Browse Research Interests

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Hide details for [<a name="Neurodegenerative Diseases"></a><A HREF="../page/Research%20Interests%20Listing?OpenDocument&start=1 Neurodegenerative Diseases
Dr Thomas Fath
    School of Medical Sciences
    Statement of Interests:

    The primary research focus of the lab is on the regulation of the cytoskeleton in neurodegenerative diseases such as Alzheimer's Disease with a particular interest in the microfilament system. For this we employ cell and tissue cultures, prepared from genetically modified mice which express altered levels of the actin dynamics-regulating protein tropomyosin. Other projects in the lab focus on the role of the cytoskeleton in early neuronal development. Recent outcome of these projects demonstrate that tropomyosin isoforms regulate early processes such as neurite formation in an isoform-specific manner.
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Dr Craig Hardman
    School of Medical Sciences - Department of Anatomy
    Statement of Interests:

    In the fields of neuropathology and neurodegeneration, research vocuses on quantitative comparisons across Parkinsonian disorders (e.g. Parkinson's disease and progressive supranuclear palsy). Other areas of interest include comparative neuroanatomy with special interest in quantitative comparison of neuronal populations across primate species and the production of stereotaixc and quantitative atlases of various mammalian brains.
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Dr Yue Huang
    School of Medical Sciences
    Statement of Interests:

    Current research is focus on Parkinson’s disease and related disorders, with a particular interest in molecular biomarkers for clinical diagnosis and prognosis of Parkinson’s disease and early detection of dementia syndrome; cross cultural comparison on epidemiological, clinical and pathological features of the disorders; as well as human brain tissue analysis on the formation and maturation of disease characteristic pathological lesions (Lewy bodies of Parkinson’s disease, glial cytoplasmic inclusions of multiple system atrophy and coil bodies of progressive supranuclear palsy).
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Dr Cindy Lin
    School of Medical Sciences - Exercise Physiology Program
    Statement of Interests:

    Clinical application of nerve excitability testing Measuring multiple excitability properties of large human motor and sensory axons using threshold tracking techniques and software (QTRAC © Institute of Neurology), provide information about human axons that is different from, and complementary to, conventional nerve conduction studies. For example, excitability measures are much more sensitive to changes in resting membrane potential than measurements of conduction velocity. These methods are being applied to a range of conditions affecting human peripheral nerves, in order to help determine the pathophysiology of the neuropathy, or to improve diagnosis. Neuropathies currently under investigation include those associated with diabetes, uraemia and other metabolic disorders, and those associated with the chemotherapy in cancers.
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