 | | |
|---|
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
| Dr Trudie Binder
School of Medical Sciences - Department of PharmacologyStatement of Interests:
Therapy for inflammatory arthritis, in particular opioid analgesics and bisphosphonates. Rheumatoid arthritis a chronic inflammatory autoimmune disorder, with a world wide distribution and is associated with significant pain and disability. Models of arthritis are used to investigate the immunopharmacological mechanisms by which opioids and bisphosphonates mediate their anti-arthritic actions and the therapeutic potential of combinational therapy.
More...
| |
| Dr Nick Di Girolamo
School of Medical Sciences - Department of PathologyStatement of Interests:
Our current research program focuses on understanding how excessive solar ultraviolet radiation triggers diseases of the eye including pterygia, tumours of the limbus and conjunctiva, and how specific enzymes called the matrix metalloproteinases (MMPs) contribute to the development of such lesions in man. These studies utilize cell culture models and fresh human tissue specimens. The second arm of our research program focuses on identifying, isolating and cultivating human fetal and adult corneal stem cells to help us understand how the ocular surface is replenished under normal physiological conditions and following trauma and to devise alternative transplantation strategies to treat patients with corneal stem cell deficiencies. The third arm of our research program focuses on associations of single nucleotide polymorphisms in MMP genes with common epithelial tumours such as colorectal, prostate, and breast. We have recently identified one such polymorphism in the collahenase-1 (MMP-1) gene promoter as a potential prognostic indicator in patients with colorectal carcinoma.
More...
| |
| Dr Ross Grant
School of Medical Sciences - Department of PharmacologyStatement of Interests:
1) Investigation of the role of oxidative stress and NAD metabolism on brain cell death and cellular degeneration.
More...
| |
| Dr Cristan Herbert
School of Medical Sciences - Department of PathologyStatement of Interests:
Asthma and in vivo models of the disease. Specific interest in the role of Th17 cell cytokines in the development of airway wall remodelling. Also interested in the effect of novel drug treatments on asthmatic lesions.
More...
| |
| Professor Rakesh Kumar
School of Medical Sciences - Department of PathologyStatement of Interests:
In vivo and in vitro models of the cellular biology and immunopathology of respiratory disease. Major focus is the role of cytokines and growth factors in the pathogenesis of chronic asthma and acute exacerbations, using novel experimental models in mice. Ongoing collaborations with colleagues at the University of Newcastle/Australian National University, using gene-targeted mice and drug/antibody treatments to study the contribution of specific cytokines to inflammation, remodelling and airway hyper-reactivity; and the influence of early-life infections on the severity of chronic disease and susceptibility to acute exacerbations. Expertise in morphometry and immunohistochemistry has led to involvement in various other collaborative projects e.g. related to pancreatic disease and hepatitis.
More...
| |
| Dr John Langlands
School of Medical Sciences - Drug Development Unit | |
| Professor Andrew Lloyd
School of Medical Sciences - Department of PathologyStatement of Interests:
The goal of the research groups which are led by Professor Lloyd is to understand the cellular and molecular basis of inflammatory processes in human infectious diseases. In particular, Professor Lloyd's research groups are seeking to define the role of cytokines, notably the chemoattractant cytokines (chemokines) in regulation of lymphocyte trafficking. The groups are focussed on studies of the pathogenesis of hepatitis C infection, and the characteristics of the host response to other infections includi ng Epstein-Barr virus, Ross River virus and Coxiella burnetii - the causative agent of Q fever. The scope of the research extends from laboratory studies of the basic biology of genes relevant to disease pathogenesis through to clinical and epidemiological studies in humans. The research includes cellular and molecular immunology techniques, and includes in vitro as well as in vivo studies in animal models of disease
More...
| |
| Dr Gila Moalem-Taylor
School of Medical Sciences - Department of AnatomyStatement of Interests:
Damage to the nervous system is often associated with chronic neuropathic pain symptoms including spontaneous pain, increased sensitivity to painful stimuli (hyperalgesia), and pain perceived in response to normally non-painful stimuli (allodynia). Such pain is extremely debilitating and difficult to treat. My current research focuses on the mechanisms underlying neuropathic pain, with particular emphasis on how immune cells and inflammatory mediators influence chronic pain following peripheral nerve injury or autoimmune inflammation in the nervous system.
More...
| |
| Ms Nalini Pather
School of Medical SciencesStatement of Interests:
In the field of medical education, collaborative work with collegues as Macquarie University and in South Africa and the USA is concerned with curriculum design and assessment. In the field of cell biology, collaborative work with colleagues in South Africa relates to wound healing and the role of keratinocyte and fibrocyte cell migration. In the field of tissue regeneration, collaborative work at the University of New South Wales focusses on the role of angiogenesis on muscle regeneration and stem cell therapy. In the field of clinical anatomy, collaborative work with clinicians in South Africa and USA is concerned anatomy in relation to new endoscopic surgical procedures.
More...
| |
| Dr David Simar
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
My research interests are mainly focused on the characterisation of metabolic dysfunctions in the immune system and skeletal muscles as well as the critical role played by inflammation in the development of those alterations in metabolic and immune conditions.
More...
| |
| Dr George Smythe
School of Medical Sciences - Department of PhysiologyStatement of Interests:
Neurodegenerative diseases of aging such as Alzheimer's Disease are associated with oxidative and free radical-induced damage to DNA, proteins, and energy metabolism in the CNS, Of particular interest are diagnostic markers of this damage and the role of anti-oxidants, radical scavengers and metal chelators in attenuating the damage. Collaborative work with neuroscientists at St Vincent's and Prince of Wales Hospitals and Monash University is investigating Alzheimer's and other demeting diseases, Other collaborations with neuroscientists in the UK is investigating malaria-induced brain dysfunction.
More...
| |
| Emeritus Professor David Tracey
School of Medical Sciences - Department of AnatomyStatement of Interests:
My research is in the processes which underlie neuropathic pain. It is based on the hypothesis that inflammatory mechanisms contribute to the pain arising from nerve damage. The research is centred on the types of cells which are likely to be involved (eg mast cells, neutrophils and macrophages) and the chemical mediators which may be responsible (eg serotonin, nerve growth factor, prostaglandins).
More...
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |