Browse Research Interests
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| Dr Romain Barres
School of Medical Sciences - Exercise Physiology ProgramStatement of Interests:
Type 2 diabetes (T2DM) remains a complex and multifaceted disease, the exact causes of which have yet to be resolved. While genetic predisposition can contribute to the development of T2DM, diet and physical activity can also have a positive impact on insulin sensitivity. Epigenetic modifications provide a mechanism by which external environmental factors such as exercise and diet can modify genetic predisposition for health and disease. My research activity is focused on the mechanisms underlying metabolic disorders with particular attention on human skeletal muscle. We identified that changes in the metabolic environment could lead to a dynamic epigenetic modulation of genes that have been implicated in the control of insulin sensitivity and the development of T2DM and related metabolic disorders.
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| Dr Thomas Fath
School of Medical SciencesStatement of Interests:
The primary research focus of the lab is on the regulation of the cytoskeleton in neurodegenerative diseases such as Alzheimer's Disease with a particular interest in the microfilament system. For this we employ cell and tissue cultures, prepared from genetically modified mice which express altered levels of the actin dynamics-regulating protein tropomyosin. Other projects in the lab focus on the role of the cytoskeleton in early neuronal development. Recent outcome of these projects demonstrate that tropomyosin isoforms regulate early processes such as neurite formation in an isoform-specific manner.
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| Dr Mark Hill
School of Medical Sciences - Department of AnatomyStatement of Interests:
My current research in the Cell Biology Laboratory is looking at the skeleton within each cell and the biological mechanisms use to change and regulate shape. The description of these mechanisms leads to a better understanding of, and perhaps influence on, these changes occurring in disease, development and during cell repair. Analysis in the School employs the powerful tools of molecular biology, tissue culture and image analysis techniques.
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| Dr Anthony Kee
School of Medical Sciences - Department of AnatomyStatement of Interests:
Interests are in the fields of muscle physiology and cell biology. Particularly interested in aspects of novel structural and cytoskeletal proteins and complexes and their involvement in normal muscle physiology and disease processes. Diseases of interest include muscular dystrophy and other congenital myopathies, diabetes and obesity. Have an interest in treatment of muscle diseases, including exercise.
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| Dr Lu Liu
School of Medical Sciences - Department of PharmacologyStatement of Interests:
Neurochemicals and receptors in regulation of gut function
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| Dr Stephen Palmer
School of Medical SciencesStatement of Interests:
1.Understanding the role of the gene Gtf2ird1 in brain development and human behaviour and its contribution towards the characteristic features of Williams-Beuren syndrome. 2. Understanding the gene regulatory networks involved in the control of muscle fibre type in order to develop strategies to combat the effects of disease and ageing.
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| Ms Nalini Pather
School of Medical SciencesStatement of Interests:
In the field of medical education, collaborative work with collegues as Macquarie University and in South Africa and the USA is concerned with curriculum design and assessment. In the field of cell biology, collaborative work with colleagues in South Africa relates to wound healing and the role of keratinocyte and fibrocyte cell migration. In the field of tissue regeneration, collaborative work at the University of New South Wales focusses on the role of angiogenesis on muscle regeneration and stem cell therapy. In the field of clinical anatomy, collaborative work with clinicians in South Africa and USA is concerned anatomy in relation to new endoscopic surgical procedures.
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