to allow the ion channel pore to open. This is concentrating particularly on the interface between the transmembrane domain and the extracellular domain of the receptor. The second strand is the relationship between the structure of the ion channel pore and what characteristics determine the ability to select for anions in preference to cations.
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| Dr Cindy Lin
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
Clinical application of nerve excitability testing Measuring multiple excitability properties of large human motor and sensory axons using threshold tracking techniques and software (QTRAC © Institute of Neurology), provide information about human axons that is different from, and complementary to, conventional nerve conduction studies. For example, excitability measures are much more sensitive to changes in resting membrane potential than measurements of conduction velocity. These methods are being applied to a range of conditions affecting human peripheral nerves, in order to help determine the pathophysiology of the neuropathy, or to improve diagnosis. Neuropathies currently under investigation include those associated with diabetes, uraemia and other metabolic disorders, and those associated with the chemotherapy in cancers.
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| Dr Lu Liu
School of Medical Sciences - Department of PharmacologyStatement of Interests:
Neurochemicals and receptors in regulation of gut function
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| Dr Gila Moalem-Taylor
School of Medical Sciences - Department of AnatomyStatement of Interests:
Damage to the nervous system is often associated with chronic neuropathic pain symptoms including spontaneous pain, increased sensitivity to painful stimuli (hyperalgesia), and pain perceived in response to normally non-painful stimuli (allodynia). Such pain is extremely debilitating and difficult to treat. My current research focuses on the mechanisms underlying neuropathic pain, with particular emphasis on how immune cells and inflammatory mediators influence chronic pain following peripheral nerve injury or autoimmune inflammation in the nervous system.
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| Dr Andrew Moorhouse
School of Medical Sciences - Department of PhysiologyStatement of Interests:
My main research area is glycine receptors; how their molecular structure relates to their function; their physiological roles at synapses and investigating novel modulators. I also research additional aspects of synaptic transmission and ion channels.
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| Dr Renee Morris
School of Medical SciencesStatement of Interests:
After an injury, the adult spinal cord fails to regenerate and damage at cervical levels are particularly devastating as they may result in quadriplegia. However, there is now evidence that the delivery of neurotrophins to the injured spinal cord can elicit axonal growth and regenerative sprouting. One aspect of my research is to use adenoviral vectors to up-regulate levels of neurotrophins into spinal cord motor neurones in an animal model of spinal cord injury. It is hypothesised that this gene therapy scenario will assist the recovery of motor control.
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| ![Show details for [<FONT SIZE=2 FACE="Verdana"><b>]Professor Margaret J Morris[</b><br>    <i>School of Medical](/icons/expand.gif) Professor Margaret J Morris
School of Medical Sciences - Department of PharmacologyStatement of Interests:
Obesity - Alterations to brain Neuropeptide Y (NPY) causes increase food intake. Our laboratory is exploring the brain mechanisms involved in appetite. Obesity is a world-wide problem. The brain regulates appetite throught the actions of a complex array of neurotransmitters that either increase or decrease feeding. Professor Morris and her team use animal models of obesity to explore the brain mechanisms involved in appetite, and the changes that occur in these systems during the development of obesity. Their work aims to improve our understanding of how the brain regulates feeding and to provide new insight into potential treatments for obesity and other feeding disorders. Diabetes - The effect of diabetes on how the brain senses hypoglycemia Epilesy - Collaboration with Royal Melbourne Hospital, examining the involvement of NPY on absence seizures. Further work examines the mechanisms by which some anti-epilepy drugs make seizures worse.
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| Dr Peregrine Osborne
School of Medical Sciences - Department of PhysiologyStatement of Interests:
I am conjoint member of staff based The Pain Management Research Institute at the Royal North Shore Hospital. I collaborate with neuroscientists and clinicians on research projects that aim to understand the neurobiology of processes that cause or alleviate human pain states. A wide range of approaches are used in this work including: molecular biology, neuroanatomy, electrophysiology, behavioural testing and psychological studies, plus fMRI and other clinical methods. My own research uses animal models to study the neurobiology of pain; pharmacology of analgesic drugs; central neuropathic pain and spinal cord injury pain; and visceral pain.
