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| Dr Romain Barres
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
Type 2 diabetes (T2DM) remains a complex and multifaceted disease, the exact causes of which have yet to be resolved. While genetic predisposition can contribute to the development of T2DM, diet and physical activity can also have a positive impact on insulin sensitivity. Epigenetic modifications provide a mechanism by which external environmental factors such as exercise and diet can modify genetic predisposition for health and disease. My research activity is focused on the mechanisms underlying metabolic disorders with particular attention on human skeletal muscle. We identified that changes in the metabolic environment could lead to a dynamic epigenetic modulation of genes that have been implicated in the control of insulin sensitivity and the development of T2DM and related metabolic disorders.
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| Dr Hui Chen
School of Medical Sciences - Department of PharmacologyStatement of Interests:
The effects of maternal nutrition interventions on appetite, body weight, hormones (plasma leptin, insulin), lipids, and brain peptide expression invovled in appetite and glucose metabolism in offspring are of interest. A palatable high fat diet (32% fat) is being used to induce maternal obesity. This approach will be used to address the possibility of preventing childhood obesity by drugs and behaviour interventions. A second area of study deals with the effects of cigarette smoking on appetite, body weight, plasma leptin, and hypothalamic peptides expression to address wasting diseases.
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| Dr Anthony Kee
School of Medical Sciences - Department of AnatomyStatement of Interests:
Interests are in the fields of muscle physiology and cell biology. Particularly interested in aspects of novel structural and cytoskeletal proteins and complexes and their involvement in normal muscle physiology and disease processes. Diseases of interest include muscular dystrophy and other congenital myopathies, diabetes and obesity. Have an interest in treatment of muscle diseases, including exercise.
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| Dr Arun Krishnan
School of Medical SciencesStatement of Interests:
My major area of interest is in the area of clinical neurophysiology, particularly in the use of nerve excitability techniques as a means of investigating the pathophysiology of neuropathic processes. Measurements of excitability are cutting-edge techniques that provide information related to the activity of a variety of ion channels, energy-dependent pumps and ion exchange processes activated during impulse conduction. These are novel techniques which our group has applied to the study of mechanisms underlying the development of neuropathy and nerve injury. Specifically, we have applied these techniques to the study of metabolic and toxic neuropathies including those that occur secondary to diabetes, end-stage kidney disease (ESKD) and chemotherapy. Other studies have explored the responses of nerves to ischaemia, natural activity and altered electrolyte balance. Recently, excitability techniques have been applied to the assessment of cortical excitability using transcranial magnetic stimulation and we propose to apply these techniques to the study of neurodegenerative processes and central channelopathies.
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| Dr Cindy Lin
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
Clinical application of nerve excitability testing Measuring multiple excitability properties of large human motor and sensory axons using threshold tracking techniques and software (QTRAC © Institute of Neurology), provide information about human axons that is different from, and complementary to, conventional nerve conduction studies. For example, excitability measures are much more sensitive to changes in resting membrane potential than measurements of conduction velocity. These methods are being applied to a range of conditions affecting human peripheral nerves, in order to help determine the pathophysiology of the neuropathy, or to improve diagnosis. Neuropathies currently under investigation include those associated with diabetes, uraemia and other metabolic disorders, and those associated with the chemotherapy in cancers.
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| ![Show details for [<FONT SIZE=2 FACE="Verdana"><b>]Professor Margaret J Morris[</b><br>    <i>School of Medical](/icons/expand.gif) Professor Margaret J Morris
School of Medical Sciences - Department of PharmacologyStatement of Interests:
Obesity - Alterations to brain Neuropeptide Y (NPY) causes increase food intake. Our laboratory is exploring the brain mechanisms involved in appetite. Obesity is a world-wide problem. The brain regulates appetite throught the actions of a complex array of neurotransmitters that either increase or decrease feeding. Professor Morris and her team use animal models of obesity to explore the brain mechanisms involved in appetite, and the changes that occur in these systems during the development of obesity. Their work aims to improve our understanding of how the brain regulates feeding and to provide new insight into potential treatments for obesity and other feeding disorders. Diabetes - The effect of diabetes on how the brain senses hypoglycemia Epilesy - Collaboration with Royal Melbourne Hospital, examining the involvement of NPY on absence seizures. Further work examines the mechanisms by which some anti-epilepy drugs make seizures worse.
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| Dr David Simar
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
My research interests are mainly focused on the characterisation of metabolic dysfunctions in the immune system and skeletal muscles as well as the critical role played by inflammation in the development of those alterations in metabolic and immune conditions.
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