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Browse Research Interests
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| Dr Romain Barres
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
Type 2 diabetes (T2DM) remains a complex and multifaceted disease, the exact causes of which have yet to be resolved. While genetic predisposition can contribute to the development of T2DM, diet and physical activity can also have a positive impact on insulin sensitivity. Epigenetic modifications provide a mechanism by which external environmental factors such as exercise and diet can modify genetic predisposition for health and disease. My research activity is focused on the mechanisms underlying metabolic disorders with particular attention on human skeletal muscle. We identified that changes in the metabolic environment could lead to a dynamic epigenetic modulation of genes that have been implicated in the control of insulin sensitivity and the development of T2DM and related metabolic disorders.
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| ![Show details for [<FONT SIZE=2 FACE="Verdana"><b>]Associate Professor Steve Boutcher[</b><br>    <i>School of M](/icons/expand.gif) Associate Professor Steve Boutcher
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
We are interested in examining the ability of exercise and diet to decrease body fat and to normalize metabolic syndrome factors such as insulin and inflammation. For example, we have shown that high intensity intermittent sprinting exercise (LifeSprints), compared to steady-state exercise, results in significant fat loss in women. We have also shown that LifeSprints reduces fasting insulin levels to a greater extent compared to steady state exercise. We are currently attempting to find out what mechanisms (e.g., EPOC, satiety hormones) underlie these LifeSprint-induced effects. An ongoing RCT called the FEM trial is examining the effect of fish oils (F), LifeSprint exercise (E), and a Mediterranean eating plan (M) on fat loss and metabolic markers in overweight women. We are also carrying out studies examining the fat oxidation and vascular effects of bioactive agents such as green tea. We are also interested in the effect of exercise and reactivity on health. Reactivity, which is typically measured by assessing autonomic and metabolic response, relates to how the body responds to psychological and physical challenge. For, example, research has shown that people at risk for hypertension and heart disease display exaggerated autonomic reactivity to psychological challenge. Ongoing studies are examining how these abnormal autonomic responses lead to vascular problems and hypertension. Impedance (cardiac output, cardiac contractility), beat-by-beat blood pressure, occlusion muscle blood flow, vascular resistance), baroreceptor sensitivity (body and neck chambers), vagal sensitivity, pulse wave analysis (arterial stiffness), metabolic cart (O2 uptake), and blood variables (e.g., catecholamines, glycerol, insulin, lactate, hemoglobin, HbA1c) are used in human subjects.
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| Dr Hui Chen
School of Medical Sciences - Department of PharmacologyStatement of Interests:
The effects of maternal nutrition interventions on appetite, body weight, hormones (plasma leptin, insulin), lipids, and brain peptide expression invovled in appetite and glucose metabolism in offspring are of interest. A palatable high fat diet (32% fat) is being used to induce maternal obesity. This approach will be used to address the possibility of preventing childhood obesity by drugs and behaviour interventions. A second area of study deals with the effects of cigarette smoking on appetite, body weight, plasma leptin, and hypothalamic peptides expression to address wasting diseases.
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| Dr Anthony Kee
School of Medical Sciences - Department of AnatomyStatement of Interests:
Interests are in the fields of muscle physiology and cell biology. Particularly interested in aspects of novel structural and cytoskeletal proteins and complexes and their involvement in normal muscle physiology and disease processes. Diseases of interest include muscular dystrophy and other congenital myopathies, diabetes and obesity. Have an interest in treatment of muscle diseases, including exercise.
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| Dr David Simar
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
My research interests are mainly focused on the characterisation of metabolic dysfunctions in the immune system and skeletal muscles as well as the critical role played by inflammation in the development of those alterations in metabolic and immune conditions.
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