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| Dr Shaun Sandow
School of Medical Sciences - Department of PharmacologyStatement of Interests:
Working with colleagues in Australia, Canada, Britain, the US and Denmark, our studies aim to determine some of the ways that cells in arteries communicate with one another and specifically, at how cells control the balance between the way that arteries narrow (constrict) and enlarge (dilate). This balance is referred to as vascular tone and is the main determinant of blood pressure and thus cardiovascular disease. Coordination of vascular tone is dependent on signals passing through junctions within and between the cellular layers in arteries. Our studies correlate anatomy and function, to identify the fundamental pathways that underlie blood vessel function.
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| Dr George Smythe
School of Medical Sciences - Department of PhysiologyStatement of Interests:
Neurodegenerative diseases of aging such as Alzheimer's Disease are associated with oxidative and free radical-induced damage to DNA, proteins, and energy metabolism in the CNS, Of particular interest are diagnostic markers of this damage and the role of anti-oxidants, radical scavengers and metal chelators in attenuating the damage. Collaborative work with neuroscientists at St Vincent's and Prince of Wales Hospitals and Monash University is investigating Alzheimer's and other demeting diseases, Other collaborations with neuroscientists in the UK is investigating malaria-induced brain dysfunction.
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| Mr Timothy South
School of Medical SciencesStatement of Interests:
In the field of neuroscience, I examine the effects of palatable feeding on the development of obesity and any subsequent changes on the brain and behaviour.
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| Ms Daina Sturnieks
School of Medical SciencesStatement of Interests:
Research interests include studies to understand human balance and walking, including sensory and motor contributions, as well as falls-related research in elderly populations.
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| Emeritus Professor David Tracey
School of Medical Sciences - Department of AnatomyStatement of Interests:
My research is in the processes which underlie neuropathic pain. It is based on the hypothesis that inflammatory mechanisms contribute to the pain arising from nerve damage. The research is centred on the types of cells which are likely to be involved (eg mast cells, neutrophils and macrophages) and the chemical mediators which may be responsible (eg serotonin, nerve growth factor, prostaglandins).
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| Dr Daniel Vianna
School of Medical Sciences - Department of AnatomyStatement of Interests:
I am interested in the brain circuits involved in psychological stress, their interface with the circuits which influence the autonomic nervous system, and their consequences regarding human health. When a person is emotionally upset, their hearts beat faster, their blood pressure rises, and this can potentially lead to clinically relevant consequences, such as triggering myocardial infarction. My research focuses on how those emotions lead to changes in autonomic responses, how could we block it centrally through pharmacological means, and where in the nervous system these drugs act.
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| Dr Richard Vickery
School of Medical Sciences - Department of PhysiologyStatement of Interests:
My broad aim is to understand the neural mechanisms that give rise to sensory perception. In collaboration with colleagues at UWS I work on the integration of binocular information in extrastriate visual cortex, and on somatosensory system. Pharmacological and electrophysiological techniques are employed to study synaptic influences on single neurons. Psychophysical and behavioural studies are carried out to look at integration.
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| Emeritus Professor Phil Waite
School of Medical Sciences - Department of AnatomyStatement of Interests:
Each year in Australia approximately 300 people suffer a traumatic spinal cord injury. As there is currently no cure, people are left with a lifetime of disability and dependence. Research in our lab focuses on potential cellular therapies to repair the cord. We are trialing olfactory ensheathing cells in rats, testing for improvements in locomotion, thermal and cardiovascular functions, and assessing pain. In parallel with this, we are working with clinicians and spinal patients at Royal North Shore Hospital to improve assessment techniques in preparation for clinical trials. [For further information see <a href="http://niru.med.unsw.edu.au" target="_blank"> http://niru.med.unsw.edu.au</a> <a href="../page/resinterestsshowperson?OpenDocument&StaffID=8700055"><br>More... </a><br><br></font>] | |
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