Browse Research Interests

Ageing
Allergy
	Dr Cristan Herbert     School of Medical Sciences - Department of Pathology Statement of Interests: Asthma and in vivo models of the disease. Specific interest in the role of Th17 cell cytokines in the development of airway wall remodelling. Also interested in the effect of novel drug treatments on asthmatic lesions. More...
	Dr John Hunt     School of Medical Sciences - Department of Pathology Statement of Interests: My research interests focus on mast cell biology and the discovery and molecular characterisation of novel mast cell proteases. We have recently discovered a number of novel human mast cell tryptases, and we are currently determining their substrate specificity. Another aspect of our work involves the characterisation of factors that control the biology of mast cells. We have demonstrated that IL-15 is one of the most potent mast cell attractants yet reported, and aslo acts to upregulate the expression of ubiquitin-protein ligase 3B, matrix metalloproteinase 9 (MMP9) and apolipoprotein CI (ApoC1) by mast cells. More...
	Professor Rakesh Kumar     School of Medical Sciences - Department of Pathology Statement of Interests: In vivo and in vitro models of the cellular biology and immunopathology of respiratory disease. Major focus is the role of cytokines and growth factors in the pathogenesis of chronic asthma and acute exacerbations, using novel experimental models in mice. Ongoing collaborations with colleagues at the University of Newcastle/Australian National University, using gene-targeted mice and drug/antibody treatments to study the contribution of specific cytokines to inflammation, remodelling and airway hyper-reactivity; and the influence of early-life infections on the severity of chronic disease and susceptibility to acute exacerbations. Expertise in morphometry and immunohistochemistry has led to involvement in various other collaborative projects e.g. related to pancreatic disease and hepatitis. More...
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