Browse Research Interests
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| Dr Arun Krishnan
School of Medical SciencesStatement of Interests:
My major area of interest is in the area of clinical neurophysiology, particularly in the use of nerve excitability techniques as a means of investigating the pathophysiology of neuropathic processes. Measurements of excitability are cutting-edge techniques that provide information related to the activity of a variety of ion channels, energy-dependent pumps and ion exchange processes activated during impulse conduction. These are novel techniques which our group has applied to the study of mechanisms underlying the development of neuropathy and nerve injury. Specifically, we have applied these techniques to the study of metabolic and toxic neuropathies including those that occur secondary to diabetes, end-stage kidney disease (ESKD) and chemotherapy. Other studies have explored the responses of nerves to ischaemia, natural activity and altered electrolyte balance. Recently, excitability techniques have been applied to the assessment of cortical excitability using transcranial magnetic stimulation and we propose to apply these techniques to the study of neurodegenerative processes and central channelopathies.
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| Dr Michael Lee
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
The broad aim of my research is to provide useful information regarding the adaptability of the human motor system and the nature of neural adaptation in response to exercise and motor learning. Other research interests include the mechanism of chronic pain, effects of pain on the control of movements and neurophysiological effects of various manual therapies commonly used in rehabilitation medicine, physiotherapy and chiropractic.
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| Dr Cindy Lin
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
Clinical application of nerve excitability testing Measuring multiple excitability properties of large human motor and sensory axons using threshold tracking techniques and software (QTRAC © Institute of Neurology), provide information about human axons that is different from, and complementary to, conventional nerve conduction studies. For example, excitability measures are much more sensitive to changes in resting membrane potential than measurements of conduction velocity. These methods are being applied to a range of conditions affecting human peripheral nerves, in order to help determine the pathophysiology of the neuropathy, or to improve diagnosis. Neuropathies currently under investigation include those associated with diabetes, uraemia and other metabolic disorders, and those associated with the chemotherapy in cancers.
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